JPH0146814B2 - - Google Patents
Info
- Publication number
- JPH0146814B2 JPH0146814B2 JP59129025A JP12902584A JPH0146814B2 JP H0146814 B2 JPH0146814 B2 JP H0146814B2 JP 59129025 A JP59129025 A JP 59129025A JP 12902584 A JP12902584 A JP 12902584A JP H0146814 B2 JPH0146814 B2 JP H0146814B2
- Authority
- JP
- Japan
- Prior art keywords
- fluid
- flow
- sheath fluid
- particles
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000012530 fluid Substances 0.000 claims description 236
- 239000002245 particle Substances 0.000 claims description 76
- 238000004458 analytical method Methods 0.000 claims description 19
- 238000001514 detection method Methods 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 238000005070 sampling Methods 0.000 claims description 13
- 238000004891 communication Methods 0.000 claims description 10
- 230000001105 regulatory effect Effects 0.000 claims description 9
- 230000005484 gravity Effects 0.000 claims description 5
- 230000003750 conditioning effect Effects 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims 1
- 238000005086 pumping Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 description 56
- 239000007788 liquid Substances 0.000 description 19
- 230000008901 benefit Effects 0.000 description 4
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 239000003792 electrolyte Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000005206 flow analysis Methods 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/131—Details
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
- G01N15/1409—Handling samples, e.g. injecting samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1024—Counting particles by non-optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1028—Sorting particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1486—Counting the particles
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US512267 | 1983-07-11 | ||
US06/512,267 US4503385A (en) | 1983-07-11 | 1983-07-11 | Apparatus and method for regulating sheath fluid flow in a hydrodynamically focused fluid flow system |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6025442A JPS6025442A (ja) | 1985-02-08 |
JPH0146814B2 true JPH0146814B2 (en, 2012) | 1989-10-11 |
Family
ID=24038380
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP59129025A Granted JPS6025442A (ja) | 1983-07-11 | 1984-06-22 | 動水力学的に収束される流体流動装置におけるシ−ス流の調製装置およびその方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US4503385A (en, 2012) |
EP (1) | EP0131287B1 (en, 2012) |
JP (1) | JPS6025442A (en, 2012) |
DE (1) | DE3467812D1 (en, 2012) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62119653U (en, 2012) * | 1986-01-21 | 1987-07-29 | ||
US4935346A (en) * | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
US5245318A (en) * | 1987-07-24 | 1993-09-14 | Canon Kabushiki Kaisha | Particle analyzing apparatus having pressure control system |
US5040890A (en) * | 1987-11-25 | 1991-08-20 | Becton, Dickinson And Company | Sheathed particle flow controlled by differential pressure |
US5380491A (en) * | 1993-01-21 | 1995-01-10 | Cdc Technologies, Inc. | Apparatus for pumping and directing fluids for hematology testing |
US6812032B1 (en) | 1993-01-21 | 2004-11-02 | Cdc Technologies, Inc. | Apparatus and method for making a plurality of reagent mixtures and analyzing particle distributions of the reagent mixtures |
US5728351A (en) * | 1993-01-21 | 1998-03-17 | Cdc Technologies, Inc. | Apparatus for making a plurality of reagent mixtures and analyzing particle distributions of the reagent mixtures |
WO1996003634A1 (en) * | 1994-07-25 | 1996-02-08 | Met One, Inc. | Particle counter for contamination analysis of liquids |
US5840254A (en) | 1995-06-02 | 1998-11-24 | Cdc Technologies, Inc. | Apparatus for mixing fluids for analysis |
US5861563A (en) * | 1997-03-20 | 1999-01-19 | Bayer Corporation | Automatic closed tube sampler |
US5895764A (en) * | 1997-11-24 | 1999-04-20 | University Of New Mexico | Controlled sheath flow injection cytometry |
