JPH01110137A - Tacky adhesive sheet for medical care - Google Patents

Abstract

PURPOSE:To make the feeling in use comfortable, while the pulling for human skin in actions in prevented by forming pressure sensitive adhesive layer on one surface of the sheetlike base composed of a specified thermoplastic resin block polymer. CONSTITUTION:In the tacky adhesive sheet 1 for medical care, a pressured sensitive adhesive layer 3 is formed on one surface of a sheetlike base. As the stock of the sheetlike base 2, the thermoplastic block polymer shown by a formula (I), is used. In the formula (I), A represents the polyamide component selected from nylon 6, nylon 6.6, nylon 10, nylon 11 and nylon 12, and B represents polyether component selected from polyethylene glycol, polyprophylene glycol and polytetramethylene glycol, and then n represents a positive integer. This stock has low modulus similar to skin, and can follow the extension and contraction of the skin, and further is excellent in moisture permeability and transparency. As the sheetlike base 2, the material having 100-500kg/cm<2> of tensile strength and 10-100kg/cm<2> for modulus in 100% elongation.

Description

Detailed Description of the Invention (Field of Industrial Application) The present invention relates to medical adhesive sheets such as adhesive bandages, surgical cloth materials, bandages, etc., and its purpose is to have low elastic behavior similar to skin and high The purpose of the present invention is to provide a medical adhesive sheet with excellent water vapor permeability, bacterial resistance, and water resistance.

(Prior art and its problems) Conventionally, medical adhesive sheets such as adhesive bandages are made by forming a pressure-sensitive adhesive layer on one side of a sheet-like base material.
It is used by being attached to the skin surface via the adhesive force of the pressure-sensitive adhesive layer.

However, since the sheet-like base material of such conventional medical adhesive sheets uses materials such as polyethylene and polyester, it does not have low elasticity behavior similar to skin, and does not expand and contract according to the expansion and contraction of the skin. The patient's skin felt tight every time he moved, making it uncomfortable to use.

In addition, these materials do not have sufficient water vapor permeability.
Sweat can accumulate between the skin and the pressure-sensitive adhesive layer, increasing the moisture content of the epidermis more than necessary, which can be harmful to healthy skin, and also reduce the adhesive strength of the pressure-sensitive adhesive layer. Therefore, there was a risk of displacement and peeling.

By the way, in order to prevent the adverse effects associated with such a lack of water vapor permeability, the sheet-like base material is made porous or microporous,
It is possible to use a material with excellent water vapor permeability for the pressure-sensitive adhesive layer, but with such a structure, there is a risk that water, bacteria, etc. may penetrate through the pores to the skin surface, and conversely, it may be possible for water, bacteria, etc. to enter the skin surface through the pores. There is a risk that secretions may leak out of the sheet-like base material, resulting in unsanitary conditions.

(Problem to be solved by the invention) In light of the above-mentioned conventional circumstances, the industry has developed materials that have low elasticity behavior similar to skin, high water vapor permeability, bacterial resistance,
It is desired to create a medical adhesive sheet with excellent water resistance.

(Means for Solving the Problems) The present invention provides a medical adhesive in which a pressure-sensitive adhesive layer is formed on one side of a sheet-like base material made of a thermoplastic block polymer represented by the following general formula (I). sheet.

(In the formula, A is nylon 6, nylon 6.6, nylon 1
B is a polyether component selected from polyethylene glycol, polypropylene glycol, and polytetramethylene glycol, and n is a positive integer. )
The above problem is solved by providing the following.

(Structure of the Invention) As shown in FIG. 1, the medical adhesive sheet (1) according to the present invention has a pressure-sensitive adhesive layer (3) formed on one side of a sheet-like base material (2). be.

As a material for the sheet-like base material, a thermoplastic block polymer represented by the following general formula (■) is used.

(In the formula, A is nylon 6, nylon 6.6, nylon 1
B is a polyether component selected from polyethylene glycol, polypropylene glycol, and polytetramethylene glycol, and n is a positive integer. ) As the block polymer represented by this general formula, those commercially available from Toshi Co., Ltd. under the trade name Pebax can also be used.

The reason for using the material for the sheet-like base material (2) is that such a material has a low elastic modulus similar to that of skin N, can follow the expansion and contraction of the skin, and also has excellent water vapor permeability and transparency. .

The sheet-like base material (2) has a tensile strength of 100~
500kg/cnT, 100% modulus 10~
It is desirable that the weight be 100 kg/d.

