JP7789667B2 - 二重パラトープ性ｃｄ７３抗体 - Google Patents

二重パラトープ性ｃｄ７３抗体

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Publication number
JP7789667B2
JP7789667B2 JP2022527957A JP2022527957A JP7789667B2 JP 7789667 B2 JP7789667 B2 JP 7789667B2 JP 2022527957 A JP2022527957 A JP 2022527957A JP 2022527957 A JP2022527957 A JP 2022527957A JP 7789667 B2 JP7789667 B2 JP 7789667B2
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JP
Japan
Prior art keywords
antibody
seq
amino acid
acid sequence
dual paratopic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022527957A
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English (en)
Japanese (ja)
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JP2023503846A (ja
JP2023503846A5 (https=
Inventor
ダナ・ロード
カタリーナ・ラドセヴィチュ
ジェームズ・イー・ステファノ
イェンファン・ジョウ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
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Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of JP2023503846A publication Critical patent/JP2023503846A/ja
Publication of JP2023503846A5 publication Critical patent/JP2023503846A5/ja
Priority to JP2025167073A priority Critical patent/JP2026026484A/ja
Application granted granted Critical
Publication of JP7789667B2 publication Critical patent/JP7789667B2/ja
Active legal-status Critical Current
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Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2022527957A 2019-11-15 2020-11-13 二重パラトープ性ｃｄ７３抗体 Active JP7789667B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025167073A JP2026026484A (ja) 2019-11-15 2025-10-03 二重パラトープ性ｃｄ７３抗体

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962936119P 2019-11-15 2019-11-15
US62/936,119 2019-11-15
US202063023542P 2020-05-12 2020-05-12
US63/023,542 2020-05-12
US202063086982P 2020-10-02 2020-10-02
US63/086,982 2020-10-02
PCT/US2020/060434 WO2021097223A2 (en) 2019-11-15 2020-11-13 Biparatopic cd73 antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025167073A Division JP2026026484A (ja) 2019-11-15 2025-10-03 二重パラトープ性ｃｄ７３抗体

Publications (3)

Publication Number Publication Date
JP2023503846A JP2023503846A (ja) 2023-02-01
JP2023503846A5 JP2023503846A5 (https=) 2023-11-17
JP7789667B2 true JP7789667B2 (ja) 2025-12-22

Family

ID=73790235

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022527957A Active JP7789667B2 (ja) 2019-11-15 2020-11-13 二重パラトープ性ｃｄ７３抗体
JP2025167073A Pending JP2026026484A (ja) 2019-11-15 2025-10-03 二重パラトープ性ｃｄ７３抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025167073A Pending JP2026026484A (ja) 2019-11-15 2025-10-03 二重パラトープ性ｃｄ７３抗体

Country Status (13)

Country Link
US (1) US20220403041A1 (https=)
EP (1) EP4058150A2 (https=)
JP (2) JP7789667B2 (https=)
KR (1) KR20220100929A (https=)
CN (1) CN115003385A (https=)
AU (1) AU2020384305A1 (https=)
BR (1) BR112022009317A2 (https=)
CA (1) CA3161717A1 (https=)
CO (1) CO2022008204A2 (https=)
IL (1) IL292959A (https=)
MX (1) MX2022005866A (https=)
PH (1) PH12022551150A1 (https=)
WO (1) WO2021097223A2 (https=)

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MY204117A (en) 2017-06-22 2024-08-08 Novartis Ag Antibody molecules to cd73 and uses thereof
PE20221409A1 (es) 2020-01-03 2022-09-20 Incyte Corp Anticuerpos anti-cd73 y usos de estos
TW202135823A (zh) 2020-01-03 2021-10-01 美商英塞特公司 Ｃｄ７３抑制劑及ａ２ａ／ａ２ｂ腺苷受體抑制劑組合療法
JP2025512384A (ja) 2022-04-13 2025-04-17 ギリアード サイエンシーズ， インコーポレイテッド Ｔｒｏｐ－２発現がんを治療するための併用療法
JP2025521231A (ja) * 2022-06-08 2025-07-08 シャンハイ フアオタ バイオファーマシューティカル カンパニー、リミテッド Ｃｄ７３抗体カクテル療法
CN115991772B (zh) * 2022-08-12 2023-09-01 南京蓬勃生物科技有限公司 抗cd73抗体或其抗原片段及其应用
WO2024040194A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
AU2024279278A1 (en) 2023-05-31 2025-12-18 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
US20250127728A1 (en) 2023-10-05 2025-04-24 Capstan Therapeutics, Inc. Constrained Ionizable Cationic Lipids and Lipid Nanoparticles
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors
US20250302763A1 (en) 2024-02-22 2025-10-02 Capstan Therapeutics, Inc. Immune engineering amplification
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles

Citations (2)

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JP2018501211A (ja) 2014-11-27 2018-01-18 ザイムワークス，インコーポレイテッド Ｈｅｒ２を標的とする二重特異性抗原結合性構築物の使用方法
WO2018237157A1 (en) 2017-06-22 2018-12-27 Novartis Ag CD73 BINDING ANTIBODY MOLECULES AND USES THEREOF

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US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
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EP1212422B1 (en) * 1999-08-24 2007-02-21 Medarex, Inc. Human ctla-4 antibodies and their uses
US8460364B2 (en) 2006-07-20 2013-06-11 Orbusneich Medical, Inc. Bioabsorbable polymeric medical device
ES2593484T3 (es) 2007-03-29 2016-12-09 Genmab A/S Anticuerpos biespecíficos y métodos de producción de los mismos
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
JP6385357B2 (ja) 2012-11-27 2018-09-05 アジュ ユニバーシティー インダストリー−アカデミック コーオペレイション ファウンデーションＡｊｏｕ Ｕｎｉｖｅｒｓｉｔｙ Ｉｎｄｕｓｔｒｙ−Ａｃａｄｅｍｉｃ Ｃｏｏｐｅｒａｔｉｏｎ Ｆｏｕｎｄａｔｉｏｎ 抗体重鎖不変部位の異種二量体、高効率の形成を誘導するｃｈ３ドメイン変異体対、その作製方法および用途
EP3204417B1 (en) * 2014-10-10 2020-07-22 Innate Pharma Cd73 blockade
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JP2018501211A (ja) 2014-11-27 2018-01-18 ザイムワークス，インコーポレイテッド Ｈｅｒ２を標的とする二重特異性抗原結合性構築物の使用方法
WO2018237157A1 (en) 2017-06-22 2018-12-27 Novartis Ag CD73 BINDING ANTIBODY MOLECULES AND USES THEREOF

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Also Published As

Publication number Publication date
JP2026026484A (ja) 2026-02-17
US20220403041A1 (en) 2022-12-22
PH12022551150A1 (en) 2023-10-09
MX2022005866A (es) 2022-08-15
WO2021097223A2 (en) 2021-05-20
JP2023503846A (ja) 2023-02-01
KR20220100929A (ko) 2022-07-18
EP4058150A2 (en) 2022-09-21
IL292959A (en) 2022-07-01
CA3161717A1 (en) 2021-05-20
AU2020384305A1 (en) 2022-06-30
CO2022008204A2 (es) 2022-06-21
BR112022009317A2 (pt) 2022-08-09
CN115003385A (zh) 2022-09-02
WO2021097223A3 (en) 2021-06-17

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