JP7841913B2 - Oil-based cosmetics - Google Patents

Description

This invention relates to an oily cosmetic composition containing a heparin-like substance.

In the recent oil-based cosmetics market, there is a demand for products that moisturize and make lips appear healthy, improve dryness, and enhance makeup application. To achieve these effects, various active ingredients have been investigated, and the use of heparinoids has also attracted attention. For example, technologies for topical compositions containing heparinoids and iron oxide that are fluid at 25°C (see, for example, Patent Document 1) and technologies for improving dryness with lip cosmetics containing heparinoids (see, for example, Patent Document 2) have been studied.

Japanese Patent Publication No. 2016-193847 Japanese Patent Publication No. 2000-204020

However, while conventional techniques allow for color correction, the heparinoid is dissolved in aqueous components, which is sometimes insufficient for oil-based cosmetics. On the other hand, insufficient dispersibility of the heparinoid can make it difficult to achieve moisturizing effects and sustained effects. Therefore, there has been a desire to develop a cosmetic that provides moisture to the skin and lips, sustains that effect, and even improves roughness, by creating an oil-based cosmetic in which the water-soluble heparinoid is stably and sufficiently dispersed in an oil-based component. This invention aims to develop a cosmetic that combines these effects.

As a result of diligent research, the inventors discovered that a specific oil agent stably disperses water-soluble heparinoid substances. By combining heparinoid substances with a specific oil agent containing hydroxyl groups and solidifying it with an oil-soluble gelling agent, the heparinoid substances can be stably and sufficiently dispersed even in oily cosmetics. This results in a product that feels good on the skin, provides ample moisture, has long-lasting effects, and even improves skin roughness. This led to the completion of the present invention.

In other words, the present invention includes the following embodiments.
[1] An oily cosmetic containing (a) a heparin-like substance, (b) one or more substances selected from ester oils and higher alcohols that are liquid at 25°C and have hydroxyl groups, and (c) an oily gelling agent.
[2] An oily cosmetic in which component (b) is a liquid ester oil at 25°C having a hydroxyl group.
[3] An oily cosmetic composition further comprising 0.001 to 5% by mass of component (a).
[4] An oily cosmetic in which component (b) is one or more selected from the group consisting of diisostearyl malate, decaglyceryl decaethylhexanoate, decaglyceryl decaisostearate, decaglyceryl nonaisostearate, decaglyceryl pentaisostearate, diglyceryl triisostearate, diglyceryl diisostearate, and diglyceryl monoisostearate.
[5]
Furthermore, an oily cosmetic in which the mass ratio (b)/(a) of component (b) to component (a) is 5 or more.
[6]
Furthermore, an oily cosmetic composition containing 0.001 to 1% by mass of component (d) polyhydric alcohol.

This invention allows for the stable dispersion of heparin-like substances in an oily formulation, resulting in a pleasant feel on the skin and providing sufficient moisture immediately after application. Furthermore, it offers sustained moisturizing effects and excellent efficacy in improving chapped skin and lips.

This study evaluated the oil-dispersibility of heparin-like substances.

The present invention will be described in detail below. In this document, "~" indicates a range including the numbers before and after it.

Component (a) heparin-like substance in the present invention is a heparin-like substance as defined in the Japanese Pharmacopoeia Standards for Non-Official Drugs, and is a polysulfated ester of a mucopolysaccharide obtained by sulfated a polysaccharide whose repeating unit is a disaccharide consisting of D-glucuronic acid and N-acetyl-D-galactosamine. Heparin-like substances are components that have a chemical structure similar to "heparin," a type of sugar produced in the human liver, and are collectively called heparin-like substances. Specifically, heparin-like substances include cellulose sulfate, chitin sulfate, chitosan sulfate, pectin sulfate, chondroitin sulfate, inulin sulfate, alginate sulfate, glycogen sulfate, starch sulfate, polyvinyl alcohol sulfate, polyglucose sulfate, polylactose sulfate, laminarin sulfate, galactan sulfate, levan sulfate, and their polysulfur oxides and their salts. Heparin-like substances are known to have moisturizing and blood circulation promoting effects. In the present invention, heparin-like substances described in the Japanese Pharmacopoeia Standards for Non-Official Drugs 2002 can be preferably used. Furthermore, the heparin-like substance defined in the Japanese Pharmacopoeia's Standards for Non-Official Drugs is primarily composed of polysulfate esters of chondroitin sulfate.

The amount of organic sulfate groups in component (a) is not particularly limited, and any can be used, but from the viewpoint of moisturizing effect, 20 to 40% by mass (hereinafter simply abbreviated as %) is preferred. The amount of organic sulfate groups in component (a) in this invention can be measured by the method described in the quantitative analysis of "Heparin-like Substances" in the Japanese Pharmacopoeia 2002.

