JP7491516B2 - 殺微生物剤の使用 - Google Patents
殺微生物剤の使用 Download PDFInfo
- Publication number
- JP7491516B2 JP7491516B2 JP2022509662A JP2022509662A JP7491516B2 JP 7491516 B2 JP7491516 B2 JP 7491516B2 JP 2022509662 A JP2022509662 A JP 2022509662A JP 2022509662 A JP2022509662 A JP 2022509662A JP 7491516 B2 JP7491516 B2 JP 7491516B2
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- Prior art keywords
- benzoxazol
- benzene
- weight
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- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
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Description
(i)水性分散体の総重量を基準として25~60重量%、好ましくは25~50重量%の、本明細書において与えられる全ての定義及び優先度を有する微粉化された1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンと;
(ii)水性分散体の総重量を基準として5~15重量%、好ましくは7~12.5重量%のC8~16アルキルポリグルコシドと;
(iii)水性分散体の総重量を基準として0~3重量%、好ましくは0~2.5重量%の、増粘剤、湿潤剤及び/又は消泡剤の群から選択される少なくとも1種の添加剤と;
(iv)水性分散体の総重量を基準として全体が100重量%となる量の水と
から基本的になる。
の末端基を有する、ドデセニルコハク酸無水物、ジイソプロパノールアミン、ビスジメチルアミノプロピルアミンのモノマーの超分岐などを含まない。
[1.1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンの調製:]
ポリリン酸702g及びメタンスルホン酸4.28mlの混合物を90℃に加熱した。テレフタル酸65g及び2-アミノフェノール107gを加えた。この混合物を不活性雰囲気下において180℃で8時間撹拌した後、氷水に移した。析出物を濾過し、水及び酢酸で洗浄した。析出物を水中に分散させ、pHを水酸化ナトリウムで8.0に調整し、濾過して水で洗浄した。粗生成物をトルエン及び1-ブタノールの3.3:1混合物中に懸濁させ、85℃で1時間撹拌し、濾過してジエチルエーテルで洗浄し、乾燥させることにより、固体非晶質1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンの粗い粒子を得た(以下、DBOと称する)。
次いで、175gの粗い粒子、324gの水及び65gのGreen APG 0810の懸濁液を調製し、この懸濁液を、LabStar実験室用粉砕機でイットリウム安定化酸化ジルコニウム粉砕用ビーズ(0.3mm、東ソー・セラミックス株式会社(Tosoh Ceramic)、日本)を使用して2時間粉砕し、粉砕チャンバ内で冷却した(-12℃の飽和食塩水)。粉砕ビーズを除去することにより、微粉化された1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンの30%水性分散体(以下、DBO aq.と称する)を得、これを以下に概説する抗微生物試験及び処方に使用した。
抗微生物効果を、規制に従う保存効力試験方法(NF EN ISO11930)に類似した方法で評価した。したがって、以下に概説する各活性物質及びNaCl濃度0.85重量%の生理食塩水の混合物を無菌条件下で調製する。対照も同様に無菌条件下で調製した。次いで、対照及び混合物を96ディープウェルプレート(1.6ml/well)に排除した。以下に概説するように、ウェルを各細菌又は真菌株で、細菌の場合には2.5×105~5.6×105cfu/mlになるように、真菌の場合には1×104~2.5×104cfu/mlになるように汚染することにより初期汚染を行った。汚染後、各ウェルを十分に混合して、微生物を確実に均一に分布させた。次いで、各プレートを22℃で24時間インキュベートした。汚染から24時間後に(生残)菌数の測定を行う。次いで、平均対数減少値を求める[-log10{(接種菌数)/(サンプルの菌数)}]。これらを表1~5に示す。
Claims (25)
- 1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンを含む抗微生物剤。
- 抗真菌剤及び/又は抗細菌剤である、請求項1に記載の抗微生物剤。
- 前記抗真菌剤及び/又は抗細菌剤は、カンディダ・アルビカンス(Candida albicans)、大腸菌(Escherichia coli)、黄色ブドウ球菌(Staphylococcus aureus)、緑膿菌(Pseudomonas aeruginosa)及び/又はアスペルギルス・ブラジリエンシス(Aspergillus brasiliensis)並びにこれらの混合物の増殖を阻害する薬剤である、請求項2に記載の抗微生物剤。
