JPH01143827A - Capsule - Google Patents

Abstract

PURPOSE:To obtain capsules having improved strength at bonded edge parts, capable of thinning a film itself and smoothly releasing a drug, etc., by protruding bond face parts in the outer peripheral direction to form sheath parts, opposingly bond the sheath each other to make a framed shape. CONSTITUTION:Outer peripheral parts 13 and 17 of an upper film 12 and a lower film 16 of halved ellipse are protruded in the outer direction to form sheath parts 14 and 18. Contents 11 to be sealed are packed into between the upper film 12 and the lower film 16, tacky faces 15 and 19 of the sheath parts 14 and 18 are mutually opposed and bonded under pressure or heat sealing. The tacky area can be enlarged by the shape of the sheath part, bonding strength can be improved, the film itself can be thinned, the film is readily dissolved in the body and a drug is smoothly released. A multi-layer film is readily adopted and consequently, an aqueous solution, etc., which have been difficult to capsulate can be encapsulated.

Description

[Detailed description of the invention] (Industrial application field) W10 type emulsions, liquid oils such as fragrances, solid substances such as powders, granules, tablets, extracts, lotions, milky lotions, seasoning liquids, aqueous medicinal liquids, etc. The present invention relates to soft capsules for enclosing aqueous liquids, organic solvents, etc.

(Conventional Technique Ifi) In the conventional capsule manufacturing method in which capsule membranes are bonded together and capsules are formed and filled, the capsule membrane is bonded by pressure cutting between two molding molds, either a rotary one-way type or a flat plate type. Since the capsules were directly joined at the cut surface of the membrane while punching out the capsules, it was difficult to adhere if the thickness of the capsule membrane (cut surface) was thin, and even if the capsule was adhered, the adhesive strength was weak, resulting in low capsule strength and the content. The problem was that the liquid leaked.

For example, the thickness of the film when filling capsules can be reduced to about 0.4 mm using conventional methods, but it can be reduced to 0.6 to 1.5 mm.
is standard, 0.4 mm or less when filled with film, 0 when dry
．． Encapsulation at a thickness of 2 mm or less is difficult with conventional bonding methods on cut surfaces. Furthermore, gelatin (protein) is most commonly used as a base for capsule membranes, but since gelatin dissolves in water, it has been impossible to encapsulate water. Similarly, it is difficult to encapsulate substances that react with proteins, organic acids, substances with low boiling points, etc. using gelatin base. However, if you create a multilayered film by coating the inner surface of the gelatin capsule film with a water-resistant resin or a chemically stable substance,
Can be filled as gelatin capsules. However, in this case, it is difficult to press-cut and heat-bond each layer of the film in pairs using the conventional adhesion method using cut surfaces, and there are few suitable film bases other than gelatin, so it is difficult to create a multilayer structure. Soft capsules have not been commercialized.

(Technical Problem) The present invention has been made in view of the shortcomings of the prior art, and aims to improve the strength of the adhesive edge of the capsule, and
The membrane itself can be made thinner, allowing for smooth release of drugs, etc. within the body and speeding up capsule disintegration, and the multi-layered membrane allows for the encapsulation of aqueous liquids, etc., which were previously difficult to encapsulate. The technical challenge is to achieve this goal.

(Technical Means) In order to solve the above-mentioned technical problem, in the present invention, a flange is formed by protruding the edge of the adhesive surface to be joined based on pressure bonding or heat sealing toward the outer periphery, so that the flange can be separated from each other. It has a wider adhesion area.

Specifically, as shown in the drawings (FIGS. 1 to 8), the configuration is as follows.

Regarding the first embodiment (FIGS. 1 to 3).

The main components of IO are gelatin, glycerin, water, etc.
In addition, it is formed with a film that maintains a moisture content within a certain range,
The capsule body has an ellipsoidal shape, and the enclosed contents 11 are mainly oily liquid, powder suspension oil, paste oil, W10
Type emulsion etc.

Reference numeral 12 designates an upper membrane having an ellipsoidal shape in half, and a flange 14 is formed on the outer peripheral edge 13 of the membrane so that the outer peripheral edge 13 has a border shape so that the cross section becomes approximately △ in the outward direction.

Reference numeral 15 indicates an adhesive surface of the flange portion 14.

Reference numeral 16 denotes a lower membrane having a shape obtained by halving an ellipsoid, and a flange 18 is formed on the outer peripheral edge 17 of the lower membrane so that the cross section becomes approximately V-shaped in the outward direction.

Reference numeral 19 indicates an adhesive surface of the flange portion 18.

Reference numeral 20 denotes an adhesive portion formed by adhering the adhesive surfaces (15, 19) facing each other, and the overall shape is a border material shape with a substantially zero cross section.

In addition, this embodiment is formed with a single layer of thin film, and the formation of the flanges (14, 18) allows for a wide adhesion area, so for example when filling the enclosed contents. Even if the film is as thin as approximately 0.4 mm, it can be bonded, and the disintegration of the capsule body IO can be accelerated.
The adhesive strength of the capsule body 10 is also improved.

(for production) The above technical means works as follows.

Pressure weld. At this time, the outer peripheral edge (1
3, 17), the flange portions (14, 18) are curved outward in an edged manner. Next, the adhesive surface (
15, 19) They may be placed facing each other and bonded together by pressure or heat sealing.

