JPH0213589B2 - - Google Patents
Info
- Publication number
- JPH0213589B2 JPH0213589B2 JP59178227A JP17822784A JPH0213589B2 JP H0213589 B2 JPH0213589 B2 JP H0213589B2 JP 59178227 A JP59178227 A JP 59178227A JP 17822784 A JP17822784 A JP 17822784A JP H0213589 B2 JPH0213589 B2 JP H0213589B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- blood purifier
- purifier
- pressure
- sealing member
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008280 blood Substances 0.000 claims description 55
- 210000004369 blood Anatomy 0.000 claims description 55
- 238000007789 sealing Methods 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 230000007423 decrease Effects 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 238000000746 purification Methods 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 4
- 239000012528 membrane Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 5
- 239000012510 hollow fiber Substances 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 3
- 230000023555 blood coagulation Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 230000008602 contraction Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 239000004945 silicone rubber Substances 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Description
【発明の詳細な説明】
［技術分野］
本発明は、吸着型血液浄化器、中空系膜等の膜
型血液浄化器などの血液浄化器に関するものであ
る。更に詳しくは、水又は水溶液が実質上液密に
充填された血液浄化器に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Technical Field] The present invention relates to blood purifiers such as adsorption type blood purifiers and membrane type blood purifiers such as hollow membranes. More specifically, the present invention relates to a blood purifier substantially liquid-tightly filled with water or an aqueous solution.
［従来技術］
近年血液浄化のために吸着型血液浄化器が用い
られているが、当初容器内が液密の状態であつた
ものが長期保管に伴い気泡の発生している血液浄
化器が多く見つけられる。このような血液浄化器
を患者に使用した場合、血液の凝固、溶血、性能
の低下等種々の問題が生ずる。従つて気泡が混入
しない方策が望まれ、容器密栓部に種々工夫がな
されている。[Prior art] In recent years, adsorption type blood purifiers have been used for blood purification, but many of the blood purifiers were originally liquid-tight inside the container, but air bubbles are generated due to long-term storage. can be found. When such a blood purifier is used on a patient, various problems occur such as blood coagulation, hemolysis, and decreased performance. Therefore, measures to prevent air bubbles from entering the container are desired, and various improvements have been made to the sealing portion of the container.
たとえばシリコンゴムを材料とする密栓の場
合、栓のズレ等を防止するた肉厚にしたり、気温
上昇による内液の膨張に耐えるため肉薄で先端を
球状にしたりしているが、双方とも長期保管にお
いて、気泡の混入を防止するには不充分である。 For example, in the case of a seal plug made of silicone rubber, the wall is thick to prevent the plug from slipping, or it is thin and has a spherical tip to withstand the expansion of the internal liquid due to temperature rises, but both types of plugs cannot be stored for long periods of time. However, it is insufficient to prevent the inclusion of air bubbles.
［発明の目的］
本発明の目的は、かかる血液浄化器における気
泡発生の問題を解決し、長期保管においても気泡
発生のなく使用時に血液凝固等のトラブルが発生
することのない優れた血液浄化器を提供すること
にある。[Object of the Invention] The object of the present invention is to solve the problem of air bubble generation in such a blood purifier, and to provide an excellent blood purifier that does not generate air bubbles even during long-term storage and does not cause troubles such as blood coagulation during use. Our goal is to provide the following.
［発明の構成］
本発明は、血液浄化機能部を内蔵した容器、血
液導入部、血液導出部、及び該導出入部の密封部
材を有した血液浄化器において、該血液浄化器内
部の圧力の増減に応じて膨張収縮可能な構造部を
有し、水又は水溶液が実質上液密に充填された状
態で密封され且つ内部の圧力が大気圧よりも高く
維持されており、該充填液の減少に追随して該構
造部が収縮し得ることを特徴とする血液浄化器に
関する。[Structure of the Invention] The present invention provides a blood purifier having a container incorporating a blood purification function section, a blood introduction section, a blood outlet section, and a sealing member for the introduction/exit section. It has a structure that can expand and contract depending on the amount of water or aqueous solution, and is sealed in a substantially liquid-tight state filled with water or an aqueous solution, and the internal pressure is maintained higher than atmospheric pressure. The present invention relates to a blood purifier characterized in that the structure can be contracted accordingly.
以下、本発明についてさらに詳細に説明する。 The present invention will be explained in more detail below.
