JP7557465B2 - Ｉｌ－１５組成物およびその使用方法 - Google Patents
Ｉｌ－１５組成物およびその使用方法 Download PDFInfo
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- JP7557465B2 JP7557465B2 JP2021534270A JP2021534270A JP7557465B2 JP 7557465 B2 JP7557465 B2 JP 7557465B2 JP 2021534270 A JP2021534270 A JP 2021534270A JP 2021534270 A JP2021534270 A JP 2021534270A JP 7557465 B2 JP7557465 B2 JP 7557465B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| MX2021003543A (es) | 2018-09-27 | 2021-06-23 | Xilio Dev Inc | Polipeptidos de citocinas enmascaradas. |
| JP2023506454A (ja) * | 2019-12-13 | 2023-02-16 | キュージーン インコーポレイテッド | サイトカインをベースとした生理活性化薬剤およびその使用法 |
| CA3174786A1 (en) | 2020-04-10 | 2021-10-14 | Sayantan Mitra | Activatable cytokine constructs and related compositions and methods |
| US20230250193A1 (en) * | 2020-06-17 | 2023-08-10 | Proviva Therapeutics (Hong Kong) Limited | Antibodies to fibroblast activation protein and b7h3 |
| JP2023553323A (ja) | 2020-11-25 | 2023-12-21 | エクシリオ デベロップメント， インコーポレイテッド | 腫瘍特異的に切断可能なリンカー |
| CA3211924A1 (en) | 2021-03-16 | 2022-09-22 | Sayantan Mitra | Masked activatable cytokine constructs and related compositions and methods |
| US20240228585A1 (en) * | 2021-05-03 | 2024-07-11 | President And Fellows Of Harvard College | Fc-fusion protein therapeutic for the treatment of pancreatitis |
| EP4580683A2 (en) * | 2022-08-31 | 2025-07-09 | Proviva Therapeutics (Hong Kong) Limited | Il-15 procytokine antibody fusion proteins |
| AU2023338694A1 (en) * | 2022-09-08 | 2025-04-03 | Cugene Inc. | Novel pd1-targeted il-15 immunocytokine and vitokine fusions |
| WO2024216170A2 (en) * | 2023-04-12 | 2024-10-17 | Cytomx Therapeutics, Inc. | Activatable cytokine constructs and related compositions and methods |
| WO2025085744A1 (en) * | 2023-10-18 | 2025-04-24 | Memorial Sloan-Kettering Cancer Center | Fusion polypeptides and uses thereof |
| WO2025180355A1 (zh) * | 2024-02-27 | 2025-09-04 | 江苏奥赛康生物医药有限公司 | Il-15前药与免疫检查点抑制剂的组合 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2012514982A (ja) | 2009-01-12 | 2012-07-05 | サイトムエックス セラピューティクス，エルエルシー | 改変した抗体組成物、それを作製および使用する方法 |
| JP2015509952A (ja) | 2012-02-28 | 2015-04-02 | ザ ユニバーシティ オブ バーミンガム | 免疫療法分子および使用 |
| JP2018518972A (ja) | 2015-06-26 | 2018-07-19 | ユニバーシティ オブ サザン カリフォルニア | 腫瘍特異的活性化のためのマスキングキメラ抗原受容体ｔ細胞 |
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| DK1527100T3 (da) * | 2002-03-29 | 2009-09-07 | Schering Corp | Humane monoklonale antistoffer mod interleukin-5 og fremgangsm der og sammens tninger omfattende samme |
| US20110178279A1 (en) * | 2009-08-03 | 2011-07-21 | Williams John C | Development of masked therapeutic antibodies to limit off-target effects: application to anti-egfr antibodies |
| RU2011138951A (ru) * | 2009-02-23 | 2013-03-27 | Сайтомкс Терапьютикс, Инк. | Пропротеины и способы их применения |
| WO2016004383A1 (en) * | 2014-07-03 | 2016-01-07 | City Of Hope | Tumor-selective ctla-4 antagonists |
| CA3024509A1 (en) * | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Mrna combination therapy for the treatment of cancer |
| SG11201903302UA (en) * | 2016-10-14 | 2019-05-30 | Xencor Inc | Bispecific heterodimeric fusion proteins containing il-15/il-15ralpha fc-fusion proteins and pd-1 antibody fragments |
| SG11201906213UA (en) * | 2017-01-10 | 2019-08-27 | Intrexon Corp | Modulating expression of polypeptides via new gene switch expression systems |
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2019
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- 2019-12-13 CA CA3121813A patent/CA3121813A1/en active Pending
- 2019-12-13 AU AU2019395266A patent/AU2019395266A1/en not_active Abandoned
- 2019-12-13 WO PCT/US2019/066287 patent/WO2020123980A1/en not_active Ceased
- 2019-12-13 CN CN201980082406.XA patent/CN114746105A/zh active Pending
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012514982A (ja) | 2009-01-12 | 2012-07-05 | サイトムエックス セラピューティクス，エルエルシー | 改変した抗体組成物、それを作製および使用する方法 |
| JP2015509952A (ja) | 2012-02-28 | 2015-04-02 | ザ ユニバーシティ オブ バーミンガム | 免疫療法分子および使用 |
| JP2018518972A (ja) | 2015-06-26 | 2018-07-19 | ユニバーシティ オブ サザン カリフォルニア | 腫瘍特異的活性化のためのマスキングキメラ抗原受容体ｔ細胞 |
Non-Patent Citations (2)
| Title |
|---|
| Mol. Cancer Ther，Vol.8, No.9，2009年，pp.2736-2745 |
| Scientific Reports，2018年，Vol.8, No.7675， pp.1-11 |
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| Publication number | Publication date |
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| CA3121813A1 (en) | 2020-06-18 |
| JP2022513888A (ja) | 2022-02-09 |
| JP2024175026A (ja) | 2024-12-17 |
| KR20210104060A (ko) | 2021-08-24 |
| CN114746105A (zh) | 2022-07-12 |
| AU2019395266A1 (en) | 2021-06-17 |
| WO2020123980A1 (en) | 2020-06-18 |
| US20230045048A1 (en) | 2023-02-09 |
| EP3893917A4 (en) | 2023-01-11 |
| EP3893917A1 (en) | 2021-10-20 |
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