JP7525162B2 - 磁性リポソームおよび関連する治療ならびにイメージング方法 - Google Patents

磁性リポソームおよび関連する治療ならびにイメージング方法 Download PDF

Info

Publication number
JP7525162B2
JP7525162B2 JP2020562639A JP2020562639A JP7525162B2 JP 7525162 B2 JP7525162 B2 JP 7525162B2 JP 2020562639 A JP2020562639 A JP 2020562639A JP 2020562639 A JP2020562639 A JP 2020562639A JP 7525162 B2 JP7525162 B2 JP 7525162B2
Authority
JP
Japan
Prior art keywords
rna
liposomes
cells
liposome
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020562639A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021523145A5 (https=
JPWO2019217593A5 (https=
JP2021523145A (ja
Inventor
グリピン、アダム、ジェイ.
ミッチェル、デュアン
ドブソン、ジョン、ピー.
セイヤー、イライアス
モンサルヴェ、アダム
Original Assignee
ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド filed Critical ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド
Publication of JP2021523145A publication Critical patent/JP2021523145A/ja
Publication of JP2021523145A5 publication Critical patent/JP2021523145A5/ja
Publication of JPWO2019217593A5 publication Critical patent/JPWO2019217593A5/ja
Priority to JP2024110694A priority Critical patent/JP2024160224A/ja
Application granted granted Critical
Publication of JP7525162B2 publication Critical patent/JP7525162B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5115Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806Suspensions, emulsions, colloids, dispersions
    • A61K49/1812Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Ceramic Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2020562639A 2018-05-08 2019-05-08 磁性リポソームおよび関連する治療ならびにイメージング方法 Active JP7525162B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024110694A JP2024160224A (ja) 2018-05-08 2024-07-10 磁性リポソームおよび関連する治療ならびにイメージング方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862668608P 2018-05-08 2018-05-08
US62/668,608 2018-05-08
PCT/US2019/031385 WO2019217593A1 (en) 2018-05-08 2019-05-08 Magnetic liposomes and related treatment and imaging methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024110694A Division JP2024160224A (ja) 2018-05-08 2024-07-10 磁性リポソームおよび関連する治療ならびにイメージング方法

Publications (4)

Publication Number Publication Date
JP2021523145A JP2021523145A (ja) 2021-09-02
JP2021523145A5 JP2021523145A5 (https=) 2022-04-08
JPWO2019217593A5 JPWO2019217593A5 (https=) 2022-04-08
JP7525162B2 true JP7525162B2 (ja) 2024-07-30

Family

ID=66677229

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020562639A Active JP7525162B2 (ja) 2018-05-08 2019-05-08 磁性リポソームおよび関連する治療ならびにイメージング方法
JP2024110694A Pending JP2024160224A (ja) 2018-05-08 2024-07-10 磁性リポソームおよび関連する治療ならびにイメージング方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024110694A Pending JP2024160224A (ja) 2018-05-08 2024-07-10 磁性リポソームおよび関連する治療ならびにイメージング方法

Country Status (6)

Country Link
US (1) US20210077399A1 (https=)
EP (1) EP3790533A1 (https=)
JP (2) JP7525162B2 (https=)
AU (1) AU2019265707B2 (https=)
CA (1) CA3099519A1 (https=)
WO (1) WO2019217593A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020037102A1 (en) 2018-08-15 2020-02-20 University Of Florida Research Foundation, Inc. Methods of sensitizing tumors to treatment with immune checkpoint inhibitors
EP3962521A1 (en) 2019-05-02 2022-03-09 University of Florida Research Foundation, Inc. Compositions for treatment of diffuse intrinsic pontine glioma
EP3999034A4 (en) * 2019-07-19 2023-08-23 University Of Florida Research Foundation, Incorporated Multilamellar rna nanoparticles
EP4099988A4 (en) * 2020-02-05 2024-03-13 University of Florida Research Foundation, Incorporated Rna-loaded nanoparticles and use thereof for the treatment of cancer
WO2022036231A1 (en) * 2020-08-14 2022-02-17 University Of Florida Research Foundation Biocompatible nanocomposite hydrogel immunotherapy vaccines and methods of use thereof
CN114848840B (zh) * 2022-03-24 2023-08-29 北京福纳康生物技术有限公司 修饰的铁基纳米材料、铁基纳米脂质体及其抗肿瘤的应用
CN119470536B (zh) * 2024-11-03 2025-09-30 中国科学院精密测量科学与技术创新研究院 利用多核磁共振预测氟化脂质纳米颗粒转染效率的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000516630A (ja) 1996-08-19 2000-12-12 アメリカ合衆国 全身への送達を増加させる新規のリポソーム複合体
JP2009512712A (ja) 2005-10-20 2009-03-26 ジョージタウン・ユニバーシティ 癌の早期mri検出を改善するための腫瘍標的化ナノ送達系
WO2011112597A1 (en) 2010-03-08 2011-09-15 Northeastern University Magnetic nanoplatforms for theranostic and multi-modal imaging applications
US20150182627A1 (en) 2013-12-31 2015-07-02 Samsung Electronics Co., Ltd. Liposome including active ingredient and imaging agent and use thereof
US20170367982A1 (en) 2016-06-24 2017-12-28 Northwestern University High density lipoprotein functionalized magnetic nanostructures

