JPH01287012A - Preventive for gray hair - Google Patents
Preventive for gray hairInfo
- Publication number
- JPH01287012A JPH01287012A JP63117410A JP11741088A JPH01287012A JP H01287012 A JPH01287012 A JP H01287012A JP 63117410 A JP63117410 A JP 63117410A JP 11741088 A JP11741088 A JP 11741088A JP H01287012 A JPH01287012 A JP H01287012A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- gray hair
- lower alkyl
- acid
- alkyl ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003449 preventive effect Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 14
- MBSJMRUSWQBXNI-OUKQBFOZSA-N (e)-nonadec-7-enoic acid Chemical compound CCCCCCCCCCC\C=C\CCCCCC(O)=O MBSJMRUSWQBXNI-OUKQBFOZSA-N 0.000 claims abstract description 12
- 125000005907 alkyl ester group Chemical group 0.000 claims abstract description 12
- INLBKXOFAJTNKG-OUKQBFOZSA-N (E)-icos-8-enoic acid Chemical compound CCCCCCCCCCC\C=C\CCCCCCC(O)=O INLBKXOFAJTNKG-OUKQBFOZSA-N 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims description 8
- 239000006071 cream Substances 0.000 abstract description 3
- 210000004761 scalp Anatomy 0.000 abstract description 3
- 239000000839 emulsion Substances 0.000 abstract description 2
- 239000000865 liniment Substances 0.000 abstract description 2
- 239000006210 lotion Substances 0.000 abstract description 2
- 239000002674 ointment Substances 0.000 abstract description 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 229940040145 liniment Drugs 0.000 abstract 1
- 230000003061 melanogenesis Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000006378 damage Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000008099 melanin synthesis Effects 0.000 description 3
- 210000002752 melanocyte Anatomy 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- -1 Polyoxyethylene Polymers 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 125000004494 ethyl ester group Chemical group 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000000118 hair dye Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 150000004702 methyl esters Chemical class 0.000 description 2
- NDWUATIHOSFJIE-UHFFFAOYSA-N nonadec-8-enoic acid Chemical compound CCCCCCCCCCC=CCCCCCCC(O)=O NDWUATIHOSFJIE-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 210000004694 pigment cell Anatomy 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- JPPRXACMNPYJNK-UHFFFAOYSA-N 1-docosoxydocosane Chemical compound CCCCCCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCCCCCC JPPRXACMNPYJNK-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- 241000512259 Ascophyllum nodosum Species 0.000 description 1
- 235000005638 Austrian pine Nutrition 0.000 description 1
- 244000056139 Brassica cretica Species 0.000 description 1
- 235000003351 Brassica cretica Nutrition 0.000 description 1
- 235000003343 Brassica rupestris Nutrition 0.000 description 1
- 101100454194 Caenorhabditis elegans mei-1 gene Proteins 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 241000257465 Echinoidea Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000001382 Experimental Melanoma Diseases 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- INKQLYSQWHBEGS-UHFFFAOYSA-N Nonadecenoicacid Chemical compound CCCCCCCCCCCCCCCCC=CC(O)=O INKQLYSQWHBEGS-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000008565 Pinus banksiana Nutrition 0.000 description 1
- 244000019397 Pinus jeffreyi Species 0.000 description 1
- 235000013264 Pinus jeffreyi Nutrition 0.000 description 1
- 235000008578 Pinus strobus Nutrition 0.000 description 1
- 235000008585 Pinus thunbergii Nutrition 0.000 description 1
- 235000014030 Podocarpus spicatus Nutrition 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 1
- 235000007215 black sesame Nutrition 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000007765 cera alba Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- WGBWLCDJBKYJRR-UHFFFAOYSA-N methyl nonadec-7-enoate Chemical compound CCCCCCCCCCCC=CCCCCCC(=O)OC WGBWLCDJBKYJRR-UHFFFAOYSA-N 0.000 description 1
- 235000010460 mustard Nutrition 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000017985 rocky mountain lodgepole pine Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
- A61Q5/065—Preparations for temporary colouring the hair, e.g. direct dyes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、地肌に塗布することにＪっ“Ｃ白髪の発ｔを
防市する白髪防１（−剤、特に７７ナデセン酸。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention provides an anti-white hair agent, particularly 77 nadecenoic acid, which is applied to the scalp to prevent the appearance of gray hair.
