JPH01207238A - Material for preventing decubitus - Google Patents

Abstract

PURPOSE:To obtain a decubitus permanently effectively suppressing growth of bacteria of decubitus such as Pseudomonas aeruginasa, useful for alleviating pains of person in bed for a long period of time such as bedridden old people, comprising sheetlike polyurethane foam having dispersed chitonate powder. CONSTITUTION:A material for preventing decubitus comprising polyurethane foam carrying chitosan as an active ingredient. The polyurethane foam carrying the chitosan is obtained by dissolving a polyurethane polymer in an organic solvent, then suspending a chitonate powder in the solution and incorporating the suspension with a crosslinking agent such as amine or water, a blowing agent such as fluorocarbon. A substance obtained by deacetylating chitin (linear poly-(beta-1,4-N-acetylglucosamine) obtained from shell of Crustacea such as crab or shell of arthropod with an conc. alkali to give a compound and depolymerizing the compound with an alkali, acid, etc., to a proper molecular weight. The active ingredient is wetted and dissolved with sweat, etc., of a patient and gradually exhibits antibacterial effects.

Description

[Detailed description of the invention] [Industrial application field]

The present invention relates to medical materials, particularly bedsore prevention materials for bedridden elderly and other long-term recumbent patients.

[Conventional technology]

(Background) ijlT (bed sore; decubitus) is a skin necrosis that occurs in critically ill patients who are on absolute bed rest, patients with spinal cord injuries, and long-term bedridden patients who cannot turn over by themselves, such as bedridden elderly people. It is particularly likely to occur in the sacral region, and when it occurs, it does not heal easily due to the effects of internal malnutrition even if a draining type poultice is applied to the wound. (Problems with the prior art) Therefore, it is better to prevent the occurrence of bedsores than to treat them, and the means to achieve this are to change the body position regularly, cleanse the body,
Although it is recommended to use a special bed that can be turned over (Ishiyaku Publishing Co., Ltd. (Latest Medical Dictionary), p. 676), in any case, it places a great physical or financial burden on the caregiver. Become. In addition, attempts have been made to prevent the concentration of local loads by supporting the body from multiple sides with air mats, and to improve cushioning properties by laying urethane foam sheets, but air mats do not allow the body to sway. The patient is not calmed down, and the urethane foam sheet only has the effect of slightly delaying the development of bedsores. Now that we have entered an aging society, it is an inevitable trend that the number of bedridden elderly people with no hope of recovery will continue to increase. Reaching the end of one's life in such agony is not only painful for the individual, but also unbearable for the family and other people around them.

[Problem to be solved by the invention]

