JPH01249049A - Artificial knee joint - Google Patents
Artificial knee jointInfo
- Publication number
- JPH01249049A JPH01249049A JP63078605A JP7860588A JPH01249049A JP H01249049 A JPH01249049 A JP H01249049A JP 63078605 A JP63078605 A JP 63078605A JP 7860588 A JP7860588 A JP 7860588A JP H01249049 A JPH01249049 A JP H01249049A
- Authority
- JP
- Japan
- Prior art keywords
- material layer
- joint
- bone
- artificial knee
- vital
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000629 knee joint Anatomy 0.000 title claims abstract description 25
- 239000000463 material Substances 0.000 claims abstract description 29
- 230000000975 bioactive effect Effects 0.000 claims description 11
- 210000000689 upper leg Anatomy 0.000 claims description 7
- 210000002745 epiphysis Anatomy 0.000 claims 2
- 239000007769 metal material Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 abstract description 18
- 229910052751 metal Inorganic materials 0.000 abstract description 8
- 239000002184 metal Substances 0.000 abstract description 8
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract description 6
- 239000011248 coating agent Substances 0.000 abstract description 5
- 238000000576 coating method Methods 0.000 abstract description 5
- 210000002303 tibia Anatomy 0.000 abstract description 5
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract description 3
- MTPVUVINMAGMJL-UHFFFAOYSA-N trimethyl(1,1,2,2,2-pentafluoroethyl)silane Chemical compound C[Si](C)(C)C(F)(F)C(F)(F)F MTPVUVINMAGMJL-UHFFFAOYSA-N 0.000 abstract description 3
- 229910000599 Cr alloy Inorganic materials 0.000 abstract description 2
- 229910001069 Ti alloy Inorganic materials 0.000 abstract description 2
- -1 titanium carbide nitride Chemical class 0.000 abstract description 2
- 239000012190 activator Substances 0.000 abstract 4
- 210000001694 thigh bone Anatomy 0.000 abstract 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 2
- NRTOMJZYCJJWKI-UHFFFAOYSA-N Titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 abstract 1
- 239000001506 calcium phosphate Substances 0.000 abstract 1
- 239000011521 glass Substances 0.000 abstract 1
- 229940078499 tricalcium phosphate Drugs 0.000 abstract 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 abstract 1
- 235000019731 tricalcium phosphate Nutrition 0.000 abstract 1
- 239000010410 layer Substances 0.000 description 13
- 238000000034 method Methods 0.000 description 4
- 238000010828 elution Methods 0.000 description 3
- 239000005313 bioactive glass Substances 0.000 description 2
- 238000005422 blasting Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000008407 joint function Effects 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- 238000004544 sputter deposition Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000007751 thermal spraying Methods 0.000 description 2
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 2
- 208000020084 Bone disease Diseases 0.000 description 1
- 101100008048 Caenorhabditis elegans cut-4 gene Proteins 0.000 description 1
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 description 1
- 208000000260 Warts Diseases 0.000 description 1
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical class [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 238000005468 ion implantation Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は人体において疾病、災害などにより失われた関
節機能を修復するための整形外科用人工膝関節に関する
ものである。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to an orthopedic artificial knee joint for restoring joint function lost due to disease, disaster, etc. in the human body.
変形性関節症や慢性関節リューマチなどの骨の疾病で手
足の関節機能に障害が生じた場合、整形外科における観
血的治療法の1つとして人工関節置換術がしばしば行わ
れている。特に荷重関節である膝関節での症例が多く、
年間2万症例を越えている。When joint function of limbs is impaired due to bone diseases such as osteoarthritis or rheumatoid arthritis, artificial joint replacement surgery is often performed as one of the open treatments in orthopedics. In particular, there are many cases in the knee joint, which is a load-bearing joint.
The number of cases exceeds 20,000 annually.
人工膝関節は膝関節の摺動部表面のみを修復する表面置
換型と、膝関節全部を置き換えるヒンジ型があるが、主
に表面置換型が用いられている。There are two types of artificial knee joints: the surface replacement type, which repairs only the sliding surface of the knee joint, and the hinge type, which replaces the entire knee joint, but the surface replacement type is mainly used.
この表面置換型の人工膝関節は第4図、第5図、第6図
にそれぞれ例示したように金属又はセラミック製の大腿
骨側部材りと脛骨側部材Kからなり、脛骨側部材にの摺
動部には超高分子量ポリエチレン部品が嵌込まれたもの
が最も多く使用されている。This surface replacement type artificial knee joint consists of a femoral side member K and a tibial side member K made of metal or ceramic, as illustrated in Figs. 4, 5, and 6, respectively. The most commonly used moving parts are those in which ultra-high molecular weight polyethylene parts are fitted.
