JP7542439B2 - 二量体抗原受容体（ｄａｒ） - Google Patents

二量体抗原受容体（ｄａｒ） Download PDF

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JP7542439B2
JP7542439B2 JP2020546854A JP2020546854A JP7542439B2 JP 7542439 B2 JP7542439 B2 JP 7542439B2 JP 2020546854 A JP2020546854 A JP 2020546854A JP 2020546854 A JP2020546854 A JP 2020546854A JP 7542439 B2 JP7542439 B2 JP 7542439B2
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sequence
heavy chain
amino acid
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JP2021515558A5 (enExample
JP2021515558A (ja
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ヘンリー ホンジュン ジ，
ウェンジョン グオ，
ヤンリャン ジャン，
ガナー エフ． カウフマン，
ベイ ベイ ディン，
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Sorrento Therapeutics Inc
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Sorrento Therapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4222—CD38 not IgG
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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JP2020546854A 2018-03-09 2019-03-11 二量体抗原受容体（ｄａｒ） Active JP7542439B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023172758A JP2023168545A (ja) 2018-03-09 2023-10-04 二量体抗原受容体（ｄａｒ）

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862640775P 2018-03-09 2018-03-09
US62/640,775 2018-03-09
PCT/US2019/021681 WO2019173837A1 (en) 2018-03-09 2019-03-11 Dimeric antigen receptors (dar)

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JP2023172758A Division JP2023168545A (ja) 2018-03-09 2023-10-04 二量体抗原受容体（ｄａｒ）

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JP2021515558A JP2021515558A (ja) 2021-06-24
JP2021515558A5 JP2021515558A5 (enExample) 2022-03-04
JP7542439B2 true JP7542439B2 (ja) 2024-08-30

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JP2020546854A Active JP7542439B2 (ja) 2018-03-09 2019-03-11 二量体抗原受容体（ｄａｒ）
JP2023172758A Pending JP2023168545A (ja) 2018-03-09 2023-10-04 二量体抗原受容体（ｄａｒ）

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US (1) US12180294B2 (enExample)
EP (1) EP3762430A4 (enExample)
JP (2) JP7542439B2 (enExample)
KR (1) KR20200130395A (enExample)
CN (1) CN112105649B (enExample)
AU (1) AU2019231315A1 (enExample)
CA (1) CA3092993A1 (enExample)
IL (1) IL277181A (enExample)
SG (1) SG11202008568WA (enExample)
WO (1) WO2019173837A1 (enExample)

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JP7637510B2 (ja) * 2018-06-20 2025-02-28 ビバソル， インコーポレイテッド Ｃｄ３８に結合するバリアント抗体
EP3938510A1 (en) 2019-03-11 2022-01-19 Sorrento Therapeutics, Inc. Improved process for integration of dna constructs using rna-guided endonucleases
CN114650829A (zh) * 2019-09-05 2022-06-21 索伦托药业有限公司 结合bcma的二聚体抗原受体(dar)
JP2023516595A (ja) * 2020-02-27 2023-04-20 ソレント・セラピューティクス・インコーポレイテッド Ｃｄ２０を結合する二量体抗原受容体（ｄａｒ）
EP4139345A1 (en) 2020-04-24 2023-03-01 Sorrento Therapeutics, Inc. Memory dimeric antigen receptors
WO2022015956A1 (en) 2020-07-15 2022-01-20 Sorrento Therapeutics, Inc. Improved process for dna integration using rna-guided endonucleases
KR102598598B1 (ko) 2020-10-08 2023-11-07 엘티소재주식회사 헤테로고리 화합물, 이를 포함하는 유기 발광 소자, 이의 제조 방법 및 유기 발광 소자의 유기물층용 조성물
CN116601174A (zh) * 2020-10-12 2023-08-15 索伦托药业有限公司 Cd19定向的嵌合抗原受体构建体
IL305175A (en) * 2021-02-19 2023-10-01 Angeles Therapeutics Inc Single-chain and multi-chain synthetic antigen receptors for diverse immune cells
CN112662631B (zh) * 2021-03-16 2021-06-29 合源生物科技(天津)有限公司 一种car-t细胞灌流培养方法
US20240197881A1 (en) * 2021-04-23 2024-06-20 Sorrento Therapeutics, Inc. Dimeric Antigen Receptors (DARs) that Bind GD2
EP4453018A1 (en) * 2021-12-24 2024-10-30 ETH Zurich Multichain antigen-specific receptors for cell-based immunotherapy

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JP2021515558A (ja) 2021-06-24
EP3762430A1 (en) 2021-01-13
EP3762430A4 (en) 2022-03-16
AU2019231315A1 (en) 2020-09-17
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US12180294B2 (en) 2024-12-31
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KR20200130395A (ko) 2020-11-18
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