JPH01500085A - suture material - Google Patents
suture materialInfo
- Publication number
- JPH01500085A JPH01500085A JP61504747A JP50474786A JPH01500085A JP H01500085 A JPH01500085 A JP H01500085A JP 61504747 A JP61504747 A JP 61504747A JP 50474786 A JP50474786 A JP 50474786A JP H01500085 A JPH01500085 A JP H01500085A
- Authority
- JP
- Japan
- Prior art keywords
- suture material
- thickness
- suture
- copolymer
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003356 suture material Substances 0.000 title claims description 44
- 238000002360 preparation method Methods 0.000 claims description 28
- 229920001577 copolymer Polymers 0.000 claims description 23
- 239000000758 substrate Substances 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 19
- 230000000845 anti-microbial effect Effects 0.000 claims description 11
- 239000004599 antimicrobial Substances 0.000 claims description 10
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 9
- 238000006065 biodegradation reaction Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- -1 alkyl methacrylate Chemical compound 0.000 claims description 4
- 125000005250 alkyl acrylate group Chemical group 0.000 claims description 3
- 229920002988 biodegradable polymer Polymers 0.000 claims description 2
- 239000004621 biodegradable polymer Substances 0.000 claims description 2
- 239000002023 wood Substances 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 description 18
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 8
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 description 8
- 239000002253 acid Substances 0.000 description 5
- 229920006051 Capron® Polymers 0.000 description 4
- 229920002292 Nylon 6 Polymers 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 229910000831 Steel Inorganic materials 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- 210000001562 sternum Anatomy 0.000 description 3
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 3
- 229940124530 sulfonamide Drugs 0.000 description 3
- RDEIXVOBVLKYNT-VQBXQJRRSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]o Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)C(C)N)N)[C@@H](N)C[C@H]1N.O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-VQBXQJRRSA-N 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000003872 anastomosis Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 2
- 229960000318 kanamycin Drugs 0.000 description 2
- 229930027917 kanamycin Natural products 0.000 description 2
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 2
- 229930182823 kanamycin A Natural products 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- OWFJMIVZYSDULZ-PXOLEDIWSA-N (4s,4ar,5s,5ar,6s,12ar)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O OWFJMIVZYSDULZ-PXOLEDIWSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 235000002991 Coptis groenlandica Nutrition 0.000 description 1
- 244000247747 Coptis groenlandica Species 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- DYAHQFWOVKZOOW-UHFFFAOYSA-N Sarin Chemical compound CC(C)OP(C)(F)=O DYAHQFWOVKZOOW-UHFFFAOYSA-N 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 206010046996 Varicose vein Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229940027988 antiseptic and disinfectant nitrofuran derivative Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 201000001352 cholecystitis Diseases 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229920005570 flexible polymer Polymers 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 229930185127 geomycin Natural products 0.000 description 1
- 230000004313 glare Effects 0.000 description 1
- 210000001983 hard palate Anatomy 0.000 description 1
- 201000000615 hard palate cancer Diseases 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229940058961 hydroxyquinoline derivative for amoebiasis and other protozoal diseases Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000001847 jaw Anatomy 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical class NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 1
- 239000000082 organ preservation Substances 0.000 description 1
- 210000004738 parenchymal cell Anatomy 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 150000003017 phosphorus Chemical class 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- 150000003252 quinoxalines Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 210000001584 soft palate Anatomy 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 208000027185 varicose disease Diseases 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S525/937—Utility as body contact e.g. implant, contact lens or I.U.D.
Abstract
(57)【要約】本公報は電子出願前の出願データであるため要約のデータは記録されません。 (57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】 縫合材 発明の分野 本発明は、医学工学の技術、より詳しくは縫合材に関する。[Detailed description of the invention] suture material Field of invention The present invention relates to medical engineering techniques, and more particularly to suture materials.