また表面置換型人工膝関節の大腿骨部材りには大腿骨遠
位端の頬面全体を置換するものが多いが、第5図に示す
外側顆又は内側顆の一方のみを置換するタイプもあり、
ヘミ人工膝関節と呼ばれている。これらいずれの人工膝
関節においても大腿骨との固定強度を増すために顎骨に
挿入する固定ピンPを一体的に具備せしめておく必要が
あった。In addition, most femoral components of surface replacement type knee joints replace the entire buccal surface of the distal end of the femur, but there are also types that replace only one of the lateral or medial condyles, as shown in Figure 5. ,
It is called a hemi artificial knee joint. In any of these artificial knee joints, it was necessary to integrally provide a fixing pin P to be inserted into the jawbone in order to increase the strength of fixation with the femur.
一般に表面置換型人工膝関節は、骨切り量を極力少なく
する事を重要視しており、顎骨の片側のみが患部となっ
ている場合はヘミ人工膝関節が好んで用いられている。In general, surface replacement type artificial knee joints emphasize minimizing the amount of bone cut as much as possible, and when only one side of the jawbone is affected, a hemi-artificial knee joint is preferred.
ヘミ人工膝関節は、一般の人工膝関節よりも肉厚が薄い
ため骨切り量が少ないという点ではより大きなメリット
をもっている。The hemi-artificial knee joint has a greater advantage in that it requires less bone cutting because it has a thinner wall thickness than a general artificial knee joint.
このうち第5図に示すヘミ人工膝関節は従来からコバル
ト−クロム合金、ステンレス鋼などでつくられており、
上述の利点を持つ反面、金属イオンの溶出がおこり患部
が黒変することすらあった。Of these, the hemi artificial knee joint shown in Figure 5 has traditionally been made of cobalt-chromium alloy, stainless steel, etc.
Although it has the above-mentioned advantages, it sometimes causes elution of metal ions and even turns the affected area black.
また、生体補綴部材として生体との固定性もあまり良好
とは言えず、経年的に骨との接合界面にクリヤーゾーン
が出現してルーズニングを発生するものが多かった。In addition, as a bioprosthetic member, its fixability to the living body is not very good, and many of them tend to become loose due to the appearance of a clear zone at the bonding interface with the bone over time.
一方、第6図に示すようなアルミナセラミック製ヘミ人
工膝関節も使用されており、耐摩耗性は格段に向上し、
金属イオンの溶出もなく、生体親和性も良好であるもの
の、アルミナ素材が生体不活性であるため、固定性の改
善が十分でなかった。On the other hand, an alumina ceramic hemi-artificial knee joint as shown in Figure 6 is also used, and its wear resistance has been greatly improved.
Although there was no elution of metal ions and the biocompatibility was good, the fixation was not sufficiently improved because the alumina material was bioinactive.
しかもアルミナセラミックは高剛性材料(脆性材)であ
るため、肉厚を厚くしなければならない結果、ヘミ人工
膝関節の特長の一つが失われるものであった。Moreover, since alumina ceramic is a highly rigid material (brittle material), the wall thickness had to be increased, and as a result, one of the features of the Hemi artificial knee joint was lost.
したがって、本発明が解決しようとする問題点をまとめ
ると次の如くである。Therefore, the problems to be solved by the present invention can be summarized as follows.
3、骨切り量の問題 □骨切量の増加
4、耐摩耗性の問題 □耐久性の低下
〔問題点を解決するための手段〕
本発明は上記5つの問題点を同時に解決せんとするもの
であって、関節部材の基体を強度の大きい金属で構成し
、骨と当接する側の面にはハイドロキシアパタイトなど
の生体活性材を被着して骨との固定性を増大せしめ、他
方の摺動面には、耐摩耗性に優れたチン化チタン、アル
ミナなどの耐摩耗性材を被着して、関節部材を構成した
。3. Problem with the amount of bone cut □Increase in the amount of bone cut 4. Problem with wear resistance □ Decrease in durability [Means for solving the problem] The present invention aims to solve the above five problems at the same time. The base of the joint member is made of a metal with high strength, and the side that contacts the bone is coated with a bioactive material such as hydroxyapatite to increase fixation with the bone, and the other side of the joint member is made of a metal with high strength. The joint member was constructed by coating the moving surface with a wear-resistant material such as titanium chloride or alumina, which has excellent wear resistance.
以下、本発明実施例を図により具体的に説明する。 Embodiments of the present invention will be specifically described below with reference to the drawings.
第1図はヘミ人工膝関節の斜視図を示し、この関節は大
腿骨の置端部に装着される関節部材1と、脛骨に装着さ
れる関節部材2から構成され、第3図に示すように、そ
れぞれ大腿骨りい脛骨に、に装着される。FIG. 1 shows a perspective view of a hemi-artificial knee joint, which is composed of a joint member 1 attached to the distal end of the femur and a joint member 2 attached to the tibia, as shown in FIG. They are attached to the femur and tibia, respectively.