The content of component (a) in the present invention is not particularly limited, but is preferably 0.001% by mass or more, more preferably 0.01% or more, even more preferably 0.05% or more, preferably 5% or less, more preferably 3% or less, and even more preferably 1% or less in the oily cosmetic composition. Furthermore, 0.001 to 5% is preferred, 0.01 to 3% is more preferred, and 0.05 to 1% is even more preferred. Within this range, the moisturizing effect, the duration of the moisturizing effect, and the dispersibility of the heparin-like substance are superior, making it more preferable.

In this invention, component (b), a liquid ester oil and higher alcohol having hydroxyl groups, refers to an oil containing hydroxyl groups in its structure that have not been modified by esterification or other means, and which exhibits fluidity at 25°C. Any oil that can be used in cosmetics can be used. The hydroxyl group mass ratio in the molecule of component (b) in this invention is not particularly limited, but for example, 1 to 20 is preferred. In particular, ester oils with a hydroxyl group mass ratio of 1 or more in the molecule of component (b) are more preferred, and ester oils with a hydroxyl group mass ratio of 2 or more are even more preferred.

Examples of such components (b) include organic acid esters such as diisostearyl malate and triethylhexyl citrate, polyglycerin fatty acid esters such as diglyceryl monoisostearate, diglyceryl diisostearate, diglyceryl triisostearate, decaglyceryl pentaisostearate, decaglyceryl nonaisostearate, decaglyceryl decaisostearate, and decaglyceryl decaethylhexanoate, and branched fatty acid higher alcohols such as octyldodecanol and decyltetradecanol. Ester oils are particularly preferred from the standpoint of dispersibility of heparin-like substances, and among these, one or more selected from the group consisting of diisostearyl malate, decaglyceryl decaethylhexanoate, decaglyceryl decaisostearate, decaglyceryl nonaisostearate, decaglyceryl pentaisostearate, diglyceryl triisostearate, diglyceryl diisostearate, and diglyceryl monoisostearate are particularly preferred.

The content of component (b) in the present invention is not particularly limited, but is preferably 10% or more, more preferably 20% or more, even more preferably 30% or more, and also preferably 90% or less, more preferably 80% or less, and even more preferably 75% or less in the oily cosmetic composition. Furthermore, 10-90% is preferred, 20-80% is more preferred, and 30-75% is even more preferred. Within this range, it is more preferable due to superior dispersibility of the heparin-like substance.

While not particularly limited, the mass ratio (b)/(a) of component (a) to component (b) is preferably 5 or more, more preferably 10 or more. It is also preferably 200 or less, more preferably 150 or less. Furthermore, it is preferably between 5 and 200, and more preferably between 10 and 150. Within this range, the dispersibility of component (a) can be further enhanced, resulting in superior moisturizing effect and longer-lasting moisturizing effect, making it more preferable.

The component (c) oily gelling agent in this invention imparts appropriate viscosity to oily cosmetics, forms a cosmetic film upon use, and enhances the moisturizing effect and its duration. Any oily gelling agent that can be used in ordinary cosmetics can be used. Examples of oily gelling agents include synthetic hydrocarbons, natural and synthetic waxes, hydrogenated oils, higher fatty acids, solid higher alcohols, dextrin fatty acid esters, metal soaps, polysaccharide fatty acid esters, fuming anhydrous silicic acid, and organically modified clay minerals. Specifically, paraffin wax, ceresin wax, ozokerite wax, microcrystalline wax, Fischer-Tropsch wax, polyethylene wax, ethylene-propylene copolymer, candelilla wax, carnauba wax, beeswax, rice wax, beeswax, Japanese wax, gypsum wax, montan wax, stearyl-modified methylpolysiloxane, behenyl-modified methylpolysiloxane, cetostearyl alcohol, behenyl alcohol, jojoba alcohol, phyto Examples of suitable materials include sterols, dextrin palmitate, dextrin myristate, (palmitic acid/2-ethylhexanoic acid) dextrin, aluminum stearate, magnesium stearate, sucrose palmitate, fructooligosaccharide stearate, inulin stearate, 12-hydroxystearic acid, fuzzy anhydrous silicic acid, stearalkonium hectorite, disteardimonium hectorite, quaternium-18 hectorite, etc., and one or more of these can be used. Furthermore, the fuzzy anhydrous silicic acid may be subjected to hydrophobic treatment, and examples of such treatment methods include trimethylsiloxy treatment with trimethylsilyl chloride or hexamethyldisilazane, octylsilanation treatment, coating and baking treatment using methylhydrogenpolysiloxane, and coating with metal soap. In this invention, one or more selected from the group consisting of natural waxes, synthetic waxes, dextrin fatty acid esters, fuming anhydrous silicic acid, and organically modified clay minerals are preferred. It is more preferable to contain fuming anhydrous silicic acid and further to contain one or more selected from the group consisting of natural waxes, synthetic waxes, and dextrin fatty acid esters.