従来の技術 抗菌活性を有する非分解性縫合材、たとえば化学結合によってそれらの上に固定 された抗菌性調製物、ゲオマイシンを有するポリエチレンテレフタレート又はポ リプロピレンに基づく縫合材は、当業界で知られている。これらの縫合材は、２ 日間、柔組織及び抗菌効果の維持を確保する（＾、＾、Ｓｈａｌｉｍｏｖ久ζ、 、Ｐｏｔ ｍｅｒｓ ｉｎ Ｍｅｄｉｃｉｎｅ、１９７７、第■巻、１．１９〜 ２６ページ）、シかしながら、そのような縫合材からの糸は、生物分解にゆだね ることができず、そしてそれらの抗菌効果の時間はかなり制限される。Conventional technology Fixed on them by non-degradable sutures with antibacterial activity, e.g. chemical bonds antibacterial preparations, polyethylene terephthalate or polymers with geomycin Lipropylene-based sutures are known in the art. These suture materials are 2 ensuring the maintenance of soft tissue and antibacterial effects for several days (^,^, Shalimov's ζ, , Potmers in Medicine, 1977, Volume ■, 1.19~ (page 26), but the threads from such suture materials cannot be left to biodegrade. and the duration of their antibacterial effect is quite limited.
共有結合によって基材に結合されたスルファニルアミド調製物を含む、生物分解 性ポリマー、たとえばヒドロキシセルロース繊維に基づく縫合材は、当業界で知 られている。スルファニルアミド調製物として、この材料は、たとえば２−（パ ラ−アミ）ベンゾスルファミド−５−エチル−１，３，４−チアジアゾール又は ０−３−アミノ−３−デツキシーα−Ｄ−グルコピラノシル−（１→６）−〇− （６−アミノ−６−デソキシーα−Ｄ−グルコピラノシル−（１→４）〕２−デ ソキシーＤ−ストレプトマイシン（カナマイシン）を含む（ＵＳＳＲ発明者証明 書第３３８５２５号、Ｉｎｔ、Ｃ１，Ｃ０８ｂ １５１０２１９６８）、この材 料からの糸は、体液の効果下で生物分解することができ、そして１６日間、抗菌 効果を確保することができる。しかしながら、そのような糸は、十分な靭性を持 たず、そして縫合材の主鎖に化学結合することができる抗菌剤の量は、ひじよう に制限される。さらに、化学物質の添加の間、抗菌性調製物の分子は、その一部 破壊を引き起こすことができる化学試薬の効果にゆだねられ、従って、その抗菌 性効果は減少するか又は完全に消滅するかのいづれかである。Biodegradation, including a sulfanilamide preparation covalently attached to a substrate Suture materials based on flexible polymers, such as hydroxycellulose fibers, are known in the art. It is being As a sulfanilamide preparation, this material can be used, for example, in benzosulfamide-5-ethyl-1,3,4-thiadiazole or 0-3-Amino-3-dextoxy α-D-glucopyranosyl-(1→6)-〇- (6-amino-6-desoxyα-D-glucopyranosyl-(1→4))2-de Contains Soxy D-Streptomycin (Kanamycin) (USSR Inventor Certification) Book No. 338525, Int, C1, C08b 151021968), this material The yarn from the material can be biodegraded under the effect of body fluids and remains antibacterial for 16 days. The effect can be ensured. However, such yarns do not have sufficient toughness. and the amount of antimicrobial agent that can be chemically bonded to the backbone of the suture material. limited to. In addition, during the addition of chemicals, molecules of antibacterial preparations, some of which It is subject to the effects of chemical reagents that can cause destruction and therefore its antibacterial The sexual effects are either diminished or completely abolished.
九乳へａ豆 本発明は、基材の変性により、高い靭性を示し、いずれの種類の抗菌性調製物を も取り入れ、そして抗菌性効果の長い持続期間を確保する縫合材の製造に向けら れる。Nine milk to a bean Due to the modification of the base material, the present invention exhibits high toughness and is suitable for any type of antibacterial preparation. In addition, we are working towards the production of suture materials that ensure long-lasting antibacterial effects. It will be done.