このうち、関節部材1の基体11はCo−Cr合金、チ
タン合金などの金属製で大腿骨Dbの置端部形状に適合
し易いような湾曲形状を成し、この基体11の大腿骨り
、に当接する側の面には生体活性材層11aが被着して
あり、また関節として摺動する側の面には耐摩耗性材J
i!fllbが被着しである。Among these, the base body 11 of the joint member 1 is made of metal such as Co-Cr alloy or titanium alloy, and has a curved shape that easily adapts to the shape of the disposed end of the femur Db. A bioactive material layer 11a is coated on the surface that comes into contact with the joint, and a wear-resistant material J is coated on the surface that slides as a joint.
i! fllb is attached.
ところで、上記の関節部材1が骨と強固に接合するため
に被着される生体活性材層11aを形成する材料として
はハイドロキシアパタイト、生体活性ガラス、β−TC
P Dリカルウシムホフオスへイト)、あるいはこれら
を組合せたものであってもよい。また、このような生体
活性材を関節部材1の基体11の表面に被着せしめる方
法とししは溶射法、スパッタリング法、イオンブレーテ
ィング法、析出法などが有効であり、生体活性ガラスで
は熔融コーティング法によることもできる。By the way, the materials forming the bioactive material layer 11a to which the above-mentioned joint member 1 is adhered in order to firmly connect with the bone include hydroxyapatite, bioactive glass, and β-TC.
It may also be a combination of these. In addition, effective methods for applying such a bioactive material to the surface of the base 11 of the joint member 1 include thermal spraying, sputtering, ion blasting, and precipitation.For bioactive glass, melt coating is effective. It can also be done by law.
さらに上記手段によって被着される生体活性材層11a
の厚みは5〜100μmが好適であり、5μm以下では
骨伝導能及び増生骨の安定性において顕著な改善が認め
られなかった。また100μm以上の厚さではコスト高
となるばかりでなく、生体活性材層11a内部の破壊が
起き易く、すなわち骨との接合強度が小さいものとなっ
た。Furthermore, a bioactive material layer 11a applied by the above-mentioned means
The preferred thickness is 5 to 100 μm, and when the thickness is 5 μm or less, no significant improvement was observed in the osteoconductivity and stability of the augmented bone. Moreover, if the thickness is 100 μm or more, not only will the cost be high, but the inside of the bioactive material layer 11a will be easily destroyed, that is, the bonding strength with the bone will be low.
一方、脛骨に装着される関節部材2と摺動する側の面に
被着する耐摩耗性材層11aとしてはチン化チタン、炭
化チタン、炭チッ化チタン、アルミナなどが適用される
が、これらの被着手段としてはイオンブレーティング法
、スパッタリング法、溶射法などのほか、チッ素イオン
などによるイオン注入法をも利用し得る。また耐摩耗性
材層11bの厚みは、50μm以下で十分な耐摩耗性を
発揮し、例えば5μm以下であっても十分長期間にわた
る使用に耐え得るものであった。ところが50μm以上
の厚みになると層間破壊が発生し易い傾向があり、好ま
しいものではなかった。On the other hand, titanium chloride, titanium carbide, titanium carbide, alumina, etc. are used as the wear-resistant material layer 11a attached to the surface that slides on the joint member 2 attached to the tibia. In addition to the ion blasting method, sputtering method, thermal spraying method, etc., ion implantation method using nitrogen ions or the like can also be used as a deposition method. Furthermore, when the thickness of the wear-resistant material layer 11b was 50 μm or less, sufficient wear resistance was exhibited, and even when the thickness was, for example, 5 μm or less, it could withstand use for a sufficiently long period of time. However, a thickness of 50 μm or more tends to cause interlayer failure, which is not preferable.
さらに、関節部材lの大腿骨と接合する側の面には第1
図(ロ)にて示すように数多くの凹凸11cを形成し、
これらの上面に生体活性材層11aを被着しておくこと
によって、より強固に骨との接合を図ることができる。Furthermore, a first
As shown in figure (b), a large number of unevenness 11c is formed,
By covering these upper surfaces with the bioactive material layer 11a, it is possible to achieve stronger bonding with the bone.
なお、上記凹凸11Cとしてはローレット加工による溝
や、多数のイボ状凸起を形成したものであってもよい。The unevenness 11C may be a groove formed by knurling or a large number of wart-like protrusions.