Therefore, even with a single thin film, the flange (14, 18)
Since it forms a large area of adhesive,
Adhesive strength can be improved.

At this time, the overall shape of the capsule body 10 becomes an ellipsoidal shape with edges as shown in FIG.

Since the membrane itself can be made thin in this way, especially when used as a drug, it can be easily dissolved in the body and the drug can be released smoothly.

Regarding the second embodiment (FIGS. 4 and 5).

In this embodiment, the same parts as in the first embodiment are given substantially recessed numbers.

The feature of the unembodied example is that the upper skin 12 and the lower skin 1916 are formed into double membranes, thereby increasing the functionality and durability of the capsule membrane against the contents, and making it possible to encapsulate substances that could not be encapsulated in the past. It's about encapsulation.

That is, the membrane 22 is made of a capsule base such as gelatin, agar, alginic acid (salt), pullulan, carrageenan, farcelan, cellulose derivatives, tamarind gum, locust Bingham, or guar gum, and has water resistance, drug resistance,
Membranes with different physical properties (membrane functions) such as breathability, such as starches, cellulose, shellac, organic silicone resins, β-pinene polymers, copolymers of poly(meth)acrylic acid and poly(meth)acrylic acid ester The present invention is characterized in that a multilayer soft capsule with a high membrane function is formed by using an inner membrane 21 made of a thermosetting resin such as a phenol resin, a urea resin, or an epoxy resin, or an ultraviolet curing resin.

In addition, glycerin, sorbitol, mannitol, polyethylene glycol, etc. are used as additives (plasticizers) for the film, and water-soluble pigments permitted for pharmaceuticals, titanium oxide, caramel, mica, etc. are used as colorants. As with conventional soft capsules, methyl, ethyl, and propyl esters of paraoxybenzoic acid can be used as preservatives.

Therefore, the enclosed contents 11 do not directly cause a chemical reaction with the outer membrane 22 and damage the outer membrane 22, and the inner membrane 2
1 is also protected by the outer membrane 22, the adhesive strength is always maintained, and there is no leakage of the enclosed contents 11 to the outside via the inner membrane 21.

That is, it is possible to encapsulate water, alcohol, etc., which could not be encapsulated with conventional gelatin-based single-layer soft capsules.

For example, if the filling material is water, a gelatin single-layer film will melt, and if the filling material is alcohol, the alcohol will pass through the film and evaporate.
Furthermore, when the filler is an emulsion, a gelatin monolayer film has
Moisture transfers to the membrane, softens the membrane, and evaporates.

In this embodiment, the capsule body 10 is formed into a double-layered film, but it is not limited to this, and may be formed with a multi-layered film, and its effects are approximately the same as those of a double-layered film. It is concave.

Regarding the third embodiment (FIGS. 6 to 8).

Incidentally, in this embodiment, substantially concave portions are given approximate concave numbers.

The feature of this embodiment is that the overall shape of the rimmed capsule body 10 is applied to various shapes other than an ellipsoid, such as an elongated ellipsoid, a spherical shape, and a double shape. The operation and effect are substantially the same as those of the first embodiment.

(Effects) The present invention has the following unique effects.

In particular, since the capsule body is formed into a rimmed shape, it is possible to improve and maintain the adhesive force at the adhesive edge during molding of the capsule body, and the thickness of the entire film can be made as thin as possible. I can do it.

For this reason, there is no risk of the enclosed contents leaking out, and the dissolution time of the membrane is fast, making it easy to release the contents.Also, a multilayer membrane is used instead of a conventional capsule that adheres at the cut surface of the capsule membrane. In some cases, it would be necessary to bond each layer at the cut surfaces of the corresponding layers, which was practically impossible, but this capsule solves this drawback.

[Brief explanation of the drawing]

1 to 3 show a first embodiment of the present invention, FIG. 1 is a perspective view of the entire capsule body, and FIG. 2 is a part of the section taken along the line x-X in FIG. 1. The vertical side view and FIG. 3 are enlarged sectional views showing the main parts of the collar. 4 and 5 show a second embodiment of the product of the present invention, in which FIG. 4 is a partially longitudinal side view, and FIG. 5 is an enlarged sectional view showing the main part of the collar. Figures 6 to 8 show the third embodiment, in which Figure 6 is an overall perspective view of an oblong capsule body, Figure 7 is an overall perspective view of a spherical capsule body, and Figure 8 is an overall perspective view of a spherical capsule body. FIG. 2 is an overall side view of a double-shaped capsule body. 14.18...Brim portion 15.19...Adhesion surface 20.
...Adhesive portion patent applicant Fuji Capsule Co., Ltd.

Claims (4)

[Claims] (1) A capsule in which a flange is formed by protruding the adhesive surface portion that is bonded by pressure and heat sealing toward the outer periphery, and the flange portions are bonded facing each other to form a rimmed shape. (2) In the statement of claim 1, the capsule with a rim is made of a single-layer thin film. (3) In the statement of claim 1, the capsule with a rim is made of a multilayer membrane of two or more layers. (4) In claims 1 to 3, the overall shape of the rimmed capsule is ellipsoidal, oblong,
Capsules applied to other shapes such as spherical, tube-shaped, double-shaped, etc.