この目的は、生物分解性ポリマー及び抗菌性調製物からの基材を含んで成る本発 明の縫合材が、本発明に従って、前記基材上に付着され、そして抗菌性調製物又 はその混合物を含み、そして該基材の生物分解の期間よりも短い生物分解の期間 を有する、Ｎ−ビニルピロリドンとアルキルアクリレート及び／又はアルキルメ タクリレートとのコポリマーの層（該層の厚さは、基材の厚さの０．１〜１．０ に等しい）を含むことによって達成される。For this purpose, the present invention comprises a biodegradable polymer and a base material from an antimicrobial preparation. A clear suture material is deposited on the substrate according to the invention and an antimicrobial preparation or comprises a mixture thereof, and has a period of biodegradation that is shorter than the period of biodegradation of the substrate. N-vinylpyrrolidone and alkyl acrylate and/or alkylmethane having A layer of copolymer with tacrylate (the thickness of this layer is 0.1 to 1.0 of the thickness of the substrate) ).
縫合材は、好ましくは適用される層の１〜４０重量％の量で抗菌性調製物又はそ の混合物を含む。本発明の縫合材は、既知の縫合材と比べて多くの利点を有し、 すなわちニ一本発明の縫合材は、既知の縫合材の引張強さよりも１５〜２０％強 い引張強さを有し； −その糸の結節部の靭性は、既知の材料の靭性よりも２５〜３０％強くニ 一本発明の縫合材は、キノキサリン誘導体としてすべての効果に対して敏感な抗 菌性調製物を含むすべての種類のそのような調製物の使用を可能にしニ ーそれは、広い時間間隔（３〜２０日）の範囲内で損傷部分における抗菌効果の 持続期間の調整を可能にする。The suture material preferably contains an antimicrobial preparation or the like in an amount of 1 to 40% by weight of the applied layer. Contains a mixture of. The suture material of the present invention has many advantages compared to known suture materials, In other words, the suture material of the present invention has a tensile strength of 15 to 20% higher than that of known suture materials. Has high tensile strength; - The knot toughness of the yarn is 25-30% stronger than that of known materials. The suture material of the present invention is a quinoxaline derivative that is sensitive to all effects. It allows the use of all types of such preparations, including fungal preparations. - It shows the antibacterial effect in the damaged area within a wide time interval (3-20 days). Allows adjustment of duration.
日を るための最良の、様 本発明の縫合材は、基材上にｆ寸着され、そして抗菌性調製物又はその混合物を 含む、Ｎ−ビニルピロリドンとアルキルアクリレート及び／又はアルキルメタク リレートとのコポリマーの層を含む。The best way to spend the day The suture material of the invention is deposited on a substrate and coated with an antimicrobial preparation or mixture thereof. containing N-vinylpyrrolidone and alkyl acrylate and/or alkyl methacrylate Contains a layer of copolymer with rylate.
抗菌性調製物として、たとえば抗生物質、スルファニルアミド調製物、キノキサ リン誘導体、ニトロフラン誘導体、ヒドロキシキノリン誘導体及び同様のものを 挙げることができる。As antibacterial preparations, for example antibiotics, sulfanilamide preparations, quinoxa Phosphorus derivatives, nitrofuran derivatives, hydroxyquinoline derivatives and similar can be mentioned.
基材上に付着された層は、その基材の生物分解の期間よりも短い生物分解の持続 期を有する。この層の厚さは、基材の厚さの０．１〜１．０である。A layer deposited on a substrate has a duration of biodegradation that is shorter than the biodegradation period of the substrate. It has a period. The thickness of this layer is 0.1 to 1.0 of the thickness of the base material.
基材の厚さの０．１よりも薄い層の厚さで、その適用方法は実質的に複雑になり 、被膜の機械的な特性はそこなわれ、そして抗菌性調製物の量はひじょうに少量 なので、それはいずれの抗菌効果も付与しない。基材の厚さの１．０よりも厚い 層で、縫合材の強度特性はまた、そこなわれ、従って貯蔵の開基材から付着され た層の分離がもたらされ、糸の剛性が相当に上昇し、そして表面の平滑性がそこ なわれる。With a layer thickness less than 0.1 of the substrate thickness, the method of application becomes substantially more complex. , the mechanical properties of the coating are impaired and the amount of antibacterial preparation is very small. So it does not confer any antibacterial effect. Thicker than 1.0 of the base material thickness With layers, the strength properties of the suture material are also compromised and therefore adhered from the open substrate of storage. separation of the layers, the stiffness of the yarn increases considerably, and the smoothness of the surface decreases. be called.
