JP7541585B2 - 発現データのデコンボリューションのためのシステム及び方法 - Google Patents

発現データのデコンボリューションのためのシステム及び方法 Download PDF

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JP7541585B2
JP7541585B2 JP2022554893A JP2022554893A JP7541585B2 JP 7541585 B2 JP7541585 B2 JP 7541585B2 JP 2022554893 A JP2022554893 A JP 2022554893A JP 2022554893 A JP2022554893 A JP 2022554893A JP 7541585 B2 JP7541585 B2 JP 7541585B2
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expression data
rna
cell
genes
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JPWO2021183917A5 (de
JP2023518185A (ja
JP2023518185A5 (de
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アレクサンドル・ザイツェフ
マクシム・チェルシュキン
エカテリーナ・ヌズディナ
ヴラジミール・ジリン
ダニア・ダイカノフ
アレクサンダー・バガエフ
ラフシャン・アタウラカノフ
イリヤ・チェレムシュキン
ボリス・シパク
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BostonGene Corp
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/18—Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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JP2022554893A 2020-03-12 2021-03-12 発現データのデコンボリューションのためのシステム及び方法 Active JP7541585B2 (ja)

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JP2024135878A JP7818662B2 (ja) 2020-03-12 2024-08-16 発現データのデコンボリューションのためのシステム及び方法

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US202062988700P 2020-03-12 2020-03-12
US62/988,700 2020-03-12
US202063108262P 2020-10-30 2020-10-30
US63/108,262 2020-10-30
PCT/US2021/022155 WO2021183917A1 (en) 2020-03-12 2021-03-12 Systems and methods for deconvolution of expression data

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JP2023518185A JP2023518185A (ja) 2023-04-28
JPWO2021183917A5 JPWO2021183917A5 (de) 2024-02-27
JP2023518185A5 JP2023518185A5 (de) 2024-02-27
JP7541585B2 true JP7541585B2 (ja) 2024-08-28

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US (3) US11315658B2 (de)
EP (2) EP4383262A3 (de)
JP (2) JP7541585B2 (de)
AU (1) AU2021233926B2 (de)
CA (1) CA3175126A1 (de)
IL (1) IL296316A (de)
WO (1) WO2021183917A1 (de)

Families Citing this family (10)

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WO2021183917A1 (en) 2020-03-12 2021-09-16 Bostongene Corporation Systems and methods for deconvolution of expression data
WO2022232615A1 (en) 2021-04-29 2022-11-03 Bostongene Corporation Machine learning techniques for estimating tumor cell expression complex tumor tissue
US20220375543A1 (en) 2021-05-18 2022-11-24 Bostongene Corporation Techniques for single sample expression projection to an expression cohort sequenced with another protocol
CN114038505B (zh) * 2021-10-19 2024-06-14 清华大学 一种在线整合多来源单细胞数据的方法和系统
AU2022376433A1 (en) 2021-10-29 2024-05-09 Bostongene Corporation Tumor microenvironment types in breast cancer
WO2024108156A2 (en) 2022-11-17 2024-05-23 Bostongene Corporation Comprehensive immunoprofiling of peripheral blood
US20240295486A1 (en) 2023-03-01 2024-09-05 Bostongene Corporation Systems and methods for analyzing cytometry data
WO2024216069A1 (en) 2023-04-13 2024-10-17 Bostongene Corporation Pan-cancer tumor microenvironment classification based on immune escape mechanisms and immune infiltration
CN116779043A (zh) * 2023-06-30 2023-09-19 京东方科技集团股份有限公司 细胞比例预测方法、模型生成方法、设备及介质
WO2025096811A1 (en) 2023-10-31 2025-05-08 Bostongene Corporation Machine learning technique for identifying ici responders and non-responders

Citations (5)

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Publication number Priority date Publication date Assignee Title
JP2018512071A (ja) 2015-01-22 2018-05-10 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 異なる細胞サブセットの比率の決定方法およびシステム
US20190018926A1 (en) 2017-07-14 2019-01-17 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
WO2019018684A1 (en) 2017-07-21 2019-01-24 The Board Of Trustees Of The Leland Stanford Junior University SYSTEMS AND METHODS FOR ANALYZING MIXED CELL POPULATIONS
WO2020004575A1 (ja) 2018-06-29 2020-01-02 株式会社Ｐｒｅｆｅｒｒｅｄ Ｎｅｔｗｏｒｋｓ 学習方法、混合率予測方法及び学習装置
US20200075169A1 (en) 2018-08-06 2020-03-05 Tempus Labs, Inc. Multi-modal approach to predicting immune infiltration based on integrated rna expression and imaging features

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7685436B2 (ja) 2018-12-31 2025-05-29 テンプス エーアイ，インコーポレイティド 転移性組織サンプルのトランスクリプトームデコンボリューション
WO2021183917A1 (en) * 2020-03-12 2021-09-16 Bostongene Corporation Systems and methods for deconvolution of expression data

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018512071A (ja) 2015-01-22 2018-05-10 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 異なる細胞サブセットの比率の決定方法およびシステム
US20190018926A1 (en) 2017-07-14 2019-01-17 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
WO2019018684A1 (en) 2017-07-21 2019-01-24 The Board Of Trustees Of The Leland Stanford Junior University SYSTEMS AND METHODS FOR ANALYZING MIXED CELL POPULATIONS
WO2020004575A1 (ja) 2018-06-29 2020-01-02 株式会社Ｐｒｅｆｅｒｒｅｄ Ｎｅｔｗｏｒｋｓ 学習方法、混合率予測方法及び学習装置
US20200075169A1 (en) 2018-08-06 2020-03-05 Tempus Labs, Inc. Multi-modal approach to predicting immune infiltration based on integrated rna expression and imaging features

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US11587642B2 (en) 2023-02-21
CA3175126A1 (en) 2021-09-16
JP2024174879A (ja) 2024-12-17
IL296316A (en) 2022-11-01
EP4383262A2 (de) 2024-06-12
JP2023518185A (ja) 2023-04-28
EP4383262A3 (de) 2024-08-14
US20220230707A1 (en) 2022-07-21
WO2021183917A8 (en) 2021-12-16
AU2021233926B2 (en) 2025-12-18
AU2021233926A1 (en) 2022-09-29
EP4118657A1 (de) 2023-01-18
US20210287759A1 (en) 2021-09-16
EP4118657B1 (de) 2024-05-01
WO2021183917A9 (en) 2021-11-04
US11315658B2 (en) 2022-04-26
JP7818662B2 (ja) 2026-02-20
US20230178178A1 (en) 2023-06-08
WO2021183917A1 (en) 2021-09-16

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