Tensile strength is 500 kg/ca or more, or 100 kg/ca or more
If the % modulus is 100 kg/cJ or more, flexibility cannot be imparted to the sheet, and when it is made into an adhesive sheet and applied to the skin, it cannot follow the expansion and contraction of the skin, causing physical irritation to the skin, which is undesirable. .

In addition, the tensile strength is 100 kg/ctM or less, 1
If the 00% modulus is less than 10 kg/cJ, the adhesive sheet becomes too flexible, making it inconvenient to handle and causing problems in use.

The tensile strength and modulus can be set within the above ranges by changing the ratio of hard segments to soft segments of the thermoplastic block polymer.

That is, polyamide component A which is a hard segment component
and the weight percentage of polyether component B with respect to the total weight of polyether component B which is a soft segment component is 50 ~
90% by weight.

The thickness of the sheet-like base material (2) is preferably 20 to 150 μm.

If it is less than 20 μm, it will be too thin and it will be inconvenient to handle such as adhesion to the skin or peeling it off. On the other hand, if it is more than 150 μm, it will not give appropriate flexibility even if the above-mentioned specific block polymer is used as a material for the sheet-like base material. On the other hand, when the specific block polymer mentioned above with a thickness of 20 to 150 μm is used as the material for the sheet-like base material, The sheet-like base material (2) imparts a low elastic modulus similar to that of skin, making it possible to follow the expansion and contraction of the skin more reliably, and ensuring high water vapor permeability.

Polyamide component A consists of polycondensation of dicarboxylic acids such as terephthalic acid, oxalic acid, adipic acid, sebacic acid, and 1-cyclohexyldicarboxylic acid with diamines such as ethylenediamine, pentamethylenediamine, and hexamethylenediamine, caprolactam, and capryloyldiamine. It can be obtained by polymerization of cyclic lactams such as lactam, caprinlactam, and laurinlactam, polycondensation of aminocarboxylic acids, or copolymerization of the above-mentioned cyclic lactams, dicarboxylic acids, and diamines.

Polyether component B is polyoxyethylene glycol,
Polyoxyalkylene glycols such as polyoxypropylene glycol and polyoxytetramethylene glycol are used.

The material for the pressure-sensitive adhesive layer (3) is preferably a copolymer of an alkyl ester monomer of acrylic acid or methacrylic acid and a carboxyl group-containing copolymerizable monomer.

The reason for using an alkyl ester monomer of acrylic acid or methacrylic acid is that this material does not cause strong irritation to the skin, has excellent water vapor permeability and transparency, and also prevents adhesiveness from decreasing even with long-term use. be.

The reason for using a material made by copolymerizing an alkyl ester monomer of acrylic acid or methacrylic acid with a carboxyl group-containing copolymerizable monomer is that the former alone lacks cohesive force, whereas copolymerizing the latter This is because a suitable cohesive force can be obtained and the skin adhesion is excellent.

Such a copolymer has a glass transition point of 250°K or less (preferably 180 to 250°K) and a weight average molecular weight of 50°K.
,000 or more (preferably 500,000 to 2,000
,000) is preferably used.

This is because if the glass transition point exceeds 250°K, appropriate adhesion and cohesive strength cannot be obtained.

Moreover, if the weight average molecular weight is less than 50,000, appropriate cohesive force cannot be obtained.

Incidentally, such a copolymer contains 100 parts by weight of the former and 1 part by weight of the latter.
Practically speaking, it is more desirable to set the amount in the range of 10 parts by weight.

If it is less than 1 part by weight, the cohesive force will be relatively weak;
This is because if the amount exceeds 1 part by weight, the cohesive force becomes unnecessarily high and a large number of polar groups are introduced, which causes a problem of skin irritation when applied to the skin.

The thickness of the pressure sensitive adhesive layer (3) is preferably 10 to 60 μm.

If it is less than 10 μm, sufficient adhesion cannot be obtained for adhesion to the skin, while if it exceeds 60 μm, sufficient water vapor permeability cannot be obtained even if the above-mentioned copolymer is used.
This is because when the thickness is 10 to 60 μm, both adhesiveness and water vapor permeability are excellent.

Examples of the alkyl ester monomer of acrylic acid or methacrylic acid in the copolymer include ethyl acrylate, butyl acrylate, propyl acrylate, isooctyl acrylate,
Isononyl acrylate, decyl acrylate, lauryl acrylate, or methacrylic esters thereof are used, and these may be used alone or in combination of two or more.

As the carboxyl group-containing copolymerizable monomer, acrylic acid, methacrylic acid, iconic acid, maleic acid, etc. are used.

In addition, a vinyl monomer can be used along with the above monomer mixture, if necessary.