The content of component (c) the oily gelling agent in the present invention is not particularly limited, but is preferably 0.1% or more, more preferably 0.5% or more, even more preferably 1% or more, preferably 15% or less, more preferably 12% or less, and even more preferably 10% or less in the oily cosmetic composition. Furthermore, 0.1 to 15% is preferred, 0.5 to 12% is more preferred, and 1 to 10% is even more preferred. Within this range, it is possible to impart appropriate viscosity to the oily cosmetic composition, create flexibility in the cosmetic film to minimize burden on the skin and lips, and impart appropriate thickness to the cosmetic film, thereby enhancing the moisturizing effect on the skin and lips and ensuring its longevity.

The oily cosmetic composition of the present invention can further enhance its moisturizing effect and its sustained effect by using component (d) polyhydric alcohol. In the present invention, any polyhydric alcohol that can be used in cosmetics can be used as component (d), for example, propylene glycol, 1,3-butylene glycol, dipropylene glycol, tripropylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octandiol, glycerin, polyethylene glycol, etc. Among these, one or more selected from the group consisting of propylene glycol, dipropylene glycol, and tripropylene glycol are preferred in terms of sustained moisturizing effect.

The content of component (d) polyhydric alcohol in the present invention is not particularly limited, but is preferably 0.001% or more, more preferably 0.01% or more, even more preferably 0.05% or more, and also preferably 1% or less, more preferably 0.8% or less, and even more preferably 0.6% or less in the oily cosmetic composition. Furthermore, 0.001 to 1% is preferred, more preferably 0.01 to 0.8%, and even more preferably 0.05 to 0.6%. Within this range, it is preferable in that it more significantly enhances the moisturizing effect and its sustained effect.

In addition to the above components (a) to (d), the lip cosmetic composition of the present invention may contain, to the extent that it does not interfere with the effects of the present invention, components commonly used in cosmetics, oily components, inorganic pigments, organic pigments and dyes, powders and their silicone-treated or fluorine compound-treated products, surfactants, fibers, oil-soluble film-forming resins, aqueous components such as humectants, sugars, UV absorbers, anti-fading agents, antioxidants, defoaming agents, beauty ingredients, preservatives, fragrances, etc.

As for oily components, any oil other than components (b) and (c) that is commonly used in cosmetics can be used without particular restrictions. Regardless of origin (animal oil, vegetable oil, synthetic oil, etc.) or properties (semi-solid oil, liquid oil, volatile oil, etc.), hydrocarbons, fats and oils, ester oils, fatty acids, higher alcohols, silicone oils, fluorinated oils, etc., can be used. Specifically, hydrocarbons such as liquid paraffin, heavy liquid isoparaffin, α-olefin oligomer, squalane, petrolatum, polyisobutylene, and polybutene; fats and oils such as olive oil, castor oil, jojoba oil, mink oil, and macadamia nut oil; and esters such as cetyl isooctanoate, isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, neopentyl glycol dioctanoate, caprylic/capric triglyceride, and glyceryl tri-2-ethylhexanoate. Fatty acids such as isostearic acid and oleic acid, amino acid ester oils such as dioctyldodecyl lauroyl glutamate, N-lauroyl-L-glutamate di(cholesteryl/behenyl/octyldodecyl), N-lauroyl-L-glutamate di(phytosteryl/behenyl/octyldodecyl), dimer dilinoleate (phytosteryl/isostearyl/cetyl/stearyl/behenyl), dimer dilinoleate di(isostearyl/phytosteryl), dimer dilinoleate dimer Examples include dimer acid derivatives such as dilinoleyl bisisostearyl, fatty acid dipentaerythritol such as hexa(12-hydroxystearic acid/stearic acid/rosinic acid) dipentaerythritol and hexa(12-hydroxystearic acid/isostearic acid) dipentaerythritol, cholesterol, cholestanol, phytosterol, dehydrocholesterol, cholesterol derivatives and phytosterol derivatives such as lanolin fatty acid cholesteryl, isostearate cholesteryl, hydroxystearate cholesteryl, ricinoleate cholesteryl, oleate phytosteryl, macadamia nut oil fatty acid phytosteryl, lanolin derivatives such as lanolin, adsorbed purified lanolin, liquid lanolin, reduced lanolin, lanolin acetate, lanolin alcohol, hydrogenated lanolin alcohol, lanolin fatty acid, and lanolin derivatives and those modified with polyoxyalkylene, dimethylpolysiloxane, phenyl-modified polysiloxane, and fluorine-modified silicone oil, and one or more of these can be used.

In particular, products containing semi-solid oil at 25°C are preferable in terms of skin feel. Here, semi-solid oil refers to oil whose viscosity value exceeds 7000 mPa·s when measured with a B-type viscometer (rotor No. 2) at 25°C and 1 atmosphere. Specifically, preferred materials include petrolatum, amino acid ester oils such as dioctyldodecyl lauroyl glutamate, di(cholesteryl/behenyl/octyldodecyl) N-lauroyl-L-glutamate, and di(phytosteryl/behenyl/octyldodecyl) N-lauroyl-L-glutamate, dimer acid derivatives such as dimer dilinoleyl (phytosteryl/isostearyl/cetyl/stearyl/behenyl), di(isostearyl/phytosteryl) dimer dilinoleyl, and dimer dilinoleyl bisisostearyl dimer dilinoleate, fatty acid dipentaerythritol such as hexa(12-hydroxystearic acid/stearic acid/rosinic acid) dipentaerythritol, cholesterol, cholestanol, phytosterol, and dehydrocholesterol.