本発明における血液浄化器とは、人工腎臓、人
工肝臓、血漿分離器、血液濾過器等の血液浄化機
能を有したいからなるものも含まれる。その容器
に内蔵された血液浄化機能部としては、吸着剤を
用いた吸着型、中空糸膜、平膜、管状膜等を用い
た膜型などが挙げられる。該容器には血液導入部
及び導出部が具備されるが、さらに例えば透析液
の導入部、導出部などが具備される場合もあり得
る。これらの導入出部には、密封部材が具備され
るが、該密封部材は導入出部各々に独立に具備さ
れても、複数の導入出部に連結した状態で具備さ
れてもよい。 The blood purifier in the present invention includes devices having a blood purification function such as an artificial kidney, an artificial liver, a plasma separator, and a blood filter. Examples of the blood purification function section built into the container include an adsorption type using an adsorbent, a membrane type using a hollow fiber membrane, a flat membrane, a tubular membrane, etc. The container is equipped with a blood introduction part and a discharge part, but may also be further equipped with, for example, a dialysate introduction part and a discharge part. These introducing/exiting parts are provided with sealing members, and the sealing members may be provided in each introducing/exiting part independently, or may be provided in a state connected to a plurality of introducing/exiting parts.
本発明は、かかる血液浄化器において、内部の
圧力の増加減少に応じて膨張収縮可能な構造部を
有し、水又は水溶液が実質上液密に充填された状
態で密封され、該充填液の減少に追随して該構造
部が収縮し得ることを特徴とするものである。 The present invention provides such a blood purifier, which has a structure that can expand and contract in response to increases and decreases in internal pressure, and which is sealed in a substantially liquid-tight state filled with water or an aqueous solution, and which is sealed in a substantially liquid-tight manner. The structure is characterized by being able to contract in accordance with the decrease.
即ち該血液浄化器は、水又は水溶液が実質上液
密に充填されたものであり、かかる水又は水溶液
は、人体に無害なものであり、例えば蒸留水、生
理食塩水等が挙げられる。また実質上液密に充填
された状態とは、内部空間に完全に液充填された
場合と、例えば吸着剤や膜などの血液浄化機能部
材の内部や、血液以外の透析液等のための空間に
空気が残留している場合等を意味する。言い換え
れば、少なくとも血液の流通する空間において、
水又は水溶液が完全に充填された状態を意味す
る。 That is, the blood purifier is substantially liquid-tightly filled with water or an aqueous solution, and such water or aqueous solution is harmless to the human body, and examples thereof include distilled water, physiological saline, and the like. In addition, a state in which the internal space is filled in a substantially liquid-tight manner means that the internal space is completely filled with liquid, and the other is the case where the internal space is completely filled with liquid, and the case where there is space inside a blood purification function member such as an adsorbent or membrane, or a space for dialysate other than blood. This means that air remains in the area. In other words, at least in the space where blood circulates,
It means completely filled with water or aqueous solution.
また本発明の血液浄化器は、その内容積を増加
せしめる膨張収縮可能な構造部を有している。即
ち第１図に示す如く、吸着剤４を内蔵した容器
１、血液導入部２、血液導出部３、密封部材５及
び膨張収縮可能な構造部１０を有する吸着型血液
浄化器である。尚、膨張収縮可能な構造部の他の
例としては、第２図に示す該構造部１１、第３図
に示す１２、第４図に示す１３、及び第５図に示
す１４等が挙げられる。尚、第４図は、容器１に
中空糸膜６が内蔵され、透析液導入部７及び透析
液導出部８を有する中空糸膜型血液浄化器を示し
ている。 Further, the blood purifier of the present invention has an expandable and deflated structure that increases its internal volume. That is, as shown in FIG. 1, this is an adsorption type blood purifier that includes a container 1 containing an adsorbent 4, a blood introduction part 2, a blood outlet part 3, a sealing member 5, and a structure part 10 that can be expanded and contracted. Other examples of structures that can be expanded and contracted include the structure 11 shown in FIG. 2, 12 shown in FIG. 3, 13 shown in FIG. 4, and 14 shown in FIG. 5. . FIG. 4 shows a hollow fiber membrane type blood purifier in which a hollow fiber membrane 6 is built into a container 1 and has a dialysate inlet 7 and a dialysate outlet 8.
