JP7796636B2 - ヒトトランスフェリンレセプター結合ペプチド - Google Patents

ヒトトランスフェリンレセプター結合ペプチド

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Publication number
JP7796636B2
JP7796636B2 JP2022501104A JP2022501104A JP7796636B2 JP 7796636 B2 JP7796636 B2 JP 7796636B2 JP 2022501104 A JP2022501104 A JP 2022501104A JP 2022501104 A JP2022501104 A JP 2022501104A JP 7796636 B2 JP7796636 B2 JP 7796636B2
Authority
JP
Japan
Prior art keywords
peptide
minutes
amino acid
solid
over
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022501104A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2021167107A1 (enExample
Inventor
健一 高橋
英士 余田
秀彦 橋本
紗希 藤山
政輝 大内
菜穂子 中村
ナセル 加藤 バシルディン
直己 澤井
武 江原
正訓 多久和
圭一 舛屋
慎之介 稲葉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JCR Pharmaceuticals Co Ltd
Peptidream Inc
Original Assignee
JCR Pharmaceuticals Co Ltd
Peptidream Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JCR Pharmaceuticals Co Ltd, Peptidream Inc filed Critical JCR Pharmaceuticals Co Ltd
Publication of JPWO2021167107A1 publication Critical patent/JPWO2021167107A1/ja
Priority to JP2025197068A priority Critical patent/JP2026032056A/ja
Application granted granted Critical
Publication of JP7796636B2 publication Critical patent/JP7796636B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022501104A 2020-02-22 2021-02-22 ヒトトランスフェリンレセプター結合ペプチド Active JP7796636B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025197068A JP2026032056A (ja) 2020-02-22 2025-11-17 ヒトトランスフェリンレセプター結合ペプチド

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020028879 2020-02-22
JP2020028879 2020-02-22
PCT/JP2021/006709 WO2021167107A1 (ja) 2020-02-22 2021-02-22 ヒトトランスフェリンレセプター結合ペプチド

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025197068A Division JP2026032056A (ja) 2020-02-22 2025-11-17 ヒトトランスフェリンレセプター結合ペプチド

Publications (2)

Publication Number Publication Date
JPWO2021167107A1 JPWO2021167107A1 (enExample) 2021-08-26
JP7796636B2 true JP7796636B2 (ja) 2026-01-09

Family

ID=77390874

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022501104A Active JP7796636B2 (ja) 2020-02-22 2021-02-22 ヒトトランスフェリンレセプター結合ペプチド
JP2025197068A Pending JP2026032056A (ja) 2020-02-22 2025-11-17 ヒトトランスフェリンレセプター結合ペプチド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025197068A Pending JP2026032056A (ja) 2020-02-22 2025-11-17 ヒトトランスフェリンレセプター結合ペプチド

Country Status (9)

Country Link
US (1) US20230203098A1 (enExample)
EP (1) EP4108676A4 (enExample)
JP (2) JP7796636B2 (enExample)
CN (1) CN115151556A (enExample)
AU (1) AU2021224412A1 (enExample)
CA (1) CA3171988A1 (enExample)
IL (1) IL295797A (enExample)
TW (1) TW202140513A (enExample)
WO (1) WO2021167107A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2023022234A1 (enExample) * 2021-08-19 2023-02-23
WO2023026994A1 (ja) * 2021-08-21 2023-03-02 武田薬品工業株式会社 ヒトトランスフェリンレセプター結合ペプチド－薬物コンジュゲート
US20240366775A1 (en) 2021-08-24 2024-11-07 Peptidream Inc. Human transferrin receptor binding antibody-peptide conjugate
EP4230638A1 (en) * 2022-02-16 2023-08-23 Lipotrue, S.L. Peptides and compositions for use in cosmetics
WO2024043341A1 (ja) 2022-08-26 2024-02-29 ペプチドリーム株式会社 シクロアルキン誘導体
TWI877887B (zh) * 2022-11-29 2025-03-21 法信諾生醫股份有限公司 轉運胜肽及其應用
TW202434613A (zh) * 2023-02-17 2024-09-01 日商肽夢想股份有限公司 人類運鐵蛋白受體結合肽
EP4682158A1 (en) * 2023-03-17 2026-01-21 FUJIFILM Corporation Cyclic peptide or salt thereof and use thereof
WO2026121297A1 (ja) * 2024-12-04 2026-06-11 ペプチドリーム株式会社 ペプチド及びペイロードを含むコンジュゲート

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012105595A1 (ja) 2011-02-02 2012-08-09 公益財団法人微生物化学研究会 血液脳関門を透過する薬物輸送体、ペプチド及びその用途

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JPS60147718A (ja) 1984-01-12 1985-08-03 Seikosha Co Ltd 太陽電池付きカラ−表示素子
US5525491A (en) 1991-02-27 1996-06-11 Creative Biomolecules, Inc. Serine-rich peptide linkers
AU656230B2 (en) * 1991-10-11 1995-01-27 F. Hoffmann-La Roche Ag Cyclic vasoactive peptides
JPH06228199A (ja) 1992-11-27 1994-08-16 Takeda Chem Ind Ltd 血液脳関門通過可能なペプチド結合体
US20090087878A9 (en) * 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
SI1724284T1 (sl) 2000-12-07 2009-12-31 Lilly Co Eli Glp-1 fuzijski proteini
EP1964916B1 (en) 2005-12-06 2012-08-01 The University of Tokyo Multi-purpose acylation catalayst and use thereof
AU2010267963B2 (en) * 2009-07-02 2015-09-24 Merz Pharma Gmbh & Co. Kgaa Neurotoxins exhibiting shortened biological activity
JP5818237B2 (ja) 2010-09-09 2015-11-18 国立大学法人 東京大学 Ｎ−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法
AU2011367230B2 (en) 2011-05-05 2017-08-10 Sarepta Therapeutics, Inc. Peptide oligonucleotide conjugates
BR112014022435B1 (pt) * 2012-03-21 2023-02-14 Takeda Pharmaceutical Company Limited Inibidores de tfpi e métodos de uso
MX367126B (es) 2012-08-29 2019-08-06 Hoffmann La Roche Transporte para atravesar la barrera hematoencefálica.
EP2952582A4 (en) 2013-01-30 2016-11-16 Peptidream Inc FLEXIBLE DISPLAY METHOD
CN103254280A (zh) * 2013-03-07 2013-08-21 广州暨南大学医药生物技术研究开发中心 具有肿瘤细胞靶向结合能力的短肽及其应用
CA2990785C (en) * 2015-06-24 2024-11-12 Jcr Pharmaceuticals Co., Ltd. ANTI-HUMAN TRANSFERRIN RECEPTOR ANTIBODIES CROSSING THE BLOOD-BRAIN BARRIER
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Also Published As

Publication number Publication date
WO2021167107A1 (ja) 2021-08-26
EP4108676A4 (en) 2024-06-05
EP4108676A1 (en) 2022-12-28
US20230203098A1 (en) 2023-06-29
JPWO2021167107A1 (enExample) 2021-08-26
TW202140513A (zh) 2021-11-01
CN115151556A (zh) 2022-10-04
CA3171988A1 (en) 2021-08-26
AU2021224412A1 (en) 2022-09-15
JP2026032056A (ja) 2026-02-25
IL295797A (en) 2022-10-01

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