７−ノナデセン酸低級アルキルニスプル、８−エイ１セ
ン１又ハ８−エイ１セン酸低級゛ア′ルキルエステルを
有効成分とする白髪防Ｙト剤に関するものである。This invention relates to an anti-grey hair agent containing 7-nonadecenoic acid lower alkyl nisper, 8-ei-1 sen-1 or 8-ei-1 senic acid lower alkyl ester as active ingredients.
白髪は、一般に年齢が高（なると発生ずるもので、一方
では白髪によってその人の年長による人柄の重厚さを与
えるものであるが、他方では、老齢の感を印象付け、特
に若年における白髪は嫌われる傾向にある。そのため、
白髪を隠まため白髪染等１．°、より白髪を黒く染める
染色剤が多く研究され２、また広く市場じ使用されこい
る。Gray hair generally occurs as you get older. On the one hand, gray hair gives a person a sense of dignity due to their age, but on the other hand, it gives an impression of old age, and gray hair, especially at a young age, They tend to be disliked.Therefore,
Gray hair dye etc. to hide gray hair 1. A lot of research has been done on dyeing agents that dye gray hair black2, and they are now widely used on the market.
ｊ２かし、白髪染は一過性のものであり、白髪の成長に
よ２．て再び染色し２なければならず、また現在広く使
用されている酸化型白髪染は、酸化剤等の使用に９Ｊ５
．って皮膚に傷害を１うえる。：、とがある。j2 However, gray hair dyeing is temporary, and it depends on the growth of gray hair. In addition, the oxidative gray hair dye that is currently widely used requires the use of oxidizing agents, etc.
．． causes 1 injury to the skin. :, there is.
従って、白髪の発生を防」ｊ−する白髪防止剤に゛つい
て種々の研究が行われて”いる。Therefore, various studies have been conducted on anti-white hair agents that prevent the occurrence of gray hair.
たとえば、黒ゴマ、黒松の葉、昆布を用いたもの（特開
昭５６４７５１５号公報）、西洋がらし葉１キスを用い
たちのく特開昭５６−７９６１’ｌ’号公報）、壬振り
の抽出液を用いたもの（看・開明！１９−７０６０５Ｑ
公報）、ウニ】ギ抽出）、“４−スな用いたもの（特開
昭６０−１７８８０５号公報）、明１」葉の抽出物イ、
・用いたちのく特開昭６２−７７３０７号公報）等の植
物抽出物を有効成分とするものがある。For example, those using black sesame seeds, black pine leaves, and kelp (Japanese Patent Application Laid-Open No. 5647515), those using one kiss of Western mustard leaves (Japanese Patent Application Laid-open No. 56-7961'l'), and those using Miburi. Those using extract liquid (Kan・Kaimei! 19-70605Q
(publication), sea urchin/giant extract), “4-su na used” (Japanese Unexamined Patent Publication No. 178805/1983), “Mei 1” leaf extract a,
・There are products that contain plant extracts such as Utsuchinoku (Japanese Unexamined Patent Publication No. 62-77307) as an active ingredient.
°」：た、脳１７垂体ホル（−ンを用いたちのく特開昭
６２−６３５１０号公報）、３１３．４−ジヒト′１コ
ー１−ジフェニル）〜Ｌ−”ｒ″；ｉ＝−ンを用いたも
の（特開昭６２−６３５０９号公報）、Ｃ−ＡＭＰ（ア
Ｙノシンー３．５’−ザイクリックホスフェイト）を用
いたもの（特開昭６２−４５５２７号公報）、ビタミン
Ｄ、を用いたもの（特開昭６０−１７４７０５公報）及
びキノキシジルを用いたもの（特開昭６１−１６５３１
０号公報、同６１−２２７５１８号公報）等が開示され
ている。°'': 17 brain hormones (Tachinoku JP-A No. 62-63510 using the -phone), 313.4-dihyto'1-co-1-diphenyl) ~ L-"r"; i=-phone (Japanese Unexamined Patent Publication No. 62-63509), one using C-AMP (AYnosine-3.5'-zylic phosphate) (Japanese Unexamined Patent Publication No. 62-45527), vitamin D, (Japanese Unexamined Patent Publication No. 60-174705) and one using quinoxidil (Japanese Unexamined Patent Publication No. 61-16531)
No. 0, No. 61-227518), etc. are disclosed.
