JP7774081B2 - 二量体造影剤の製造 - Google Patents

二量体造影剤の製造

Info

Publication number
JP7774081B2
JP7774081B2 JP2023577348A JP2023577348A JP7774081B2 JP 7774081 B2 JP7774081 B2 JP 7774081B2 JP 2023577348 A JP2023577348 A JP 2023577348A JP 2023577348 A JP2023577348 A JP 2023577348A JP 7774081 B2 JP7774081 B2 JP 7774081B2
Authority
JP
Japan
Prior art keywords
solution
formula
compound
aqueous
gadolinium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2023577348A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024527691A5 (cg-RX-API-DMAC7.html
JP2024527691A (ja
Inventor
バニン，アンドレア
バラーレ，アンドレア
ボイ，ヴァレリア
ガッツェット，ソニア
ブオンサンティ，フェデリカ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Publication of JP2024527691A publication Critical patent/JP2024527691A/ja
Publication of JP2024527691A5 publication Critical patent/JP2024527691A5/ja
Application granted granted Critical
Publication of JP7774081B2 publication Critical patent/JP7774081B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/122—Macromolecular compounds dimers of complexes or complex-forming compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2023577348A 2021-07-27 2022-07-26 二量体造影剤の製造 Active JP7774081B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21187883.0 2021-07-27
EP21187883 2021-07-27
PCT/EP2022/070901 WO2023006721A1 (en) 2021-07-27 2022-07-26 Manufacturing of dimeric contrast agents

Publications (3)

Publication Number Publication Date
JP2024527691A JP2024527691A (ja) 2024-07-26
JP2024527691A5 JP2024527691A5 (cg-RX-API-DMAC7.html) 2025-01-31
JP7774081B2 true JP7774081B2 (ja) 2025-11-20

Family

ID=77367218

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023577348A Active JP7774081B2 (ja) 2021-07-27 2022-07-26 二量体造影剤の製造

Country Status (13)

Country Link
US (1) US12290576B2 (cg-RX-API-DMAC7.html)
EP (1) EP4377323B1 (cg-RX-API-DMAC7.html)
JP (1) JP7774081B2 (cg-RX-API-DMAC7.html)
KR (1) KR20240034693A (cg-RX-API-DMAC7.html)
CN (1) CN117412980A (cg-RX-API-DMAC7.html)
AU (1) AU2022317221A1 (cg-RX-API-DMAC7.html)
BR (1) BR112023022921A2 (cg-RX-API-DMAC7.html)
CA (1) CA3216972A1 (cg-RX-API-DMAC7.html)
ES (1) ES3041651T3 (cg-RX-API-DMAC7.html)
IL (1) IL308888A (cg-RX-API-DMAC7.html)
MX (1) MX2023014582A (cg-RX-API-DMAC7.html)
PL (1) PL4377323T3 (cg-RX-API-DMAC7.html)
WO (1) WO2023006721A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2991736T3 (es) * 2020-07-27 2024-12-04 Bracco Imaging Spa Fabricación de agentes de contraste diméricos
AU2022318032A1 (en) * 2021-07-27 2023-12-21 Bracco Imaging Spa Process for the manufacturing of a gadolinium complex solution

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19849465A1 (de) 1998-10-21 2000-04-27 Schering Ag Dimere Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
US20180362511A1 (en) 2015-12-10 2018-12-20 Bracco Imaging S.P.A. Dimeric contrast agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
IT1291624B1 (it) * 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
IT1304501B1 (it) * 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
IL293806B1 (en) * 2019-12-13 2026-05-01 Bracco Imaging Spa Production of protected DO3A salts

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19849465A1 (de) 1998-10-21 2000-04-27 Schering Ag Dimere Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
US20180362511A1 (en) 2015-12-10 2018-12-20 Bracco Imaging S.P.A. Dimeric contrast agents

Also Published As

Publication number Publication date
EP4377323A1 (en) 2024-06-05
CN117412980A (zh) 2024-01-16
AU2022317221A1 (en) 2023-11-16
IL308888A (en) 2024-01-01
CA3216972A1 (en) 2023-02-02
PL4377323T3 (pl) 2025-12-01
EP4377323C0 (en) 2025-07-02
KR20240034693A (ko) 2024-03-14
ES3041651T3 (en) 2025-11-13
US12290576B2 (en) 2025-05-06
MX2023014582A (es) 2023-12-13
WO2023006721A1 (en) 2023-02-02
BR112023022921A2 (pt) 2024-02-27
US20240269330A1 (en) 2024-08-15
JP2024527691A (ja) 2024-07-26
EP4377323B1 (en) 2025-07-02

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