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA195563A (en) 1919-08-08 1919-12-30 Aaron Terry Heating system
US7001614B2 (en) * 1996-08-19 2006-02-21 The United States Of America As Represented By The Department Of Health And Human Services Liposome complexes for increased systemic delivery
NZ592917A (en) * 2003-09-15 2012-12-21 Protiva Biotherapeutics Inc Stable polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000516630A (ja) 1996-08-19 2000-12-12 アメリカ合衆国 全身への送達を増加させる新規のリポソーム複合体
JP2009512712A (ja) 2005-10-20 2009-03-26 ジョージタウン・ユニバーシティ 癌の早期mri検出を改善するための腫瘍標的化ナノ送達系
WO2011112597A1 (en) 2010-03-08 2011-09-15 Northeastern University Magnetic nanoplatforms for theranostic and multi-modal imaging applications
US20150182627A1 (en) 2013-12-31 2015-07-02 Samsung Electronics Co., Ltd. Liposome including active ingredient and imaging agent and use thereof
US20170367982A1 (en) 2016-06-24 2017-12-28 Northwestern University High density lipoprotein functionalized magnetic nanostructures

Also Published As

Publication number Publication date
CA3099519A1 (en) 2019-11-14
JP2024160224A (ja) 2024-11-13
EP3790533A1 (en) 2021-03-17
WO2019217593A1 (en) 2019-11-14
US20210077399A1 (en) 2021-03-18
AU2019265707B2 (en) 2025-03-27
JP2021523145A (ja) 2021-09-02
AU2019265707A1 (en) 2020-11-26

Similar Documents

Publication Publication Date Title
JP7525162B2 (ja) 磁性リポソームおよび関連する治療ならびにイメージング方法
Munakata et al. Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice
US12514930B2 (en) Methods of sensitizing tumors to treatment with immune checkpoint inhibitors
JP2014196344A (ja) 標的遺伝子の発現を抑制する組成物
US20230096704A1 (en) Rna-loaded nanoparticles and use thereof for the treatment of cancer
JP7783628B2 (ja) 多層rnaナノ粒子
CA3174187A1 (en) Multilamellar rna nanoparticle vaccine against sars-cov-2
US20230346700A1 (en) Multilamellar RNA Nanoparticles and Methods of Sensitizing Tumors to Treatment with Immune Checkpoint Inhibitors
US20230226218A1 (en) Red Cell Extracellular Vesicles (RCEVs) Containing Cargoes and Methods of Use and Production Thereof
US20240238418A1 (en) Car t cell therapy method
US20250231177A1 (en) Method of characterizing tumors
CA3166934A1 (en) Rna-loaded nanoparticles and use thereof for the treatment of cancer
WO2025207807A1 (en) Ctc rna-loaded nanoparticles and use thereof for the treatment of cancer
Grippin Engineering Nanoparticles for Treatment of Glioblastoma
Choi Engineering Lipid Nanoparticles with Tunable Kinetics for Cancer Immunotherapy

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20201224

RD01 Notification of change of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7426

Effective date: 20201224

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220331

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220331

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230411

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230711

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230912

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231211

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240206

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240430

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240611

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240710

R150 Certificate of patent or registration of utility model

Ref document number: 7525162

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150