In this invention, the content of the semi-solid oil at 25°C is not particularly limited, but it is preferably 5% or more, preferably 10% or more, more preferably 15% or more, preferably 45% or less, more preferably 40% or less, and even more preferably 35% or less in the oily cosmetic composition. Furthermore, 5-45% is preferred, 10-40% is more preferred, and 15-35% is even more preferred. Within this range, the texture and moisturizing effect are superior, making it more preferable.

The powder components are not particularly limited in terms of shape (spherical, plate-shaped, needle-shaped, etc.), particle size (fuzzy, fine, pigment-grade, etc.), particle structure (porous, non-porous, etc.), etc., as long as they are powders commonly used in cosmetics. Examples include inorganic powders, lustrous powders, organic powders, pigment powders, metal powders, and composite powders. Specifically, examples include white inorganic pigments such as titanium dioxide, zinc oxide, cerium oxide, and barium sulfate; colored inorganic pigments such as iron oxide, carbon black, titanium/titanium oxide sintered products, chromium oxide, chromium hydroxide, Prussian blue, and ultramarine; talc, muscovite, phlogopite, red mica, biotite, synthetic mica, sericite, synthetic sericite, kaolin, silicon carbide, bentonite, smectite, aluminum oxide, magnesium oxide, zirconium oxide, antimony oxide, diatomaceous earth, aluminum silicate, and magnesium aluminum metasilicate. White body powders such as calcium silicate, barium silicate, magnesium silicate, calcium carbonate, magnesium carbonate, hydroxyapatite, and boron nitride; titanium dioxide-coated mica; titanium dioxide-coated bismuth oxychloride; iron oxide titanium mica; Prussian blue-treated titanium mica; carmine-treated titanium mica; bismuth oxychloride; fish scale foil; polyethylene terephthalate-aluminum-epoxy laminated powder; polyethylene terephthalate-polyolefin laminated film powder; polyethylene terephthalate-polymethyl methacrylate laminated film Finest luminous powders, polyamide resins, polyethylene resins, polyacrylic resins, polyester resins, fluororesins, cellulose resins, polystyrene resins, copolymer resins such as styrene-acrylic copolymer resins, polypropylene resins, urethane resins and other organic polymer resin powders, zinc stearate, N-acyllysine and other organic low molecular weight powders, silk powder, cellulose powder, dextrin powder and other natural organic powders, Red No. 201, Red No. 202, Red No. 205, Red No. 226, Red No. 228, Orange No. 203, Orange No. 2 Examples include organic pigment powders such as zirconium, barium, or aluminum lake, such as No. 04, Blue No. 404, Yellow No. 401, Red No. 3, Red No. 104, Red No. 106, Orange No. 205, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1; or further, metal powders such as aluminum powder, gold powder, and silver powder; composite powders such as fine-particle titanium oxide-coated titanium mica, fine-particle zinc oxide-coated titanium mica, barium sulfate-coated titanium mica, titanium oxide-containing silicon dioxide, and zinc oxide-containing silicon dioxide; and fibers such as nylon, polyester, rayon, and cellulose. These may be surface-treated with fluorine compounds, silicone oil, powders, oils, gelling agents, emulsion polymers, surfactants, etc. These powders can be used individually or in combination of two or more types, and further composites may be used.

Any surfactant commonly used in cosmetics can be used, including nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.

Examples of UV absorbers include benzophenone-based, PABA-based, cinnamic acid-based, and salicylic acid-based agents, such as 4-tert-butyl-4'-methoxydibenzoylmethane, oxybenzone, 2-ethylhexyl paramethoxycinnamate 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, diethylamino hydroxybenzoyl hexyl benzoate, and bis-ethylhexyloxyphenol methoxyphenyl triazine.

Examples of antioxidants include tocopherol and ascorbic acid; examples of cosmetic ingredients include vitamins, anti-inflammatory agents, and herbal medicines; and examples of preservatives include parahydroxybenzoic acid esters and phenoxyethanol.

The oil-based cosmetic composition of the present invention can be obtained by commonly known manufacturing methods. Examples of manufacturing methods are shown below, but are not limited thereto. For example, it can be obtained by heating and mixing components (a) to (c), adding component (d) and other components as needed, filling into containers, and molding as needed.

The oil-based cosmetic composition of the present invention is not particularly limited and includes lip balm, lip essence, lipstick, lip gloss, blush, eye color, foundation, sunscreen, cosmetic oil, hair protectant, etc. However, lip cosmetics are particularly preferred because they provide a sufficient feeling of moisture and sustained moisture.

