JP7763166B2 - 水溶性粘膜付着性ポリマーを有するイオン交換組成物 - Google Patents

水溶性粘膜付着性ポリマーを有するイオン交換組成物

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Publication number
JP7763166B2
JP7763166B2 JP2022521453A JP2022521453A JP7763166B2 JP 7763166 B2 JP7763166 B2 JP 7763166B2 JP 2022521453 A JP2022521453 A JP 2022521453A JP 2022521453 A JP2022521453 A JP 2022521453A JP 7763166 B2 JP7763166 B2 JP 7763166B2
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JP
Japan
Prior art keywords
water
nicotine
tablet
present
particles
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022521453A
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English (en)
Japanese (ja)
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JP2022552491A5 (enExample
JP2022552491A (ja
Inventor
ケント・アルビン・ニールセン
Original Assignee
フェルティン ファルマ アー／エス
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Publication of JP2022552491A5 publication Critical patent/JP2022552491A5/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022521453A 2019-10-11 2020-10-09 水溶性粘膜付着性ポリマーを有するイオン交換組成物 Active JP7763166B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16/599,991 2019-10-11
US16/599,991 US12702643B2 (en) 2019-10-11 2019-10-11 Ion-exchange composition with water-soluble mucoadhesive polymers
PCT/DK2020/050280 WO2021069044A1 (en) 2019-10-11 2020-10-09 An ion-exchange composition with water-soluble mucoadhesive polymers

Publications (3)

Publication Number Publication Date
JP2022552491A JP2022552491A (ja) 2022-12-16
JP2022552491A5 JP2022552491A5 (enExample) 2023-10-19
JP7763166B2 true JP7763166B2 (ja) 2025-10-31

Family

ID=73198078

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022521453A Active JP7763166B2 (ja) 2019-10-11 2020-10-09 水溶性粘膜付着性ポリマーを有するイオン交換組成物

Country Status (6)

Country Link
US (1) US12702643B2 (enExample)
EP (1) EP4041191A1 (enExample)
JP (1) JP7763166B2 (enExample)
CN (1) CN114555060A (enExample)
CA (1) CA3153792A1 (enExample)
WO (1) WO2021069044A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022234522A1 (en) * 2021-05-06 2022-11-10 Nicoventures Trading Limited Oral compositions and related methods for reducing throat irritation
JP2024536230A (ja) 2021-09-30 2024-10-04 ニコベンチャーズ トレーディング リミテッド 塩基性アミン及びイオン対形成剤を含む口腔用製品
US12295412B2 (en) 2022-01-28 2025-05-13 Altria Client Services Llc Oral pouch product
US20260224493A1 (en) * 2023-01-27 2026-08-06 Fertin Pharma A/S An Adhesive Oral Disc For Sustained Release Of Cannabinoids
DK182278B1 (en) * 2023-07-07 2026-02-04 Fertin Pharma As Dissolvable orally adhering tablet
US20260224480A1 (en) * 2023-01-27 2026-08-06 Philip Morris Products S.A. System for oral delivery of an active ingredient
DK182273B1 (en) * 2023-07-07 2026-01-30 Fertin Pharma As Dissolvable orally adhering nicotine tablet
AU2024296756A1 (en) * 2023-07-07 2026-01-22 Fertin Pharma A/S Dissolvable orally adhering nicotine tablet

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2012083947A1 (en) 2010-12-21 2012-06-28 Fertin Pharma A/S Chewing gum composition comprising cross-linked polyacrylic acid
US20170172995A1 (en) 2015-09-08 2017-06-22 Venkateswara Rao Repaka Pharmaceutical compositions of Nicotine and process for preparation thereof
WO2018113916A1 (en) 2016-12-20 2018-06-28 Fertin Pharma A/S A mucoadhesive oromucosal formulation comprising a nicotine complex

