JP7488857B2 - 血液ポンプ - Google Patents
血液ポンプ Download PDFInfo
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- JP7488857B2 JP7488857B2 JP2022142061A JP2022142061A JP7488857B2 JP 7488857 B2 JP7488857 B2 JP 7488857B2 JP 2022142061 A JP2022142061 A JP 2022142061A JP 2022142061 A JP2022142061 A JP 2022142061A JP 7488857 B2 JP7488857 B2 JP 7488857B2
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- 239000008280 blood Substances 0.000 title claims description 158
- 210000004369 blood Anatomy 0.000 title claims description 158
- 238000011010 flushing procedure Methods 0.000 claims description 104
- 230000017531 blood circulation Effects 0.000 claims description 28
- 239000012530 fluid Substances 0.000 description 11
- 238000004891 communication Methods 0.000 description 8
- 238000001816 cooling Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 230000007704 transition Effects 0.000 description 6
- 230000023555 blood coagulation Effects 0.000 description 5
- 210000000709 aorta Anatomy 0.000 description 3
- 239000000919 ceramic Substances 0.000 description 3
- 230000002169 extracardiac Effects 0.000 description 3
- 239000004020 conductor Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 210000001765 aortic valve Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000012809 cooling fluid Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- -1 for example Substances 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000036316 preload Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001846 repelling effect Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
- A61M60/237—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly axial components, e.g. axial flow pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
- A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
- A61M60/232—Centrifugal pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/211—Non-positive displacement blood pumps using a jet, venturi or entrainment effect for pumping the blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
- A61M60/117—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body for assisting the heart, e.g. transcutaneous or external ventricular assist devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/135—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
- A61M60/221—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having both radial and axial components, e.g. mixed flow pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/403—Details relating to driving for non-positive displacement blood pumps
- A61M60/422—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/804—Impellers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/804—Impellers
- A61M60/806—Vanes or blades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/818—Bearings