The oily cosmetic composition of the present invention is substantially water-free, with an oily component, such as an oil or oil-soluble compound, forming a continuous phase. "Substantially water-free" means that the water content is 1% or less, preferably 0.5% or less, and more preferably 0.1% or less. The properties are not particularly limited, but examples include liquid, semi-solid, and solid forms.

The present invention will be further described in detail below with reference to examples. However, these examples do not limit the present invention in any way.

[Evaluation of the dispersibility of heparin-like substances]
The dispersibility of heparin-like substances when using the oils shown in Table 1 was evaluated by the following method, and the resulting dispersibility is shown in Figure 1.
(Evaluation method)
At 25°C, 30 g of the oil shown in Table 1 and 0.3 g of heparinoid were placed in a cup and mixed for 5 minutes using a Mazelstar KK-V350W (manufactured by Kurabo Corporation). Approximately 9 ^cm³ was dispensed into a cylindrical container (diameter 1.5 cm, height 6.5 cm, internal volume approximately 11.5 ^cm³ ), and after standing for 24 hours, the degree to which the heparinoid did not settle and remained uniformly opaque was visually evaluated on a four-point scale (◎, ○, △, ×) as shown below.
◎: No change in dispersion state, no sedimentation observed ○: Clear liquid greater than 0 mm and up to 10 mm in height is visible above the liquid surface △: Overall liquid transparency has increased, and clear liquid greater than 10 mm and up to 30 mm in height is visible above the liquid surface ×: Clear liquid greater than 30 mm in height is visible above the liquid surface

*1: S-Face IS-1005P (manufactured by Sakamoto Pharmaceutical Co., Ltd.)
*2: KEH-1010 (manufactured by Sakamoto Pharmaceutical Co., Ltd.)

As shown in Table 1, ester oils and hydrocarbon oils without hydroxyl groups were unable to disperse heparin-like substances. While higher alcohols were confirmed to disperse heparin-like substances, ester oils containing hydroxyl groups performed better. Furthermore, among ester oils containing hydroxyl groups, those with a hydroxyl group mass ratio of 1 or higher, particularly 2 or higher, exhibited superior dispersibility of heparin-like substances.

Examples 1-9 and Comparative Examples 1-2: Lip balm Lip balms with the formulations shown in Table 2 below were prepared using the manufacturing method shown below, and evaluated for the following: a. pleasant feel on the skin (lips), b. moisturizing effect, c. duration of moisturizing effect, and d. improvement of chapped lips, using the evaluation method shown below. The evaluation results for a-c are shown in Table 2. The results for d. improvement of chapped lips are shown in Table 3.

*3: CIREWAX90 (manufactured by CIREBELLE)
*4: LIPWAX A-4 (manufactured by Nippon Natural Products Co., Ltd.)
*5: MULTIWAX W445 (manufactured by SONNEBORN)

(Manufacturing method)
A: Heat components (1) to (13) uniformly at 110°C until dissolved.
B: Add components (14) to (21) to A and mix and disperse uniformly in a roll mill while cooling.
C: Melt B at 95°C, fill into a jar container, and let it cool and solidify at room temperature.

(Evaluation method)
Each of the following evaluation items was evaluated using the method described below.
(Evaluation criteria)
a. Pleasant feel on the skin (lips) b. Moisture retention c. Duration of moisture For each of items a through c, a usage test was conducted by a panel of 20 cosmetic evaluation specialists. Each panel member evaluated each sample on a 7-point scale according to the evaluation criteria 1 below and assigned a score. The average score was calculated from the sum of all panel members' scores and judged according to the judgment criteria 1 below. For evaluation items a and b, the evaluation was conducted immediately after applying the sample to the skin or lips, while for evaluation item c, the panel members were allowed to go about their normal daily lives after applying the sample and the evaluation was conducted 8 hours later.

<Evaluation Criterion 1>
(Rating): (Evaluation)
6: Excellent 5: Good 4: Fairly Good 3: Average 2: Fairly Poor 1: Poor 0: Very Poor

<Judgment Criteria 1>
(Judgment): (Average score of the grades)
◎: More than 5 points ○: More than 3.5 points and 5 points or less △: More than 1 point and 3.5 points or less ×: 1 point or less

(Evaluation criteria)
II. Effect on improving chapped lips For evaluation item II, each sample from Examples 1, 4, and 9, and Comparative Example 2, was subjected to a two-week continuous use test by five cosmetic evaluation panel members. They evaluated whether they felt an improvement in chapped lips, and the results, judged according to evaluation criteria 2 below, are shown in Table 3.
<Judgment Criteria 2>
(Judgment): (Number of people who felt improvement in skin condition)
◎ : 4 or more people ○ : 2-3 people × : 1 or less

As is clear from the results in Tables 2 and 3, the lip balm of the embodiment of the present invention had a better feel on the lips during use, superior moisturizing effect and duration of moisturizing effect compared to the comparative example, and also showed an improvement in chapped lips.
On the other hand, Comparative Example 1, which did not contain ingredient (a) heparinoid, did not yield satisfactory results in terms of moisturizing effect, duration of moisturizing effect, and improvement of rough skin.
Furthermore, in Comparative Example 2, which did not contain component (b) liquid ester oil/higher alcohol having a hydroxyl group, the dispersibility of the heparin-like substance was poor, resulting in a rough texture when applied to the lips, and insufficient sustained moisturizing effect and improvement of chapped lips were not achieved.

