JP7511242B2 - 自己免疫関連疾患を治療するための治療用ペプチドおよび方法 - Google Patents

自己免疫関連疾患を治療するための治療用ペプチドおよび方法 Download PDF

Info

Publication number
JP7511242B2
JP7511242B2 JP2020557124A JP2020557124A JP7511242B2 JP 7511242 B2 JP7511242 B2 JP 7511242B2 JP 2020557124 A JP2020557124 A JP 2020557124A JP 2020557124 A JP2020557124 A JP 2020557124A JP 7511242 B2 JP7511242 B2 JP 7511242B2
Authority
JP
Japan
Prior art keywords
peptide
seq
cells
protein
diabetes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020557124A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021510174A (ja
JP2021510174A5 (https=
Inventor
ハル ワグナー,ジュニア,デイビッド
グレン ユスマン,マーティン
ダブリュー ヘンリー,チャールズ
Original Assignee
オーピー-ティー エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/184,129 external-priority patent/US20190194290A1/en
Application filed by オーピー-ティー エルエルシー filed Critical オーピー-ティー エルエルシー
Publication of JP2021510174A publication Critical patent/JP2021510174A/ja
Publication of JP2021510174A5 publication Critical patent/JP2021510174A5/ja
Priority to JP2024097199A priority Critical patent/JP2024123100A/ja
Application granted granted Critical
Publication of JP7511242B2 publication Critical patent/JP7511242B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/03Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30 CD40 or CD95
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders
    • G01N2800/042Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/323Arteriosclerosis, Stenosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
JP2020557124A 2018-01-05 2019-01-04 自己免疫関連疾患を治療するための治療用ペプチドおよび方法 Active JP7511242B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024097199A JP2024123100A (ja) 2018-01-05 2024-06-17 自己免疫関連疾患を治療するための治療用ペプチドおよび方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862614262P 2018-01-05 2018-01-05
US62/614,262 2018-01-05
US16/184,129 2018-11-08
US16/184,129 US20190194290A1 (en) 2010-10-19 2018-11-08 Methods for preventing, modulating and/or reducing cardiovascular disease
PCT/US2019/012425 WO2019136307A1 (en) 2018-01-05 2019-01-04 Therapeutic peptides and methods for treating autoimmune related disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024097199A Division JP2024123100A (ja) 2018-01-05 2024-06-17 自己免疫関連疾患を治療するための治療用ペプチドおよび方法

Publications (3)

Publication Number Publication Date
JP2021510174A JP2021510174A (ja) 2021-04-15
JP2021510174A5 JP2021510174A5 (https=) 2023-06-19
JP7511242B2 true JP7511242B2 (ja) 2024-07-05

Family

ID=67144298

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020557124A Active JP7511242B2 (ja) 2018-01-05 2019-01-04 自己免疫関連疾患を治療するための治療用ペプチドおよび方法
JP2024097199A Pending JP2024123100A (ja) 2018-01-05 2024-06-17 自己免疫関連疾患を治療するための治療用ペプチドおよび方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024097199A Pending JP2024123100A (ja) 2018-01-05 2024-06-17 自己免疫関連疾患を治療するための治療用ペプチドおよび方法

Country Status (9)

