JPH01296973A - Membrane-type reactor with draft tube - Google Patents
Membrane-type reactor with draft tubeInfo
- Publication number
- JPH01296973A JPH01296973A JP12762588A JP12762588A JPH01296973A JP H01296973 A JPH01296973 A JP H01296973A JP 12762588 A JP12762588 A JP 12762588A JP 12762588 A JP12762588 A JP 12762588A JP H01296973 A JPH01296973 A JP H01296973A
- Authority
- JP
- Japan
- Prior art keywords
- draft tube
- tank
- membrane
- filtration
- membranes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000001914 filtration Methods 0.000 claims abstract description 28
- 239000012528 membrane Substances 0.000 claims abstract description 27
- 238000005273 aeration Methods 0.000 claims description 8
- 238000000855 fermentation Methods 0.000 abstract description 10
- 230000004151 fermentation Effects 0.000 abstract description 10
- 230000002093 peripheral effect Effects 0.000 abstract description 10
- 238000010564 aerobic fermentation Methods 0.000 abstract description 6
- 239000000047 product Substances 0.000 abstract description 6
- 239000000706 filtrate Substances 0.000 abstract description 4
- 102000004190 Enzymes Human genes 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 239000011942 biocatalyst Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 238000009434 installation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000009295 crossflow filtration Methods 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
- C12M29/08—Air lift
Landscapes
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は酵母、菌体、酵素等の生体触媒を利用して好気
性条件下で発酵生成物を得るために使用されるドラフト
チューブ成膜型反応装置に関するものである。Detailed Description of the Invention (Industrial Application Field) The present invention relates to a draft tube film forming method used to obtain fermentation products under aerobic conditions using biocatalysts such as yeast, bacterial cells, and enzymes. This relates to type reactors.
（従来の技術）
好気性の生体触媒を利用して発酵生成物を生産させる場
合には、液中の酸素溶存濃度を高めるとともに生体触媒
と基質との接触を十分に行わせることが必要であり、こ
のための手段として第２図に示されるようなドラフトチ
ューブ式の発酵槽が知られている。このような従来装置
は槽体（２ｏ）の内部に円筒状のドラフト千五−プ（２
１）を立設するとともにその底部に散気手段（２２）を
設け、ブロア（２３）によって大量の空気をドラフトチ
ューブ（２１）の内部に吹込んでそのエアリフト効果に
より図示のような循環流を発生させ、酸素移動容量係数
を高いレベルに維持しつつ発酵を行わせるものである。(Prior art) When producing fermentation products using an aerobic biocatalyst, it is necessary to increase the dissolved oxygen concentration in the liquid and to ensure sufficient contact between the biocatalyst and the substrate. As a means for this purpose, a draft tube type fermenter as shown in FIG. 2 is known. Such a conventional device has a cylindrical draft pipe (2o) inside the tank body (2o).
1) is installed upright, and an aeration means (22) is provided at the bottom of the draft tube, and a large amount of air is blown into the draft tube (21) by a blower (23) to generate a circulating flow as shown in the figure due to the air lift effect. This allows fermentation to occur while maintaining the oxygen transfer capacity coefficient at a high level.
そして槽内の発酵液中から生成物を取出すためには、ク
ロスフロー型分離膜モジュール（２４）を外部に設けて
膜循環ポンプ（２５）により槽内の発酵液を循環させ、
生成物濃度の高い濾過液を取り出すとともに、槽内の生
体触媒を高濃度に維持するために生体触媒濃度の高い濃
縮液を槽体（２０）へ返送している。In order to take out the product from the fermentation liquid in the tank, a cross-flow type separation membrane module (24) is installed outside and the fermentation liquid in the tank is circulated by a membrane circulation pump (25).
While taking out the filtrate with a high product concentration, a concentrated liquid with a high biocatalyst concentration is returned to the tank body (20) in order to maintain the biocatalyst in the tank at a high concentration.