かかる本発明の膨張収縮可能な構造部は、該血
液浄化器内に充填された水が、密封部材やシール
部等を透過するなどして該浄化器外に蒸発し、さ
らには該浄化器内の圧力が大気圧よりも低くなる
ために密封部材等を透過して該浄化器内に空気が
入り込んで気泡が発生することに着目し、たとえ
水が蒸発しても充填液の減少に追随して該構造部
が収縮することによつて、器内の圧力が大気圧よ
りも低くならないように工夫されたものである。 Such an expandable/contractable structure of the present invention allows the water filled in the blood purifier to pass through a sealing member, a sealing part, etc. and evaporate outside the blood purifier, and furthermore, to evaporate inside the blood purifier. Focusing on the fact that air enters the purifier through the sealing member and generates bubbles because the pressure of This structure is designed to prevent the pressure inside the container from becoming lower than atmospheric pressure due to the contraction of the structure.
即ち、該構造部の具体例としては、第１図、第
３図、第４図及び第５図に示す如き容器の一部、
導入出管の一部又は密封部材の少なくとも一部に
設けられた蛇腹状のもの、第２図に示す如き密封
部材として用いられたチユーブ少なくとも一部を
偏平化せしめたもの、密封部材として用いられた
キヤツプ状又は風船状のもの、及び容器や導入出
力部の少なくとも一部を肉薄の伸縮可能な状態に
したもの等が挙げられる。 That is, specific examples of the structure include parts of containers as shown in FIGS. 1, 3, 4, and 5;
A bellows-shaped tube provided on a part of an inlet/outlet pipe or at least a part of a sealing member, a tube used as a sealing member as shown in FIG. 2, with at least a part flattened, Examples include cap-shaped or balloon-shaped ones, and ones in which at least a part of the container or introduction/output part is made thin and expandable.
尚、該構造部の形態としては、風船状の密封部
材の場合にはそれだけで液密状態にすることが困
難であり、液密で溶封することが容易なもの、即
ち偏平チユーブ等が最も好ましい。また該構造部
は血液浄化器に少なくとも１ケ所具備されていれ
ばよく、他の密封部材はいかなるものでもよい。 Regarding the form of the structure, it is difficult to make it liquid-tight with just a balloon-shaped sealing member, and the most suitable form is one that is liquid-tight and easy to melt-seal, such as a flat tube. preferable. Further, it is sufficient that the blood purifier is provided with at least one structure, and any other sealing member may be used.
かかる構造部を形成する材質としては、該浄化
器内の圧力に増減に応じて膨張収縮が可能なもの
であればいずれでもよく、生体過合性に優れたも
のが好ましい。かかる材質の具体例としては、シ
リコンゴム、ポリビニルクロライド等が挙げられ
る。 The material for forming such a structure may be any material as long as it can expand and contract in response to increases and decreases in the pressure within the purifier, and materials with excellent bio-polymerizability are preferred. Specific examples of such materials include silicone rubber and polyvinyl chloride.
該構造部の膨張又は収縮による内容積の変化が
大きい程、気泡の混入防止効果が大きい。 The greater the change in internal volume due to expansion or contraction of the structure, the greater the effect of preventing air bubbles from entering.
さらに本発明の血液浄化器は、内部の圧力が常
圧でもよいが、大気圧よりも高い圧力に加圧され
た状態に保持されていることがより好ましい。即
ち、内圧を大気圧よりも高く維持して前記膨張収
縮可能な構造部を膨張された状態にせしめたもの
であれば、水の蒸発等で充填体積が減少した場合
には、該充填体積の減少に追随して該構造部が収
縮することによつて、内部の圧力が大気圧以下と
なつて気泡が混入することを防止することがより
容易に行い得る。 Further, the blood purifier of the present invention may have an internal pressure at normal pressure, but it is more preferable that the blood purifier is maintained at a pressure higher than atmospheric pressure. That is, if the internal pressure is maintained higher than atmospheric pressure and the expandable/contractable structure is made to be in an expanded state, when the filling volume decreases due to water evaporation, etc., the filling volume will decrease. By contracting the structure following the decrease, the internal pressure becomes lower than atmospheric pressure, and it is easier to prevent air bubbles from being mixed in.
