JPH01290613A - Remedy for dermatosis and cosmetic - Google Patents

Abstract

PURPOSE:To obtain a remedy for dermatosis and cosmetic capable of exhibiting better effects with high safety by blending tocopherol acetate with stearin glycyrrhetinate and gamma-oryzanol and further squalene. CONSTITUTION:A remedy for dermatosis obtained by adding 0.03-0.08 g tocopherol acetate, 0.03-0.08 g stearin glycyrrhetinate, 0.03-0.08 g gamma-oryzanol and 99-99.7 g squalene to other ingredients, heating the resultant blend to 60 deg.C for 15 min allowing the blend to stand at ambient temperature overnight and subsequently filtering the blend through cloth.

Description

[Detailed Description of the Invention] [Field of Industrial Application] The present invention relates to novel skin disease therapeutic agents and cosmetics, and more specifically, tocopherol acetate and glycyrrhetinic acid, which have been conventionally used in various skin disease therapeutic agents and cosmetics. 9. Skin diseases caused by adding squalene, a completely new natural extract as a material for pharmaceuticals or cosmetics, in addition to acid stearin and γ-oryzanol.9. Regarding therapeutic agents and cosmetics.

Squalene exists in small amounts in olive oil and other plant ingredients, meat, and poultry meat, and is most commonly found in the liver of the eye shark, which lives in the deep sea around 1000 meters! 1AVct is applied.

Squalene is biosynthesized even under human internal pressure, and is distributed throughout the body's organs. Squalene secreted from the sebaceous glands to the skin surface through the upper pores is mixed with water from the sweat glands and emulsified, and has the effect of protecting the skin surface, such as moisturizing and eliminating pathogenic microorganisms.

In addition, squalene is biosynthesized into important substances such as vitamin D3, various sex hormones, and various adrenal cortical hormones through some intermediates in the human body.

[Problem to be solved by the invention]

By incorporating squalene, which has not previously been used as a single agent or as a compounding agent in pharmaceuticals or cosmetics, we are able to obtain skin disease treatment agents and cosmetics that exhibit excellent efficacy and are highly safe. This is particularly the significance of the present invention.

[Means to solve the problem]

The skin disease therapeutic agent and cosmetics of the present invention include tocopherol acetate from 0.3 to 0.08 g, stearic glycyrrhetinate from 0.03 to 0.08 g,
0.03 g to 0.08 g of γ-oryzanol and 99 g to 99.7 g of squalene were added and heated to 60°C.

Stir for 15 minutes. After leaving this still in the night vortex,
Obtained by filtering through cloth.

〔Effect of the invention〕

This principle has more significant therapeutic and preventive effects than conventional skin disease treatment agents or cosmetics, and no side effects are observed.

〔Example〕

The following examples demonstrate the effectiveness and safety of the present invention.
Apply the basic and existing acne treatment agents to the affected areas of different patients 4 times 10 times a day after washing your face in the morning, noon, evening, and before bedtime.
When applied for several days, a remarkable effect was seen on the main rules.

Its composition M is shown in Table 1).

Example 2゜ Targeting infants and adult heat rash patients, administer the standard and existing heat rash treatment agents to the affected areas of different patients one day after bathing.
It was applied three times a day for 15 days, including once, and showed remarkable effects.

The results are shown in Table 2).

Table 2) Examples of heat rash treatment results 3゜For children aged 5 to 1) with chilblains,
When Honjoku and an existing chilblain treatment were applied to the affected areas of different patients five times a day, including once after taking a bath, for seven days, Honjoku had a significant effect.

The results are shown in Table 3).

Table 3) Practical results of skin irritation treatment 4゜ Targeted at housewives with cracked and chapped hands and women who wash dishes in cafeterias, etc., the main treatment and existing crack and chapped treatment were applied to the affected areas of different patients for one day. When applied 5 times for 15 days, significant effects were seen on the main principle.

The results are shown in Table 4).

Example & Targeting female patients between the ages of 35 and 58 who have rough skin, regular and existing treatment agents for rough skin and rough skin were applied to the affected areas of different patients 5 times a day for 10 days. However, we saw a significant effect on the main rules.

