JP7770028B2 - 細胞を抗原提示に有能な樹状細胞2型に初期化するための組成物、その方法及び使用 - Google Patents
細胞を抗原提示に有能な樹状細胞2型に初期化するための組成物、その方法及び使用Info
- Publication number
- JP7770028B2 JP7770028B2 JP2022530281A JP2022530281A JP7770028B2 JP 7770028 B2 JP7770028 B2 JP 7770028B2 JP 2022530281 A JP2022530281 A JP 2022530281A JP 2022530281 A JP2022530281 A JP 2022530281A JP 7770028 B2 JP7770028 B2 JP 7770028B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4242—Transcription factors, e.g. SOX or c-MYC
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/30—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cancer cells, e.g. reversion of tumour cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2780/00—Naked RNA viruses
- C12N2780/00011—Details
- C12N2780/00041—Use of virus, viral particle or viral elements as a vector
- C12N2780/00043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT115933 | 2019-11-25 | ||
| PT11593319 | 2019-11-25 | ||
| EP20190159.2 | 2020-08-07 | ||
| EP20190159 | 2020-08-07 | ||
| PCT/EP2020/083400 WO2021105234A1 (en) | 2019-11-25 | 2020-11-25 | Compositions for reprogramming cells into dendritic cells type 2 competent for antigen presentation, methods and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023506707A JP2023506707A (ja) | 2023-02-20 |
| JP2023506707A5 JP2023506707A5 (https=) | 2023-12-04 |
| JP7770028B2 true JP7770028B2 (ja) | 2025-11-14 |
Family
ID=73497794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022530281A Active JP7770028B2 (ja) | 2019-11-25 | 2020-11-25 | 細胞を抗原提示に有能な樹状細胞2型に初期化するための組成物、その方法及び使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240139239A1 (https=) |
| EP (1) | EP4065697A1 (https=) |
| JP (1) | JP7770028B2 (https=) |
| KR (1) | KR20220105161A (https=) |
| CN (1) | CN114729320B (https=) |
| CA (1) | CA3156954A1 (https=) |
| IL (1) | IL292894B2 (https=) |
| WO (1) | WO2021105234A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023176806A1 (ja) | 2022-03-18 | 2023-09-21 | 国立研究開発法人産業技術総合研究所 | 線維芽細胞または線維芽細胞様細胞を従来型2型樹状細胞にリプログラミングするための方法 |
| WO2024030930A2 (en) * | 2022-08-01 | 2024-02-08 | The Johns Hopkins University | Compositions and methods for modifying muller glial cells |
| CN120285149A (zh) * | 2024-01-09 | 2025-07-11 | 清华大学 | Pou2f2蛋白或其突变体在预防和治疗感染中的用途 |
| WO2026003071A2 (en) * | 2024-06-25 | 2026-01-02 | Asgard Therapeutics Ab | Novel transcription factor combinations for immune cell reprogramming and related methods |
| CN119708155B (zh) * | 2024-12-30 | 2025-12-09 | 中国药科大学 | 地龙抗血小板寡肽及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016143826A1 (ja) | 2015-03-09 | 2016-09-15 | 学校法人慶應義塾 | 多能性幹細胞を所望の細胞型へ分化する方法 |
| WO2018185709A1 (en) | 2017-04-05 | 2018-10-11 | Centro De Neurociencias E Biologia Celular | Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof |
| JP2023502318A (ja) | 2019-10-10 | 2023-01-24 | アスガード セラピューティクス エービー | 細胞を再プログラム化して形質細胞様樹状細胞またはi型インターフェロン産生細胞に変換する組成物、その方法および用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| US20040236091A1 (en) * | 2001-03-28 | 2004-11-25 | Chicz Roman M. | Translational profiling |
| US20090215875A1 (en) * | 2008-02-25 | 2009-08-27 | Deneault Eric | Methods and kits for expanding hematopoietic stem cells |
| US8802438B2 (en) | 2010-04-16 | 2014-08-12 | Children's Medical Center Corporation | Compositions, kits, and methods for making induced pluripotent stem cells using synthetic modified RNAs |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| WO2013070563A1 (en) * | 2011-11-07 | 2013-05-16 | Merck Sharp & Dohme Corp. | Treatment of autoimmune and inflammatory disorders by inhibition of blimp-1 |
| EP3385373A1 (en) | 2017-04-05 | 2018-10-10 | Centro de Neurociências e Biologia Celular | Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof |
-
2020
- 2020-11-25 KR KR1020227019462A patent/KR20220105161A/ko active Pending
- 2020-11-25 CA CA3156954A patent/CA3156954A1/en active Pending
- 2020-11-25 EP EP20810982.7A patent/EP4065697A1/en active Pending
- 2020-11-25 JP JP2022530281A patent/JP7770028B2/ja active Active
- 2020-11-25 US US17/778,901 patent/US20240139239A1/en active Pending
- 2020-11-25 CN CN202080078541.XA patent/CN114729320B/zh active Active
- 2020-11-25 WO PCT/EP2020/083400 patent/WO2021105234A1/en not_active Ceased
-
2022
- 2022-05-10 IL IL292894A patent/IL292894B2/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016143826A1 (ja) | 2015-03-09 | 2016-09-15 | 学校法人慶應義塾 | 多能性幹細胞を所望の細胞型へ分化する方法 |
| WO2018185709A1 (en) | 2017-04-05 | 2018-10-11 | Centro De Neurociencias E Biologia Celular | Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof |
| JP2023502318A (ja) | 2019-10-10 | 2023-01-24 | アスガード セラピューティクス エービー | 細胞を再プログラム化して形質細胞様樹状細胞またはi型インターフェロン産生細胞に変換する組成物、その方法および用途 |
Non-Patent Citations (1)
| Title |
|---|
| ROSA, FF et al.,Direct reprogramming of fibroblasts into antigen-presenting dendritic cells,Science Immunology,2018年,Vol. 3, eaau4292,pp. 1-15 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021105234A1 (en) | 2021-06-03 |
| IL292894B2 (en) | 2023-07-01 |
| US20240139239A1 (en) | 2024-05-02 |
| CN114729320A (zh) | 2022-07-08 |
| CA3156954A1 (en) | 2021-06-03 |
| KR20220105161A (ko) | 2022-07-26 |
| EP4065697A1 (en) | 2022-10-05 |
| JP2023506707A (ja) | 2023-02-20 |
| CN114729320B (zh) | 2023-12-15 |
| IL292894A (en) | 2022-07-01 |
| IL292894B1 (en) | 2023-03-01 |
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