JP7689494B2 - 患者コホートの反応、増悪、および生存を予測し解析するための方法およびプロセス - Google Patents

患者コホートの反応、増悪、および生存を予測し解析するための方法およびプロセス Download PDF

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JP7689494B2
JP7689494B2 JP2021538761A JP2021538761A JP7689494B2 JP 7689494 B2 JP7689494 B2 JP 7689494B2 JP 2021538761 A JP2021538761 A JP 2021538761A JP 2021538761 A JP2021538761 A JP 2021538761A JP 7689494 B2 JP7689494 B2 JP 7689494B2
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ヘイリー・レフコフスキー
アシュラフ・ハーフェズ
ジュリアン・ハビブ
カリン・フィシェル
キャロライン・エプスタイン
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テンパス・エーアイ・インコーポレイテッド
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JP2021538761A 2018-12-31 2019-12-31 患者コホートの反応、増悪、および生存を予測し解析するための方法およびプロセス Active JP7689494B2 (ja)

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US201862786739P 2018-12-31 2018-12-31
US62/786,739 2018-12-31
PCT/US2019/069149 WO2020142551A1 (en) 2018-12-31 2019-12-31 A method and process for predicting and analyzing patient cohort response, progression, and survival

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JPWO2020142551A5 JPWO2020142551A5 (https=) 2023-01-19
JP2022516172A5 JP2022516172A5 (https=) 2023-01-19
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Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019173283A1 (en) 2018-03-05 2019-09-12 Marquette University Method and apparatus for non-invasive hemoglobin level prediction
US20210082111A1 (en) * 2018-03-29 2021-03-18 Sony Corporation Information processing device, information processing method, and program
US20230028954A1 (en) * 2018-08-30 2023-01-26 Qvh Systems, Llc Method and system for displaying medical claim information
US10978196B2 (en) 2018-10-17 2021-04-13 Tempus Labs, Inc. Data-based mental disorder research and treatment systems and methods
JP7689494B2 (ja) 2018-12-31 2025-06-06 テンパス・エーアイ・インコーポレイテッド 患者コホートの反応、増悪、および生存を予測し解析するための方法およびプロセス
US11875903B2 (en) 2018-12-31 2024-01-16 Tempus Labs, Inc. Method and process for predicting and analyzing patient cohort response, progression, and survival
WO2020214988A1 (en) 2019-04-17 2020-10-22 Tempus Labs Collaborative artificial intelligence method and system
EP3745409A1 (en) * 2019-05-29 2020-12-02 Koninklijke Philips N.V. Methods and apparatus for generating a graphical representation
US20220310208A1 (en) * 2019-06-13 2022-09-29 Roche Sequencing Solutions, Inc. Systems and methods with improved user interface for interpreting and visualizing longitudinal
US20210065914A1 (en) * 2019-09-04 2021-03-04 SIVOTEC BioInformatics LLC Dynamic, real-time, genomics decision support, research, and simulation
EP3799074A1 (en) * 2019-09-30 2021-03-31 Siemens Healthcare GmbH Healthcare network
WO2021081253A1 (en) 2019-10-22 2021-04-29 Tempus Labs, Inc. Systems and methods for predicting therapeutic sensitivity
EP4070232A4 (en) 2019-12-05 2024-01-31 Tempus Labs, Inc. SYSTEMS AND METHODS FOR HIGH-THROUGHPUT ACTIVE SCREENING
US20230187074A1 (en) * 2019-12-31 2023-06-15 Tempus Labs, Inc. Method and process for predicting and analyzing patient cohort response, progression, and survival
US11599800B2 (en) * 2020-01-28 2023-03-07 Color Genomics, Inc. Systems and methods for enhanced user specific predictions using machine learning techniques
US11476002B2 (en) * 2020-03-17 2022-10-18 Flatiron Health, Inc. Clinical risk model
US11561178B2 (en) 2020-04-20 2023-01-24 Tempus Labs, Inc. Artificial fluorescent image systems and methods
CA3174332A1 (en) 2020-04-21 2021-10-28 Jason PERERA Tcr/bcr profiling
CA3178405A1 (en) 2020-05-14 2021-11-18 Katherine A. OWEN Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus
US11581082B2 (en) * 2020-05-15 2023-02-14 Omniscient Neurotechnology Pty Limited Subsetting brain data