In producing this pressure-sensitive adhesive, common polymerization catalysts such as azobis compounds and peroxide compounds can be used.

As the polymerization method, any of solution polymerization, emulsion polymerization, and suspension polymerization can be used.

For example, acrylic acid, an acrylic acid alkyl ester ammonium, a monomer mixture such as the copolymerizable vinyl monomer, a solvent such as ethyl acetate, and a radical generating catalyst are added to a reaction vessel for 10 to 20 hours. to complete the polymerization.

The above sheet-like base material (2) and pressure-sensitive adhesive layer (3)
) means that the overall water vapor permeability in a laminated state is 500g/r.
d・24hr・40℃ or more (preferably 5oo~2
It is desirable to set it to oOOg/M, 24 hr, and 40°C.

This is because the amount of sweat from the skin varies from person to person and depending on the region of the skin, and if the temperature is less than 500 g/rd, 24 hr, and 40° C., there is a risk that water vapor may not be able to permeate sufficiently in areas that sweat a lot.

When manufacturing medical sheets, a pressure-sensitive adhesive is directly applied to a sheet-like base material made of a thermoplastic block polymer, dried, and a releasable sheet is pasted, or the above-mentioned pressure-sensitive adhesive is applied onto a releasable sheet. This can be done by applying the adhesive, drying it, and then laminating a sheet-like base material to obtain a medical adhesive sheet in which the pressure-sensitive adhesive is protected by a releasable sheet.

The structure of the medical adhesive sheet (1) according to the structure of the present invention is as described above, and when using this medical adhesive sheet (1), as shown in FIG. The medical adhesive sheet (1) may be attached using the adhesive force of the pressure adhesive, and the medical adhesive sheet (1) expands and contracts following the expansion and contraction of the affected area due to the patient's movements, and sweat evaporates as water vapor (4).

(Effects of the Invention) The present invention provides a medical adhesive sheet in which a pressure-sensitive adhesive layer is formed on one side of a sheet-like base material made of a thermoplastic block polymer represented by the following general formula (1).

(In the formula, A is nylon 6, nylon 6.6, nylon 1
B is a polyether component selected from polyethylene glycol, polypropylene glycol, and polytetramethylene glycol, and n is a positive integer. )
Therefore, the following effects are achieved.

Since the sheet-like base material has a low elastic modulus similar to that of skin, it expands and contracts in accordance with the expansion and contraction of the skin, and does not cause twitching on the skin during operation, providing a comfortable feeling of use.

Due to the high water vapor permeability of the sheet-like substrate, sweat from the skin evaporates effectively and does not accumulate between the skin and the pressure-sensitive adhesive layer, increasing the moisture content of the epidermis more than necessary and keeping it healthy. There is no risk of harmful effects on the skin, and there is no risk of the adhesive force of the pressure-sensitive adhesive layer decreasing and causing displacement or peeling.

Since there is no need for water vapor permeation holes, there is no risk of water, bacteria, etc. invading the skin surface, and conversely, there is no risk of secretions from skin wounds leaking out of the sheet-like base material. Hygienic.

Particularly in this invention, when the sheet-like base material has a tensile strength of 100 to 500 kg/cd and a 100% modulus of 10 to 100 kg/cJ, a low elastic modulus more similar to that of skin is imparted. There is no inconvenience in handling such as adhesion and peeling, and it can more reliably follow the expansion and contraction of the skin.

In particular, in this invention, the thickness of the sheet-like base material is 20 to 15
When the thickness is 0 μm, low elasticity similar to that of the skin is imparted, the expansion and contraction of the skin can be more reliably followed, and high water vapor permeability can be ensured.

Particularly in this invention, the pressure-sensitive adhesive layer is made of a copolymer of an alkyl ester monomer of acrylic acid or methacrylic acid and a carboxyl group-containing copolymerizable monomer, and has a glass transition point of 2.
If the weight average molecular weight is less than 50" and the weight average molecular weight is 50,000 or more, there will be no strong irritation to the skin, excellent water vapor permeability, less tendency to decrease in adhesiveness even after long-term use, and improved safety and stability. It has excellent transparency and can be applied without checking the area of the skin to which it is applied.

In particular, in this invention, the thickness of the pressure sensitive adhesive layer is 20 to 5.
When the thickness is 0 μm, both adhesiveness and water vapor permeability are excellent.

In particular, in this invention, the overall water vapor permeability of the laminated state of the sheet-like base material and the pressure-sensitive adhesive layer is set to 5°0 gIn?・
When the duration is 24 hr/40'c or more, perspiration can be sufficiently permeated regardless of individual differences and skin regions.