US6830729B1 (en) | 1998-05-18 | 2004-12-14 | University Of Washington | Sample analysis instrument |
EP1046032A4 (en) | 1998-05-18 | 2002-05-29 | Univ Washington | LIQUID ANALYSIS CARTRIDGE |
US6331437B1 (en) * | 1998-07-14 | 2001-12-18 | Bayer Corporation | Automatic handler for feeding containers into and out of an analytical instrument |
US6458326B1 (en) | 1999-11-24 | 2002-10-01 | Home Diagnostics, Inc. | Protective test strip platform |
US6562625B2 (en) | 2001-02-28 | 2003-05-13 | Home Diagnostics, Inc. | Distinguishing test types through spectral analysis |
US6541266B2 (en) | 2001-02-28 | 2003-04-01 | Home Diagnostics, Inc. | Method for determining concentration of an analyte in a test strip |
US6525330B2 (en) | 2001-02-28 | 2003-02-25 | Home Diagnostics, Inc. | Method of strip insertion detection |
KR20060134942A (ko) * | 2003-10-30 | 2006-12-28 | 사이토놈, 인크. | 다중 층의 유체 역학적 쉬스 유동 구조 |
US7340957B2 (en) | 2004-07-29 | 2008-03-11 | Los Alamos National Security, Llc | Ultrasonic analyte concentration and application in flow cytometry |
US7835000B2 (en) * | 2006-11-03 | 2010-11-16 | Los Alamos National Security, Llc | System and method for measuring particles in a sample stream of a flow cytometer or the like |
US7837040B2 (en) | 2007-04-09 | 2010-11-23 | Los Alamos National Security, Llc | Acoustic concentration of particles in fluid flow |
US8266950B2 (en) | 2007-12-19 | 2012-09-18 | Los Alamos National Security, LLP | Particle analysis in an acoustic cytometer |
JP5117963B2 (ja) * | 2008-09-17 | 2013-01-16 | アークレイ株式会社 | 分析装置 |
WO2010141096A1 (en) * | 2009-06-05 | 2010-12-09 | Xy, Llc | Continuously regulated precision pressure fluid delivery system |
CN105283753B (zh) | 2013-03-14 | 2020-07-10 | 塞通诺米/St有限责任公司 | 流体动力聚焦设备和方法 |
EP3108219B1 (en) * | 2014-02-20 | 2020-04-01 | Malvern Panalytical Limited | Heterogeneous fluid sample characterization |
CN111122422A (zh) * | 2020-01-14 | 2020-05-08 | 梨薯(厦门)科技有限公司 | 带反馈式的高精度鞘流检测设备及其工作方法 |
CN115078324B (zh) * | 2022-06-30 | 2023-03-10 | 嘉兴市唯真生物科技有限公司 | 一种高通量流式荧光检测方法、智能终端及存储介质 |
CN116359484B (zh) * | 2023-05-31 | 2023-09-15 | 深圳市帝迈生物技术有限公司 | 一种样本分析仪 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US28558A (en) * | 1860-06-05 | Thacker t | ||
US3654439A (en) * | 1970-04-28 | 1972-04-04 | Gen Science Corp | Particle counting apparatus having automatic display and threshold setting |
US3746976A (en) * | 1971-04-07 | 1973-07-17 | Coulter Electronics | Self-cleaning aperture tube for coulter study apparatus |
USRE28558E (en) | 1971-04-07 | 1975-09-23 | Self-cleaning aperture tube for coulter study apparatus | |
US4070617A (en) * | 1974-05-08 | 1978-01-24 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Device for controlling the particle flow in an apparatus for measuring the properties of particles suspended in liquid |
US4110604A (en) * | 1976-11-04 | 1978-08-29 | Becton, Dickinson And Company | Particle density measuring system |
US4165484A (en) * | 1977-03-23 | 1979-08-21 | Becton, Dickinson And Company | Particle counting apparatus utilizing various fluid resistors to maintain proper pressure differentials |
US4434398A (en) * | 1978-05-18 | 1984-02-28 | Particle Data, Inc. | Porous passage means and method for particle analyzing systems |
US4240029A (en) * | 1979-04-20 | 1980-12-16 | Becton Dickinson & Company | Apparatus for counting particles in a liquid suspension |
-
1983
- 1983-07-11 US US06/512,267 patent/US4503385A/en not_active Expired - Lifetime
-
1984
- 1984-06-22 JP JP59129025A patent/JPS6025442A/ja active Granted
- 1984-07-06 DE DE8484107942T patent/DE3467812D1/de not_active Expired
- 1984-07-06 EP EP84107942A patent/EP0131287B1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE3467812D1 (en) | 1988-01-07 |
EP0131287B1 (en) | 1987-11-25 |
JPS6025442A (ja) | 1985-02-08 |
US4503385A (en) | 1985-03-05 |
EP0131287A1 (en) | 1985-01-16 |
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