従来の白髪防止剤の有効成分は、主として植物。 The active ingredients of conventional anti-greying agents are mainly plants.
動物成分の抽出物又は動物の生体活動に関与する成分で
ある。そのため、その製造に制約があり、また効果も不
安定で充分とはいえなかった。Extracts of animal components or components that are involved in the biological activities of animals. Therefore, there were restrictions on its production, and its effects were unstable and unsatisfactory.
本発明は、構造が比較的簡単で！ｌＩ造が簡易で人手し
易（、又は市販品で人手容易で白髪防止効果の優れた物
質を有効成分とする白髪防止剤を提供することを目的と
するものである。The structure of the present invention is relatively simple! The object of the present invention is to provide an anti-greying agent that is easy to prepare and can be carried out by hand (or a commercially available substance that is easy to prepare by hand and has an excellent anti-greying effect) as an active ingredient.
毛髪におけるメラニンは、毛髪に色調を決定する重要な
因子で、毛母上部に存在する色素細胞メラノサイト内に
おいて生成され毛髪皮質細胞ケラチノサイトに摂取され
た後、毛の成長と共に上方に移動する。生理的老化の一
現象として認められる白髪は、毛母メラノサイトの数的
減少及びメラノサイトの機能低下によるメラニン生成の
減少によって発症する。Melanin in hair is an important factor that determines the color tone of hair, and is produced in melanocytes, which are pigment cells present in the upper part of the hair matrix, and is taken up by keratinocytes, which are cells in the hair cortex, and then moves upward as the hair grows. Gray hair, which is recognized as a phenomenon of physiological aging, develops due to a decrease in the number of hair matrix melanocytes and a decrease in melanin production due to a decline in melanocyte function.
本発明者は、白髪の発生現象並びにその機構について基
礎研究を行い、培養色素細胞（Ｂ１６メラノーマ細胞）
を使った実験において、色素細胞のメラニン生成を活性
化する物質を検索した結果、不飽和脂肪酸のうち、７−
ノナデセン酸、７−ノナデセン酸低級アルキルエステル
、８−エイコセン酸又は８−エイコセン酸低級アルキル
エステルがメラニン生成を顕著に活性化することを見い
出し、本発明を完成した。The present inventor conducted basic research on the phenomenon and mechanism of gray hair development, and developed cultured pigment cells (B16 melanoma cells).
In an experiment using
The present invention was completed based on the discovery that nonadecenoic acid, 7-nonadecenoic acid lower alkyl ester, 8-eicosenoic acid, or 8-eicosenoic acid lower alkyl ester significantly activates melanin production.
本発明は、７−ノナデセン酸、７−ノナデセン酸低級ア
ルキルエステル、８−エイコセン酸又は８−エイコセン
酸低級アルキルエステルを有効成分とする白髪防止剤で
ある。The present invention is an anti-white hair agent containing 7-nonadecenoic acid, 7-nonadecenoic acid lower alkyl ester, 8-eicosenoic acid, or 8-eicosenoic acid lower alkyl ester as an active ingredient.
本発明の有効成分である７−ノナデセン酸は、ＣＨｓ
（Ｃ）１２） ｒ。Ｃ）Ｉ ＝ＣＨ（Ｃ１１２） ｓｃ
Ｏ叶の構造を有する物質である。その低級アルキルエス
テルはメチルエステル、エチルエステル等である。7-nonadecenoic acid, which is the active ingredient of the present invention, is CHs
(C)12) r. C) I=CH(C112) sc
It is a substance with an oval structure. The lower alkyl esters include methyl ester, ethyl ester, and the like.
８−エイコセン酸はＣ）＋３ （ＣＬ） Ｉ。ＣＨ＝Ｃ
）Ｉ （ＣＨ２） ｓｃＯ［ｌＨの構造を有する物質で
ある。その低級アルキルエステルはメチルエステル、エ
チルエステル等である。8-eicosenoic acid is C)+3 (CL) I. CH=C
)I (CH2) scO[lH. The lower alkyl esters include methyl ester, ethyl ester, and the like.
これらの物質は、皮膚に対して何らの傷害を与えるもの
ではなく、安全な物質である。These substances do not cause any damage to the skin and are safe.
本発明の白髪防止剤は、クリーム、ローション。The anti-white hair agent of the present invention can be used in creams and lotions.
乳剤、軟膏、リニメント等の製剤型にして用いられる。It is used in formulations such as emulsions, ointments, and liniments.
