JP7832128B2 - 心房機能不全の治療 - Google Patents

心房機能不全の治療

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Publication number
JP7832128B2
JP7832128B2 JP2022577105A JP2022577105A JP7832128B2 JP 7832128 B2 JP7832128 B2 JP 7832128B2 JP 2022577105 A JP2022577105 A JP 2022577105A JP 2022577105 A JP2022577105 A JP 2022577105A JP 7832128 B2 JP7832128 B2 JP 7832128B2
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JP
Japan
Prior art keywords
pharmaceutical composition
compound
patient
composition according
atrial
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JP2022577105A
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English (en)
Japanese (ja)
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JP2023529502A (ja
JP2023529502A5 (https=
Inventor
タンビー，ジャン－フランソワ
エム エデルバーグ，ジェイ
ハワード タケオ クリオ，グレゴリー
ライル ケリー，シンシア
ヤン，チュン
パトリック ヘンツェ，マーカス
リオ，カルロス エル デル
リー アンダーソン，ロバート
ピー スマンデア，モーリス
ガンジュ，ジテンドラ
Original Assignee
マイオカーディア，インク
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Publication of JP2023529502A publication Critical patent/JP2023529502A/ja
Publication of JP2023529502A5 publication Critical patent/JP2023529502A5/ja
Priority to JP2025252108A priority Critical patent/JP2026048841A/ja
Application granted granted Critical
Publication of JP7832128B2 publication Critical patent/JP7832128B2/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
JP2022577105A 2020-06-15 2021-06-14 心房機能不全の治療 Active JP7832128B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025252108A JP2026048841A (ja) 2020-06-15 2025-12-16 心房機能不全の治療

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063039438P 2020-06-15 2020-06-15
US63/039,438 2020-06-15
US202063042512P 2020-06-22 2020-06-22
US63/042,512 2020-06-22
PCT/US2021/037230 WO2021257456A1 (en) 2020-06-15 2021-06-14 Treatment of atrial dysfunction

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025252108A Division JP2026048841A (ja) 2020-06-15 2025-12-16 心房機能不全の治療

Publications (3)

Publication Number Publication Date
JP2023529502A JP2023529502A (ja) 2023-07-10
JP2023529502A5 JP2023529502A5 (https=) 2024-06-24
JP7832128B2 true JP7832128B2 (ja) 2026-03-17

Family

ID=76845320

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022577105A Active JP7832128B2 (ja) 2020-06-15 2021-06-14 心房機能不全の治療
JP2025252108A Pending JP2026048841A (ja) 2020-06-15 2025-12-16 心房機能不全の治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025252108A Pending JP2026048841A (ja) 2020-06-15 2025-12-16 心房機能不全の治療

Country Status (13)

Country Link
US (1) US20230233545A1 (https=)
EP (1) EP4164644A1 (https=)
JP (2) JP7832128B2 (https=)
KR (1) KR20230024977A (https=)
CN (1) CN116056703A (https=)
AU (1) AU2021293817A1 (https=)
BR (1) BR112022025551A2 (https=)
CA (1) CA3180943A1 (https=)
CL (1) CL2022003548A1 (https=)
IL (1) IL298885A (https=)
MX (1) MX2022015488A (https=)
TW (1) TW202214241A (https=)
WO (1) WO2021257456A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11759640B2 (en) * 2022-01-07 2023-09-19 Xyra, Llc Methods for reducing the risk of strokes by pharmacotherapy to reduce the number and duration of atrial fibrillations
CN116082326B (zh) * 2022-12-16 2024-12-27 药康众拓(江苏)医药科技有限公司北京分公司 一种氘代吡唑磺酰甲基-哌啶异噁唑脲类化合物及其用途
CN117379683B (zh) * 2023-12-12 2024-02-27 苏州晟智医疗科技有限公司 反搏辅助装置、计算设备、存储介质及反搏系统
CN118304374A (zh) * 2024-04-01 2024-07-09 山东省中医药研究院附属医院 一种组合物在制备治疗心动过速和/或瓣膜反流药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018502883A (ja) 2015-01-22 2018-02-01 マイオカーディア，インク 拡張型心筋症（ｄｃｍ）の処置のための４−メチルスルホニル置換ピペリジンウレア化合物
WO2019006235A1 (en) 2017-06-30 2019-01-03 Amgen Inc. METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10758525B2 (en) * 2015-01-22 2020-09-01 MyoKardia, Inc. 4-methylsulfonyl-substituted piperidine urea compounds
AU2018266199A1 (en) * 2017-05-10 2019-11-07 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
KR20220009440A (ko) * 2019-05-19 2022-01-24 미요카디아, 인크. 화합물 (r)-4-(1-((3-(디플루오로메틸)-1-메틸-1h-피라졸-4-일)술포닐)-1-플루오로에틸)-n-(이속사졸-3-일)피페리딘-1-카르복스아미드를 사용한 수축기 기능장애 및 감소된 박출 계수를 가진 심부전의 치료

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018502883A (ja) 2015-01-22 2018-02-01 マイオカーディア，インク 拡張型心筋症（ｄｃｍ）の処置のための４−メチルスルホニル置換ピペリジンウレア化合物
WO2019006235A1 (en) 2017-06-30 2019-01-03 Amgen Inc. METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
John R Teerlink et al.，"Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study"，Lancet，2011年，Vol.378，p.667-675
Sarah Fernandes et al.，"MYK-491, a Novel Small-Molecule Cardiac Myosin Activator Increases Cardiac Systolic Function and Preserves Mechanical Efficiency: Pre-Clinical in vivo and in vitro Evidence"，Circulation，2019年，Vol.140, No.Suppl_1，Abstract 15707

Also Published As

Publication number Publication date
EP4164644A1 (en) 2023-04-19
BR112022025551A2 (pt) 2023-03-07
US20230233545A1 (en) 2023-07-27
TW202214241A (zh) 2022-04-16
MX2022015488A (es) 2023-03-21
CA3180943A1 (en) 2021-12-23
JP2023529502A (ja) 2023-07-10
WO2021257456A1 (en) 2021-12-23
IL298885A (en) 2023-02-01
CL2022003548A1 (es) 2023-06-09
CN116056703A (zh) 2023-05-02
JP2026048841A (ja) 2026-03-17
KR20230024977A (ko) 2023-02-21
AU2021293817A1 (en) 2023-01-19

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