JPH01305014A - Manicure - Google Patents

Abstract

PURPOSE:To obtain a manicure having excellent water retention power, maintaining healthy surface of nail, even having repairing effects on damaged surface of nail by blending a manicure base with cholesteryl sulfate and/or a salt thereof. CONSTITUTION:A manicure base is blended with 0.01-10wt.%, preferably 0.01-4wt.% based on sum of the manicure base of one or more selected from cholesteryl sulfate and salts thereof, e.g., alkali metal salt such as sodium salt or potassium salt or alkaline earth metal such as calcium or magnesium or organic amine salt such as lysine salt or triethanolamine salt or basic amino acid to give a manicure having excellent water retention power, maintaining a healthy state of surface of nail, even having repairing effects on damaged surface of nail free from fear of safety even in the case of long-term continuous use.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a nail beauty product containing cholesteryl sulfate or its salt as an active ingredient, and is particularly useful for repairing acquired damage to human nail plates and for restoring normal nail plate. The aim is to provide a nail polish that protects the nails.

[Conventional technology]

Conventionally, nail enamel mainly composed of nitrocellulose is the most well-known cosmetic that is applied to the nail plate of a person and exerts an aesthetic effect.

This nail enamel is mainly composed of nitrocellulose as a film material, a plasticizer, pigments, etc., which are dissolved or dispersed in an organic solvent such as toluene or ethyl acetate. .

Furthermore, organic solvents such as acetone are also used in nail removers for removing nail enamel.

However, when these nail enamels and nail removers are used, the lipids originally present on the surface of the nail plate are removed by the organic solvent, and the nail plate becomes dry at times. Furthermore, with continued use, a healthy nail plate usually contains 10 to 10
It contains 15% water, but some of this water evaporates more easily because the lipids on the surface are removed, causing the nail plate to become dry and damaged, resulting in a condition called double nails.
Problems have been pointed out, such as causing symptoms such as loss of gloss on the entire nail plate.

[Problem to be solved by the invention]

To solve the above problems by making human nail plates less susceptible to acquired damage. Alternatively, nail beauty products that have a repair function are also being considered. Products with increased moisture content have been proposed.

However, although these improved products can be expected to have some effect in making people less susceptible to acquired damage to the nail plate, they have not yet demonstrated sufficient effectiveness in repairing acquired damage. is the current situation.

The present invention solves such problems, has excellent moisture retention ability, and has (
l! To provide a nail beauty agent that maintains healthy nail plates and also has the effect of repairing damaged nail plates.

[Means to solve the problem]

Therefore, in view of the current situation, the present inventors repeatedly conducted various experimental studies on many substances and found that cholesteryl sulfate or its salts enhance the moisture retention function of the nail plate and repair damage to the nail plate. It was found that the present invention was effective, and based on this knowledge, the present invention was completed.

That is, the present invention relates to a nail beauty product characterized by containing 0.01 to 10% by weight of one or more selected from cholesteryl sulfate and its salts based on the entire base.

The present invention will be explained in detail below.

Cholesteryl sulfate applied to the present invention is a known substance, and can be obtained by sulfate-esterifying cholesterol according to a conventional method.

For example, cholesterol is dissolved in a basic solvent such as pyridine, dimethylformamide, or morpholine, and this is reacted with a sulfuric acid esterifying agent such as sulfuric anhydride, fuming sulfuric acid, or chlorosulfonic acid, and then a conventional method such as fractional precipitation is carried out. Therefore, it can be obtained by purification.

Cholesteryl sulfate may also be used in the form of its salts; specific examples include alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as calcium and magnesium salts, lysine salts, and salts of cholesteryl sulfate. Examples include organic amine salts such as ethanolamine salts and basic amino acid salts.

In the nail beauty preparation of the present invention, the above-mentioned cholesteryl sulfate or its salt is used alone or as a mixture of two or more of them in an amount of 0.01 to 10% by weight, preferably 0.01 to 10% by weight, based on the entire base of the nail beauty agent. It is blended in a range of 0.01 to 4% by weight.

