JP7482782B2 - 配列に基づくタンパク質の構造と特性の決定 - Google Patents

配列に基づくタンパク質の構造と特性の決定 Download PDF

Info

Publication number
JP7482782B2
JP7482782B2 JP2020544750A JP2020544750A JP7482782B2 JP 7482782 B2 JP7482782 B2 JP 7482782B2 JP 2020544750 A JP2020544750 A JP 2020544750A JP 2020544750 A JP2020544750 A JP 2020544750A JP 7482782 B2 JP7482782 B2 JP 7482782B2
Authority
JP
Japan
Prior art keywords
protein
proteins
structural features
model
determining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020544750A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021521503A5 (https=
JP2021521503A (ja
Inventor
アミムー,タイルリ
シェイヴァー,ジェレミー,マーティン
ケッチェム,ランダル,アール.
Original Assignee
ジャスト-エヴォテック バイオロジクス,インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジャスト-エヴォテック バイオロジクス,インコーポレイテッド filed Critical ジャスト-エヴォテック バイオロジクス,インコーポレイテッド
Publication of JP2021521503A publication Critical patent/JP2021521503A/ja
Publication of JP2021521503A5 publication Critical patent/JP2021521503A5/ja
Application granted granted Critical
Publication of JP7482782B2 publication Critical patent/JP7482782B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/20Protein or domain folding
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks

Landscapes

  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2020544750A 2018-02-26 2019-02-26 配列に基づくタンパク質の構造と特性の決定 Active JP7482782B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862635529P 2018-02-26 2018-02-26
US62/635,529 2018-02-26
PCT/US2019/019688 WO2019165476A1 (en) 2018-02-26 2019-02-26 Determining protein structure and properties based on sequence

Publications (3)

Publication Number Publication Date
JP2021521503A JP2021521503A (ja) 2021-08-26
JP2021521503A5 JP2021521503A5 (https=) 2022-03-07
JP7482782B2 true JP7482782B2 (ja) 2024-05-14

Family

ID=65995830

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020544750A Active JP7482782B2 (ja) 2018-02-26 2019-02-26 配列に基づくタンパク質の構造と特性の決定

Country Status (5)

Country Link
US (1) US20210043272A1 (https=)
EP (1) EP3759714A1 (https=)
JP (1) JP7482782B2 (https=)
CA (1) CA3092098C (https=)
WO (1) WO2019165476A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114974397B (zh) * 2021-02-23 2025-11-28 腾讯科技(深圳)有限公司 蛋白质结构预测模型的训练方法和蛋白质结构预测方法
CN118402005A (zh) * 2021-08-31 2024-07-26 贾斯特-埃沃泰克生物制品有限公司 用于生成蛋白质序列的残差人工神经网络
US20230217956A1 (en) 2022-01-10 2023-07-13 Climax Foods Inc. Compositions and methods for phosphorylated consumables
CN118511224A (zh) * 2022-01-21 2024-08-16 索尼集团公司 信息处理装置、信息处理方法和程序
GB202303808D0 (en) 2023-03-15 2023-04-26 Nuclera Nucleics Ltd System and method for protein sequence screening
KR102846206B1 (ko) * 2023-09-27 2025-08-18 주식회사 에이인비 표적 단백질의 단백질 응집성 추정 방법 및 장치
WO2025076393A1 (en) * 2023-10-06 2025-04-10 Genentech, Inc. Machine learning enabled estimation of differences between protein sequences

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034876A2 (en) 2000-09-27 2002-05-02 Affinium Pharmaceuticals, Inc. Protein data analysis
JP2002523057A (ja) 1998-08-25 2002-07-30 ザ スクリップス リサーチ インスティテュート タンパク質の機能を予測するための方法およびシステム
JP2011133962A (ja) 2009-12-22 2011-07-07 National Institute Of Advanced Industrial Science & Technology 可溶性予測装置および可溶性予測方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6832162B2 (en) * 2001-02-16 2004-12-14 The Trustees Of Princeton University Methods of ab initio prediction of α helices, β sheets, and polypeptide tertiary structures
KR101681426B1 (ko) * 2015-05-08 2016-12-12 숙명여자대학교산학협력단 위치 지향성 단백질 소수성 분석방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002523057A (ja) 1998-08-25 2002-07-30 ザ スクリップス リサーチ インスティテュート タンパク質の機能を予測するための方法およびシステム
WO2002034876A2 (en) 2000-09-27 2002-05-02 Affinium Pharmaceuticals, Inc. Protein data analysis
JP2011133962A (ja) 2009-12-22 2011-07-07 National Institute Of Advanced Industrial Science & Technology 可溶性予測装置および可溶性予測方法

Also Published As

Publication number Publication date
CA3092098C (en) 2023-07-11
JP2021521503A (ja) 2021-08-26
US20210043272A1 (en) 2021-02-11
WO2019165476A1 (en) 2019-08-29
EP3759714A1 (en) 2021-01-06
CA3092098A1 (en) 2019-08-29

Similar Documents

Publication Publication Date Title
JP7482782B2 (ja) 配列に基づくタンパク質の構造と特性の決定
Lin et al. A combinatorial approach to the peptide feature matching problem for label-free quantification
Chetnik et al. MetaClean: a machine learning-based classifier for reduced false positive peak detection in untargeted LC–MS metabolomics data
Stacey et al. A rapid and accurate approach for prediction of interactomes from co-elution data (PrInCE)
Giri et al. De novo atomic protein structure modeling for cryoEM density maps using 3D transformer and HMM
Zhang et al. Identification of DNA–protein binding sites by bootstrap multiple convolutional neural networks on sequence information
JP7602055B2 (ja) マスクされたタンパク質表現からの完全なタンパク質表現の予測
CN111879710B (zh) 钢结构涂层防腐性能评定方法、系统、服务器和存储介质
Ji et al. DeepCDpred: Inter-residue distance and contact prediction for improved prediction of protein structure
Walsh et al. RUBI: rapid proteomic-scale prediction of lysine ubiquitination and factors influencing predictor performance
Maboudi Afkham et al. Uncertainty estimation of predictions of peptides’ chromatographic retention times in shotgun proteomics
Egertson et al. A theoretical framework for proteome-scale single-molecule protein identification using multi-affinity protein binding reagents
US8831316B2 (en) Point source detection
Smith et al. Estimating error rates for single molecule protein sequencing experiments
Wang et al. A generalizable Hi-C foundation model for chromatin architecture, single-cell and multi-omics analysis across species
US20250246008A1 (en) Imaging systems and methods useful for sparse signal extraction
Silva et al. Improving protein interaction prediction in GenPPi: a novel interaction sampling approach preserving network topology
CN116030883A (zh) 蛋白质结构预测方法、装置、设备及存储介质
Sun et al. BPDA2d—a 2D global optimization-based Bayesian peptide detection algorithm for liquid chromatograph–mass spectrometry
González-Rodríguez et al. Automated and modular protein binder design with binderflow
Arias-Giraldo et al. enmpa: An R package for ecological niche modeling using presence-absence data and generalized linear models
KR20250126722A (ko) 분석 수행 모니터링
CN113971747B (zh) 拉曼光谱数据处理方法、装置、设备与可读存储介质
Has et al. PGMiner: Complete proteogenomics workflow; from data acquisition to result visualization
CN117043585A (zh) 用于化合物的基于拉曼光谱的鉴定的方法和系统

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220225

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220225

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230411

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230707

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20231010

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240109

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240402

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240430

R150 Certificate of patent or registration of utility model

Ref document number: 7482782

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150