JPH02111714A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic having anti-inflammatory effect by compounding potassium alum and an acid. CONSTITUTION:The objective product can be produced by compounding a cos metic with 0.001-10wt.% of potassium alum and 0.001-10wt.% of an acid. The cosmetic used as a base is a processed product derived from oils and fats, waxes, hydrocarbons, fatty acids, alcohols, esters, amine-amide or metallic soap, a processed oil and fat product such as surfactant, a perfumery, a gum, a water-soluble polymer or vitamins. The cosmetic can be used in the form of face lotion, milky lotion, cream, lip cream, rouge, foundation, perfumery, eau de Cologne, etc. The anti-inflammatory effect is an action to suppress the inflammation causing the skin eruption such as pimple, folliculitis, rash, heat rashes, etc. Potassium alum is a compound having a chemical name of aluminum potassium sulfate. The acid to be used in the above cosmetic is carboxylic acid or amino acid.

Description

[Detailed description of the invention] (Industrial use) The present invention relates to cosmetics having anti-inflammatory effects.

(Prior Art) Potassium alum is known to have a local astringent effect by binding to proteins and coagulating them. For this reason, it is used in cosmetics such as lotions such as Astringent, aftershave lotions, facial cleansers, and bath additives.

Acids are mainly used in cosmetics to adjust pH.

(Problems to be Solved by the Invention) If cosmetics are to have a specific effect, a specific drug must be added to the cosmetic. However, adding drugs can cause skin problems or significantly reduce the stability of the base over time.For example, sulfa drugs, which are added to acne cosmetics as anti-inflammatory agents, There were problems such as a change in odor and discoloration of the base.

(Means for Solving the Problem) As a result of intensive research, the present inventors discovered that combining potassium alum and acid in cosmetics in a specific ratio has an anti-inflammatory effect, and conducted further research. Result 1 The present invention was completed.

TECHNICAL FIELD The present invention relates to a cosmetic having an anti-inflammatory effect characterized by containing potassium alum and an acid.

The potassium alum used in the present invention has the chemical name potassium aluminum sulfate.

The acid used in the present invention is one used in cosmetics,
Examples of carboxylic acids include malonic acid, citric acid, oxalic acid, succinic acid, fumaric acid, malic acid, tartaric acid, lactic acid, and pyrrolidone carboxylic acid. Examples of amino acids include aspartic acid and glutamic acid.

The anti-inflammatory effect as used in the present invention refers to the effect of suppressing inflammation that causes pimples such as acne, folliculitis (boils), rashes, and heat rash. Pimples such as acne, rash, folliculitis (boils), and heat rash are caused by inflammation in the skin. There are many causes of these inflammations. For example, the sebum trapped within a hair follicle is Pr, the acne-causing bacteria.

Stimulation of fatty acids that are broken down and liberated by lipase produced by bacteria such as Pionibacterium acnes (hereinafter referred to as P acnes);
Staphylococcus aureus infects the hand and causes suppuration, histamine is released from mast cells in the skin tissue and dilates the capillaries, causing erythema, and increased capillary permeability causes plasma proteins and water to drain from the blood vessels. There are some that are caused by leakage into the tissue.

The cosmetics of the present invention include oils and fats, waxes, hydrocarbons, fatty acids, alcohols, esters, amines, amides,
Processed products manufactured from processed oil products such as metal soaps, surfactants, fragrances, gums, water-soluble polymer compounds, vitamins, etc.

Processed products manufactured using these base materials include lotions, milky lotions, creams, lip balms, lipsticks, foundations, perfumes, and colognes.

The amount of potassium alum and acid used in the cosmetic composition of the present invention is preferably 0.001-10% by weight of potassium alum, 0.001-10% by weight of acid, preferably 0.01-5% by weight of potassium alum. %, and the acid is blended at a ratio of 0.01 to 5% by weight.

Regarding the method of adding potassium alum and acid, they may be prepared in advance as an aqueous solution and added during production, or may be selected as appropriate in consideration of workability, but it is sufficient that they are uniform throughout the product.

(Effects of the Invention) The present invention will be explained in more detail below with reference to experimental examples and examples. The present invention is not limited thereby. Note that the numerical values indicate weight percent unless otherwise specified.

The effects of the anti-inflammatory cosmetics of the present invention on the cause of inflammation in pimples were measured.

Tests were conducted on antibacterial activity, inhibition of lipase activity, suppression of histamine release, and antioxidant activity. In addition, actual use tests were conducted to evaluate the effect on breakouts.

1. Antibacterial activity test a, method using acne-causing bacteria (P, acnes) Weigh the anaerobic bacteria broth medium into a test tube, and adjust it to the specified concentration using the sample and distilled water. After sterilization, P. acnes bacterial suspension is added and cultured at 37°C. After culturing, the turbidity of the test tube was observed to determine whether it had antibacterial activity.

b. Method using Staphylococcus aureus Weigh the solid powder of trypto soy broth into a test tube, and adjust it to the specified concentration using the sample and distilled water. After sterilization, Staphylococcus aureus is added and cultured at 37°C. After culturing, the turbidity of the test tube was observed to determine whether it had antibacterial activity.

