JPH0157085B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to pellets that are orally administered to ruminants and are beneficial to ruminants after passing through the rumen and reaching the abomasum and/or intestines. More specifically, the present invention protects the nucleus in the presence of nuclear substances such as nutrients or drugs and in the environment of the rumen, but loses its continuity under the more acidic conditions of the abomasum. The present invention relates to a pellet having a non-porous coating over the nuclear material which renders the nuclear material usable to animals. In ruminants, ingested food first enters the rumen, where it is predigested or broken down by fermentation. During this fermentation period, the ingested food passes through the reticulum (abumina) and is returned to the mouth, where it is covered with saliva and chewed. After completion of fermentation, regulated by natural processes and variables that vary from animal to food, absorption of the ingested nutrients begins and continues in subsequent parts of the digestive tract by the ruminant. This process is described in “Digestive” by DCChunch.
Phycology and Nutrition of Ruminants”
Vol.1, OSUBook Stores, Inc, Corvallis
detailed in Oregon. The rumen is the largest of the four gastric chambers of ruminants and serves as an important site for the metabolic breakdown of ingested food through the action of the microorganisms that reside within it. Ingested food typically remains in the rumen for about 6 to 30 hours, and sometimes longer, during which time it undergoes metabolic breakdown by the rumen's microorganisms. Much of the ingested protein material is degraded in the rumen to soluble peptides and amino acids that are utilized by the rumen microorganisms. Once the ruminal contents enter the abomasum and intestine, the microbial population is digested, thus providing protein to the ruminant. Thus, the natural nutritional balance of ruminants is primarily a function of microbial composition and individuality. During nutrition and manufacturing for administration to ruminants, the environmental conditions of the rumen, protecting the active ingredients from the effects of microbial degradation and a pH of approximately 5.5, allow the active substances to reach a specific point where absorption occurs. It is important to keep it up to. Meat, wool and/or milk production rates are increased if essential amino acid sources and/or drugs are kept unchanged by microorganisms living in the rumen and later absorbed directly by the animal in the gastrointestinal tract. is well known. The substances that protect the nucleus from degradation by the ruminal contents resist the attack of the rumen fluid containing enzymes or microorganisms, but the more acidic fluid of the abomasum at a pH in the normal physiological range of about 2 to 3.5. The active ingredient must be rapidly available within the system. In order to more easily coat or encapsulate the active ingredient with a protective substance, the protective substance must be soluble in the specific organic solvent for the purpose of coating. Since proteins are degraded in the rumen, it has been proposed to treat protein-containing nutrients given to ruminants so that they can pass through the abomasum without being degraded by microorganisms in the rumen. Proposed methods include coating protein-containing substances, for example with fats or vegetable oils, heat treating proteins, treating protein-containing substances with various compounds such as formaldehyde, acetylenic esters, polymerized unsaturated carboxylic acids or anhydrides and phosphorus. This included reactions with nitrile halides, etc. All proteins found in animals and plants are
It is a compound that contains more than 20 different combinations of amino acids, and the number and arrangement of such acids is determined in any particular protein. Although 12 of these amino acids can be synthesized in nutritionally sufficient quantities from other substances through biochemical processes that are normally present in most animals, the remaining 10 essential amino acids cannot be synthesized in sufficient quantities. , animals must ingest these. Since the proportion of amino acids that make up a particular protein cannot be changed, the essential amino acid that is supplied in the least amount limits the amount of protein material that can be produced by an animal. Thus, for any given diet, a particular essential amino acid will limit the production of the protein containing it, but of course more than one such amino acid may be limiting together. . Recognizing the above principles results in formulations of non-ruminant diets that provide optimal proportions of amino acids and allow significant increases in protein production to be achieved. In ruminants, dietary proteins and amino acids are degraded to varying degrees by microbial fermentation in the first two chambers of the stomach (ie, the rumen and reticulum) into ammonia and various organic compounds. Bacteria and protozoa in these organs utilize this metabolite for their own growth and multiplication, and the microbial proteins thus produced pass into the abomasum. The abomasum is a gastric chamber corresponding to the stomach of non-ruminants, where it is partially digested. This process is completed in the small intestine, where the amino acids are absorbed. It is also known that the drug is more effective when it is protected from the ruminal environment. For example, US Patent No. 3041243, US Patent No. 3697640, US Patent No.