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US3901248A (en) 1970-07-22 1975-08-26 Leo Ab Chewable smoking substitute composition
TR199802305T2 (xx) 1996-05-13 2002-06-21 Norvartis Consumer Health S.A. Yanaktan uygulama y�ntemi.
US6368625B1 (en) * 1998-08-12 2002-04-09 Cima Labs Inc. Orally disintegrable tablet forming a viscous slurry
WO2000025757A1 (en) * 1998-10-29 2000-05-11 Merck & Co., Inc. Sustained release delivery of highly water-soluble compounds
EP1578422B1 (en) 2002-12-20 2007-04-11 NicoNovum AB A physically and chemically stable nicotine and micorcrystalline cellulose containing particulate material
SE0302947D0 (sv) 2003-01-24 2003-11-07 Magle Ab A composition material for transmucosal delivery
KR20120066688A (ko) 2003-02-24 2012-06-22 파마슈티칼 프로덕션스, 인크. 경점막 약물 전달 시스템
WO2005053691A2 (en) * 2003-12-02 2005-06-16 Fertin Pharma A/S Nicotine delivery product and method for producing it
US8529939B2 (en) * 2003-12-08 2013-09-10 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
US20050181050A1 (en) * 2004-01-28 2005-08-18 Collegium Pharmaceutical, Inc. Dosage forms using drug-loaded ion exchange resins
DK200401195A (da) * 2004-08-06 2004-08-06 Gumlink As Layered chewing gum tablet
WO2009007768A1 (en) * 2007-07-06 2009-01-15 Gumlink A/S Compressed tablet comprising polyol
CL2009001025A1 (es) 2008-05-01 2010-09-24 Smithkline Beecham Corp Composicion de pastilla para chupar que comprende: a) un granulo patron con al menos: un agente tampon alcalino, un modificador de la disolucion y una carga, b) un principio activo de nicotina definido extragranular y al menos un agente tampon alcalino; procedimiento de preparacion; util para eliminar o reducir el uso de tabaco.
GR20080100696A (el) * 2008-10-23 2010-05-13 Genepharm �.�. Φαρμακοτεχνικη μορφη με βελτιωμενη γευση του φαρμακευτικα αποδεκτου αλατος εσιταλοπραμης
PL2405942T3 (pl) 2009-03-13 2018-04-30 Excellent Tech Products I Sverige Ab Produkt do podawania doustnego
EP2233134A1 (en) 2009-03-27 2010-09-29 McNeil AB Multi-portion intra-oral dosage form with organoleptic properties
CA2757419C (en) 2009-04-03 2017-09-12 X-International Aps Plant fiber product and method for its manufacture
CN102481257B (zh) * 2009-04-24 2014-08-13 Omya国际股份公司 用于控释活性成分的颗粒材料
SE535587C2 (sv) 2011-03-29 2012-10-02 Chill Of Sweden Ab Produkt innehållande ett fritt nikotinsalt och en ej vattenlöslig påse
SE536491C2 (sv) 2012-03-26 2013-12-27 Bionicotine Ab Påse innehållande nikotin och en tuggummikomposition
EP3622834A1 (en) 2013-07-19 2020-03-18 Altria Client Services LLC Methods and systems for incorporating nicotine into oral products
GB201603866D0 (en) 2016-03-07 2016-04-20 British American Tobacco Co Smokeless oral tobacco product and preperation thereof
JP6840849B2 (ja) * 2016-11-18 2021-03-10 フェルティン ファルマ アー／エス 別個の結合剤及びエリスリトールを含む錠剤
EP3854383A1 (en) 2016-11-18 2021-07-28 Fertin Pharma A/S Oral delivery vehicle
US10632076B2 (en) * 2016-11-18 2020-04-28 Fertin Pharma A/S Tablet comprising separate binder and erythritol
US11058633B2 (en) * 2018-05-17 2021-07-13 Fertin Pharma A/S Disintegrating oral tablet suitable for active pharmaceutical ingredients
PH12021553026A1 (en) 2019-07-05 2023-08-23 Swedish Match North Europe Ab An oral pouched nicotine product including a filling material comprising nicotine-containing particles

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2012083947A1 (en) 2010-12-21 2012-06-28 Fertin Pharma A/S Chewing gum composition comprising cross-linked polyacrylic acid
US20170172995A1 (en) 2015-09-08 2017-06-22 Venkateswara Rao Repaka Pharmaceutical compositions of Nicotine and process for preparation thereof
WO2018113916A1 (en) 2016-12-20 2018-06-28 Fertin Pharma A/S A mucoadhesive oromucosal formulation comprising a nicotine complex

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CALUM R PARK ; ET AL，DEVELOPMENT AND EVALUATION OF A BIPHASIC BUCCAL ADHESIVE TABLET FOR NICOTINE REPLACEMENT THERAPY，INTERNATIONAL JOURNAL OF PHARMACEUTICS，NL，ELSEVIER，2002年04月26日，VOL:237, NR:1-2，PAGE(S):215 - 226，http://dx.doi.org/10.1016/S0378-5173(02)00041-8

Also Published As

Publication number Publication date
WO2021069044A1 (en) 2021-04-15
CA3153792A1 (en) 2021-04-15
JP2022552491A (ja) 2022-12-16
EP4041191A1 (en) 2022-08-17
US20210106516A1 (en) 2021-04-15
CN114555060A (zh) 2022-05-27
US12702643B2 (en) 2026-08-11

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