かかる本発明の血液浄化器の内圧は、大気圧以
上、好ましくは0.01Kg／cm2Ｇであり、その上限と
しては１Kg／cm2Ｇが好ましく、0.5Kg／cm2Ｇがさ
らに好ましく、特に0.2Kg／cm2Ｇが好ましい。ま
た該血液浄化器の内部が加圧状態における内容積
（V1）と内部が常圧の場合の内容積（V2）の差
（V1−V2）は、長期保存のうえで、0.05〜10c.c.の
範囲にあることが望ましく、更に好ましくは0.1
〜５c.c.、特に好ましくは0.2〜２c.c.である。 The internal pressure of the blood purifier of the present invention is equal to or higher than atmospheric pressure, preferably 0.01 Kg/cm 2 G, and its upper limit is preferably 1 Kg/cm 2 G, more preferably 0.5 Kg/cm 2 G, particularly 0.2 Kg/cm 2 G is preferred. In addition, the difference (V 1 - V 2 ) between the internal volume (V 1 ) when the inside of the blood purifier is under pressure and the internal volume (V 2 ) when the inside is under normal pressure is 0.05 after long-term storage. It is desirable that it is in the range of ~10 c.c., more preferably 0.1
-5 c.c., particularly preferably 0.2-2 c.c.
尚、本発明の血液浄化器は、滅菌された状態の
ものがそのまま使用できるので好ましい。その滅
菌法としては高温高圧の熱滅菌が好ましく、液密
で密封された状態のまま熱滅菌可能であり、該構
造部がその際の熱膨張の緩衝機能をはたすので操
作が容易である。 The blood purifier of the present invention is preferable because it can be used in a sterilized state as is. The preferred sterilization method is high-temperature and high-pressure heat sterilization; heat sterilization can be performed in a liquid-tight sealed state, and the structure functions as a buffer against thermal expansion, making operation easy.
［発明の効果］
本発明の血液浄化器は、長期間の保存、特に水
が蒸発しやすい高温での長期保存に際し、内部に
気泡が混入することがなく、それ故使用時におけ
る血液凝固等のトラブル発生の危険性がなく、非
常に優れたものである。[Effects of the Invention] The blood purifier of the present invention prevents air bubbles from being mixed inside the blood purifier during long-term storage, particularly at high temperatures where water easily evaporates, and therefore prevents blood coagulation during use. There is no risk of trouble occurring, and it is very good.
［実施例］
容器本体がポリプロピレン内容積500c.c.の血液
浄化器について、密栓部が
Ａ；第２図の１１の如く円筒状の栓（材質塩化ビ
ニール）を金型により偏平状にした後熱水又は
蒸気により70℃〜130℃に加熱処理したもの
（肉厚１ｍ／ｍ）
Ｂ；第１図の１０の如く蛇腹状に成形した栓（材
質塩化ビニール、肉厚0.5ｍ／ｍ）
Ｃ；Ａは同形状の栓（材質塩化ビニール）で偏平
化処理をしないもの（肉厚１ｍ／ｍ）
の各々について温度60℃の熱風乾燥機内で苛酷試
験を行つた。但し、常温での初期内圧及び前記常
圧との内容積差（V1−V2）が各々、Ａでは約0.1
Kg／cm2Ｇ、0.1c.c.、Ｂでは約0.1Kg／cm2Ｇ、0.15c.c.
、
Ｃでは約0.1Kg／cm2Ｇ、約０c.c.であつた。[Example] Regarding a blood purifier with a polypropylene container body having an internal volume of 500 c.c., the sealing part is A; after a cylindrical stopper (made of vinyl chloride) is made into a flat shape with a mold as shown in 11 in Fig. 2. Heat-treated at 70°C to 130°C with hot water or steam (wall thickness 1m/m) B; Plug shaped into a bellows shape as shown in 10 in Figure 1 (material: vinyl chloride, wall thickness 0.5m/m) C A is a plug of the same shape (made of vinyl chloride) without flattening treatment (thickness: 1 m/m) and subjected to a severe test in a hot air dryer at a temperature of 60°C. However, the initial internal pressure at room temperature and the internal volume difference (V 1 - V 2 ) from the normal pressure are each about 0.1 in A.
Kg/cm 2 G, 0.1cc, B approximately 0.1Kg/cm 2 G, 0.15cc
,
In C, it was about 0.1 Kg/cm 2 G, about 0 c.c.
その結果、ＡとＣは、肉厚、表面積が等しい密
栓を使用しているため、同一減少重量直線上にあ
り、気泡の発生はＣが14日、Ａが36日であつた。 As a result, since A and C used airtight plugs with the same wall thickness and surface area, they were on the same weight loss straight line, and bubbles were generated in C in 14 days and in A in 36 days.