Please refer to No. 3619200 and No. 3275518. Polymeric substances containing at least one basic amino group and having a nitrogen content of 3 to 14% of its molecular weight, such as cellulose propionate morpholinobutyrate, a copolymer of styrene and 2-methyl-5-vinylpyridine The protection of the nuclear material in the abomasum is not sufficient to make it available in the abomasum and/or intestine. The present invention relates to nuclear substances and basic amino groups and 3 to 14
% nitrogen content and a protective coating containing a polymeric material that provides sufficient protection to the nuclear material in the ruminant environment. The invention has a PH higher than 5.5,
having a nuclear material beneficial to the ruminant in the bag than the rumen and a covering surrounding the nuclear material, the covering being insoluble in the ruminant medium in the ruminant but soluble after the ruminant; and the coating comprises a polymeric substance and a hydrophobic substance dispersed in the polymeric substance, a) the polymeric substance contains at least one basic amino group, and the nitrogen content in the polymeric substance is is 3 to 14% of the molecular weight of the polymeric substance; and b the hydrophobic substance is selected from fatty acids having 12 to 32 carbon atoms, aluminum salts of fatty acids having 12 to 32 carbon atoms, dimer acids and trimer acids. selected from the group consisting of; the hydrophobic substance is present in the coating in an amount of 2 to 75% by weight of the polymeric substance, the coating comprises 5 to 50% by weight of the pellet, and at least
This is a pellet for oral administration to ruminants, characterized by having a sticking temperature of 50°C. The coating or film-forming material according to the invention provides protective and release properties and contains a mixture or blend of at least one "polymeric" material and at least one "hydrophobic" material. The polymeric material is a substantially continuous matrix and accounts for 25-98% by weight of the coating material.
In general, more acidic and more soluble nuclear materials require a higher ratio of hydrophobic to polymeric materials in the above range, while more basic and less soluble materials require a higher ratio of hydrophobic to polymeric materials in the above range. It is necessary that the ratio is lower in the above range. The hydrophobic material is dispersed in the polymeric matrix and accounts for 75-2%, preferably 50-5% by weight of the coating material. The coating material has the ability to withstand the environmental conditions of the abomasum and to expose the core material of the pellet in the abomasum environment. Thus, the coating material is at least
Tolerant to PH conditions of 5.5 for 24 hours. The coating material is PH
When exposed to abomasum or intestinal environmental conditions of 3.5, it releases nuclear material within 10 minutes to 6 hours. Exposure of the core occurs by the coating becoming permeable to liquid or by dissolution or decomposition. Another requirement for the coating material is that it be resistant to relatively high temperature and/or humidity storage conditions without significant amounts of blocking. Nuclear materials with a PH higher than 5.5 are very useful in the present invention. Thus, any nuclear material that is beneficial to ruminants, such as nutrients or drugs, that has properties that fall within these parameters can be used.
Preferred nuclear materials include amino acids, proteins, various other nutrients, and antibiotics and other drugs. [Pellets] The pellets produced according to the present invention are suitable for oral administration to ruminants. The pellets have a suitable size, such as 0.05 to 0.75 inches in diameter. Similarly, the pellets must have a suitable density, i.e., a specific gravity of 1 to 1.4, and have acceptable odor, taste, texture, etc. The pellet contains a core and a continuous membrane or coating that completely encapsulates the core. The shape is usually not important except that the pellets are usually spherical for ease of coating. [Nuclear material] The nucleus contains substances that are beneficial to the ruminant when it reaches the abomasum and/or intestine. A core is a solid material that has been shaped into particles, for example by granulation.
The core may then be rounded, if desired, by conventional means such as inversion. The core must have sufficient stickiness and consistency so that it remains unchanged during handling, especially during coating operations. Suitable nuclear substances include various drugs and nutrients such as antibiotics, relaxants, drugs, anthelmintics, amino acids, proteins, sugars, carbohydrates, and the like. The core may also contain an inert filler such as clay. The ability of the coating to protect the core is related to the PH and water solubility of the core. Nuclear materials to which the present invention can be applied are
It has a pH higher than 5.5. Several amino acids suitable for use as nuclear materials, their PH and solubility are listed below.

[Coating]

The coating material can form a continuous film around the core by evaporating the solvent from the coating material. It has the ability to withstand the environmental conditions of the abomasum and to expose the core material of the pellet in the abomasum environment.
Thus, the coating material must withstand PH conditions higher than 5.5 for at least 24 hours, preferably 30 hours. The coating material must release nuclear material after exposure to abomasum environmental conditions of pH 2-3.3. Release occurs during residence time in the abomasum or later intestine, provided that
You must wake up within at least 6 hours after coming into contact with a pH below 3.5. Exposure of the core occurs, for example, by dissolution, disintegration or extensive swelling, which causes the coating to become permeable to the ruminal contents.