In view of the above circumstances, an object of the present invention is to provide a means for effectively suppressing the occurrence of bedsores. (Summary) In order to solve the above-mentioned problems, the gist of the present invention is a bed-splash prevention material characterized by being made of a sheet-like polyurethane foam in which chitosanate powder is dispersed. (Production of foamed sheet) The foamed polyurethane supporting chitosan used in the present invention can be prepared by, for example, (1) dissolving a polyurethane prepolymer in an organic solvent and suspending chitosanate powder in this solution;
Add a crosslinking agent such as amine, water, or a blowing agent such as Freon, or suspend the chitosanate powder in an aqueous dispersion made by self-emulsifying or force-emulsifying polyurethane. It is manufactured by spreading and forming a film or coating it on trt and drying it. (Polyurethane) The polyurethane that is the base material of the sheet of the present invention does not need to have a special structure, and is made by adding TDI (lylene diisocyanate) or MDI (diphenylmethadiisocyanate) to a very ordinary polyether polyol or polyester polyol. The reaction may produce a urethane prepolymer having terminal incyanate groups, which may be processed as described above. (Chitosan and its acid 111) The chitosan used here is chitin CM-like poly(β- Poly-(β-1,4-glucosamine) obtained by deacetylating 1,4-N-7 cetylglucosamine)) with a concentrated alkali. Suitable molecules such as hydrogen peroxide and chlorous acid! It is used after depolymerization (thinning) to 11. For the purposes of the present invention, the molecular weight of the chitosan used is 1.00.
It is preferably 0 or more and 100,000 or more, and the degree of deacetylation of chitosan is 50% or more, preferably 70% or more. Since the above chitosan is not soluble in water as it is, it is made water-soluble by converting it into an inorganic acid such as hydrochloric acid or an organic acid such as formic acid, acetic acid or lactic acid. The antibacterial and antifungal properties of chitosanate have already been published by Omuro et al. Then, Escherichia coli, Bacillus natto, Bacillus aeruginosa,
Although it has been shown to be effective against Staphylococcus and other molds such as Fusarium, it has no antibacterial properties when dried. It only exhibits its antibacterial properties when it is dissolved in the surrounding wood. Incidentally, the MIC (minimum inhibition degree C) for the six compounds listed in L is about 200 to 400 ppm, and is completely harmless to humans and higher animals. The above antibacterial spectrum of chitosanate shows that the bacteria that cause bedsores are Pseudomonas aeruginosa and Staphylococcus (Pharmaceutical Society of Japan No. 1
(Refer to Abstracts of the 2007 Meeting 4J (1987), p. 800), it is extremely effective in preventing bedsores. The particle size of the chitosanate is preferably finer, and is preferably 48 mesh 1 or less when sieved according to the JIS standard, and the content in the polyurethane is arbitrarily selected between 1 and 30%. If the amount is less than -E, the effect will be poor, and if it exceeds the range, foaming will become unnecessary, and addition efficiency will decrease, resulting in uneconomical results. (Foamed sheet) The thickness of the sheet of the present invention is preferably selected between 0.2 and 10III6. If the thickness is too thin, the dust on the body will be strong and the anti-bedsore effect will be reduced. , if it is too thick, the supported chitosanate cannot be utilized effectively. The sheet of the present invention is cut into an appropriate size and the sheet is cut into a suitable size to remove the skin f? , by attaching it directly to the surface or holding it in a nightgown or diaper.

[Effect]

In the polyurethane sheet for preventing decubitus ulcers of the present invention, the chitosanate supported inside the sheet becomes wetted and dissolved by the patient's sweat and gradually exhibits antibacterial properties, thereby preventing decubitus infections such as Pseudomonas aeruginosa and Staphylococcus. Because it effectively and sustainably suppresses the growth of pathogenic bacteria,

[Example] As described in the section, it exhibits an excellent anti-fleckstone effect.

【Example】

Hereinafter, embodiments of the present invention will be shown, but the examples are for illustration only and do not imply any limitation or limitation on the inventive concept. Water-dispersed polyurethane (manufactured by Osaka Daisha (Superflex E-2000) "Solid content 50%) 390 weight i1
4.5 parts by weight of (Chitosan Kw-5 >> (manufactured by Shin Nippon Kagaku ■, molecular weight approximately 50,000, degree of acetylation 80%, particle size 48 mesh pass) 4.5 parts by weight (Scoremin Former RF) @ (Foaming agent, manufactured by a major company) 5.0
-! 11 parts by weight (Guiflon 113) ■ (foaming agent, manufactured by Daikin Industries ■) 2.5i (Okibe and (Superflex VF) > 4 parts by weight (thickening agent, manufactured by Daikin Industries),
Stir at high speed with an electric household stirrer and overrun approximately 3 times.
00$ fresh cream state. This was coated on a polyester nonwoven fabric to a thickness of 5 mm, and then dried to obtain a breathable foam sheet having a thickness of 31 mm. The above-mentioned sheets were applied directly to the skin of 100 bedridden patients in areas prone to AM (mainly the lumbosacral region), and observation was continued for half a year while changing them once a week. The results were as follows. The results were good, with 52 cases being effective (no bulges), somewhat effective (no linings) in 38 cases, and 10 cases being ineffective (with lins), that is, 90% of the 100 cases did not develop T'jln. Obtained.

[Effects of 11 syllables] As explained above, 1 ppun j is able to provide a bedjar prevention material with excellent preventive effects, resulting in a reduction of +51 syllables for bedridden masters and other long-term bedridden patients, or a reduction of 51 syllables for caregivers. This can contribute to reducing fatigue.

Claims (1)

[Claims] 1. An anti-bedsore material comprising a sheet-like polyurethane foam in which chitosanate powder is dispersed.