又、Ｂについては密栓部の肉厚がＡ、Ｃより薄
くかつ表面積が大であるため重量減少が大きく32
日で気泡が発生した。 In addition, for B, the wall thickness of the sealing part is thinner than A and C, and the surface area is larger, so the weight decrease is large32
Bubbles appeared in the sun.
第１〜５図は、本発明の血液浄化器を例示した
ものである。
１は容器、２，３は血液導入出部、４は吸着型
血液浄化機能部、５は密封部材、６は中空糸膜型
血液浄化機能部、７，８が透析液導入出部、１
０，１１，１２，１３，及び１４が膨張収縮可能
な構造部である。
1 to 5 illustrate the blood purifier of the present invention. 1 is a container, 2 and 3 are blood inlet/outlet parts, 4 is an adsorption type blood purification function part, 5 is a sealing member, 6 is a hollow fiber membrane type blood purification function part, 7 and 8 are dialysate inlet/output parts, 1
0, 11, 12, 13, and 14 are structural parts that can be expanded and contracted.
Claims (1)
部、血液導出部、及び該導出入部の密封部材を有
した血液浄化器において、該血液浄化器内部の圧
力の増減に応じて膨張収縮可能な構造部を有し、
水又は水溶液が実質上液密に充填された状態で密
封され且つ内部の圧力が大気圧よりも高く維持さ
れており、該充填液の減少に追随して該構造部が
収縮し得ることを特徴とする血液浄化器。 ２ 該構造部が、血液と接触する部分に具備され
た特許請求の範囲第１項記載の血液浄化器。 ３ 該構造部が、密封部材に具備された特許請求
の範囲第１項記載の血液浄化器。[Scope of Claims] 1. A blood purifier having a container with a built-in blood purification function part, a blood introduction part, a blood outlet part, and a sealing member for the inlet/outlet part, according to an increase or decrease in the pressure inside the blood purifier. It has a structure that can be expanded and contracted,
The structure is characterized by being substantially liquid-tightly filled with water or an aqueous solution and sealed, and the internal pressure is maintained higher than atmospheric pressure, and the structure is capable of contracting as the filling liquid decreases. Blood purifier. 2. The blood purifier according to claim 1, wherein the structure is provided at a portion that comes into contact with blood. 3. The blood purifier according to claim 1, wherein the structure is provided in a sealing member.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59178227A JPS6158661A (en) | 1984-08-29 | 1984-08-29 | Blood purifier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59178227A JPS6158661A (en) | 1984-08-29 | 1984-08-29 | Blood purifier |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6158661A JPS6158661A (en) | 1986-03-25 |
| JPH0213589B2 true JPH0213589B2 (en) | 1990-04-04 |
Family
ID=16044812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59178227A Granted JPS6158661A (en) | 1984-08-29 | 1984-08-29 | Blood purifier |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6158661A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07107582B2 (en) * | 1986-03-17 | 1995-11-15 | セイコーエプソン株式会社 | Optical scanning device |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53101890A (en) * | 1977-02-18 | 1978-09-05 | Asahi Chemical Ind | Enclosed container for highhpressure steam sterilization |
| JPS572024A (en) * | 1980-06-06 | 1982-01-07 | Seiko Epson Corp | Display cell |
| JPS578620A (en) * | 1980-04-10 | 1982-01-16 | Masson Scott Thrissell Eng Ltd | Forming device for sheet bundle |
| JPS5819266A (en) * | 1981-07-28 | 1983-02-04 | 川澄化学工業株式会社 | Blood purifying device |
-
1984
- 1984-08-29 JP JP59178227A patent/JPS6158661A/en active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53101890A (en) * | 1977-02-18 | 1978-09-05 | Asahi Chemical Ind | Enclosed container for highhpressure steam sterilization |
| JPS578620A (en) * | 1980-04-10 | 1982-01-16 | Masson Scott Thrissell Eng Ltd | Forming device for sheet bundle |
| JPS572024A (en) * | 1980-06-06 | 1982-01-07 | Seiko Epson Corp | Display cell |
| JPS5819266A (en) * | 1981-07-28 | 1983-02-04 | 川澄化学工業株式会社 | Blood purifying device |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6158661A (en) | 1986-03-25 |
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