The coating material is physiologically suitable. That is, the covering must not interfere with the healthy, ie, normal, bodily functions of the ruminant. Another requirement for the coating material is the ability to withstand relatively high heat and/or humidity storage conditions without significant amounts of blocking. This is 50℃
It must have a higher adhesive density.
Adhesion temperature is defined as the temperature at which sufficient adhesion occurs to cause failure of the coating when the coated particles are forced apart when the particles are kept in contact for 24 hours by applying a force of 0.25 kg/ ^cm2 . be done. In addition, the coating material is 40 to 140%, so that conventional coating methods such as spray application can be used.
It is preferably dissolved or dispersed in an organic solvent having a boiling point of °C. In particular, suitable solvents are methylene chloride, chloroform, ethanol, methanol, ethyl acetate, acetone, toluene, isopropanol or mixtures thereof. The coating or film-forming material according to the invention contains a mixture or blend of at least one "polymeric" material and one "hydrophobic" material. The polymer material is a continuous matrix and accounts for 25-8% of the coating weight.
occupies Generally, for more acidic and more soluble nuclear materials the ratio of hydrophobic to polymeric material should be at the higher end of this range, while for more basic and less soluble nuclear materials the ratio of hydrophobic to polymeric material should be at the higher end of this range. The ratio of material to polymeric material should be lower.
The hydrophobic material is usually dispersed within the polymeric matrix and is preferably present in an amount of 5 to 50% by weight of the polymeric material. [Polymer] The polymerizable material useful in the coating of the present invention, in combination with the hydrophobic material described below, is physiologically suitable and has a PH of greater than 5.5 at normal body temperature for ruminants (37°C). Including those capable of releasing pellet kernels at pH lower than 3.5.
Suitably, this polymeric material has a nitrogen content of 3 to 14% of its molecular weight and has at least one basic amino group. polymer,
It includes a copolymer and a mixture of polymers and/or copolymers, and preferably has a molecular weight of 5,000 to 300,000. The basic amino group may be of an aliphatic type or an aromatic type in which it is directly bonded to or forms part of an aromatic ring. In the case of aliphatic type, it contains 3 to 10% by weight of nitrogen in the basic amino group, and in the case of aromatic type, it contains 6 to 14% by weight of nitrogen in the basic amino group. is suitable. Polymeric substances with the properties defined in this document include specific modified natural polymers, monopolymers and copolymers obtained by addition polymerization methods, monopolymers and copolymers obtained by condensation polymerization methods, and Contains a mixture of. The polymeric substance is a cellulose derivative such as cellulose propionate morpholinobutyrate; one type of monomer is acrylontolyl, vinylpyridine,
Copolymers of vinylcarbazole, vinylquinoline, N-vinylpyrrole and 5-vinylpyrazoline; nitrogen-containing monomers and styrene, methylstyrene, vinyltoluene, esters and amides of methacrylic acid, esters and amides of acrylic acid, ethylene, propylene, butadiene, vinyl acetate,
Copolymers with comonomers such as vinyl propionate and vinyl stearate; diacids such as phthalic acid, terephthalic acid, and succinic acid are combined with polyfunctional alcohols so that the acid or glycol moieties are polymerized. In a polymerization process, a condensation-type polyester and the same or similar diacid react with a polyfunctional amine to form a polyester that may contain basic nitrogen that is unreactive but reactive to variable PH environments. Condensation-type polyesters to form polyamide-type polymers containing unreacted basic nitrogen and pre-made polymers formed by reacting the polymer present with nitrogen-containing organic or inorganic moieties, e.g. leaving behind ammonia. at least one polymer, copolymer, or polymer blend selected from the group consisting of other basic nitrogen-containing polymers, such as polybutadiene, which have been reacted with double bonds that are attached thereto. Particularly preferred are copolymers of various isomers and derivatives of vinylpyridine copolymerized with one or more monomers of the addition type mentioned above, such as 65% by weight of 2-methyl-5-vinylpyridine and 35% by weight of vinylpyridine. % acrylontrile. Similarly, particularly preferred is 2-methyl-5-
Copolymers of vinylpyridine and styrene, and especially copolymers of 80% by weight 2-methyl-5-vinylpyridine and 20% by weight styrene, are commercially available, but using conventional techniques well known in the art. It can be manufactured by [Hydrophobic substance] High molecular weight polymers and hydrophobic substances have properties such that the membrane does not change in the rumen environment and allows rumen juice to penetrate into the nucleus when pellets are present in the rumen. is necessary. For this purpose, the hydrophobic substance must be compatible with the polymer. Hydrophobic substances that are physiologically relevant and have suitable compatibility with high molecular weight polymers are available commercially. A valuable and usable hydrophobe is the carbon atom
fatty acids having 12 to 32 carbon atoms, aluminum salts of fatty acids having 12 to 32 carbon atoms, dimer acids or trimer acids. These hydrophobic substances need to be dissolved or colloidally dispersed in the solvent used during coating formation. here,