ところがこのような従来のものはクロスフロー濾過を行
わせるためにリアクター外循環量を大流量としなければ
ならず、リアクター内の発酵条件が制約を受けるうえに
、大容量循環を行わせるために大型のポンプや配管が必
要となり、装置費、運転費が過大となり、また広い設置
スペースが必要でメンテナンスの手数も嵩む等の問題が
あった。However, in such conventional systems, a large flow rate must be circulated outside the reactor in order to perform cross-flow filtration, which limits the fermentation conditions inside the reactor. This requires additional pumps and piping, resulting in excessive equipment and operating costs, and requires a large installation space, which increases the amount of maintenance required.
そこでこのような問題を解決するために、特公昭６２−
５５９５号公報に示されるように、槽体内部のドラフト
チューブの上方位置に外圧式円筒型濾過材を設けたもの
も提案されている。しかしこの形式の装置は濾過膜表面
の剪断力を十分に確保することができないために単位面
積当たりの濾過速度が低下するという欠点がある。Therefore, in order to solve such problems,
As shown in Japanese Patent No. 5595, there has also been proposed a system in which an external pressure type cylindrical filter material is provided above the draft tube inside the tank body. However, this type of device has the disadvantage that the filtration rate per unit area is reduced because it is not possible to ensure sufficient shearing force on the surface of the filtration membrane.
（発明が解決しようとする課題）
本発明はこのような従来の問題点を解決して、リアクタ
ー外循環量を減少させて発酵条件の制約を緩和させると
ともに、装置費、運転費等を大幅に削減することができ
、また濾過膜表面の剪断力を確保して高い濾過速度を保
つことができる脱型反応装置を目的として完成されたも
のである。(Problems to be Solved by the Invention) The present invention solves these conventional problems, reduces the amount of circulation outside the reactor, alleviates restrictions on fermentation conditions, and significantly reduces equipment costs, operating costs, etc. It was completed with the aim of creating a demolding reaction device that can reduce the amount of water used and maintain a high filtration rate by ensuring the shear force on the surface of the filtration membrane.
（課題を解決するための手段）
本発明は槽内に散気手段とドラフトチューブとを設けた
好気性発酵槽の、発酵槽の内周面あるいはドラフトチュ
ーブの内周面あるいは外周面の少くともひとつに、濾過
膜を設けたことを特徴とするものである。(Means for Solving the Problems) The present invention provides an aerobic fermentation tank in which an aeration means and a draft tube are provided, at least on the inner peripheral surface of the fermenter or the inner peripheral surface or outer peripheral surface of the draft tube. One feature is that it is equipped with a filtration membrane.
（実施例）
次に本発明を第１図により更に詳細に説明すると、ｆｉ
＋はりアクタ−となる好気性発酵槽、（２）はその槽内
底部に設けられた散気手段、（３）は空気吹込用のプロ
アである。（４）は槽内に立設された円筒状のドラフト
チューブであるが、本実施例においてはこのドラフトチ
ューブ（４）は内外両表面が濾過膜（５）、（６）によ
って構成されている。濾過膜（５）、（６）の材質は何
隻限定されるものではないが、セラミック多孔膜を用い
れば強度、耐久性、濾過特性等の多くの面で有利である
。また本実施例においては、好気性発酵槽（１）の内周
面にも濾過膜（７）が内張すしてあり、ドラフトチュー
ブ（４）の内外面の濾過膜（５）、（６）及び好気性発
酵槽ｆｉ＋の内面の濾過膜（７）によって濾過された濾
過液は流路（８）、（９）を介して槽外へ取出される構
造となっている。なおｏｌは基質投入口、Ｑυは排気口
である。(Example) Next, the present invention will be explained in more detail with reference to FIG.
+ An aerobic fermenter serving as a beam actor, (2) an aeration means provided at the bottom of the tank, and (3) an air blower. (4) is a cylindrical draft tube installed vertically in the tank, and in this example, both the inner and outer surfaces of this draft tube (4) are composed of filter membranes (5) and (6). . Although the material of the filtration membranes (5) and (6) is not limited, the use of porous ceramic membranes is advantageous in many aspects such as strength, durability, and filtration characteristics. In this embodiment, the inner peripheral surface of the aerobic fermentor (1) is also lined with a filtration membrane (7), and the filtration membranes (5) and (6) are lined with the inner and outer surfaces of the draft tube (4). The filtrate filtered by the filtration membrane (7) on the inner surface of the aerobic fermentation tank fi+ is taken out of the tank via channels (8) and (9). Note that ol is a substrate input port, and Qυ is an exhaust port.