生物体の体液の影響下で外科的な縫合の適用の後、縫合材の使用においては、抗 菌性調製物が、基材上に付着されたコポリマーのフィルムを通して拡散し、そし て囲りの組織中へのその遊離の時間は、そのコポリマーフィルムの厚さに依存す る。抗菌性調製物の合計量は、基材上への適用のために組成物の調製の段階であ らかじめ広い範囲内で決定され、そして抗菌性調製物を含む付着された層は、縫 合材の生理学的−機械的特性を低めない。抗菌性調製物を含むコポリマーが基材 よりも短い生物分解の持続期間を有するために、縫合材の靭性は、抗菌性調製物 の解放の全期間、必要なレベルで保持される。In the use of suture materials after the application of surgical sutures under the influence of body fluids of living organisms, anti-resistance The fungal preparation diffuses through the copolymer film deposited on the substrate and The time of its release into the surrounding tissue depends on the thickness of the copolymer film. Ru. The total amount of antimicrobial preparation is determined at the stage of preparation of the composition for application onto the substrate. The applied layer, which has been predetermined within a wide range and contains the antibacterial preparation, is Do not reduce the physiological-mechanical properties of the composite material. Based on a copolymer containing an antimicrobial preparation The toughness of the suture material to have a shorter duration of biodegradation than that of antimicrobial preparations is maintained at the required level for the entire period of release.
本発明の縫合材は“インビトロ”及び″インビボ”の両者で試験された。The suture material of the present invention was tested both "in vitro" and "in vivo".
Ｎ−ビニルピロリドンとアルキルメタクリレートとのコポリマーのフィルムによ り被覆された糸の性質の研究の間、酸処理されたカプロン（Ｋａｐｒｏｎ）糸上 での抗生物質を含むポリマーの付着が５．７から６．１ｋｇに糸番号１ （９３ ，５テツクス）の切断強さの上昇をもたらし、そしてその結節強さは３．６から ４．４ｋｇに高められる。A film of a copolymer of N-vinylpyrrolidone and alkyl methacrylate During the study of the properties of coated yarns, acid-treated Kapron yarns were tested. The adhesion of polymer containing antibiotics increased from 5.7 to 6.1 kg with thread number 1 (93 , 5 tex), and the knot strength increased from 3.6 to It can be increased to 4.4 kg.
類似する結果がまた、乾燥糸のためにも得られた。この場合、ポリマー性被膜の 適用の前及び後の両者での糸の切断強さは、それぞれ４．３及び５．１ｋｇであ り、そしてその結節強さはそれぞれ、２，２及び３．２に、に等しい。Similar results were also obtained for dry threads. In this case, the polymeric coating The cutting strength of the yarn both before and after application is 4.3 and 5.1 kg, respectively. and its knot strength is equal to 2, 2 and 3.2, respectively.
本発明の縫合材が次の態様で臨床試験にゆだねられた：（１）糸において６重量 ％の含有率の抗菌性調製物に相当する、基材の厚さの０．２４に等しい付着され た層の厚さで、１．４−ジ−Ｎ−オキシド−２，３−ビス（ヒドロキシメチル） −キノキサリン２２重量％を含む、Ｎ−ビニルピロリドンとブチルメタクリレー トとのコポリマーにより被覆された、酸処理されたカプロンに基づく縫合材；（ ２）糸において１．９重量％の含有率の第１抗菌性調製物及び３．９重量％の含 有率の第２抗菌性調製物に相当する、基材の厚さの０．２３に等しい付着された 層の厚さで、１．４−ジ−Ｎ−オキシド−２，３−ビス＝（ヒドロキシメチル） −キノキサリン１０重量％及び１．４−ジ−Ｎ−オキシド−２，３−ビス−（ア セトキシメチル）−キノキサリン２１重量％を含む類似するコポリマーにより被 覆された、酸処理されたカプロンに基づく縫合材；（３）糸において４．５重量 ％の含有率の抗菌性調製物に相当する、基材の厚さの０．１４に等しい付着され た層の厚さで、ゲンタマイシンスルフェート３２重量％を含む類似するコポリマ ーにより被覆された、酸処理されたカプロンに基づく縫合材。この縫合材は、胃 腸管上の吻合（２９人の患者）、急性虫垂炎（１７人の患者）、胃のペプシン潰 瘍疾患（２６人の患者）、結石胆嚢炎（１９人の患者）、胃癌（１１人の患者） 及び肢の静脈瘤の形成に対して使用された。すべての場合、組織の確かな固定化 が、手術後の創傷及び小腸の吻合の化膿性合併症の完全な不在を伴って観察され た。The suture material of the present invention was subjected to clinical trials in the following manner: (1) 6 weight in thread; % of the antibacterial preparation applied, equal to 0.24 of the thickness of the substrate. 