Dimer acids are viscous liquids produced by dimerization of medium molecular weight fatty acids;
Usually contains 36 carbon atoms. It is a stable and heat-resistant compound that can be polymerized with alcohols and polyols to produce products such as plasticizers, lubricating oils, and hydraulic fluids. Trimer acids are viscous liquids produced by trimerization of medium molecular weight fatty acids, usually containing 54 carbon atoms. Properties, uses, etc. are similar to dimer acid. Fatty acids having 12 to 32 carbon atoms include lauric acid, oleic acid, stearic acid, palmitic acid and linoleic acid. Although these acids are insoluble in water due to the long hydrocarbon radical, it is well known that they react with water due to the polar nature of the carboxyl group. In selected basic amino group-containing polymers, the carboxyl groups of fatty acids can react with basic nitrogen groups to form weak salt-type bonds. This bonding to the polymer fixes the fatty acid to the polymer matrix. The hydrophobic hydrocarbon chains of the fatty acids make the matrix water resistant and reduce the swelling of water sensitive polar membranes. As a result, the interior and surface of the matrix membrane becomes water resistant in an aqueous environment with a pH higher than 5.5.
However, at PH below 4.5, especially below PH 3.5, the affinity of basic nitrogen for water and hydrogen atoms outweighs the increased water resistance. The membrane reacts in the acid environment, loses its blocking properties, and the nuclear material is released into the surrounding environment. Further, specific examples of aluminum salts of fatty acids having 12 to 32 carbon atoms include stearates, oleates, palmitates, and the like. It is also possible for natural or synthetic waxes and/or resins to be present in the coating. wax and resin
It has a molecular weight of 500 to 2000 and has a “Contact Angle”
Wettability and Adhesion”，Advances in
Chemistry Series #43, edited by Robert F. Gould,
When measured by the Zisman method described in Chapter 1, published by the American Chemical Society, 1963,
Those having a critical surface tension of less than 31 dynes/cm and a solubility in the coating of less than 5% are useful. These waxes and resins can be dispersed in the coating in an amount equal to or more than twice the solubility and less than 30% of the total amount of high molecular weight polymer in the coating. Examples of typical waxes and resins include beeswax, petrinium wax, dammar, hard manila, phenolic resins, rosin, and maleated low molecular weight polyhydrocarbons. Similarly, it has a molecular weight of 2000 to 10000 and a critical surface tension of less than 31 dynes/cm as measured by the Zisman method described above;
Polymers having a solubility in the coating of less than 5% by weight can also be used. The polymer may also be present in the coating in an amount greater than or equal to twice its solubility and less than 30% of the total amount of high molecular weight polymer in the coating. Particularly useful polymers are polymers and copolymers containing silicone groups in the backbone or side chains, and polymers and copolymers containing fluorinated carbon groups in the side chains. There is no particular theory as to why coatings containing hydrophobes are more protective. However, its function is usually thought to be due to the greatly reduced susceptibility of the entire matrix membrane or coating to aqueous, slightly acidic environments. Furthermore, given the inherent polarity of polymers containing sufficient basic nitrogen for the differences in rumen and abomasum PH, especially when the nuclear material is acidic and/or very water soluble. , a reduction in the water sensitivity of the membrane is considered necessary. Although the above is generally considered, there are subtle differences in how a hydrophobic substance exerts its function depending on its form. We have shown that the function of hydrophobic substances when used as a dispersed phase in a coating layer is to a) reduce the wetting of the coating and thus reduce the initial attack by water, and b reduce the total volume of the coating soaked by water. and c to increase the length of the penetration path required for water to reach the core. The following examples provide a better understanding of the invention. Although the Examples are based on in vitro studies, the in vitro experiments shown in the Examples mimic conditions existing in ruminant animals and therefore can be coated without using actual live animals. You can research pellets. Testing of the pellets in the aqueous medium used in the examples, which mimics the environmental conditions of the rumen and abomasum in terms of temperature, pH, etc., provides reliable data regarding the protection afforded by the coating within the rumen and the release properties of the coating within the abomasum. It was confirmed through actual in-vivo tests that it provides the following properties. It is known that nutrients such as amino acids and proteins available in nuclear material are beneficial to ruminants when they are in the intestinal tract downstream from the rumen. Reference example 1 600g of finely powdered lysine monohydrochloride, 60g of particle size 250
A substantially homogeneous mixture was obtained by dry mixing the mesh microcrystalline cellulose and 6 g of gum arabic. 195 g of water was extruded into a powder mixture and a homogeneous plastic dough was cut to a diameter of 2.38 mm (3/32 inch) and height.