（作用）
このように構成されたものは、好気性発酵槽（１）の内
部に散気手段（２）により空気を気泡として吹込み、そ
のエアリフト効果によってドラフトチューブ（４）の内
側に生ずる強い上昇流を利用して槽内に循環流を発生さ
せ、槽内の酸素移動容量係数を高いレベルに維持しつつ
生体触媒により基質を発酵させることは従来のこの種装
置と同様である。しかし本実施例においてはドラフトチ
ューブ（４）の内外両表面を濾過膜（５）、（６）によ
り構成するとともに、好気性発酵槽（１１の内周面にも
濾過ＷＪ、＋７１を設けであるので、槽内の発酵液は槽
内を循環しつつこれらの濾過膜（５）、（６）、（７）
によって濾過され、生成物濃度の高い濾過液のみが流路
（８）、（９）から外部へ取出される。ドラフトチュー
ブ内面の濾過膜は、チュウブ内では強い上方への散気噴
流により生じている気液混和流により高い濾過速度を得
ることができ、一方、発酵槽内面の濾過膜は、下方への
循環流がドラフトチューブ内の散気噴流に比べ弱いため
、高い濾過速度を期待できないがその大きな膜面積によ
り十分な濾過量を得ることができる。(Function) In this structure, air is blown into the aerobic fermentation tank (1) as bubbles by the aeration means (2), and strong air is generated inside the draft tube (4) due to the air lift effect. Similar to conventional devices of this type, the upward flow is used to generate a circulation flow within the tank, and the substrate is fermented using a biocatalyst while maintaining the oxygen transfer capacity coefficient within the tank at a high level. However, in this embodiment, both the inner and outer surfaces of the draft tube (4) are constructed with filtration membranes (5) and (6), and a filtration WJ, +71 is also provided on the inner peripheral surface of the aerobic fermenter (11). Therefore, the fermentation liquid in the tank circulates through these filter membranes (5), (6), (7).
, and only the filtrate with a high product concentration is taken out from the channels (8) and (9). The filtration membrane on the inside of the draft tube can achieve a high filtration rate due to the gas-liquid mixing flow generated by the strong upward aeration jet inside the tube, while the filtration membrane on the inside of the fermenter can achieve a high filtration rate due to the gas-liquid mixing flow generated by the strong upward aeration jet inside the tube. Since the circulation flow is weaker than the aeration jet in the draft tube, a high filtration rate cannot be expected, but a sufficient filtration rate can be obtained due to the large membrane area.
このように本発明においては槽体外部に濾過装置を設置
する必要がなく、またＩＩ＊循環用のポンプや配管が不
要となるので装置費や運転費を大幅に削減することがで
きる。またドラフトチューブ（４）の内外には強い循環
流が発生しているために濾過膜（５）、（６）、（７）
の表面における剪断力を十分に確保することができ、濾
過速度を高めることができる。As described above, in the present invention, there is no need to install a filtration device outside the tank body, and there is no need for a pump or piping for II* circulation, so equipment costs and operating costs can be significantly reduced. In addition, strong circulating flow occurs inside and outside the draft tube (4), so the filtration membranes (5), (6), and (7)
It is possible to secure sufficient shear force on the surface of the filter, thereby increasing the filtration rate.
なお生体触媒は外部に取出されないため、その濃度が減
少するおそれもない。Note that since the biocatalyst is not taken out to the outside, there is no fear that its concentration will decrease.
上記の実施例では発酵槽の内周面とドラフトチューブ（
４）の内外両表面にそれぞれ濾過膜（５）、（６）、（
７）を設けたが、いずれか−個所又は二個所に濾過膜を
設けても良いことは言うまでもない。In the above example, the inner peripheral surface of the fermenter and the draft tube (
filtration membranes (5), (6), (
7), but it goes without saying that a filter membrane may be provided at either or both locations.