1,4-di-N-oxide-2,3-bis(hydroxymethyl) - N-vinylpyrrolidone and butyl methacrylate containing 22% by weight of quinoxaline suture material based on acid-treated capron coated with a copolymer with 2) a content of 1.9% by weight of the first antibacterial preparation and a content of 3.9% by weight in the yarn; A proportion of the second antibacterial preparation applied equal to 0.23 of the thickness of the substrate was In the layer thickness, 1,4-di-N-oxide-2,3-bis=(hydroxymethyl) - 10% by weight of quinoxaline and 1,4-di-N-oxide-2,3-bis-(alpha) coated with a similar copolymer containing 21% by weight of Suture material based on overturned, acid-treated capron; (3) 4.5 weight in thread % of the antibacterial preparation applied equal to 0.14 of the thickness of the substrate. A similar copolymer containing 32% by weight of gentamicin sulfate at a layer thickness of suture material based on acid-treated capron coated with This suture material Supraintestinal anastomosis (29 patients), acute appendicitis (17 patients), pepsin collapse of the stomach ulcer disease (26 patients), stone cholecystitis (19 patients), gastric cancer (11 patients) and for the formation of varicose veins in the limbs. Reliable immobilization of tissue in all cases observed with complete absence of purulent complications of the postoperative wound and anastomosis of the small intestine. Ta.
内部器官のための 結合メンバーと一緒に本発明の縫合材が、２７人の患者（小 腸、肝臓の組織の縫合）及び器官を維持する手術（牌Ｍｉ＞を行う上での１７人 の患者の実質の器官上における小児手術において試験された。手術後の縫合の非 緊張に関連する合併症又は化膿性合併症は観察されなかった。血液及び尿の性質 は正常であった。Sutures of the invention together with binding members for internal organs were used in 27 patients (small 17 people in performing suturing of intestine, liver tissue) and organ preservation surgery (Pai Mi>) tested in pediatric surgery on parenchymal organs of patients. Non-suture after surgery No strain-related or purulent complications were observed. Properties of blood and urine was normal.
心臓手術の後、胸骨の縦切断部の縫合のために、１．４−ジ−Ｎ−オキシド−２ ，３−ビス−（ヒドロキシメチル）−キノキサリン６重量％を含む、Ｎ−ビニル ピロリドンとブチルメタクリレートとのコポリマーにより被覆された、酸処理さ れたカプロンに基づく本発明の縫合材が試験された。通常使用される鋼線の代わ りに、５〜６ｚ−ａｌｌ金糸がその胸骨上に適用された。創傷部の治癒及び胸骨 の付着成長は、通常の期間で生じた。縫合部の化膿に伴う合併症は観察されなか った。鋼線の使用の場きに通常、観察される動きにおける苦痛の完全な不在が示 された。鋼線の除去のためのくり返し手術は除外された。1,4-di-N-oxide-2 for suturing longitudinal cuts in the sternum after cardiac surgery. , 6% by weight of 3-bis-(hydroxymethyl)-quinoxaline, N-vinyl Acid-treated, coated with a copolymer of pyrrolidone and butyl methacrylate A suture material of the present invention based on capron was tested. Alternative to normally used steel wire Finally, 5-6z-all gold threads were applied over the sternum. Wound healing and sternum Adhesive growth occurred in a normal period. No complications associated with suture suppuration were observed. It was. It shows the complete absence of pain in the movements normally observed when using steel wires. It was done. Repeat surgeries for steel wire removal were excluded.
本発明の縫合材がまた、軟口蓋及び硬口蓋の部分の形成においても試験された。The suture material of the present invention was also tested in the formation of soft and hard palate sections.