Country Link
EP (1) EP3735260B1 (https=)
JP (2) JP7511242B2 (https=)
CN (2) CN119157997A (https=)
AU (1) AU2019205328B2 (https=)
BR (1) BR112020013716A2 (https=)
CA (1) CA3086193A1 (https=)
MX (1) MX2020007081A (https=)
SG (1) SG11202006494VA (https=)
WO (1) WO2019136307A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190263888A1 (en) 2010-10-19 2019-08-29 Op-T Llc Therapeutic peptides and methods for treating autoimmune related disease
ES2957957T3 (es) 2010-10-19 2024-01-30 Op T Llc Péptidos para modular la actividad de linfocitos T y usos de los mismos
US11793854B2 (en) 2019-03-21 2023-10-24 Op-T Llc Methods for reducing symptoms of multiple sclerosis using a six-amino acid long peptide that inhibits CD40-CD150 interaction
JP2022540731A (ja) * 2019-07-12 2022-09-16 オーピー-ティー エルエルシー ペプチドおよび疾患の治療方法
EP4135742A2 (en) * 2020-04-17 2023-02-22 Op-T Llc Bioactive peptides and methods of use thereof
WO2021231898A2 (en) * 2020-05-14 2021-11-18 Op-T Llc Nanoparticle compositions and uses thereof
WO2022036495A1 (en) * 2020-08-17 2022-02-24 Utc Therapeutics Inc. Lymphocytes-antigen presenting cells co-stimulators and uses thereof
CN115807071B (zh) * 2022-09-02 2025-09-26 宁夏医科大学 检测试剂在制备2型糖尿病伴动脉粥样硬化诊断工具中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170355747A1 (en) 2010-10-19 2017-12-14 The Regents Of The University Of Colorado, A Body Corporate Peptides for modulating t-cell activity and uses therof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7495090B2 (en) * 2002-05-23 2009-02-24 The Regents Of The University Of California Nucleic acids encoding chimeric CD154 polypeptides
WO2005006949A2 (en) * 2003-07-07 2005-01-27 Wagner David H Methods for predicting development of auto-immune diseases and treatment of same
US7449200B2 (en) * 2006-04-17 2008-11-11 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means
JP6285923B2 (ja) * 2012-06-22 2018-02-28 トラスティーズ・オブ・ダートマス・カレッジ 新規VISTA−Igコンストラクト及び自己免疫、アレルギー性及び炎症性障害の処置のためのVISTA−Igの使用
EP3123176A4 (en) * 2014-03-23 2018-04-25 The Regents of the University of Colorado Diagnosis of multiple sclerosis in human and animal subjects

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170355747A1 (en) 2010-10-19 2017-12-14 The Regents Of The University Of Colorado, A Body Corporate Peptides for modulating t-cell activity and uses therof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Diabetes & Vascular Disease Research,2012年,Vol.10, No.2,pp.115-122
Diabetologia,2012年,Vol.55, Suppl.1,p.S71,Abstract No.157
Nature, 1998, Vol.394, No.6689, pp.200-203,http://dx.doi.org/10.1038/28204
日本臨床免疫学会会誌,2004年,Vol.27, No.6,pp.379-388

Also Published As

Publication number Publication date
MX2020007081A (es) 2020-10-28
CN119157997A (zh) 2024-12-20
CN111801110B (zh) 2024-10-18
EP3735260B1 (en) 2026-03-04
WO2019136307A1 (en) 2019-07-11
AU2019205328B2 (en) 2025-04-03
EP3735260A1 (en) 2020-11-11
JP2021510174A (ja) 2021-04-15
SG11202006494VA (en) 2020-08-28
CN111801110A (zh) 2020-10-20
CA3086193A1 (en) 2019-07-11
BR112020013716A2 (pt) 2020-12-22
EP3735260A4 (en) 2021-12-08
JP2024123100A (ja) 2024-09-10
AU2019205328A1 (en) 2020-08-06

Similar Documents

Publication Publication Date Title
JP7511242B2 (ja) 自己免疫関連疾患を治療するための治療用ペプチドおよび方法
EP2629797B1 (en) Peptides for modulating t-cell activity and uses thereof
US12428465B2 (en) Therapeutic peptides and methods for treating type 2 diabetes
US12226450B2 (en) Peptides and methods for treating disease
US12472223B2 (en) Methods for reducing symptoms of multiple sclerosis using a six-amino acid long peptide that inhibits CD40-CD154 interaction
US20200072837A1 (en) Methods for preventing, modulating and/or reducing cardiovascular disease
US20190194290A1 (en) Methods for preventing, modulating and/or reducing cardiovascular disease
EP3706799B1 (en) Peptide for preventing, modulating and/or reducing cardiovascular disease
HK40095385A (en) Peptides for modulating t-cell activity and uses thereof

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20211228

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230110

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230405

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20230609

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230905

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20231204

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240131

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240423

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240521

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240618

R150 Certificate of patent or registration of utility model

Ref document number: 7511242

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150