- A61M60/825—Contact bearings, e.g. ball-and-cup or pivot bearings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/403—Details relating to driving for non-positive displacement blood pumps
- A61M60/408—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
- A61M60/411—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
- A61M60/414—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted by a rotating cable, e.g. for blood pumps mounted on a catheter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/818—Bearings
- A61M60/82—Magnetic bearings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/818—Bearings
- A61M60/824—Hydrodynamic or fluid film bearings
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Mechanical Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Structures Of Non-Positive Displacement Pumps (AREA)
- External Artificial Organs (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
Description
回転軸9を中心にして回転可能であるようにして、前記ポンプケーシング2内に配置されたインペラ3であって、通路7に沿って血流入口5から血流出口6まで血液を運搬するようにサイズおよび形状が決められた羽根4を備え、ポンプケーシング2の軸受表面に面するインペラ3の軸受表面を有する少なくとも1つの接触型軸受20によってポンプケーシング2内で回転可能に支持された、インペラ3とを備え、
少なくとも1つの洗い流しチャネル30が、インペラ3を通って延在すると共に、第1の開口部34を介して通路7と、また第2の開口部35を介して軸受20と流体接続しており、洗い流しチャネル30が、洗い流しチャネル30を通って軸受20に向かって血液を給送する補助ポンプと動作的に関連付けられ、
補助ポンプが、少なくとも1つの接線方向成分を有する方向に沿ってインペラ3を通って延在する、前記少なくとも1つの洗い流しチャネル30によって少なくとも部分的に形成される、血液ポンプ1。
Claims (13)
- 通路(7)によって接続された血流入口(5)および血流出口(6)を有するポンプケーシング(2)と、
回転軸(9)を中心にして回転可能であるようにして、前記ポンプケーシング(2)内に配置されたインペラ(3)であって、前記通路(7)に沿って前記血流入口(5)から前記血流出口(6)まで血液を運搬するようにサイズおよび形状が決められた羽根(4)を備え、前記ポンプケーシング(2)の軸受表面に面するインペラ(3)の軸受表面を備える少なくとも1つの接触型軸受(20)によって前記ポンプケーシング(2)内で回転可能に支持された、インペラ(3)とを備え、
少なくとも1つの洗い流しチャネル(43’)が、前記インペラ(3)を通って延在すると共に、第1の開口部(44’)を介して前記通路(7)と、また第2の開口部を介して前記軸受(20)と流体接続しており、前記洗い流しチャネル(43’)が、前記洗い流しチャネル(43’)を通って前記軸受(20)に向かって血液を給送する補助ポンプと動作的に関連付けられ、
前記補助ポンプが、前記羽根(4)のうち1つを通るように前記インペラ(3)を通って、前記回転軸(9)に対して径方向に延在する、前記少なくとも1つの洗い流しチャネル(43’)によって少なくとも部分的に形成され、
前記洗い流しチャネル(43’)は、前記羽根(4)のうち1つの径方向外縁部に配設された出口開口部(45’)を出て、前記第1の開口部(44’)が、前記出口開口部(45’)の反対側に配設されることを特徴とする血液ポンプ。 - 請求項1に記載の血液ポンプであって、前記回転軸(9)と前記第1の開口部(44’)との間の距離が、前記回転軸(9)と洗い流しフローが前記通路(7)に出る地点(36)との間の距離の50%未満であることを特徴とする血液ポンプ。
- 請求項1または2に記載の血液ポンプであって、前記インペラ(3)が、前記回転軸(9)に沿って延在し、前記軸受(20)を受け入れる中央開口部(32)を備え、前記第2の開口部が前記中央開口部(32)と流体接続していることを特徴とする血液ポンプ。
- 請求項1から3のいずれか1項に記載の血液ポンプであって、前記第1の開口部(44’)の断面が円形または非円形であることを特徴とする血液ポンプ。
- 請求項1から4のいずれか1項に記載の血液ポンプであって、前記第1の開口部(44’)は、前記洗い流しチャネル(43’)が前記インペラ(3)の表面に対して傾斜していることによって少なくとも部分的に露出した、前記洗い流しチャネル(43’)の端部部分によって形成されることを特徴とする血液ポンプ。
- 請求項1から5のいずれか1項に記載の血液ポンプであって、突起(38)が、前記洗い流しチャネル(43’)の前記第1の開口部(44’)内へと延在し、前記第1の開口部(44’)を通って前記洗い流しチャネル(43’)に入る血流を増加させるようにサイズおよび形状が決められていることを特徴とする血液ポンプ。
- 請求項1から6のいずれか1項に記載の血液ポンプであって、前記インペラ(3)が、前記インペラから径方向に延在し、前記洗い流しチャネル(43’)の前記第1の開口部(44’)に隣接して、また回転方向に対して前記第1の開口部の後方に配設された、少なくとも1つのウィング(39)を備えることを特徴とする血液ポンプ。
- 請求項7に記載の血液ポンプであって、前記ウィング(39)が、前記洗い流しチャネル(43’)の前記第1の開口部(44’)の上を延在し、血液が前記第1の開口部(44’)に入ることができるように回転方向で開いていることを特徴とする血液ポンプ。
- 請求項1から8のいずれか1項に記載の血液ポンプであって、前記回転軸(9)に対して対称的に配置された2つ以上の洗い流しチャネル(43’)を備えることを特徴とする血液ポンプ。
