JP7822597B2 - チロシンキナーゼ阻害剤耐性ｅｇｆｒ変異を有するがん細胞に対する抗腫瘍活性を有する化合物 - Google Patents

チロシンキナーゼ阻害剤耐性ｅｇｆｒ変異を有するがん細胞に対する抗腫瘍活性を有する化合物

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JP7822597B2
JP7822597B2 JP2021561677A JP2021561677A JP7822597B2 JP 7822597 B2 JP7822597 B2 JP 7822597B2 JP 2021561677 A JP2021561677 A JP 2021561677A JP 2021561677 A JP2021561677 A JP 2021561677A JP 7822597 B2 JP7822597 B2 JP 7822597B2
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cancer
egfr
mutations
tki
mutation
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JP2022529016A (ja
JP2022529016A5 (https=
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ジャクリーン ロビショー
モニーク ニルソン
ジョン ブイ． ヘイマッハ
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University of Texas System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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JP2021561677A 2019-04-17 2020-04-16 チロシンキナーゼ阻害剤耐性ｅｇｆｒ変異を有するがん細胞に対する抗腫瘍活性を有する化合物 Active JP7822597B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962835354P 2019-04-17 2019-04-17
US62/835,354 2019-04-17
PCT/US2020/028547 WO2020214831A1 (en) 2019-04-17 2020-04-16 Compounds with anti-tumor activity against cancer cells bearing tyrosine kinase inhibitor resistant egfr mutations

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JP2022529016A JP2022529016A (ja) 2022-06-16
JP2022529016A5 JP2022529016A5 (https=) 2023-04-24
JP7822597B2 true JP7822597B2 (ja) 2026-03-03

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US (1) US20220193074A1 (https=)
EP (1) EP3955928A4 (https=)
JP (1) JP7822597B2 (https=)
KR (1) KR20220003546A (https=)
CN (1) CN113784718A (https=)
CA (1) CA3132816A1 (https=)
WO (1) WO2020214831A1 (https=)

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BR112021016149A2 (pt) 2019-02-26 2021-10-13 Janssen Biotech, Inc. Terapias de combinação e estratificação de pacientes com anticorpos biespecíficos anti-egfr/c-met
US11850248B2 (en) 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors
US11879013B2 (en) 2019-05-14 2024-01-23 Janssen Biotech, Inc. Combination therapies with bispecific anti-EGFR/c-Met antibodies and third generation EGFR tyrosine kinase inhibitors
JP7783182B2 (ja) 2020-02-12 2025-12-09 ヤンセン バイオテツク，インコーポレーテツド ｃ－ＭＥＴエクソン１４スキッピング変異を有する患者の治療
MX2024008057A (es) 2021-12-30 2024-08-28 Biomea Fusion Inc Compuestos de pirazina como inhibidores de flt3.
WO2024097994A1 (en) * 2022-11-03 2024-05-10 Board Of Regents, The University Of Texas System Methods for the detection and treatment of non-small-cell lung cancer
CN115998743B (zh) * 2023-01-16 2024-05-28 威尚（上海）生物医药有限公司 喹唑啉类化合物在克服奥希替尼耐药中的用途

Citations (2)

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WO2018094225A1 (en) 2016-11-17 2018-05-24 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 mutations
WO2018156812A1 (en) 2017-02-22 2018-08-30 G1 Therapeutics, Inc. Treatment of egfr-driven cancer with fewer side effects

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Publication number Priority date Publication date Assignee Title
RU2017136709A (ru) * 2015-04-23 2019-05-23 Медиммьюн Лимитед Комбинированное лечение немелкоклеточного рака легкого с выявленной мутацией в egfr

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018094225A1 (en) 2016-11-17 2018-05-24 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 mutations
WO2018156812A1 (en) 2017-02-22 2018-08-30 G1 Therapeutics, Inc. Treatment of egfr-driven cancer with fewer side effects

Non-Patent Citations (7)

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Title
Cancer Res. Treat.，2018年，50(3)，pp.835-842，DOI: https://doi.org/10.4143/crt.2017.303
Cell，2018年，7，212, page 1-16
Clinical Cancer Research，2015年，21(23)，pp.5305-5313
Clinical Cancer Research，2016年，22(13)，pp.3281-3285
Lancet Oncol.，2015年，16，pp.830-838
Rapid Commun. Mass Spectrom.，2013年，27，pp.1183-1195，DOI: 10.1002/rcm.6559
Signal Transduction and Targeted Therapy，2019年03月，4(5)，page 1-10，https://doi.org/10.1038/s41392-019-0038-9

Also Published As

Publication number Publication date
CN113784718A (zh) 2021-12-10
JP2022529016A (ja) 2022-06-16
WO2020214831A1 (en) 2020-10-22
KR20220003546A (ko) 2022-01-10
EP3955928A4 (en) 2023-05-31
US20220193074A1 (en) 2022-06-23
CA3132816A1 (en) 2020-10-22
EP3955928A1 (en) 2022-02-23

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