この手術の特別な特徴は、この場合、その特異性のために、常に長い治癒の期間 （１２〜１８日）が存在し、そして癒着が永久的な感染の条件下で及び口内の液 体媒体の影響下でもたらされることにある。２４人の患者に対する観察は、すべ ての場合、創傷がいずれの合併症も伴わない１９重晋γ）を含む 前ニー基材ト に付着されたヘキシルアクで一次癒合によって治癒されたことを示しな。A special feature of this operation is that in this case, due to its specificity, there is always a long healing period (12-18 days) and under conditions of permanent infection and adhesions and oral fluid It consists in being brought about under the influence of body media. All observations on the 24 patients were In most cases, the wound is treated with an anterior knee base material containing The hexylaque attached to the membrane indicates that it was healed by primary fusion.
本発明の縫合材が、フラグメントの実質的な置換が観察されない場合の３５人の 患者の顎の骨接合のために使用された。The suture material of the present invention was used in 35 cases where no substantial displacement of fragments was observed. It was used for osteosynthesis of the patient's jaw.
縫合材の靭性特徴は、十分に目的にかない、そして抗菌性被膜の存在は、開放骨 折の１１人の患者においてこの方法の使用を可能にした。The toughness characteristics of the suture material are sufficient for the purpose, and the presence of an antimicrobial coating The use of this method was possible in 11 patients at the time.
本発明をより理解するために、縫合材を例示するいくつかの特定の例が下記に与 えられる。In order to better understand the invention, some specific examples illustrating suture materials are given below. available.
例１ 縫合材は、基材−９３，５テツクスの厚さのカプロン糸及び眩光の６重量％の１ ．４−ジ−Ｎ−オキシド−２，３−ビス−（ヒドロキシメチル）−キノキサリン を含む、前記基材上に付着されたブチルメタクリレートとＮ−ビニルピロリドン とのコポリマーの層を含んで成る。その付着された層の厚さは、基材の厚さの０ ．２４に等しい。この材料は、１．４−ジ−Ｎ−オキシド−２，３−ビス−（ヒ ドロキシメチル）−キノキサリン４２ｇ（コポリマーの２２重置火）を含む、Ｎ −ビニルピロリドンとブチルメタクリレ−１−のコポリマーのエタノール溶液（ エタノール１００ｍ１’中、コポリマー１５ｇ）を前記カプロン糸上に適用する ことによって製造される。この糸を乾燥せしめる。得られた縫合材を試験する。Example 1 The suture material consists of a base material - 93.5 tex thick Kapron thread and 6% by weight of glare 1 ．． 4-di-N-oxide-2,3-bis-(hydroxymethyl)-quinoxaline butyl methacrylate and N-vinylpyrrolidone deposited on the substrate comprising: comprising a layer of a copolymer with. The thickness of the deposited layer is 0 of the thickness of the substrate. ．． Equal to 24. This material is 1,4-di-N-oxide-2,3-bis-(hydrogen). (Droxymethyl)-quinoxaline 42g (22x copolymerization), N - Ethanol solution of copolymer of vinylpyrrolidone and butyl methacrylate-1- ( 15 g of copolymer in 100 ml of ethanol) is applied onto the Kapron yarn. Manufactured by Let this thread dry. The resulting suture material is tested.
その試験の結果は、下記の表に示される。The results of that test are shown in the table below.
例２ 縫合材は、基材−４８テツクスの厚さのポリビニルアルコール糸及び眩光の２重 量％のカナマイシン（コポリマーの、＆廿ＩＪ−１４ｑ Ｍｈ １＋’ｌ Ｅ −７−１１９ハ舌Ｊｌ １４＝ハＭゼ＋Ｉ −ｙ −ＷＦＪ ＤＩリレートとＮ −ビニルピロリドンとのコポリマーの層と含んで成る。付着された層の厚さは、 基材の厚さの０．１に等しい。Example 2 The suture material is a base material - polyvinyl alcohol thread with a thickness of 48 tex and a double layer of dazzling material. Amount % of kanamycin (copolymer, &廿IJ-14q Mh 1+’l E -7-119 Hatongue Jl 14 = HaMze + I -y -WFJ DI Relate and N - a layer of a copolymer with vinylpyrrolidone. The thickness of the deposited layer is Equal to 0.1 of the thickness of the substrate.