本発明の上記有効成分は、製剤中に０．０１〜１０重量
％、好ましくは０．５〜２．０重量％を含有する。The above-mentioned active ingredient of the present invention is contained in the formulation in an amount of 0.01 to 10% by weight, preferably 0.5 to 2.0% by weight.
次に、本発明の白髪防止剤の実施例並びにその白髪防止
効果の試験例を挙げる。Next, examples of the anti-white hair agent of the present invention and test examples of its anti-white hair effect will be given.
実施例１ （トリートメントオイル）
ホホバ油２０． Ｏｇ、ミンク油２０．０ｇ、 ７−ノ
ナデセン酸１．０ｇ、 香料微量にスラワランを加え
、全量を１００ｇとしこれを均一に撹拌し容器に充填し
て製品とする。Example 1 (Treatment oil) Jojoba oil 20. Add Og, 20.0 g of mink oil, 1.0 g of 7-nonadecenoic acid, a trace amount of fragrance, and slawalan to make a total amount of 100 g. Stir the mixture uniformly and fill it into a container to prepare a product.
実施例２ （ヘヤクリーム）
ポ’Ｊ、？−１−シエチレンベへニルエーテル２、 ０
ｇ． テトラオレイン酸ポリオキシエチレンソルビッ
ト（４０Ｅ， ａ， ） １． ０ｇ， 親油型モス
ノステアリン酸グリセリン２． ０ｇ． サラシミツ
ロウ３． ０ｇ， マイクロスリスタリンワックス５
． ０ｇ． ベヘニルアルコール１、 ３ｇ．流動パ
ラフィン２０． ０ｇ．オクタン酸セチル１０．０ｇ，
７ーノナデセン酸メチル１．０ｇ及びパラオキシ安息香
酸ブチル０．１ｇを均一に混合し、加温溶解しＡ液とす
る。Example 2 (hair cream) Po'J,? -1-cyethylene behenyl ether 2,0
g. Polyoxyethylene sorbitol tetraoleate (40E, a, ) 1. 0g, lipophilic glyceryl mosnostearate2. 0g. White beeswax 3. 0g, Microlistalin Wax 5
．． 0g. Behenyl alcohol 1.3g. Liquid paraffin20. 0g. Cetyl octoate 10.0g,
1.0 g of methyl 7-nonadecenoate and 0.1 g of butyl paraoxybenzoate are mixed uniformly and dissolved by heating to obtain a solution A.
バラオキシ安息香酸ブチル０．１ｇ． １．３−ブチレ
ングリコール５，Ｏｇ及び精製水５０． ０ｇを加え、
加温溶解しＢ液とする。Butyl roseoxybenzoate 0.1g. 1.3-butylene glycol 5,0g and purified water 50. Add 0g,
Dissolve by heating to obtain Solution B.
Ａ液にＢ液を加え撹拌混合し、冷却して容器に充填して
製品とする。Add liquid B to liquid A, stir and mix, cool and fill into containers to produce a product.
実施例３（ヘヤトニック）
ポリオキシエチレン硬化ヒマシ油（６０Ｂ．０．Ｈ．Ｏ
ｇ。Example 3 (Hair Tonic) Polyoxyethylene hydrogenated castor oil (60B.0.H.O.
g.
ショウキョウチンキ１．０ｇ． イソプロピルメチル
フェノール０． ０５ｇ，香料 微量，エタノール５５
． ０ｇ．プラ）ニン１．Ｏｇに精製水４１．９３ｇを
均一に撹拌し容器に充填して製品とする。Ginger tincture 1.0g. Isopropyl methylphenol 0. 05g, fragrance trace amount, ethanol 55
．． 0g. Pla) Nin 1. 41.93 g of purified water is uniformly stirred in Og and filled into a container to prepare a product.
試験例
（１） ８１６細胞のメラニーン生成試験（ａ）試験
方法
マウスメラノーマ由来Ｂ１６細胞４ ＸＩＯ！１Ｍ’ｓ
ニー１０％生胎児血清１０１！１２を含んだイーグルＭ
鼎培地に懸濁し、２５ａｌｌ＋培養用ルー瓶にて５％Ｃ
Ｄ、Ｊ：在下３７′１′′二で培養する。Test Example (1) Melanin production test of 816 cells (a) Test method Mouse melanoma-derived B16 cells 4 XIO! 1M's
Eagle M containing 10% live fetal serum 101!12
Suspend in Ding medium and add 5% C in a 25all+culture Lou bottle.