CN115917668A (zh) * 2020-06-12 2023-04-04 霍夫曼-拉罗奇有限公司 用于促进个体多发性硬化症受试者的协同治疗的大数据处理
WO2021252853A1 (en) * 2020-06-12 2021-12-16 Flatiron Health, Inc. Systems and methods for extracting dates associated with a patient condition
US11151480B1 (en) * 2020-06-22 2021-10-19 Sas Institute Inc. Hyperparameter tuning system results viewer
US20220076836A1 (en) * 2020-09-08 2022-03-10 Genentech, Inc. Pan-Indication Gradient Boosting Model Using Tumor Kinetics for Survival Prediction
CA3192386A1 (en) * 2020-09-10 2022-03-17 Jim ABRAHAM Metastasis predictor
CN112086199B (zh) * 2020-09-14 2023-06-09 中科院计算所西部高等技术研究院 基于多组学数据的肝癌数据处理系统
US20220084649A1 (en) * 2020-09-17 2022-03-17 Medtronic Minimed, Inc. Infusion systems and methods for patient predictions using association mining
JP2023544335A (ja) * 2020-10-02 2023-10-23 プレノシス,インコーポレイテッド 機械学習モデルの適応訓練システム及び方法
CN116348960A (zh) * 2020-10-13 2023-06-27 伯恩森斯韦伯斯特(以色列)有限责任公司 个性化心律失常治疗计划
WO2022081712A1 (en) * 2020-10-14 2022-04-21 nference, inc. Systems and methods for retrieving clinical information based on clinical patient data
TWI777319B (zh) * 2020-12-03 2022-09-11 鴻海精密工業股份有限公司 幹細胞密度確定方法、裝置、電腦裝置及儲存介質
WO2022120075A1 (en) * 2020-12-03 2022-06-09 Foundation Medicine, Inc. Tree-based model for selecting treatments and determining expected treatment outcomes
US11476003B2 (en) * 2020-12-15 2022-10-18 Biodesix, Inc. Method for predicting risk of unfavorable outcomes, e.g., in COVID-19 hospitalization, from clinical characteristics and basic laboratory findings
WO2022128622A1 (en) * 2020-12-17 2022-06-23 Koninklijke Philips N.V. Automatic ranking and rank order display of medical information, and associated devices, systems, and methods
US11775878B2 (en) 2020-12-22 2023-10-03 Sas Institute Inc. Automated machine learning test system
US11613783B2 (en) 2020-12-31 2023-03-28 Tempus Labs, Inc. Systems and methods for detecting multi-molecule biomarkers
US20220215900A1 (en) 2021-01-07 2022-07-07 Tempus Labs, Inc. Systems and methods for joint low-coverage whole genome sequencing and whole exome sequencing inference of copy number variation for clinical diagnostics
WO2022159774A2 (en) 2021-01-21 2022-07-28 Tempus Labs, Inc. METHODS AND SYSTEMS FOR mRNA BOUNDARY ANALYSIS IN NEXT GENERATION SEQUENCING
CN112735606B (zh) * 2021-01-22 2023-04-25 张厚德 结直肠癌风险预测方法、设备及存储介质
DE102021200650A1 (de) * 2021-01-26 2022-07-28 Siemens Healthcare Gmbh Verfahren zum Erstellen eines individuellen Gen-Panel-Plans
US20220246297A1 (en) * 2021-02-01 2022-08-04 Anthem, Inc. Causal Recommender Engine for Chronic Disease Management
US12361542B2 (en) 2021-03-03 2025-07-15 Tempus Ai, Inc. Systems and methods for deep orthogonal fusion for multimodal prognostic biomarker discovery
US20220285035A1 (en) * 2021-03-08 2022-09-08 Electronics And Telecommunications Research Institute Device and method of predicting disease by using elderly cohort data
KR102632155B1 (ko) 2021-03-16 2024-01-31 재단법인 아산사회복지재단 의료 데이터에 기초한 코호트 데이터 처리 장치 및 방법
US12119103B2 (en) 2021-03-30 2024-10-15 Tempus Ai, Inc. GANs for latent space visualizations
US12288603B2 (en) 2021-04-09 2025-04-29 Endocanna Health, Inc. Machine-learning based efficacy predictions based on genetic and biometric information
CN115249215A (zh) * 2021-04-28 2022-10-28 北京字跳网络技术有限公司 图像处理方法、装置、电子设备以及可读存储介质
CN113270200B (zh) * 2021-05-24 2022-12-27 平安科技(深圳)有限公司 基于人工智能的异常患者识别方法及相关设备
WO2022256782A1 (en) * 2021-06-02 2022-12-08 Elekta, Inc. Discreet parameter automated planning
CN113488127B (zh) * 2021-07-28 2023-10-20 中国医学科学院医学信息研究所 一种人口健康数据集敏感度处理方法及系统
US12548645B2 (en) * 2021-07-30 2026-02-10 Guardant Health, Inc. Computer architecture for identifying lines of therapy
US12399940B2 (en) * 2021-09-23 2025-08-26 Yahoo Ad Tech Llc System and method for generating relevant sets of results using datasets