この縫合材は、それぞれ１０ ： ２．１ ： ８０の重量比のコポリマーニ調 製物：溶媒により前記例１に記載されたようにして製造される。この材料の試験 の結果は下記の表に示される。This suture material was made of copolymer monotone with a weight ratio of 10:2.1:80, respectively. Product: Prepared as described in Example 1 above with solvent. Testing this material The results are shown in the table below.
例３ 縫合材は、基材−５０，６テツクスの厚さのモノカルボキシセルロースからの糸 及び眩光のｒＯ０１重量％のゲンタマイシンスルフェート及び０．４０重量％の ４−（パラ−アミノベンゾスルファミド）−６−メドキシヒリミジン（コポリマ ーの１重量％）を含む、前記基材上に付着されなＮ−ビニルピロリドンとエチル アクリレートのコポリマー及びＮ−ビニルピロリドンとメチルメタクリレートの コポリマー（１：１の割合）の層を含んで成る。付着された層の厚さは基材の直 径に等しい。この縫合材は、それぞれ１００ ： ０．５ ： ９５の重量比の コポリマー：調製物の混合物：溶媒により前記例１に記載されたようにして製造 される。この縫合材の試験の結果は下記の表に示される。Example 3 The suture material is a thread made of monocarboxycellulose with a thickness of -50.6 tex. and dazzling rO01 wt% gentamicin sulfate and 0.40 wt% 4-(para-aminobenzosulfamide)-6-medoxyhyrimidine (copolymer (1% by weight) of N-vinylpyrrolidone and ethyl Copolymer of acrylate and N-vinylpyrrolidone and methyl methacrylate It comprises a layer of copolymer (1:1 ratio). The thickness of the deposited layer is directly on the substrate. equal to the diameter. This suture material has a weight ratio of 100: 0.5: 95, respectively. Copolymer: mixture of preparations: prepared as described in Example 1 above with solvent be done. The results of testing this suture material are shown in the table below.
例４ 縫合材は、基材−９３，５テツクスの厚さのカプロン糸及び眩光の４．２２重量 ％の１．４−ジ−Ｎ−オキシド−２，３−ビス−（アセトキシメチル）−キノキ サリン（コポリマーの４０重置火）を含む、前記基材上に付着されたＮ−ビニル ピロリドンとブチルメタクリレートとのコポリマーの層を含んで成る。Example 4 The suture material is a base material - 93.5 tex thick Kapron thread and a dazzling 4.22 weight % of 1.4-di-N-oxide-2,3-bis-(acetoxymethyl)-minoki N-vinyl deposited on the substrate containing sarin (40 ply of copolymer) It comprises a layer of a copolymer of pyrrolidone and butyl methacrylate.
付着された層の厚さは、基材の厚さの０．１２に等しい、この縫物の混合物：溶 媒により前記例１に記載されたようにして製造される。この試験の結果は下記の 表に示される。The thickness of the applied layer is equal to 0.12 of the thickness of the base material. Prepared as described in Example 1 above with a medium. The results of this test are below. Shown in the table.
例５ 縫合材は、基材−９３，５テツクスの厚さのカプロン糸及び該国際調査報告Example 5 The suture material is the base material - Kapro thread with a thickness of 93.5 tex and the international investigation report.
