JP7626774B2 - HER2阻害薬としての[1,3]ジアジノ[5,4-d]ピリミジン - Google Patents

HER2阻害薬としての[1,3]ジアジノ[5,4-d]ピリミジン Download PDF

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JP7626774B2
JP7626774B2 JP2022542952A JP2022542952A JP7626774B2 JP 7626774 B2 JP7626774 B2 JP 7626774B2 JP 2022542952 A JP2022542952 A JP 2022542952A JP 2022542952 A JP2022542952 A JP 2022542952A JP 7626774 B2 JP7626774 B2 JP 7626774B2
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compound
cancer
salt
her2
pharma
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JP2023512175A5 (enExample
JP2023512175A (ja
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ビルギット ワイルディング
ディートリッヒ ベーゼ
ハーラルト エンゲルハルト
ユリアン フックス
ラルフ ノイミュラー
マルク ペトロンスキ
ディルク シャルン
マティアス トロイ
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2022542952A 2020-02-03 2021-02-01 HER2阻害薬としての[1,3]ジアジノ[5,4-d]ピリミジン Active JP7626774B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20155161 2020-02-03
EP20155161.1 2020-02-03
PCT/EP2021/052263 WO2021156180A1 (en) 2020-02-03 2021-02-01 [1,3]diazino[5,4-d]pyrimidines as her2 inhibitors

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JP2023512175A JP2023512175A (ja) 2023-03-24
JP2023512175A5 JP2023512175A5 (enExample) 2024-02-08
JP7626774B2 true JP7626774B2 (ja) 2025-02-04

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JP2022542952A Active JP7626774B2 (ja) 2020-02-03 2021-02-01 HER2阻害薬としての[1,3]ジアジノ[5,4-d]ピリミジン