Table 5) Examples of treatment results for rough skin and rough skin 6゜Targeting women aged 16 to 22 who usually experience frequent acne from spring to early summer, we applied the basic rule to the face once every night after washing for 30 days to prevent acne. When it was discontinued, it had a wonderful effect.

Table 6) Acne prevention results example 7゜Targeting infants and women who usually develop heat rash in the summer, for the purpose of fattening, the main rule was applied every day after bathing and on the trunk and thighs where the onset is expected for 20 days. When applied, a remarkable effect was observed.

The results are shown in Table 7).

Example 8゜I see the onset of chilblains on my fingers and toes every winter! For the purpose of prevention, 20 days after taking a bath every day.
When I applied it for a day, I saw a remarkable effect.

The results are shown in Table 8).

Example 9゜In order to prevent cracks and chapped hands and fingers during the winter season, a woman applied this product to her hands and fingers three times a day for 30 days, and found that it had a remarkable effect.

The results are shown in Table 9).

Table 9) Example of results for prevention of cracks and chapped skin once on the face, back of the palms, and fingers for 30 days.
When this agent was applied as a pine surge, remarkable results were obtained.

The results are shown in Table 10).

Table 10) Examples of preventive results for rough skin and rough skin 1) The presence or absence of side effects of the main rule and the extent of side effects when they occur were also examined.

Experiments were conducted using the following method on 16 patients who already had contact dermatitis or some other skin disease and were thought to have a high possibility of developing skin problems.

Taisho Pharmaceutical's patch PK was applied thickly and applied to the back of each patient, avoiding the affected area. After 48 hours, the area was observed and recorded, and the area was then irradiated with UV-860tsZ of Delmarray (Eisai), that is, an amount of light energy that normally does not cause any reaction, for 48 hours. And 72 hours later, the presence or absence of induction of inflammatory reactions was observed in detail in comparison with the control, and phototoxicity or photoallergic reactions were searched.

The results are as follows.

1) - None showed a reaction worse than erythema, - secondary irritation reaction F
i was not recognized.

2) Contact allergic reaction This reaction is called polymorphism, which is a reaction in which various skin lesions such as erythema, papules, and small vesicles are mixed together in one area, and at the same time, it protrudes beyond the area where the patch was applied. It is characterized by a reaction that appears in a delayed form, and a reaction that peaks after 48 hours, so it is called a delayed allergic reaction.

Samemilon was used in 16 cases conducted this time. None of the cases tested positive by Ace.

3) Photosensitivity reaction When erythema or other reactions occur at the application site due to irradiation with light energy, which normally does not cause any reaction on the skin, it is determined to be a photosensitivity reaction - phototoxicity and photoallergy.

All of the 16 cases tested negative at the site where the base was applied, and no phototoxicity or photoallergy was detected.

As a precaution, 12 cases that were observed 72 hours later also remained negative.

The above experimental results are shown in Table 1)).

Table 1)) Samemilon Ace Photobatch Test Procedures Amendment (No. 1, 2013) 2nd Day Patent Guardian Former “Mr. C. Ogawa Kunio 3, Relationship with the Person Who Makes the Amendment Case” Patent Applicant Date Each or Mason A Business (2'; Ki 4, Agent 5, Date of amendment order: 1925, month, day, date, date, date, date) Amendment Contents 1. The perennial "% claim scope" is corrected as follows.

r(1) A therapeutic agent for skin diseases comprising tocopherol acetate, stearyl glycyrrhetinate, γ-oryzanol and squalene.

(21ff [Cosmetic product consisting of tocopherol, stearyl glycyrrhetinate, γ-oryzanol, and squalene.) At the beginning of line 16 of the second application, the words "stearyl phosphate" are corrected to "stearyl phosphate." do.

3. At the beginning of page 3, line 5 of the circular, the words "stearyl glycyrrhetinate" are corrected to "stearyl glycyrrhetinate."

Claims (2)

[Claims] (1) A therapeutic agent for skin diseases consisting of tocopherol acetate, stearin glycyrrhetinate, γ-oryzanol and squalene. (2) A cosmetic product comprising tocopherol acetate, stearin glycyrrhetinate, γ-oryzanol and squalene.