Claims (2)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/SU1986/000072 WO1988000062A1 (en) | 1986-07-04 | 1986-07-04 | Ligature material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01500085A true JPH01500085A (en) | 1989-01-19 |
| JPH0236265B2 JPH0236265B2 (en) | 1990-08-16 |
Family
ID=21617019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61504747A Granted JPH01500085A (en) | 1986-07-04 | 1986-07-04 | suture material |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4875479A (en) |
| EP (1) | EP0280732B1 (en) |
| JP (1) | JPH01500085A (en) |
| DE (1) | DE3675395D1 (en) |
| WO (1) | WO1988000062A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5447966A (en) * | 1988-07-19 | 1995-09-05 | United States Surgical Corporation | Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin |
| US5269783A (en) * | 1991-05-13 | 1993-12-14 | United States Surgical Corporation | Device and method for repairing torn tissue |
| CA2100532C (en) | 1992-09-21 | 2004-04-20 | David T. Green | Device for applying a meniscal staple |
| US5534288A (en) * | 1993-03-23 | 1996-07-09 | United States Surgical Corporation | Infection-resistant surgical devices and methods of making them |
| CA2117967A1 (en) * | 1993-10-27 | 1995-04-28 | Thomas W. Sander | Tissue repair device and apparatus and method for fabricating same |
| US5607686A (en) * | 1994-11-22 | 1997-03-04 | United States Surgical Corporation | Polymeric composition |
| US5645568A (en) * | 1995-11-20 | 1997-07-08 | Medicinelodge, Inc. | Expandable body suture |
| NL1001746C2 (en) * | 1995-11-27 | 1997-05-30 | Belden Wire & Cable Bv | Guide wire for medical application. |
| ATE493939T1 (en) | 2000-04-11 | 2011-01-15 | United States Surgical Corp | DEVICE FOR REPAIRING THE MENISCUS IN A SINGLE OPERATION |
| US7343920B2 (en) * | 2002-12-20 | 2008-03-18 | Toby E Bruce | Connective tissue repair system |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896813A (en) * | 1967-06-23 | 1975-07-29 | Sutures Inc | Sutures having long-lasting biocidal properties |
| IT1046781B (en) * | 1968-07-24 | 1980-07-31 | Ceskoslovenska Akademie Ved | SURGICAL SUTOR WIRES AND PROCESS FOR THEIR PRODUCTION |
| IT1048251B (en) * | 1969-08-26 | 1980-11-20 | Sutures Inc | SUTURES HAVING LONG LIFE GERMICIDE PROPERTIES |
| US3938515A (en) * | 1971-12-20 | 1976-02-17 | Alza Corporation | Novel drug permeable wall |
| US4036227A (en) * | 1973-04-25 | 1977-07-19 | Alza Corporation | Osmotic releasing device having a plurality of release rate patterns |
| US3987797A (en) * | 1974-02-25 | 1976-10-26 | Ethicon, Inc. | Antimicrobial sutures |
| US4192827A (en) * | 1974-06-27 | 1980-03-11 | Ciba-Geigy Corporation | Water-insoluble hydrophilic copolymers |
| FR2293947A1 (en) * | 1975-12-10 | 1976-07-09 | Ethicon Inc | Antimicrobial sutures, dressings, prostheses - coated with an elastomeric polyurethane with pendant anionic or cationic antimicrobial cpds |
| US4136250A (en) * | 1977-07-20 | 1979-01-23 | Ciba-Geigy Corporation | Polysiloxane hydrogels |
| US4277582A (en) * | 1978-03-03 | 1981-07-07 | Ciba-Geigy Corporation | Water-insoluble hydrophilic copolymers |
| US4275183A (en) * | 1979-07-27 | 1981-06-23 | Peter Kuzma | Hydrophilic polymers and contact lenses therefrom |
| SU1243627A3 (en) * | 1979-12-05 | 1986-07-07 | Дзе Кендалл Компани (Фирма) | Jelly-forming composition |
| US4582052A (en) * | 1982-03-23 | 1986-04-15 | Repromed, Inc. | Povidone-iodine dispensing fiber |
-
1986
- 1986-07-04 JP JP61504747A patent/JPH01500085A/en active Granted
- 1986-07-04 US US07/191,149 patent/US4875479A/en not_active Expired - Fee Related
- 1986-07-04 WO PCT/SU1986/000072 patent/WO1988000062A1/en active IP Right Grant
- 1986-07-04 EP EP86905483A patent/EP0280732B1/en not_active Expired - Lifetime
- 1986-07-04 DE DE8686905483T patent/DE3675395D1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4875479A (en) | 1989-10-24 |
| DE3675395D1 (en) | 1990-12-06 |
| EP0280732A4 (en) | 1988-11-02 |
| EP0280732B1 (en) | 1990-10-31 |
| JPH0236265B2 (en) | 1990-08-16 |
| WO1988000062A1 (en) | 1988-01-14 |
| EP0280732A1 (en) | 1988-09-07 |
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