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US (1) US20230131720A1 (enExample)
EP (1) EP4100412A1 (enExample)
JP (1) JP7626774B2 (enExample)
CN (1) CN115052881B (enExample)
WO (1) WO2021156180A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11608343B2 (en) 2020-04-24 2023-03-21 Boehringer Ingelheim International Gmbh Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors
TW202214641A (zh) * 2020-06-30 2022-04-16 美商艾瑞生藥股份有限公司 Her2突變抑制劑
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
EP4359082A1 (en) 2021-06-26 2024-05-01 Array BioPharma Inc. Her2 mutation inhibitors
WO2023081637A1 (en) 2021-11-02 2023-05-11 Enliven Therapeutics, Inc. Fused tetracyclic quinazoline derivatives as inhibitors of erbb2
CN114031619A (zh) * 2021-12-17 2022-02-11 山东汇海医药化工有限公司 一种图卡替尼中间体的制备方法
CN114621221B (zh) * 2022-03-12 2022-10-11 陕西海辰风扬医药科技有限公司 妥卡替尼关键中间体及其制备方法
US20250206760A1 (en) 2022-03-28 2025-06-26 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Nitrogen-containing heterocyclic compound, preparation method therefor, and pharmaceutical application thereof
CN117384162A (zh) * 2022-05-17 2024-01-12 浙江文达医药科技有限公司 选择性her2抑制剂
WO2024027695A1 (zh) * 2022-08-04 2024-02-08 微境生物医药科技(上海)有限公司 作为her2抑制剂的化合物
CA3263309A1 (en) 2022-08-22 2024-02-29 Iambic Therapeutics, Inc. HER2 COMPOUNDS AND MODULATION METHODS
CN121487738A (zh) 2023-03-30 2026-02-06 锐新医药公司 诱导ras gtp水解的组合物和其用途
AR132562A1 (es) * 2023-05-01 2025-07-16 Enliven Inc Formas polimórficas de (e)-1-((10s)-4-((4-([1,2,4]triazolo[1,5-a]piridin-7-iloxi)-2-fluoro-5-metilfenil)amino)-7,8,10,11-tetrahidro-9h-6,10-metanopirimido[4’,5’:5,6]pirido[3,2-b][1,4,7]oxadiazonin-9-il)-4-(dimetilamino)but-2-en-1-ona
KR20260019479A (ko) 2023-05-04 2026-02-10 레볼루션 메디슨즈, 인크. Ras 관련 질환 또는 장애를 위한 병용 요법
CN116903615A (zh) * 2023-06-21 2023-10-20 江苏丽源医药有限公司 一种妥卡替尼及其中间体的制备方法
CN121889155A (zh) 2023-08-07 2026-04-17 锐新医药公司 用于治疗ras蛋白相关疾病或病症的rmc-6291
CN122270275A (zh) 2023-08-07 2026-06-23 科景特生物科学公司 用于fgfr抑制的化合物
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
CN121270563A (zh) * 2024-07-01 2026-01-06 北京鞍石生物科技股份有限公司 稠环化合物及其制备方法和应用
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer
WO2026090116A2 (en) 2024-10-21 2026-04-30 Revolution Medicines, Inc. Ras inhibitors
US20260108528A1 (en) 2024-10-22 2026-04-23 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2026090245A1 (en) 2024-10-22 2026-04-30 Revolution Medicines, Inc. Use of ras inhibitors for treating cancer
WO2026106912A1 (en) 2024-11-12 2026-05-21 Revolution Medicines, Inc. Ras inhibitors
WO2026112260A1 (en) 2024-11-21 2026-05-28 Revolution Medicines, Inc. Ras inhibitors
WO2026122764A2 (en) 2024-12-06 2026-06-11 Revolution Medicines, Inc. Ras inhibitors
WO2026128688A2 (en) 2024-12-13 2026-06-18 Revolution Medicines, Inc. Ras inhibitors
WO2026161839A1 (en) 2025-01-27 2026-07-30 Revolution Medicines, Inc. Ras inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009515988A (ja) 2005-11-15 2009-04-16 アレイ バイオファーマ、インコーポレイテッド 過剰増殖性疾患の処置のためのErbBI型受容体チロシンキナーゼ阻害剤としてのN4−フェニルキナゾリン−4−アミン誘導体および関連化合物
JP2019507170A (ja) 2016-03-01 2019-03-14 シャンハイ ファーマシューティカルズ ホールディング カンパニー,リミティド 含窒素ヘテロ環化合物、製造方法、中間体、組成物及び応用
JP2020531553A (ja) 2017-09-01 2020-11-05 シャンハイ ファーマシューティカルズ ホールディング カンパニー,リミティド 窒素含有複素環化合物、製造方法、中間体、組成物および使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19608588A1 (de) 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
IL161908A0 (en) * 2001-12-12 2005-11-20 Pfizer Prod Inc Quinazoline derivatives for the treatment of abnormal cell growth
WO2005044302A1 (en) * 2003-11-06 2005-05-19 Pfizer Products Inc. Selective erbb2 inhibitor/anti-erbb antibody combinations in the treatment of cancer
US20170166598A1 (en) 2014-05-13 2017-06-15 Ariad Pharmaceuticals, Inc. Heteroaryl compounds for kinase inhibition
CA2949793C (en) 2014-06-19 2024-02-27 Ariad Pharmaceuticals, Inc. Heteroaryl compounds for kinase inhibition
US20210323976A1 (en) 2015-05-13 2021-10-21 Ariad Pharmaceuticals, Inc. Heteroaryl compounds for kinase inhibition
AU2018325442B2 (en) 2017-08-31 2023-04-13 Dana-Farber Cancer Institute, Inc. Inhibitors of EGFR and/or HER2 and methods of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009515988A (ja) 2005-11-15 2009-04-16 アレイ バイオファーマ、インコーポレイテッド 過剰増殖性疾患の処置のためのErbBI型受容体チロシンキナーゼ阻害剤としてのN4−フェニルキナゾリン−4−アミン誘導体および関連化合物
JP2019507170A (ja) 2016-03-01 2019-03-14 シャンハイ ファーマシューティカルズ ホールディング カンパニー,リミティド 含窒素ヘテロ環化合物、製造方法、中間体、組成物及び応用
JP2020531553A (ja) 2017-09-01 2020-11-05 シャンハイ ファーマシューティカルズ ホールディング カンパニー,リミティド 窒素含有複素環化合物、製造方法、中間体、組成物および使用

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US20230131720A1 (en) 2023-04-27
EP4100412A1 (en) 2022-12-14
WO2021156180A1 (en) 2021-08-12
JP2023512175A (ja) 2023-03-24
CN115052881A (zh) 2022-09-13
CN115052881B (zh) 2024-07-09

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