(Example) <Example 1> Butyl acrylate 97 parts methacrylic acid
3 parts Ethyl acetate 150 parts Azoisobutyronitrile 0.3 parts The above components were charged into a polymerization reaction vessel, and the reactor was stirred while purging with nitrogen.

Thereafter, the internal temperature was maintained at 55 to 65°C, and polymerization was started. Polymerization is completed in about 10 hours.

Thereafter, the internal temperature was raised to 70°C and stirring was continued for about 2 hours.

The glass transition point of this copolymer was 221°K, and the weight average molecular weight (based on GPC measurement) was 570,000.

Next, this copolymer was applied to a release paper whose surface had been treated with silicone under drying conditions of 130° C. for 5 minutes so that the thickness after drying was 45 μm.

A sheet of 35 μm thick product name Pebasox 3533 (manufactured by Toshi Co., Ltd.), which has been corona-treated on one side, is pasted and pressure-bonded to the pressure-sensitive adhesive side of the release paper containing this pressure-sensitive adhesive to form a medical adhesive sheet. did.

The water vapor permeability, adhesive strength, and holding power of this product were as shown in Table 1.

<Examples 2 and 3> The glass transition point and weight average molecular weight of each sample were also listed in Table 1. Examples 2 and 3 were carried out in the same manner as in Example 1, except that the monomer mixture shown below was used.

Example 2 2 Ethylhexyl acrylate 90 parts Ethyl acrylate 5 parts Acrylic acid
5 parts Example 3 Isonolyl acrylate 60 parts Butyl acrylate 35 parts Acrylic acid
5 parts table 1 Quantity Uniform weight 10,000,000 *1 (Adhesive force measurement method) Using a medical adhesive sheet with a width of 2 (1+n) and a Bakelite plate as the adherend, the adhesive strength was measured at 1 in accordance with JIS Z-1528.
The 80° peeling adhesive strength (g/19m+a) was measured.

*2 (Holding force) A 10 mm x 20 mm adhesive sheet was attached to a Bakelite plate, and a load of 500 g was applied at 40° C., and the time (minutes) until the adhesive sheet fell was measured.

The adhesive sheet was lined with a polyester film to prevent it from stretching during the measurement.

*3 (Water vapor permeability) Put 10ml of distilled water into a glass container with an inner diameter of 38mm and a height of 40+m, and place an adhesive sheet with a diameter of 5mm (pressure-sensitive adhesive layer on the bottom) over the mouth of the container. Cover and secure.

Next, this is placed in a constant temperature and humidity machine at a temperature of 40° C. and a relative temperature of 30% and left for 24 hours.

The amount of water lost from this container is then measured.

Water vapor permeability is expressed as g/m・24 hours・40”C.

[Brief explanation of the drawing]

FIG. 1 is a side view of a medical adhesive sheet according to the present invention;
FIG. 2 is an explanatory diagram of its use. (1) Medical adhesive sheet (2) Sheet-like base material (3) Pressure-sensitive adhesive layer Fig. 1

Claims (6)

[Claims] (1) A medical adhesive sheet comprising a sheet-like base material made of a thermoplastic block polymer represented by the following general formula (I) and a pressure-sensitive adhesive layer formed on one side thereof. ▲There are mathematical formulas, chemical formulas, tables, etc.▼(I) (In the formula, A is nylon 6, nylon 6.6, nylon 1
B is a polyether component selected from polyethylene glycol, polypropylene glycol, and polytetramethylene glycol, and n is a positive integer. ) (2) The sheet-like base material has a tensile strength of 100 to
500kg/cm^2, 100% modulus 10-1
The medical adhesive sheet according to claim 1, characterized in that the weight is 00 kg/cm^2. (3) The thickness of the sheet-like base material is 20 to 150 μm.
A medical adhesive sheet according to any of claims 1 to 2, characterized in that: (4) The pressure-sensitive adhesive layer is a copolymer of an alkyl ester monomer of acrylic acid or methacrylic acid and a carboxyl group-containing copolymerizable monomer, and has a glass transition point of 250°K.
The medical adhesive sheet according to any one of claims 1 to 3, characterized in that the weight average molecular weight is 50,000 or more. (5) The pressure-sensitive adhesive layer has a thickness of 10 to 60 μm.
A medical adhesive sheet according to any one of claims 1 to 4, characterized in that: (6) The overall water vapor permeability of the sheet-like base material and the pressure-sensitive adhesive layer in a laminated state is 500 g/m^2・24 hr.
- A medical adhesive sheet according to claims 1 to 5, characterized in that the temperature is 40°C or higher.