JP7716406B2 - 共通のリーダー配列を有するｂｃｒトランスジェニックマウス - Google Patents

共通のリーダー配列を有するｂｃｒトランスジェニックマウス

Info

Publication number
JP7716406B2
JP7716406B2 JP2022537413A JP2022537413A JP7716406B2 JP 7716406 B2 JP7716406 B2 JP 7716406B2 JP 2022537413 A JP2022537413 A JP 2022537413A JP 2022537413 A JP2022537413 A JP 2022537413A JP 7716406 B2 JP7716406 B2 JP 7716406B2
Authority
JP
Japan
Prior art keywords
human
leader
gene segments
leader peptide
coding sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022537413A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023508290A5 (OSRAM
JP2023508290A (ja
Inventor
エム バーンズ，ロールストン
ラジパル，アルビンド
ルー，アイラン
ウー，ガブリエル
エム マイェルチャク，ジョン
フリードバーガー，アナスタシア
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2023508290A publication Critical patent/JP2023508290A/ja
Publication of JP2023508290A5 publication Critical patent/JP2023508290A5/ja
Application granted granted Critical
Publication of JP7716406B2 publication Critical patent/JP7716406B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2022537413A 2019-12-18 2020-12-17 共通のリーダー配列を有するｂｃｒトランスジェニックマウス Active JP7716406B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962949707P 2019-12-18 2019-12-18
US62/949,707 2019-12-18
PCT/US2020/065450 WO2021127068A1 (en) 2019-12-18 2020-12-17 Bcr transgenic mice with a common leader sequence

Publications (3)

Publication Number Publication Date
JP2023508290A JP2023508290A (ja) 2023-03-02
JP2023508290A5 JP2023508290A5 (OSRAM) 2023-12-25
JP7716406B2 true JP7716406B2 (ja) 2025-07-31

Family

ID=74106210

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022537413A Active JP7716406B2 (ja) 2019-12-18 2020-12-17 共通のリーダー配列を有するｂｃｒトランスジェニックマウス

Country Status (6)

Country Link
US (1) US20230071042A1 (OSRAM)
EP (1) EP4075965A1 (OSRAM)
JP (1) JP7716406B2 (OSRAM)
KR (1) KR20220116490A (OSRAM)
CN (1) CN114867345A (OSRAM)
WO (1) WO2021127068A1 (OSRAM)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120365434A (zh) * 2024-01-23 2025-07-25 上海苹谱医疗科技有限公司 一种提高凝血因子ⅷ分泌水平的双信号肽及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007537704A (ja) 2003-07-15 2007-12-27 セラピューティック ヒューマン ポリクローナルズ， インコーポレイテッド ヒト化免疫グロブリン遺伝子座

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633425A (en) * 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
AU8507191A (en) * 1990-08-29 1992-03-30 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
IL162111A0 (en) * 2001-12-22 2005-11-20 4Antibody Ag Method for the generation of generically modified vertebrate precursor lymphocytes and use thereof for the production of heterologo
US20140045472A1 (en) * 2012-08-13 2014-02-13 Qualcomm Incorporated Provisioning-free memberless group communication sessions
JP6621750B2 (ja) * 2013-09-18 2019-12-18 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒスチジン操作軽鎖抗体およびそれを生成するための遺伝子改変非ヒト動物
GB201518792D0 (en) 2015-10-23 2015-12-09 Univ Manchester Production of proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007537704A (ja) 2003-07-15 2007-12-27 セラピューティック ヒューマン ポリクローナルズ， インコーポレイテッド ヒト化免疫グロブリン遺伝子座

Also Published As

Publication number Publication date
KR20220116490A (ko) 2022-08-23
EP4075965A1 (en) 2022-10-26
CN114867345A (zh) 2022-08-05
WO2021127068A1 (en) 2021-06-24
JP2023508290A (ja) 2023-03-02
US20230071042A1 (en) 2023-03-09

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