A 2.38 mm (3/32 inch) cylindrical pellet was obtained.
These pellets were rolled by inversion for 5 minutes in a rotating drum and dried at 60°C. The dried pellets were divided to obtain pellets in the range of 8 to 12 meshes with a yield of 85%. The pellets were passed through a spray zone containing atomized droplets of polymer dispersed in a luminescent solvent. The coating equipment could recirculate the pellets through (a) the coating zone, (b) the drying zone, and (c) the storage zone so that multiple coats of polymer could be applied to each pellet. In this example, the polymer was cellulose propionate morpholinobutyrate containing 3.0% basic nitrogen. The polymers were soluble in organic solvents such as ketones, esters, aromatic hydrocarbon-alcohol mixtures, halogenated aliphatic hydrocarbon-alcohol mixtures, and water with a PH below 3.5. The polymer was dissolved in acetone at a content of 6% by weight relative to the total weight of the solution. The coating operation continued for a period of time necessary to coat substantially all of the pellets with a layer of dry polymer having a thickness of 0.15 mm (0.006 inches) and representing 17-20% of the final weight of the coated pellets. . During the coating operation, samples of coated pellets were obtained with coatings deposited at 5, 10 and 15% based on their total weight. These pellets were tested for pellet dissolution resistance at PH 5.5 and 3.0 as a function of coating weight. PH5.5 test is 24
The test for PH3.0 was 1 hour. All pellets were not stable in aqueous media with pH values between 3.0 and 8.0. The pellets were also unstable in the rumen of sheep and cattle. Example 1 Lysine hydrochloride prepared by the method described in Reference Example 1 was coated with a mixture consisting of 60% by weight of cellulose propionate morpholinobutyrate and 40% by weight of -basic aluminum dioleate. This mixture was used as a 4% by weight solution in a mixed solvent of 90% methylene chloride and 10% methanol by volume. The pellets were coated in the same manner as described in Reference Example 1. The final coating applied to the pellets constitutes 20% by weight of the coated pellets. Lysine-hydrochloride was 65% retained after 24 hours in pellets exposed to aqueous medium at pH 5.5. All amino acids were removed from the pellet by treating the pellet at PH3.0 for 1 hour. Example 2 A substantially homogeneous powder was obtained by dry mixing 730 g of lysine-hydrochloride, 91 g of basic magnesium carbonate, 73 g of microcrystalline cellulose with a particle size of 250 mesh, and 73 g of gum arabic. 250 g of water was mixed with this powdered mixture until a plastic dough-like consistency was obtained. The dough was extruded, cut, rolled and dried as described in Reference Example 1. It was then coated with a polymer mixture as described in Example 1. The pellets containing 20% dry coating resisted dissolution upon exposure to aqueous conditions of PH 5.5 as indicated by 94% recovery of lysine-hydrochloride after 24 hours exposure. Lysine-hydrochloride was removed from the pellet in 1 hour when exposed to aqueous conditions below 3.0. Reference Example 2 The pellets described in Example 2 containing lysine-hydrochloride and basic magnesium carbonate were coated with 20% by weight of cellulose propionate morpholinobutyrate. 85% when tested for stability at PH5.5
of lysine-hydrochloride was eluted from the pellet. Therefore, the pellets have a pH typically found within the rumen.