US12562275B2 (en) * 2021-10-08 2026-02-24 International Business Machines Corporation Interactive subgroup discovery
WO2023064309A1 (en) 2021-10-11 2023-04-20 Tempus Labs, Inc. Methods and systems for detecting alternative splicing in sequencing data
US20250226114A1 (en) * 2021-10-19 2025-07-10 Koninklijke Philips N.V. Determining a measure of subject similarity
US20230153757A1 (en) * 2021-11-16 2023-05-18 Atropos LLC System and Method for Rapid Informatics-Based Prognosis and Treatment Development
US20230162815A1 (en) 2021-11-19 2023-05-25 Tempus Labs, Inc. Methods and systems for accurate genotyping of repeat polymorphisms
JP7699529B2 (ja) * 2021-11-25 2025-06-27 株式会社日立製作所 計算機システム及びデータ解析方法
KR102837531B1 (ko) * 2021-11-29 2025-07-23 서울대학교병원 생존곡선의 수학적 모델링을 통한 검사간격 설정 장치 및 그 방법
US20250062023A1 (en) * 2021-12-16 2025-02-20 Plan Heal Health Companies, Inc. Machine learning methods and systems for phenotype classifications
US20230237384A1 (en) * 2022-01-13 2023-07-27 General Electric Company Methods and apparatus to implement a random forest
US11526261B1 (en) * 2022-02-18 2022-12-13 Kpmg Llp System and method for aggregating and enriching data
WO2023159224A1 (en) * 2022-02-18 2023-08-24 Rajant Health Incorporated Automated demographic feature space partitioner to create disease ad-hoc demographic sub- population clusters
EP4239647A1 (en) 2022-03-03 2023-09-06 Tempus Labs, Inc. Systems and methods for deep orthogonal fusion for multimodal prognostic biomarker discovery
CA3193098A1 (en) * 2022-03-16 2023-09-16 Treasure Data, Inc. Machine learning methods to determine a likelihood for an event to occur through sentiment analysis of digital conversations
US20230297781A1 (en) * 2022-03-16 2023-09-21 Treasure Data, Inc. Machine learning methods to determine a likelihood for an event to occur through sentiment analysis of digital conversations
JP2025510769A (ja) * 2022-03-25 2025-04-15 サノフイ 疾患進行予測
WO2023229980A1 (en) * 2022-05-23 2023-11-30 The Johns Hopkins University Graphical user interfaces and systems for presenting and analyzing large patient data sets
EP4287212A1 (en) 2022-05-30 2023-12-06 Sophia Genetics S.A. Machine learning predictive models of treatment response
AU2023281175A1 (en) 2022-05-30 2024-12-12 Sophia Genetics Sa Machine learning predictive models of treatment response
EP4307315A1 (en) 2022-07-11 2024-01-17 Sophia Genetics SA Machine learning predictive models of treatment response
WO2024006702A1 (en) * 2022-06-27 2024-01-04 Foundation Medicine, Inc. Methods and systems for predicting genotypic calls from whole-slide images
EP4336516A1 (en) * 2022-09-08 2024-03-13 Koninklijke Philips N.V. Methods and systems for visualizing survival statistics for a patient cohort
US12204548B2 (en) * 2022-12-05 2025-01-21 Cedaron Medical, Inc. User cohort query engine
US20240221873A1 (en) * 2023-01-03 2024-07-04 Unitedhealth Group Incorporated Systems and methods for evaluating programs
US11862324B1 (en) * 2023-01-23 2024-01-02 Kpn Innovations, Llc. Apparatus and method for outputting an alimentary program to a user
US12592319B1 (en) * 2023-03-24 2026-03-31 Iqvia Inc. Early prediction of clinical trial signals
EP4447056A1 (en) 2023-04-13 2024-10-16 Tempus AI, Inc. Systems and methods for predicting clinical response
TW202522504A (zh) * 2023-05-09 2025-06-01 美商再生元醫藥公司 用於減少樣本數之系統及方法
WO2024249579A2 (en) * 2023-05-30 2024-12-05 The Trustees Of Columbia University In The City Of New York System, method, and program product for out of distribution generalization via interventional style transfer
JP2024171429A (ja) * 2023-05-30 2024-12-12 キヤノンメディカルシステムズ株式会社 医用情報処理装置、方法及びプログラム
