JP7432652B2 - Ophthalmology image display device - Google Patents

Description

The present invention relates to an ophthalmological image display device.

Image diagnosis occupies an important position in the field of ophthalmology. In recent years, the use of OCT has progressed. OCT has come to be used not only to obtain B-mode images and three-dimensional images of the eye to be examined, but also to obtain en-face images such as C-mode images and shadowgrams. Furthermore, it is also possible to obtain an image in which a specific part of the eye to be examined is emphasized, and to obtain functional information. For example, an image (angiogram) in which retinal blood vessels and choroidal blood vessels are emphasized can be constructed based on time-series data collected by OCT. Furthermore, it is also possible to obtain blood flow information (blood flow velocity, blood flow volume, etc.) from phase information in time series data collected by OCT. Such imaging techniques are disclosed in, for example, Patent Documents 1 to 3.

JP2014-200680A Special Publication No. 2015-515894 Special Publication No. 2010-523286

In ophthalmological image diagnosis, a plurality of images are generally referred to sequentially or as a list. Particularly in OCT image diagnosis, a user observes various types of images, such as B-mode images, frontal images, morphological images, and functional images, while appropriately changing slice positions, slice thicknesses, and slice ranges. However, it has been difficult to perform such observations smoothly and quickly using conventional techniques.

For example, if you want to observe a site of interest (vessels, lesions, layered tissue, etc.) at various depths of the fundus, you can use conventional technology that can display multiple images sequentially. Because it is necessary to display images, it is difficult to comprehensively understand the state of the region of interest at different depth positions. In addition, according to the conventional technology that can display multiple frontal images as a list, it is possible to individually grasp the state of the target area at multiple depth positions, but it is difficult to understand which range of the eye each frontal image represents. There has been a problem in that it is not easy to determine whether the front images are present or what the positional relationship is between the front images. Furthermore, it is also difficult to comprehensively understand how the region of interest is distributed in the depth direction.

The purpose of the ophthalmological image display device according to the present invention is to easily and comprehensively understand the conditions of the eye to be examined at various depth positions.

The ophthalmological image display device of the embodiment includes a storage unit that stores a three-dimensional data set obtained by scanning a three-dimensional region of the eye to be examined including a part of the fundus and a part of the vitreous body using optical coherence tomography. and a segmentation processing unit that performs segmentation of the three-dimensional data set to identify a plurality of partial data sets corresponding to a plurality of layer tissues of the fundus and a partial data set corresponding to the vitreous body; a B-mode image representing both the fundus of the eye and the vitreous body based on a dimensional data set, the plurality of partial data sets corresponding to the plurality of layer tissues of the fundus, and the partial data set corresponding to the vitreous body; an image processing unit that forms a plurality of frontal images of the fundus having different depth positions and synthesizes the plurality of frontal images to form a composite frontal image; The display device includes a display control unit that causes a display unit to display the composite frontal image in a predetermined layout, and an operation unit. After the display control unit displays the B-mode image, the plurality of frontal images, and the composite frontal image on the display means, the three-dimensional data set is displayed by one frontal image among the plurality of frontal images. When an operation for changing the slice range of the first front image is performed using the operation unit, the image processing unit forms a new front image based on this new slice range, and is replaced with the new front image to form a new composite front image. The display control unit displays new slice range information indicating a partial area of the B-mode image corresponding to the new slice range, and displays the new front image in place of the first front image, and , the new composite front image is displayed instead of the composite front image.

According to the embodiment, it is possible to easily and comprehensively understand the conditions of the eye to be examined at various depth positions.

1 is a schematic diagram showing an example of the configuration of an ophthalmologic image display device according to an embodiment. 1 is a schematic diagram showing an example of the configuration of an ophthalmologic image display device according to an embodiment. FIG. 2 is a schematic diagram showing an example of a screen displayed by the ophthalmologic image display device according to the embodiment. FIG. 2 is a schematic diagram for explaining an example of a screen displayed by the ophthalmologic image display device according to the embodiment. FIG. 2 is a schematic diagram for explaining an example of a screen displayed by the ophthalmologic image display device according to the embodiment. 1 is a schematic diagram showing an example of the configuration of an ophthalmologic imaging apparatus according to an embodiment.

Exemplary embodiments of the invention will be described with reference to the drawings. Note that matters described in the documents cited in this specification and known techniques can be incorporated into the present invention and its embodiments.

The embodiment provides a GUI (Graphical User Interface) for observing an image of a subject's eye. This GUI is used at least for observing OCT images. An image in any cross-sectional mode (B-mode image, C-mode image, multi-planar reconstruction (MPR) image, etc.) or any range of three-dimensional data set (volume data, stack data, etc.) can be projected onto the OCT image. blood vessel-enhanced images (angiograms) formed based on three-dimensional data sets composed of multiple two-dimensional data sets obtained by repeatedly scanning substantially the same area of the eye to be examined. be. This three-dimensional data set is created by, for example, scanning a plurality of B cross sections B1, B2, . . Such imaging techniques are known.