（発明の効果）
本発明は以上の説明からも明らかなように、リアクター
外循環をゼロとすることができるのでリアクター内の発
酵条件に制約が加わらず、また外部に濾過装置を設置す
る必要もないので設置スペースの削減、設備費、運転費
の削減を図ることができる。しかも本発明においてはド
ラフトチューブの内外に生ずる強い循環流によって濾過
膜表面の剪断力を確保することができるので、高い濾過
速度を保つことができる。よって本発明は従来の問題点
を一掃したドラフトチューブ式膜型反応装置として、産
業の発展に寄与するところは橿めて大である。(Effects of the Invention) As is clear from the above description, the present invention can eliminate external circulation of the reactor, so there are no restrictions on the fermentation conditions inside the reactor, and there is no need to install an external filtration device. Since there is no such thing, it is possible to reduce installation space, equipment costs, and operating costs. Moreover, in the present invention, the shearing force on the surface of the filtration membrane can be ensured by the strong circulating flow generated inside and outside the draft tube, so that a high filtration rate can be maintained. Therefore, the present invention greatly contributes to the development of industry as a draft tube type membrane reactor that eliminates the problems of the conventional method.
第１図は本発明の実施例を示す断面図、第２図は従来例
を示す断面図である。
（１）：好気性発酵槽、（２）二敗気手段、（４）；ド
ラフトチューブ、（５）、（６）、（７）：濾過膜。
特許出願人 日本碍子株式会社FIG. 1 is a sectional view showing an embodiment of the present invention, and FIG. 2 is a sectional view showing a conventional example. (1): Aerobic fermentation tank, (2) Double degasification means, (4); Draft tube, (5), (6), (7): Filtration membrane. Patent applicant Nippon Insulator Co., Ltd.
Claims (1)
設けた好気性発酵槽（１）の、発酵槽の内周面あるいは
ドラフトチューブ（４）の内周面あるいは外周面の少く
ともひとつに、濾過膜（５）、（６）、（７）を設けた
ことを特徴とするドラフトチューブ式膜型反応装置。At least the inner circumferential surface of the fermenter or the inner circumferential surface or the outer circumferential surface of the draft tube (4) of an aerobic fermenter (1) in which an aeration means (2) and a draft tube (4) are provided in the tank. One of them is a draft tube type membrane reactor characterized by being provided with filtration membranes (5), (6), and (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63127625A JPH0811062B2 (en) | 1988-05-25 | 1988-05-25 | Draft tube membrane reactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63127625A JPH0811062B2 (en) | 1988-05-25 | 1988-05-25 | Draft tube membrane reactor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01296973A true JPH01296973A (en) | 1989-11-30 |
| JPH0811062B2 JPH0811062B2 (en) | 1996-02-07 |
Family
ID=14964713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63127625A Expired - Lifetime JPH0811062B2 (en) | 1988-05-25 | 1988-05-25 | Draft tube membrane reactor |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0811062B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03219866A (en) * | 1990-01-24 | 1991-09-27 | Shokuhin Sangyo Chiyoukouatsu Riyou Gijutsu Kenkyu Kumiai | Culturing method and device therefor |
| WO2004060533A1 (en) * | 2002-12-30 | 2004-07-22 | Arco Chemical Technology, L.P. | In situ filtration draught tube reactor system |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5847485A (en) * | 1981-08-18 | 1983-03-19 | デ−・エル・エム・ドクトル・ミユラ−・アクチエンゲゼルシャフト | Method and apparatus for culturing microorganism |
-
1988
- 1988-05-25 JP JP63127625A patent/JPH0811062B2/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5847485A (en) * | 1981-08-18 | 1983-03-19 | デ−・エル・エム・ドクトル・ミユラ−・アクチエンゲゼルシャフト | Method and apparatus for culturing microorganism |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03219866A (en) * | 1990-01-24 | 1991-09-27 | Shokuhin Sangyo Chiyoukouatsu Riyou Gijutsu Kenkyu Kumiai | Culturing method and device therefor |
| WO2004060533A1 (en) * | 2002-12-30 | 2004-07-22 | Arco Chemical Technology, L.P. | In situ filtration draught tube reactor system |
| CN100396357C (en) * | 2002-12-30 | 2008-06-25 | 阿克奥化学技术有限公司 | In-situ filtration draught tube reactor system |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0811062B2 (en) | 1996-02-07 |
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