US20240403628A1 (en) * 2023-06-01 2024-12-05 Optum Services (Ireland) Limited Machine learning techniques for generating impact measures using nonlinear causal inference and predictive risk scores
US20240412878A1 (en) * 2023-06-08 2024-12-12 Fred Hutchinson Cancer Center Personalized insights into tumor evolution and ai-based treatment decision support systems and methods
EP4503046A1 (en) * 2023-08-01 2025-02-05 Tempus AI, Inc. Graph based metadata structuring algorithm to enable machine learning
WO2025042969A2 (en) * 2023-08-21 2025-02-27 Manifest Technologies Inc. Methods of identifying subjects for inclusion and/or exclusion in a clinical trial
US20250069713A1 (en) * 2023-08-24 2025-02-27 GE Precision Healthcare LLC Systems and methods for longitudinal timeline presentation and predictive clinical decision support
US20250079002A1 (en) * 2023-08-28 2025-03-06 NEC Laboratories Europe GmbH Interpretable domain adaptation for optimizing cross-cohort predictions from medical data
US20250111910A1 (en) 2023-09-29 2025-04-03 Tempus Al, Inc. Methods and systems for disease phenotyping using multimodal ehr data and weak supervision
CN117198550B (zh) * 2023-11-07 2024-03-19 北京青颜博识健康管理有限公司 基于大数据的胶原蛋白肽抗衰老评估系统
WO2025111531A1 (en) * 2023-11-24 2025-05-30 Mayo Foundation For Medical Education And Research Predicting a therapeutic response to a disease using a large language model
WO2025122662A1 (en) 2023-12-04 2025-06-12 Tempus Ai, Inc. Systems and methods for detecting somatic variants derived from circulating tumor nucleic acids
US20250201386A1 (en) * 2023-12-13 2025-06-19 Altis Labs, Inc. Predicting adverse reaction to medical treatment by applying artificial intelligence to medical image data
CN117407728B (zh) * 2023-12-15 2024-03-15 湖南南华生物技术有限公司 一种用于干细胞的存储环境实时监测方法及系统
US20250259702A1 (en) 2024-02-12 2025-08-14 Tempus Ai, Inc. Methods and systems for determining blood tumor mutational burden in a liquid biopsy assay
US20250316338A1 (en) 2024-04-04 2025-10-09 Tempus Ai, Inc. Methods and systems for tumor informed circulating tumor fraction estimation
WO2026006850A1 (en) 2024-06-28 2026-01-02 Tempus Ai, Inc. Functional biological modeling system
CN119741979B (zh) * 2024-12-12 2025-10-17 北京工业大学 一种基于全局交互传递性与特征融合的多层调控网络关键节点识别方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120041772A1 (en) 2010-08-12 2012-02-16 International Business Machines Corporation System and method for predicting long-term patient outcome
US20160203287A1 (en) 2013-08-20 2016-07-14 Ohio State Innovation Foundation Methods for predicting prognosis
US20170177822A1 (en) 2015-12-18 2017-06-22 Pointright Inc. Systems and methods for providing personalized prognostic profiles
US20170199965A1 (en) 2015-04-21 2017-07-13 Medaware Ltd. Medical system and method for predicting future outcomes of patient care

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10134229A1 (de) * 2000-08-17 2002-02-28 Ibm Verfahren und System zum Ermitteln von Abweichungen in Datentabellen
US7007035B2 (en) * 2001-06-08 2006-02-28 The Regents Of The University Of California Parallel object-oriented decision tree system
EP1579383A4 (en) 2002-10-24 2006-12-13 Univ Duke BINARY PREDICTION TREE MODELING WITH MANY PREDICTORS AND USES THEREOF FOR CLINICAL AND GENETIC APPLICATIONS
US7505948B2 (en) 2003-11-18 2009-03-17 Aureon Laboratories, Inc. Support vector regression for censored data
US7729865B2 (en) 2003-10-06 2010-06-01 Cerner Innovation, Inc. Computerized method and system for automated correlation of genetic test results
US7917376B2 (en) 2003-12-29 2011-03-29 Montefiore Medical Center System and method for monitoring patient care
US20090061422A1 (en) 2005-04-19 2009-03-05 Linke Steven P Diagnostic markers of breast cancer treatment and progression and methods of use thereof