(Reference material CIIEMOTHERAPY Jan, 1
981Jo129. No. 176-79) 2. Lipase activity inhibition test Using olive oil as a substrate, lipase and a sample were added, fatty acids liberated by lipase action were quantified by alkaline titration, and the lipase activity inhibition effect was measured by comparison with a control. .

(Enzyme Utilization Handbook, Chijin Shokan, 230 Michihin, Kozaki)
233) 3. Histamine release inhibition test Using mast cells taken out and isolated from rats, samples,
Mast cells and a histamine-releasing substance were mixed, the amount of histamine released from the mast cells was quantified, and the inhibitory effect on histamine release was determined by comparison with a control. Concanavalin A (hereinafter referred to as Concanavalin A) is a histamine-releasing substance.
, A) and Compound 48/80 (hereinafter Comp.
48/80) was used.

(Pharmaceutical Journal, 37(4), 374-380.19
83) 4. Antioxidant test Due to the autooxidation of linoleic acid, Fe" becomes Fe" due to the peroxide produced. This is N Ha
Red Rodan iron Fe (SCN) reacts with S CN
The amount of peroxide was measured from its absorbance.

(^gric Biol, Chem, 45(3),
735-739.1981) Table 1 (Examples 1-3) and Table 2 (Comparative Examples 1-3) The manufacturing method of the lotions is as shown in Table 1.2, and the composition is 1 part ethanol, 2-5 parts 9 (BH
A lotion was obtained by mixing a solution of T) and a solution of 6 to 8 in purified water of 10.

Table 3 is Table 1 (Examples 1-3) and Table 2 (Comparative Examples 1-3)
The results of an antioxidant test are shown for the following. Examples 1 to 3 are based on B, which is well known as an antioxidant.
Even when compared with Comparative Example 3 in which HT was blended, there is not much difference in the change in absorbance over time (It can be seen that Examples 1 to 3 have an antioxidant effect.

Comparative example 1 without potassium alum compared to Examples 1 to 3
．． It can be seen that Comparative Example 2, which was acid removed, has almost no antioxidant effect.

Table 4 is Table 1 (Examples 1-3) and Table 2 (Comparative Examples 1-2)
The results of a lipase activity inhibition test are shown below.

The lipase activity inhibition rates of Examples 1 to 3 were 50% or more, indicating that they were quite effective. In comparison, the lipase activity inhibition rates of Comparative Examples 1 and 2 were 6% or less, indicating that there was almost no effect.

As for the manufacturing method of the emulsion in Table 5, the oil phase (1 to 6)
is heated and dissolved at 70°C, and into the solution, 7 and 8 to 12 are dissolved in advance by heating and heated to 70°C, and then added with stirring to emulsify. This was cooled to 30°C to obtain a milky lotion.

Table 6.7 shows the results of an antibacterial activity test against P. acnes and Staphylococcus aureus for Table 1 and Table 5 (Example 4.5 and Comparative Example 4.5).
No. 5 exhibited antibacterial activity against P. acnes and Staphylococcus aureus at sample concentrations of 70% or higher. However, in Comparative Example 4.5, P, acnes
It did not show antibacterial activity against bacteria and Staphylococcus aureus.

In Table 8, the histamine release inhibiting effect was measured for Table 5 (Example 4.5 and Comparative Examples 4 and 5).

Example 4.5 shows that histamine releasing substances Con, A and C
In both cases of omp and 48/80, the histamine release inhibition rate was 90% or more, indicating high effectiveness. However, in Comparative Examples 4.5, the concentrations were all 6% or less, and there was no effect of inhibiting histamine release.

The cream in Table 9 was manufactured in the same manner as the emulsion in Table 1, by heating and dissolving the oil phase (1 to 5) at 70°C, and then heating and dissolving the aqueous phase (6 to 11), which had been previously heated and dissolved at 70°C. Add to the oil phase while stirring and emulsify. This was cooled to 30°C to obtain cream.

Table 10 shows the results of the use tests shown in Table 9 (Example 6.7 and Comparative Example 6.7). The test subjects were people who were suffering from breakouts, and they used the product for two weeks to see the effect on breakouts before and after use. The effect on breakouts was evaluated by the method shown below in Table 10. From this result, it can be seen that Examples 6 and 7 are quite effective against breakouts.

(Margin below) Shu IX Shiki” Table 3 Converting test Lλ” L Keiyu Table 4 Lipase activity inhibition Fruit Table 5 Example 1 Comparison Table 7 yellow grape bulb against 6' P.

Force against O: No bacterial growth Δ; Slight bacterial growth ×: The sample concentration at which bacterial growth is observed is the ratio of the sample to distilled water during the antibacterial activity test operation. For example, the sample concentration is 60%.

The sample and distilled water were mixed at a ratio of 6:4 and measured.

Table 8 Histamine release inhibition Fruit 9 Stream side Philippines and Italy “Mori” “Shima” uL heavy A pond that is effective for 30 Å or more out of 50 people It was effective for more than 20 Å out of 50 people.

It was effective for more than 10 Å out of 50 people.

It was effective in less than 10 Å out of 50 people.

Claims (1)

[Claims] A cosmetic having an anti-inflammatory effect characterized by containing potassium alum and acid.