D, J: Cultured at 37'1''2.
０日日及、び３日日に供試試料４０μ！Ｊｏｌ ／ １
１及び６０μ！Ｊｏｌ／１βを含む培地で交換し、５］
−１間培養する。Test sample 40μ on day 0 and day 3! Jol / 1
1 and 60μ! Replace with medium containing Jol/1β, 5]
- Incubate for 1 hour.
細胞を０．８Ｗ／ν食塩を含有する燐酸媛術゛液（ｐＨ
７，２）で洗浄後、トリプシン及びＥＤＴ八含へ溶液を
使用Ｉ。Cells were immersed in a phosphoric acid solution (pH
After washing with 7, 2), trypsin and EDT were added to the solution.
て剥離し、濾過により細胞を回収した。濾紙士、１、工
回収された細胞中のメラニン単を測定し７た４゜１ｌｂ
）供試試料
１）７−ノナデセン酸（試料Ｎα１）
２）８−エイ」セン酸（試料Ｎ０２）
（Ｃ）試験結果
次の第１表の通りであった。The cells were detached by filtration and collected by filtration. Filter paper technician, 1. Measuring mono melanin in the recovered cells 7.4゜1lb
) Test samples 1) 7-nonadecenoic acid (sample Nα1) 2) 8-nonadecenoic acid (sample N02) (C) Test results The results were as shown in Table 1 below.
第 １ 表
（２） 人に６１る白髪防止試験
（ａ）試験方法
白髪の認められる３５〜・６０才の男６名、女４名の被
検音に試料剤を１回約１．５１１．１目２回（朝。Table 1 (2) Human gray hair prevention test (a) Test method: Approximately 1.511. 1st and 2nd time (morning.
夕）頭皮：二塗擦しまた。１
塗擦前及び１１！、擦６カ月後におけろ頭頂部の毛９１
．０００本当Ｌ・りの白すの本数を数えた。Evening) Scalp: Apply two coats and rub again. 1 Before rubbing and 11! , Hair on the top of the head that should be removed after 6 months of rubbing 91
．． I counted the number of 000 L/Rino whites.
（ｂ）供試試料
７−ノナデセン酸又は８−上イ」セン酸 １％９５％エ
タノール ５０％グリセリン
５％ｍ製水
４４％〈％は重量％である）
（ｃ）試験結果
次の表２の通りであった。(b) Test sample 7-nonadecenoic acid or 8-nonadecenoic acid 1% 95% ethanol 50% glycerin
5%m water
44% (% is weight %) (c) Test results as shown in Table 2 below.
表 ２ 〔発明の効果〕 本発明は、人手容易な物質を用い、人の皮膚。Table 2 〔Effect of the invention〕 The present invention uses materials that are easy to handle and are applied to human skin.
毛髪に傷害を与えず、白髪発生防止効果の優れた白髪防
止剤を提供する極めて有用な発明である。This is an extremely useful invention that provides an anti-white hair agent that does not damage the hair and has an excellent effect on preventing the occurrence of gray hair.
Claims (1)
エステル、８−エイコセン酸又は８−エイコセン酸低級
アルキルエステルを有効成分とすることを特徴とする白
髪防止剤。An anti-white hair agent comprising 1,7-nonadecenoic acid, 7-nonadecenoic acid lower alkyl ester, 8-eicosenoic acid or 8-eicosenoic acid lower alkyl ester as an active ingredient.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63117410A JPH01287012A (en) | 1988-05-13 | 1988-05-13 | Preventive for gray hair |
| US07/328,997 US4978525A (en) | 1988-03-31 | 1989-03-27 | Agents for preventing the formation of gray hairs |
| KR1019890004125A KR970010813B1 (en) | 1988-03-31 | 1989-03-30 | Agents for preventing the formation of gray hair |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63117410A JPH01287012A (en) | 1988-05-13 | 1988-05-13 | Preventive for gray hair |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH01287012A true JPH01287012A (en) | 1989-11-17 |
Family
ID=14710959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63117410A Pending JPH01287012A (en) | 1988-03-31 | 1988-05-13 | Preventive for gray hair |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01287012A (en) |
-
1988
- 1988-05-13 JP JP63117410A patent/JPH01287012A/en active Pending
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