- 化粧用組成物、家庭用品、プラスチック、紙及び/又は塗料の群から選択される製品のためのものである、請求項1~3のいずれか一項に記載の抗微生物剤。
- 防腐力を向上させるためのものである、請求項1~4のいずれか一項に記載の抗微生物剤。
- 非治療的使用のための、1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンを含む防臭剤。
- 前記1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンは、微粉化された形態である、請求項1~6のいずれか一項に記載の剤。
- ヒドロキシアセトフェノン、アルカンジオール及び安息香酸又はその塩の群から選択される少なくとも1種の化合物を更に含む、請求項1~7のいずれか一項に記載の剤。
- 前記少なくとも1種の化合物は、p-ヒドロキシアセトフェノン、安息香酸、安息香酸ナトリウム及び1,3-プロパンジオールの群から選択される、請求項8に記載の剤。
- 抗微生物剤としての1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンの使用。
- 前記抗微生物剤は、抗真菌剤及び/又は抗細菌剤である、請求項10に記載の使用。
- 前記抗真菌剤及び/又は抗細菌剤は、カンディダ・アルビカンス(Candida albicans)、大腸菌(Escherichia coli)、黄色ブドウ球菌(Staphylococcus aureus)、緑膿菌(Pseudomonas aeruginosa)及び/又はアスペルギルス・ブラジリエンシス(Aspergillus brasiliensis)並びにこれらの混合物の増殖を阻害する薬剤である、請求項11に記載の使用。
- 化粧用組成物、家庭用品、プラスチック、紙及び/又は塗料の群から選択される製品におけるものである、請求項10~12のいずれか一項に記載の使用。
- 防腐力を向上させるためのものである、請求項10~13のいずれか一項に記載の使用。
- 防臭活性化合物としての1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンの非治療的使用。
- 前記1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンは、微粉化された形態で使用される、請求項10~15のいずれか一項に記載の使用。
- 前記1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンは、ヒドロキシアセトフェノン、アルカンジオール及び安息香酸又はその塩の群から選択される少なくとも1種の化合物と組み合わせて使用される、請求項10~16のいずれか一項に記載の使用。
- 前記少なくとも1種の化合物は、p-ヒドロキシアセトフェノン、安息香酸、安息香酸ナトリウム及び1,3-プロパンジオールの群から選択される、請求項17に記載の使用。
- 化粧用及び/若しくは医薬用組成物、家庭用品、プラスチック、紙並びに/又は塗料の群から選択される製品の微生物による腐食及び分解を防止する方法であって、前記製品に、前記製品の総重量を基準として0.1~20重量%の範囲において選択される量で1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンを添加することを含む方法。
- 前記製品は、水と、界面活性剤、乳化剤、増粘剤及び油からなる群から選択される少なくとも1種の薬剤とを更に含む、請求項19に記載の方法。
- 前記製品は、O/Wエマルション、W/Oエマルション又はゲルの形態の化粧用組成物である、請求項19又は20に記載の方法。
- 微生物細胞を死滅させ、且つ/又はその増殖を阻害するための方法であって、前記微生物細胞を、1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンと接触させることを含む方法。
- 1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンが、ヒドロキシアセトフェノン、アルカンジオール、安息香酸又はその塩の群から選択される少なくとも1種の化合物と混合されている、請求項22に記載の方法。
- 前記少なくとも1種の化合物は、p-ヒドロキシアセトフェノン、安息香酸、安息香酸ナトリウム及び1,3-プロパンジオールの群から選択される、請求項23に記載の方法。
- 微生物は、カンディダ・アルビカンス(Candida albicans)、大腸菌(Escherichia coli)、黄色ブドウ球菌(Staphylococcus aureus)、緑膿菌(Pseudomonas aeruginosa)及び/又はアスペルギルス・ブラジリエンシス(Aspergillus brasiliensis)並びにこれらの混合物からなる群から選択される、請求項22~24のいずれか一項に記載の方法。
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