When the amount is less than 0.01% by weight, the effect of the nail beauty agent of the present invention can be exhibited; on the other hand, even when the amount exceeds 10% by weight, no enhancement of the effect is observed and there is no point in increasing the amount. do not have.

Next, there are no particular restrictions on the dosage form of the nail beauty preparation of the present invention, and solution-based, solubilized-based, emulsified-based, and other dosage forms may be used as appropriate. Here, highly hydrophilic cholesteryl sulfate, such as alkali metal salts, organic amine salts, and basic amino acid salts, are used as one of the water phase components, while hydrophobic cholesteryl sulfate and its alkaline earth metal salts, etc. It is preferable that those having a large value be dissolved or dispersed and uniformly mixed into the nail beauty base as one of the oil phase components.

〔Example〕

The present invention will be explained in more detail below using Examples and Comparative Examples.

Examples 1 to 4 and Comparative Example 1 (Nail treatment liquid) Nail treatment liquids having the components and composition shown in Table 1 were prepared. The preparation method is to follow the usual method and add 70% of each ingredient.
After stirring and mixing at ℃, the mixture was cooled.

Note that the numbers for each component in Table 1 are weight %.

Table 1 (Evaluation 1) The effectiveness of the nail beauty agent (nail treatment liquid) of the present invention was tested by use test.

In the method, 40 women who normally use nail enamel were randomly divided into 5 groups of 8 women as panels, and a continuous use test was conducted for a total of 1 month. Also, one cycle of the usage test consists of: ■Nail enamel (applied for 2 days), ■Removal with nail remover, and ■Nail treatment liquid (applied for 2 days).

For evaluation purposes, the nail treatment liquid was applied only to the nail plate of the right hand, and the nail plate of the left hand was left unapplied (blank) as a control site. The results are shown in Table 2.

Table 2 Usage Test As shown in the results of Table 2, the nail treatment liquid of the present invention (Examples 1 to 4) exhibited significant effects compared to the comparative nail treatment liquid (Comparative Example 1). Ta.

Examples 5 to 8 and Comparative Example 2 (Nail treatment cream) Nail treatment creams having the ingredients and composition shown in Table 3 were prepared. The preparation method follows the conventional method, (A
) was dissolved at 80°C and heated to 80°C (B)
Add, mix and emulsify, then cool.

Note that the numbers for each component in Table 3 are weight %.

Table 3 (Evaluation 2) The water retention ability of the nail beauty product (heavy treatment cream) of the present invention was tested. The method is to uniformly apply 1 g of each sample on a lx1aa filter paper under conditions of a temperature of 25°C and a humidity of 50%, weigh the weight after 30 minutes, and calculate the ratio of the remaining water content to the composition water content (residual water content). The results are shown in Table 4 as percentage (%). .

(Evaluation 3) The effectiveness of the nail beauty agent (heavy treatment cream) of the present invention was tested by use test. The method is
Forty people with especially weak nails who tend to develop double nails when using regular nail enamel were randomly divided into five groups of eight people each.
We conducted a continuous use test (for 3 months) in which the drug was used once every 3 days.
Nail abnormalities, particularly the percentage of panels with two nails (number of panels with two nails/total number of panels) were evaluated. The evaluation criteria were as follows, and the results are shown in Table-5. - Anal JLt semi- ◎ (good): O/8 to 1/8 Q (slightly good): 2/8 to 3/8Δ (slightly poor)
: 4/8~6/8×(defective) : 7/8
~878 As is clear from the results shown in Tables 4 and 5, the heavy duty treatment creams of the present invention (Examples 5 to 8) have excellent moisture retention ability and are effective against damage to nails such as bipolar nails. It has been proven to be extremely effective.

〔Effect of the invention〕

The nail beauty product of the present invention has excellent water retention ability, maintains a healthy nail condition, acts on damaged nail molds, has the effect of promoting repair thereof, and is suitable for long-term use. There is no safety concern in any case.

Claims (1)

[Claims] 1) One or more selected from cholesteryl sulfate and its salts in an amount of 0.01 to 0.01 to the entire base.
A nail beauty product characterized by containing 10% by weight.