US20070178501A1 (en) * 2005-12-06 2007-08-02 Matthew Rabinowitz System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
US7917525B2 (en) 2005-12-06 2011-03-29 Ingenix, Inc. Analyzing administrative healthcare claims data and other data sources
US8069055B2 (en) * 2006-02-09 2011-11-29 General Electric Company Predictive scheduling for procedure medicine
WO2007143401A2 (en) 2006-06-02 2007-12-13 Koninklijke Philips Electronics, N.V. Multi-modal imaging system and workstation with support for structured hypothesis testing
US20130080134A1 (en) 2008-07-25 2013-03-28 Fundação D. Anna Sommer Champalimaud e Dr. Carlos Montez Champalimaud Systems and methods for predicting favorable-risk disease for patients enrolled in active surveillance
EP2353113A4 (en) 2008-10-24 2016-01-06 Optuminsight Inc DEVICE, SYSTEM AND METHOD FOR FAST KOHORTENTESTUNG
EP2322658A1 (en) 2009-11-13 2011-05-18 Centre National de la Recherche Scientifique (CNRS) Signature for the diagnosis of breast cancer aggressiveness and genetic instability
WO2011153543A2 (en) 2010-06-04 2011-12-08 Georgetown University Systems and methods of predicting a subject's medical outcome
WO2011163234A1 (en) 2010-06-21 2011-12-29 Clinical Semantics Technologies Llc Cohort-selectable faceted display
CN103201743B (zh) 2010-11-08 2017-07-18 皇家飞利浦电子股份有限公司 患者疾病严重性、死亡率和住院时长的连续预测方法
CA2826657A1 (en) 2011-02-04 2012-08-09 Bioarray Therapeutics, Inc. Methods of using gene expression signatures to select a method of treatment, predict prognosis, survival, and/or predict response to treatment
WO2012119013A1 (en) * 2011-03-01 2012-09-07 Yale University PREDICTING GASTROENTEROPANCREATIC NEUROENDOCRINE NEOPLASMS (GEP-NENs)
JP2014523589A (ja) 2011-07-13 2014-09-11 ザ マルチプル ミエローマ リサーチ ファウンデーション, インコーポレイテッド データ収集及び配信のための方法
WO2013025561A1 (en) 2011-08-12 2013-02-21 Dnanexus Inc Sequence read archive interface
US20130226612A1 (en) 2012-02-26 2013-08-29 International Business Machines Corporation Framework for evidence based case structuring
US9104786B2 (en) 2012-10-12 2015-08-11 International Business Machines Corporation Iterative refinement of cohorts using visual exploration and data analytics
WO2014100509A1 (en) 2012-12-20 2014-06-26 Dnanexus Inc Application programming interface for tabular genomic datasets
US20140249761A1 (en) 2013-03-01 2014-09-04 DNANEXUS, Inc. Characterizing uncharacterized genetic mutations
US9414776B2 (en) 2013-03-06 2016-08-16 Navigated Technologies, LLC Patient permission-based mobile health-linked information collection and exchange systems and methods
US9317578B2 (en) * 2013-03-14 2016-04-19 International Business Machines Corporation Decision tree insight discovery
WO2015116721A1 (en) 2014-01-31 2015-08-06 Intermountain Invention Management, Llc Visualization techniques for population data
US10049772B1 (en) 2014-07-09 2018-08-14 Loyola University Of Chicago System and method for creation, operation and use of a clinical research database
US10755369B2 (en) 2014-07-16 2020-08-25 Parkland Center For Clinical Innovation Client management tool system and method
SG11201701051RA (en) * 2014-08-11 2017-03-30 Agency Science Tech & Res A method for prognosis of ovarian cancer, patient's stratification
US20160063212A1 (en) 2014-09-02 2016-03-03 Kyron, Inc. System for Generating and Updating Treatment Guidelines and Estimating Effect Size of Treatment Steps
US20160196394A1 (en) 2015-01-07 2016-07-07 Amino, Inc. Entity cohort discovery and entity profiling
WO2016118771A1 (en) * 2015-01-23 2016-07-28 Data4Cure, Inc. System and method for drug target and biomarker discovery and diagnosis using a multidimensional multiscale module map
US20180144003A1 (en) 2015-05-18 2018-05-24 Saul Formoso Automated entity-resolution methods and systems