Example 10: Lip Essence (Ingredients) (%)
1. Dextrin palmitate*6 3.5
2. Liquid paraffin 5
3. Polybutene *73
4. Vaseline 10
5. Decaglyceryl pentaisostearate *1 10
6. Diisostearyl malate 20
7. Diglyceryl triisostearate (remaining amount) 8. Pentaerythritol tetraethylhexanoate 18
9. Tri(caprylic/capric acid) glyceryl 1
10. Jojoba oil 0.5
11. Sesame oil 0.5
12. Sodium hyaluronate 0.01
13. Silylated anhydrous silicic acid *8 3
14. Dibutylhydroxytoluene 0.01
15. Dipropylene glycol 0.3
16. l-Menthyl Glyceryl Ether 3
17. Heparin-like substance 1
18. Allantoin 0.5
19. Astaxanthin 0.25
20. Tocopherol 0.001
21. Fragrance 0.1
*6: Leopard KL2 (manufactured by Chiba Flour Milling Co., Ltd.)
*7: Purified polybutene HV-100F(S) (manufactured by Nippon Natural Products Co., Ltd.)
*8: AEROSIL R-976S (manufactured by Nippon Aerosil Co., Ltd.)
(Manufacturing method)
A: Heat components (1) to (12) uniformly at 90°C until dissolved.
B: Add components (13) to (21) to A and mix and disperse uniformly.
C: Fill the applicator container with B.

The lip essence of Example 10 exhibited good dispersibility of the heparinoid, a pleasant feel on the lips, and excellent moisturizing properties, long-lasting moisture, and improvement of chapped lips.

Example 11: Lipstick (Ingredients) (%)
1. (Ethylene/Propylene) Copolymer 4.5
2. Synthetic wax *9 5
3. Candelilla Low 1.5
4. Polyethylene wax 1
5. Decaglyceryl Decaisostearate 10
6. Diglyceryl triisostearate (remaining amount) 7. Diisostearyl malate 12
8. Tridecyl isononanoate 5
9. Triethylhexanoin 15
10. Hydrogenated polyisobutene 5
11. Dimer dilinoleate (phytosteryl/isostearyl/
(Cetyl/Stearyl/Behenyl) *10 5
12. Lauroyl glutamate di(octyldodecyl/
Phytostearyl/Behenyl) *11 3
13. Shea butter 0.1
14. Dimethylsilylated Silica 1
15. (Vinyl dimethicone/Lauryl dimethicone)
Crosspolymer mixture *12 5
16. Lecithin-treated talc *13 1
17. Methyl methacrylate crosspolymer *14 10
18. PET *15 5
19. Calcium carbonate 0.5
20. Heparin-like substance 0.3
21. Capsicum Tincture 0.05
22. Conference 0.5
23. Menthol 0.3
24. Red No. 202 0.05
25. Red No. 104 0.2
26. Yellow No. 4 0.8
27. Yellow No. 5 0.1
28. Titanium dioxide 5
29. Black iron oxide 0.2
*9: CIREWAX80 (manufactured by CIREBELLE)
*10: PLANDOOL-S (manufactured by Nippon Seika Co., Ltd.)
*11: Eldew PS-306 (manufactured by Ajinomoto Co., Inc.)
*12: KSG-43 (manufactured by Shin-Etsu Chemical Co., Ltd.)
*13: TL-LC5(N) (manufactured by Toshoku Pigment Co., Ltd.)
*14: Matsumoto Microsphere M305QD7 (manufactured by Matsumoto Oil & Fat Pharmaceutical Co., Ltd.)
*15: Snowleaf P (manufactured by Oaken Co., Ltd.)
(Manufacturing method)
A: Heat components (1) to (13) uniformly at 90°C until dissolved.
B: Add components (14) to (29) to A and mix and disperse uniformly in a roll mill while cooling.
C: Melt B at 110°C, fill into a mold container, and then cool.
D: Load C into the container.

The lipstick of Example 11 exhibited good dispersibility of the heparinoid, a pleasant feel on the lips, and excellent moisturizing properties, long-lasting moisturizing effect, and improvement of chapped lips.

