JPH0117705B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a dropper with improved functionality. Although conventional dropper bottles are used to dispense small amounts of liquid quickly and accurately, they have the disadvantage that liquid tends to remain in the nozzle. For this reason, if you drop the liquid in the dropper bottle once and then continue dropping it, the liquid may run out in the nozzle, or droplets may remain outside the end opening, resulting in an insufficient amount of each drop. It is accurate and often dirty due to droplets around the distal opening. BACKGROUND ART Recently, immunological quantitative methods have been widely used for quantifying substances in living organisms using agglutination or agglutination inhibition reactions using latex reagents sensitized with antigens or antibodies. At this time, it is necessary that the amount of reagent dripped from the dropper bottle containing the latex reagent is always constant, and any variation in the amount dropped may lead to erroneous measurement results and misdiagnosis. Also, if you shake the dropper bottle vigorously during use, the liquid will seep into the nozzle, and this will cause the internal air to expand, pushing out the reagent.
I wipe off the droplets before use. These phenomena often occur when products require storage in a cool place, or when they are stored at room temperature but used during high temperatures such as summer. In addition, suspensions of medical supplies such as drugs and quasi-drugs are sometimes used by shaking the container to homogenize the contents, and when the cap is removed, the contents may spray out from the nozzle. Otherwise, the contents may adhere to the cap, reducing the product value. Furthermore, in order to ensure the accuracy of the amount of drops for each sample, the operation is complicated as the end opening must be wiped while dropping onto the plate. In order to eliminate these drawbacks, the present invention was completed as a result of intensive research, and includes a filler material at the base of the nozzle or the center of the nozzle so that the content liquid can easily pass through when pressed by the bottle body. This is a drop bottle for immunological diagnosis or quantitative measurement that has a nozzle with a built-in nozzle. The dropper of the present invention can be of any shape as long as it can discharge the filled solution drop by drop by applying pressure from the outside. Suitable materials for the dropper include, for example, polyethylene and other synthetic resins, and soft resins such as rubber, which may be used alone or in appropriate combinations. Also used is a glass container having openings at both ends, with a rubber cap attached to one opening and a nozzle body attached to the other opening. The filler is preferably a porous material or a fibrous material that is insoluble in the solvent used and allows the solution to pass through easily by pressing the bottle body. Examples of the porous body include synthetic resin foams, sintered bodies, more specifically, foamed porous bodies having polyvinyl formal as a substrate, fused or sintered polyethylene, polypropylene, polyamide, and the like. Examples of the fibrous material include synthetic fibers such as polypropylene, polyester, vinylon, nylon, and polyethylene, glass wool, and absorbent cotton. Synthetic resin porous bodies have continuous pores and high porosity, and are particularly preferred. These fillers can be used alone or in appropriate combinations. The filler can be used in any shape depending on the shape of the nozzle, such as a block, cylinder, sheet, plate, or other shape. For example, when a porous synthetic resin material is used as a filler, it is preferable that the filler be formed into a shape having approximately the same diameter as the central hollow part at the bottom of the nozzle and tightly inserted into this hollow part. Furthermore, an auxiliary body having a hole corresponding to the nozzle capillary can be inserted into the upper and/or lower part of the filling material. This auxiliary body is made of acrylic resin, phenolic resin, silicone resin, urea resin, fluororesin, etc. Hereinafter, one example of the dropper of the present invention will be explained with reference to the drawings. Fig. 1 is a side view showing one example of the dropper bottle of the present invention;
The figure and FIG. 3 are longitudinal sectional views thereof. The bottle body 1 is a cylindrical container made of soft synthetic resin, and when the side surface is pressed, it deforms and the internal pressure increases. The nozzle body 2, also made of synthetic resin, is fitted into the opening 1 of the bottle body, preferably with a threaded structure, and placed thereon, and has a central hollow part 4 and a thin tube 5, and the central hollow part 4 is filled with a filler material 6. has been done. FIG. 3 shows an embodiment in which an auxiliary body 7 having a central pore is inserted above the filler 6. The cap 3 is detachably attached to the nozzle body 2, and the cap 3 and the nozzle body 2 may be connected by a screw structure. When using the dropper bottle of the present invention, after removing the cap 3, point the thin tube 5 of the nozzle downward and press the side of the container body 1 with your finger, so that the liquid in the bottle passes through the filler 6. and falls from the end opening of the capillary tube 5 as a droplet. When the pressure on the container body is removed after dropping, the container returns to its original shape and the inside of the container becomes negative pressure. In conventional drop bottles, when the inside of the container becomes negative pressure, air suddenly flows in from the thin tube 5, so liquid remains in the thin tube 5, and when dripping again, the amount of one drop may be inaccurate. It was a lot. On the other hand, the dropper of the present invention does not cause a sudden inflow of air, so
No liquid remains in the thin tube 5. Further, even if the dropper is shaken strongly, the liquid does not enter the thin tube 5, so the amount of the droplet is always kept constant. Experimental example: Put anti-human antithrombin antibody sensitizing latex reagent into five dropper bottles with a 2 mm tip opening.
The weight of each drop of latex reagent dropped from this dropper was measured 10 times for each dropper. The measurements were performed as follows. A: Drop the latex reagent while wiping the opening at the tip of the nozzle. B:
Drop the latex reagent without wiping the tip opening. C: 4.5mm polyvinyl formal porous material (PVF: Kanebo Sponge Bell Eater A-3420
A latex reagent (method of the present invention) is dripped from a dropper bottle filled with a dropper (manufactured by Kanebo Synthetic Chemical Co., Ltd.). The average values of the results are shown in the table below.