IL258309B2 (en) 2015-09-24 2023-03-01 Caris Science Inc Method, device and product of computer software for analyzing biological data
WO2017059022A1 (en) 2015-09-30 2017-04-06 Inform Genomics, Inc. Systems and methods for predicting treatment-regiment-related outcomes
US10790049B2 (en) 2015-09-30 2020-09-29 University Of Central Florida Research Foundation, Inc. Method and system for managing health care patient record data
JP6991134B2 (ja) 2015-10-09 2022-01-12 ガーダント ヘルス, インコーポレイテッド 無細胞dnaを使用する集団ベースの処置レコメンダ
WO2017072628A1 (en) 2015-10-27 2017-05-04 Koninklijke Philips N.V. Pattern discovery visual analytics system to analyze characteristics of clinical data and generate patient cohorts
US20170177597A1 (en) 2015-12-22 2017-06-22 DNANEXUS, Inc. Biological data systems
US20170237805A1 (en) 2016-02-12 2017-08-17 DNANEXUS, Inc. Worker reuse deadline
CN108960514B (zh) * 2016-04-27 2022-09-06 第四范式(北京)技术有限公司 展示预测模型的方法、装置及调整预测模型的方法、装置
US20180165604A1 (en) * 2016-12-09 2018-06-14 U2 Science Labs A Montana Systems and methods for automating data science machine learning analytical workflows
US11017324B2 (en) 2017-05-17 2021-05-25 Microsoft Technology Licensing, Llc Tree ensemble explainability system
US11935634B2 (en) 2017-07-28 2024-03-19 Google Llc System and method for predicting and summarizing medical events from electronic health records
EP3451219A1 (en) * 2017-08-31 2019-03-06 KBC Groep NV Improved anomaly detection
US20190108912A1 (en) 2017-10-05 2019-04-11 Iquity, Inc. Methods for predicting or detecting disease
US10977106B2 (en) * 2018-02-09 2021-04-13 Microsoft Technology Licensing, Llc Tree-based anomaly detection
US11756667B2 (en) 2018-05-30 2023-09-12 Siemens Healthcare Gmbh Decision support system for medical therapy planning
US11574718B2 (en) 2018-05-31 2023-02-07 Perthera, Inc. Outcome driven persona-typing for precision oncology
WO2020023671A1 (en) * 2018-07-24 2020-01-30 Protocol Intelligence, Inc. Methods and systems for treating cancer and predicting and optimizing treatment outcomes in individual cancer patients
US11101043B2 (en) 2018-09-24 2021-08-24 Zasti Inc. Hybrid analysis framework for prediction of outcomes in clinical trials
EP3857564A1 (en) 2018-09-29 2021-08-04 F. Hoffmann-La Roche AG Multimodal machine learning based clinical predictor
US20200258601A1 (en) 2018-10-17 2020-08-13 Tempus Labs Targeted-panel tumor mutational burden calculation systems and methods
US10395772B1 (en) 2018-10-17 2019-08-27 Tempus Labs Mobile supplementation, extraction, and analysis of health records
US11200985B2 (en) 2018-10-23 2021-12-14 International Business Machines Corporation Utilizing unstructured literature and web data to guide study design in healthcare databases
US11676719B2 (en) 2018-12-20 2023-06-13 Oregon Health & Science University Subtyping heterogeneous disorders using functional random forest models
JP7689494B2 (ja) 2018-12-31 2025-06-06 テンパス・エーアイ・インコーポレイテッド 患者コホートの反応、増悪、および生存を予測し解析するための方法およびプロセス
US11715565B2 (en) 2019-11-08 2023-08-01 Tempus Labs, Inc. Evaluating effect of event on condition using propensity scoring

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120041772A1 (en) 2010-08-12 2012-02-16 International Business Machines Corporation System and method for predicting long-term patient outcome
US20160203287A1 (en) 2013-08-20 2016-07-14 Ohio State Innovation Foundation Methods for predicting prognosis
US20170199965A1 (en) 2015-04-21 2017-07-13 Medaware Ltd. Medical system and method for predicting future outcomes of patient care
US20170177822A1 (en) 2015-12-18 2017-06-22 Pointright Inc. Systems and methods for providing personalized prognostic profiles

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