Example 12: Eye Color (Ingredients) (%)
1. (Ethylene/Propylene) Copolymer 2.5
2. Candelilla Low 1
3. Paraffin 1
4. Microcrystalline wax 0.5
5. Triethylhexanoin 10
6. PG dicaprate 5
7. Diglyceryl triisostearate 25
8. Dimethicone 3
9. Hexa(hydroxystearic acid/stearic acid/rosinic acid)
Dipentaerythrityl *16 2
10. Silica *17 1
11. Polymethylsilsesquioxane *18 10
12. (Vinyl dimethicone/methicone silsesquioxane)
Crosspolymer *19 3
13. Heparin-like substance 0.25
14. Dimethicone-treated sericite (remaining amount) 15. Carmine 0.7
16. Ultramarine 0.05
17. Black iron oxide 0.01
18. Bengara (red iron oxide pigment) 0.4
19. Treatment with methicone (1%) and dimethicone (3%)
Red iron oxide coated mica titanium *20 3
20. Dimethicone (2%) treated titanium mica *21 5
21. Iron Oxide, Titanium Oxide, and Silica Treatment
Borosilicate (Ca/Na) *22 2
*16: Cosmoll 168ARNV (manufactured by Nisshin Oillio Co., Ltd.)
*17: AEROSIL 380S (manufactured by Nippon Aerosil Co., Ltd.)
*18: TOSPEARL 150KA (manufactured by MOMENTIVE)
*19: KSP-102 (manufactured by Shin-Etsu Chemical Co., Ltd.)
*20: TIMICA RADIANT GOLD 222G (BASF) treated with 1% methicone and 3% dimethicone. *21: FLAMENCO GOLD 220C (BASF) treated with 2% dimethicone. *22: REFLECKS MULTIDIMENSIONS TWISTERED TERRACOTTA (BASF)
(Manufacturing method)
A: Heat components (1) to (9) uniformly at 110°C until dissolved.
B: Add components (10) to (21) to A and mix and disperse uniformly in a roll mill while cooling.
C: Melt B at 100°C and fill the gold dish.

The eye color of Example 12 exhibited good dispersibility of heparinoid, a pleasant feel on the skin, and excellent moisturizing properties, long-lasting moisturizing effect, and skin roughness improvement.

Example 13: Oil-based foundation (ingredients) (%)
1. Treatment with dilauroyl glutamate lysine sodium (1%)
Titanium dioxide 10
2. Lecithin (0.5%) treated titanium dioxide 4
3. Silicon-treated zinc oxide *23 14
4. Octylsilylated (2%) treated red iron oxide 0.25
5. Octylsilylated (2%) treated yellow iron oxide 1
6. Octylsilylated (2%) treated black iron oxide 0.15
7. Octylsilylated (2%) treated talc 2.5
8. Heparin-like substance 0.3
9. Diglyceryl triisostearate 5.5
10. Diglyceryl diisostearate 1
11. PEG-9 Polydimethylsiloxyethyl Dimethicone *24 2.5
12. Cetyl dimethicone *25 0.5
13. Disteardimonium hectorite 0.2
14. Isododecane 1.5
15.1,3-Butylene glycol 0.03
16. Ethylhexyl palmitate 5.5
17. Neopentyl glycol dicaprate 5
18. Decyltetradecanol 5
19. Diisostearyl malate (remaining amount) 20. Ethylhexyl paramethoxycinnamate 2
21. Isododecane 5
22. Methyltrimethicone 15
23. Fragrance 0.4
*23: MZY-505S (manufactured by Teika Co., Ltd.)
*24: KF-6028 (manufactured by Shin-Etsu Chemical Co., Ltd.)
*25: ABIL WAX 9840 (manufactured by EVONIK GOLDSCHMIDT GmbH)
(Manufacturing method)
A: Mix and disperse components (1) to (12) uniformly using a roll mill.
B: Components (13) to (15) are uniformly swelled using a roll mill.
C: Add B and components (16) to (23) to A and mix and disperse uniformly.
D: Fill the bottle container with C.

The oil-based foundation of Example 13 exhibited good dispersibility of heparinoid, a pleasant feel on the skin, and excellent moisturizing properties, long-lasting moisturizing effect, and skin roughness improvement.