- 請求項1から9のいずれか1項に記載の血液ポンプであって、前記インペラ(3)が、径方向外側に延在する下流方向に部分(33)を有し、前記洗い流しチャネル(43’)の前記第1の開口部(44’)が前記部分(33)に配設されることを特徴とする血液ポンプ。
- 請求項1から10のいずれか1項に記載の血液ポンプであって、前記洗い流しチャネル(43’)の前記第1の開口部(44’)が前記インペラ(3)の下流側半分に配設されることを特徴とする血液ポンプ。
- 請求項1から11のいずれか1項に記載の血液ポンプであって、前記洗い流しチャネル(43’)の前記第1の開口部(44’)が、前記血液ポンプ(1)の動作中、血流を前記第1の開口部(44’)から前記洗い流しチャネル(43’)を通って前記軸受(20)に至らせるように前記軸受(20)が配設された前記インペラ(3)の区域よりも高い圧力下にある、前記インペラ(3)の区域に配設されたことを特徴とする血液ポンプ。
- 請求項1から12のいずれか1項に記載の血液ポンプであって、前記第1の開口部(44’)から前記洗い流しチャネル(43’)に至る血流が、前記ポンプケーシング(2)の前記血流出口(6)に向かう方向であることを特徴とする血液ポンプ。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15159680.6A EP3069740B1 (en) | 2015-03-18 | 2015-03-18 | Blood pump |
EP15159680.6 | 2015-03-18 | ||
JP2017549269A JP6861638B2 (ja) | 2015-03-18 | 2016-03-16 | 血液ポンプ |
JP2021057879A JP7139477B2 (ja) | 2015-03-18 | 2021-03-30 | 血液ポンプ |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021057879A Division JP7139477B2 (ja) | 2015-03-18 | 2021-03-30 | 血液ポンプ |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022176207A JP2022176207A (ja) | 2022-11-25 |
JP7488857B2 true JP7488857B2 (ja) | 2024-05-22 |
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ID=52684140
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017549269A Active JP6861638B2 (ja) | 2015-03-18 | 2016-03-16 | 血液ポンプ |
JP2021057879A Active JP7139477B2 (ja) | 2015-03-18 | 2021-03-30 | 血液ポンプ |
JP2022142061A Active JP7488857B2 (ja) | 2015-03-18 | 2022-09-07 | 血液ポンプ |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017549269A Active JP6861638B2 (ja) | 2015-03-18 | 2016-03-16 | 血液ポンプ |
JP2021057879A Active JP7139477B2 (ja) | 2015-03-18 | 2021-03-30 | 血液ポンプ |
Country Status (8)
Country | Link |
---|---|
US (3) | US10773002B2 (ja) |
EP (2) | EP3812001A1 (ja) |
JP (3) | JP6861638B2 (ja) |
KR (2) | KR102603666B1 (ja) |
CN (4) | CN107427617B (ja) |
DK (1) | DK3069740T3 (ja) |
ES (1) | ES2839081T3 (ja) |
WO (1) | WO2016146661A1 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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EP3069740A1 (en) | 2016-09-21 |
JP2021107711A (ja) | 2021-07-29 |
US20240108875A1 (en) | 2024-04-04 |
US11819678B2 (en) | 2023-11-21 |
CN117563124A (zh) | 2024-02-20 |
JP7139477B2 (ja) | 2022-09-20 |
JP2022176207A (ja) | 2022-11-25 |
US20180050140A1 (en) | 2018-02-22 |
CN107427617B (zh) | 2020-07-03 |
CN117563125A (zh) | 2024-02-20 |
CN107427617A (zh) | 2017-12-01 |
JP2018510708A (ja) | 2018-04-19 |
EP3812001A1 (en) | 2021-04-28 |
JP6861638B2 (ja) | 2021-04-21 |
CN111870751B (zh) | 2023-12-01 |
EP3069740B1 (en) | 2020-12-16 |
KR102603666B1 (ko) | 2023-11-17 |
CN111870751A (zh) | 2020-11-03 |
WO2016146661A1 (en) | 2016-09-22 |
KR20230162995A (ko) | 2023-11-29 |
US10773002B2 (en) | 2020-09-15 |
US20210023282A1 (en) | 2021-01-28 |
ES2839081T3 (es) | 2021-07-05 |
DK3069740T3 (da) | 2021-01-25 |
KR20170129169A (ko) | 2017-11-24 |
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