The value was not stable. Example 3 40g cellulose propionate morpholinobutyrate and 13g oleic acid (0.047 equivalents) were mixed with 900ml trichlorethylene, 100ml methanol and 100ml
of dichloromethane. The solution was coated using a fluidized bed method onto 150 g pellets consisting of 83% lysine-hydrochloride, 6% calcium carbonate and 11% of a suitable binder. The coated pellets retained 48% of the lysine content after 24 hours of stirring with an aqueous buffer at pH 5.5;
Release 100% of the contained amino acids during a stirring period of 2.9 hours in the presence of an aqueous buffer. Example 4 This example is the same as Example 3 except that 0.094 equivalents of oleic acid was included in the coating composition. The coated pellets retained 54.5% of the lysine content after water treatment at pH 5.5 for 2 hours, and released 100% of the amino acids after stirring for 1 hour at pH 2.9. Example 5 This example is the same as Example 3 except that 0.047 equivalents of stearic acid was used in place of oleic acid. 71% of the pellet sample remained unchanged after stirring in an aqueous solution at pH 5.5 for 24 hours. Example 6 This example uses Empol1010Dimer Acid (C ₃₆ aliphatic dibasic acid, Emery Industries, Inc.,
Same as Example 3 except that oleic acid (Cincinnatti, Ohio) was used instead of oleic acid. coated pellets
After 24 hours of extraction with an aqueous solution at pH 5.5, 90% of the amino acids contained were retained, and 100% of the lysine contained was released during stirring at pH 2.9 for 1 hour. Example 7 80% 2-methyl-5-vinylpyridine/20% styrene and dodecanoic acid calculated to be equivalent to the basic functionality present are dissolved in trichlorethylene or other suitable solvent and methionine pellets are dissolved. A nutritional composition useful for ruminants was obtained. Examples 8-35 In the examples in the table below, the coating was about 20% of the pellet weight. The results were expressed in terms of percentage of pellets retained and percentage of pellets released under different environmental conditions.

[Table] Tolyl copolymer

【table】

[Table] Unless otherwise specified, all percentages, ratios, parts, etc. are by weight. The liquid used to mimic the environmental conditions of the rumen (PH 5.5) was 11.397 g of sodium acetate and 1.322 g of sodium acetate.
of acetic acid and dilute this mixture with deionized water for 1 hour.
It was adjusted by diluting it to The liquid used to mimic the environmental conditions of the abomasum (PH 2.9) was a mixture of 7.505 g of glycine and 5.85 g of sodium chloride, and the mixture was diluted with deionized water.
It was prepared by diluting it to Eight parts of this solution were mixed with two parts of 0.1N hydrochloric acid for the test liquid. The above fluid was found to give reliable results when tested on pellets following similar experiments using actual ruminal and abomasal fluids extracted from ruminants. In order to be useful and practical as ruminant feed, the core of the pellet to which this invention relates should contain at least 60%, preferably at least 75%, of the active substance.
is stable in the abomasum and must be released in the abomasum. The coating may also contain physiologically suitable flake materials within the coating. The flake material must be substantially inert under the rumen environment. Suitable flake materials include metal flakes, mineral flakes, crosslinked organic polymers, and the like. Particularly suitable flake materials are aluminum flakes, talc, graphite and ground mica.

Claims (1)

[Scope of Claims] 1. Having a pH higher than 5.5 and having a nuclear material beneficial to the ruminant after the ruminant and a coating surrounding the nuclear material, the coating is present in the ruminant medium within the ruminant. insoluble but soluble after the rumen, and the coating consists of a polymeric substance and a hydrophobic substance dispersed in the polymeric substance, a polymeric substance containing at least one base the nitrogen content in the polymeric substance is 3 to 14% of the molecular weight of the polymeric substance; and b. the hydrophobic substance is a fatty acid having 12 to 32 carbon atoms, 12 to selected from the group consisting of aluminum salts of fatty acids, dimer acids and trimer acids having 32 acids;
Pellet for oral administration to ruminants, characterized in that it is present in the coating in an amount of ~75%, the coating constitutes 5-50% of the weight of the pellet, and has a sticking temperature of at least 50°C. . 2. The pellet according to claim 1, wherein the polymeric substance is cellulose propionate morpholinobutyrate. 3. The pellet agent according to claim 1, wherein the polymeric substance is a copolymer of vinylpyridine and styrene. 4. The pellet agent according to claim 1, wherein the polymeric substance is a copolymer of 80% by weight of 2-methyl-5-vinylpyridine and 20% by weight of styrene. 5. The pellet agent according to claim 2, wherein the hydrophobic substance is aluminum dioleate. 6. The pellet agent according to claim 4, wherein the hydrophobic substance is stearic acid. 7. The pellet agent according to claim 4, wherein the hydrophobic substance is dimer acid.