上記実施例においてはヘミ人工膝関節について説明した
が、本発明の要旨は他の型式の人工膝関節にも適用可能
であることは勿論である。In the above embodiment, a hemi-artificial knee joint has been described, but the gist of the present invention is of course applicable to other types of artificial knee joints.
〔発明の効果]
軟土のように、本発明によれば、機械的強度の大きな金
属製の基体の骨との接する側には生体活性材層を、摺動
する側には耐摩耗製材層を各々被着せしめであることに
よって、骨内での固定強度が大幅に向上することから関
節部材自体に固定ビンを形成する必要がないばかりでは
なく、固定ビンが存在しないことによって関節置換術に
おける骨切り量が極小で済む。また装着する骨端部の整
形加工も簡単となるため術式も容芹qる。[Effect of the invention] Like soft soil, according to the present invention, a bioactive material layer is provided on the side of the metal base with high mechanical strength that comes into contact with bones, and a wear-resistant lumber layer is provided on the sliding side. Since the fixation strength within the bone is greatly improved by attaching each of The amount of bone cut is minimal. In addition, the surgical procedure is also more convenient because the shaping of the bone end to which it is attached is easier.
また、金属製基体の外表面を生体活性材層、耐摩耗性材
層でもって覆ったことから、関節部材の耐蝕性を向上さ
せることができ、かつイオン溶出を阻止することができ
るなど優れた人工膝関節、特にヘミ人工膝関節をもたら
すことができる。In addition, since the outer surface of the metal base is covered with a bioactive material layer and a wear-resistant material layer, it is possible to improve the corrosion resistance of joint members and to prevent ion elution. A knee prosthesis can be produced, especially a hemi-prosthesis.
第1図は本発明実施例による人工膝関節の斜視図、第2
図(イ)は第1図におけるX−X線断面図、同図(ロ)
は第1図におけるX−X線部分に相当する他の実施例に
よる断面図、第3図は本発明に係る人工膝関節を大腿骨
−脛骨間に装着した状態を示す斜視図、第4図、第5図
及び第6図はともに従来の人工膝関節の例を示す斜視図
である。
1.2:関節部材
11a :生体活性材層
11b :耐摩耗性材層FIG. 1 is a perspective view of an artificial knee joint according to an embodiment of the present invention, and FIG.
Figure (a) is a cross-sectional view taken along line X-X in Figure 1, and figure (b)
1 is a cross-sectional view of another embodiment corresponding to the line X-X in FIG. 1, FIG. 3 is a perspective view showing the state in which the artificial knee joint according to the present invention is installed between the femur and tibia, and FIG. 4 , FIG. 5, and FIG. 6 are both perspective views showing examples of conventional artificial knee joints. 1.2: Joint member 11a: Bioactive material layer 11b: Wear-resistant material layer
Claims (1)
が金属材で湾曲状をした基体から成り、該基体の上記骨
端部に当接する側の面には生体活性材層を、関節として
摺動する側の面には耐摩耗性材層が各々被着してあるこ
とを特徴とする人工膝関節。A joint member to be attached to the epiphysis of the femur, the member comprising a curved base made of a metal material, and a bioactive material layer on the side of the base that comes into contact with the epiphysis, An artificial knee joint characterized in that a layer of wear-resistant material is applied to each side of the joint that slides.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63078605A JP2784766B2 (en) | 1988-03-30 | 1988-03-30 | Artificial knee joint |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63078605A JP2784766B2 (en) | 1988-03-30 | 1988-03-30 | Artificial knee joint |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH01249049A true JPH01249049A (en) | 1989-10-04 |
JP2784766B2 JP2784766B2 (en) | 1998-08-06 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP63078605A Expired - Fee Related JP2784766B2 (en) | 1988-03-30 | 1988-03-30 | Artificial knee joint |
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WO1995023567A1 (en) * | 1994-03-03 | 1995-09-08 | Ben Nissan Besim | Modular ceramic knee prosthesis |
USRE43282E1 (en) | 1998-09-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and devising treatment |
US8690945B2 (en) | 2001-05-25 | 2014-04-08 | Conformis, Inc. | Patient selectable knee arthroplasty devices |
US8862202B2 (en) | 1998-09-14 | 2014-10-14 | The Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and preventing damage |
US8882847B2 (en) | 2001-05-25 | 2014-11-11 | Conformis, Inc. | Patient selectable knee joint arthroplasty devices |
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US9286686B2 (en) | 1998-09-14 | 2016-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and assessing cartilage loss |
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS63154179A (en) * | 1986-12-19 | 1988-06-27 | 川崎製鉄株式会社 | Surface modification of medical metal implant material |
-
1988
- 1988-03-30 JP JP63078605A patent/JP2784766B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63154179A (en) * | 1986-12-19 | 1988-06-27 | 川崎製鉄株式会社 | Surface modification of medical metal implant material |
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