Example 14: Oil-based stick sunscreen (ingredients) (%)
1. Synthetic wax 9
2. Dibutyl Lauroyl Glutamide 2
3. Ethylhexyl Methoxycinnamate 7
4. Diethylaminohydroxy
Hexyl benzoyl benzoate *26 2.5
5. Bis-ethylhexyloxyphenol
Methoxyphenyltriazine *27 2
6. Decaglyceryl decaethylhexanoate (remaining amount) 7. Triethylhexanoin (10)
8. Mineral oil 5
9. Cetyl ethylhexanoate 5
10. Isostearic acid 1
11. Polyhydroxystearic acid 0.5
12. Silicon-treated zinc oxide *23 13
13. Silicon-treated titanium oxide *28 2
14. Silicone-treated sericite *29 10
15. (HDI/Trimethylol Hexyllactone)
Crosspolymer *30 5
16. Polymethylsilsesquioxane *31 3
17. Silica *32 4
18. Dimethylsilylated Silica 1
19. Heparin-like substances 3
20. DL-α-tocopherol acetate 0.5
21. Blue 1 0.01
22. Red 202 0.01
23. Lavender oil 0.01
24. BHT 0.05
25. Dipropylene glycol 0.1
26. Fragrance 0.1
*26: UVINUL A PLUS GRANULAR (manufactured by BASF)
*27: TINOSORB S (BASF)
*28: 2% dimethicone-treated titanium dioxide *29: 3% dimethicone-treated sericite *30: D-400 (manufactured by Negami Kogyo Co., Ltd.)
*31: TOSPEARL 3000A (manufactured by MOMENTIVE)
*32: Silysia 550 (manufactured by Fuji Silysia Chemical Co., Ltd.)
(Manufacturing method)
A: Heat components (1) to (11) uniformly at 130 to 150°C until dissolved.
B: Add components (12) to (22) to A and mix and disperse uniformly using a roll mill.
C: Add components (23) to (26) to B and mix until dissolved.
D: Dissolve C at 110°C, fill into stick containers, and cool to solidify.

The oil-based stick sunscreen of Example 14 exhibited good dispersibility of heparinoid, a pleasant feel on the skin, and excellent moisturizing properties, long-lasting moisturizing effect, and skin roughness improvement.

Example 15: Cosmetic oil (components) (%)
1. Beeswax 10
2. Candelilla Low 5
3. Dextrin palmitate *6 2
4. Squalane 3
5. Rice bran oil 25
6. Meadowfoam oil 10
7. Diglyceryl triisostearate (remaining amount) 8. Avocado oil 0.5
9. Apricot kernel oil 0.1
10. Rosa Canina Fruit Oil 0.1
11. Safflower oil 0.1
12. Sunflower seed oil 0.1
13. Grape seed oil 0.1
14. Camellia seed oil 0.1
15. Coconut oil 0.1
16. Heparin-like substance 1
17. Ascorbyl tetrahexyldecanoate 0.1
18.1,2-pentanediol 0.2
19. BHT 0.01
(Manufacturing method)
A: Heat components (1) to (15) uniformly at 90°C until dissolved.
B: Add components (16) to (19) to A and mix and disperse uniformly.
C: Fill the jar container with B.

The cosmetic oil of Example 15 exhibited good dispersibility of heparinoid, a pleasant feel on the skin, and excellent moisturizing properties, sustained moisturizing effect, and improvement of rough skin.

Example 16: Stick-type lip balm (ingredients) (%)
1. Synthetic wax 6
2. (Ethylene/Propylene) Copolymer 1
3. Microcrystalline wax 5
4. Polypropylene 1
5. Dimer dilinoleate (phytosteryl/isostearyl/
(Cetyl/Stearyl/Behenyl) *10 24
6. Hydrogenated polyisobutene 22
7. Lauroyl glutamate
Di(phytostearyl/octyldodecyl) 10
8. Triethylhexanoin 10
9. Decaglyceryl nonaisostearate (remaining amount) 10. Decyltetradecanol 2
11. Ethylhexyl Hydroxystearate 1
12. Heparin-like substance 0.05
13. Dimethylsilylated Silica 2
14. Caprylyl glycol 2
15. 1,2-Hexanediol 1
16. Vanillylbutyl 0.02
17. Paprika pigment 0.2
18. Safflower red pigment 0.3
(Manufacturing method)
A: Heat components (1) to (11) uniformly at 110°C until dissolved.
B: Add components (12) to (18) to A and mix and disperse uniformly using a roll mill.
C: Dissolve B at 100°C, fill into stick containers, and cool to solidify.

The stick-type lip balm of Example 16 exhibited good dispersibility of heparinoid, a pleasant feel on the lips, and excellent moisturizing properties, moisture retention, and improvement of chapped lips.

Claims (5)

The following components (a) to (c);
An oily cosmetic comprising (a) a heparin-like substance, (b) one or more selected from the group consisting of ester oils and higher alcohols that are liquid at 25°C and have hydroxyl groups, and (c) an oily gelling agent, wherein component (b) contains one or more selected from the group consisting of diisostearyl malate, decaglyceryl decaethylhexanoate, decaglyceryl decaisostearate, decaglyceryl nonaisostearate, decaglyceryl pentaisostearate, diglyceryl triisostearate, diglyceryl diisostearate, and diglyceryl monoisostearate . The oily cosmetic composition according to claim 1, wherein component (b) is a liquid ester oil having a hydroxyl group at 25°C. The oily cosmetic composition according to claim 1 or 2, wherein the content of component (a) is 0.001 to 5% by mass. An oily cosmetic composition according to any one of claims 1 to 3 , wherein the mass ratio of component (b) to component (a) (b)/(a) is 5 or more. Furthermore, the oily cosmetic composition according to any one of claims 1 to 4 , further containing 0.001 to 1% by mass of component (d) polyhydric alcohol.