[Table] As is clear from the results, when using the dropper of the present invention, there is almost no difference in the amount of each drop from the conventional method, which involves wiping the tip opening of the nozzle after each drop, and moreover, The difference in dropped weight (or standard deviation) of this method is approximately half that of the conventional method, resulting in extremely excellent efficacy. Furthermore, it was confirmed that by using the dropper of the present invention, there was no loss of reagent and the number of sample measurements increased by two to three times compared to the conventional method of dropping reagent while wiping the tip opening of the nozzle. Ta. Similar results were obtained when fibrous polypropylene was used as the filler. Example 1 A polyvinyl formal porous material (Kanebosu Siber Eater A-3420 Kanebo Synthetic Chemical Co., Ltd.) was placed in a polyethylene dropper with a tip opening of 2 mm in diameter.
) was formed into a cylindrical shape with a diameter of 4.5 mm and a height of 8 mm,
It was attached to a drop bottle. Example 2 A polyvinyl formal porous material (Kanebo Sponge Bell Eater A-3410) with a diameter of 5.6 mm was placed in a polyethylene dropper with a tip opening of 1.0 mm in diameter.
It was formed into a cylindrical shape with a height of 3 mm and a height of 3 mm, and was attached to a drop bottle. Example 3 Polypropylene synthetic fibers were tightly packed into a glass dropper bottle made of partially rubber and having a tip opening with a diameter of 2 mm to a length of 3 mm without any gaps.

[Brief explanation of drawings]

FIG. 1 is a side view showing one example of the dropper bottle of the present invention, and FIGS. 2 and 3 are longitudinal cross-sectional views showing two types of the dropper bottle, in which symbol 1 is the container body, and 2 is the container body. In the nozzle body, 3 is a cap, 6 is a filling material, and 7 is an auxiliary body.

Claims (1)

[Scope of Claims] 1. A dropper bottle for immunodiagnosis or metering that has a nozzle with a built-in filler at the base or center of the nozzle so that the liquid can easily pass through by pressing the bottle body. . 2 The filler is a porous material or a fibrous material,
A dropper bottle according to claim 1. 3. The dropper according to claim 1 or 2, wherein the filler is a porous polyvinyl formal resin or a polypropylene sintered body.