The ophthalmological image display device of the embodiment has a function (rendering function, image forming unit) of forming an image from a three-dimensional data set. The ophthalmological image display device acquires the 3D data set acquired by the ophthalmology OCT device via a network (in-hospital LAN, etc.) or recording medium, and renders the 3D data set according to instructions from the user or computer. Form an image for observation. Note that the display device on which the image is displayed may or may not be included in the ophthalmologic image display apparatus.

In addition to the ophthalmologic image display device as described above, the ophthalmologic imaging apparatus of the embodiment includes an optical system, a drive system, a control system, and a data processing system for performing OCT. The ophthalmologic imaging device is configured to be able to perform, for example, Fourier domain OCT (frequency domain OCT). Fourier domain OCT includes spectral domain OCT and swept source OCT. Spectral domain OCT is a method that uses a broadband low-coherence light source and a spectrometer to acquire the spectrum of interference light by spatial division, and images the eye by Fourier transforming the spectrum. Swept source OCT uses a wavelength swept light source (tunable wavelength light source) and a photodetector (balanced photodiode, etc.) to acquire the spectrum of interference light in a time-division manner, and then Fourier transforms it to detect the eye being examined. This is a method of creating images. The ophthalmologic imaging device may include modalities other than OCT. Such modalities include fundus cameras, SLOs (Scanning Laser Ophthalmoscopes), slit lamp microscopes, and ophthalmic surgery microscopes.

<Ophthalmological image display device>
[composition]
An embodiment of an ophthalmologic image display device will be described. An example of the configuration of an ophthalmologic image display device is shown in FIGS. 1 and 2. The ophthalmological image display apparatus 1 causes the display device 2 to display a GUI for observing an image of the eye to be examined and various information regarding the eye to be examined. The display device 2 may be a part of the ophthalmological image display apparatus 1 or may be an external device connected to the ophthalmological image display apparatus 1.

The ophthalmological image display device 1 includes a control section 10, a storage section 20, a data input/output section 30, a data processing section 40, and an operation section 50.

(Control unit 10)
The control unit 10 controls each part of the ophthalmologic image display device 1. Control unit 10 includes a processor. Note that in this specification, "processor" refers to, for example, a CPU (Central Processing Unit), a GPU (Graphics Processing Unit), an ASIC (Application Specific Integrated Circuit), a programmable logic device ( For example, SPLD (Simple Programmable Logic Device), CPLD (Complex Programmable Logic Device), FPGA (Field Programmable Gate Array), and other circuits. The control unit 10 realizes the functions according to the embodiment by, for example, reading and executing a program stored in a storage circuit or a storage device (such as the storage unit 20).

The control section 10 includes a display control section 11 . The display control unit 11 executes control for causing the display device 2 to display information. The display control unit 11 can perform display control based on information stored in the storage unit 20.

As shown in FIG. 2, the display control section 11 includes a GUI display control section 111, a front image display control section 112, a composite front image display control section 113, a B-mode image display control section 114, and a segment display control section. 115.

The GUI display control unit 111 causes the display device 2 to display a screen, dialog, icon, etc. as a GUI based on the GUI template 21 and display control program 22 stored in the storage unit 20.

The frontal image display control unit 112 displays frontal images such as a C-mode image, a shadowgram, and a blood vessel enhanced image (angiogram) on the GUI screen based on the display control program 22 . Although details will be described later, in this embodiment, each of the plurality of frontal images formed from the three-dimensional data set D is displayed in a predetermined display area of the GUI screen.

The composite frontal image display control unit 113 displays a composite image (combined frontal image) of a plurality of frontal images of the subject's eye in a predetermined display area of the GUI screen. Note that the composite frontal image may be an image based on single image data, or may be an image based on multiple image data. In the former case, the composite front image display control unit 113 displays the composite front image formed by the data processing unit 40 on the GUI screen. In the latter case, the composite front image display control unit 113 performs this display control to display a plurality of image data in an overlapping manner using, for example, a layer display function. Specifically, the composite front image display control unit 113 performs a process of displaying a plurality of images based on a plurality of image data on a plurality of layers, a process of setting the opacity (α value) of each layer, and a process of setting the opacity (α value) of each layer. It is possible to execute processing for displaying layers in an overlapping manner.

The B-mode image display control unit 114 displays the B-mode image formed from the three-dimensional data set D in a predetermined display area of the GUI screen.

The segment display control unit 115 causes the GUI screen to display information (segment information) indicating a partial region of the B-mode image corresponding to the slice range (segment) of the three-dimensional data set D represented by each frontal image. Segment information is displayed in the color assigned to the corresponding front image.

Specific examples of processing executed by the display control unit 11 (GUI display control unit 111, front image display control unit 112, composite front image display control unit 113, B-mode image display control unit 114, segment display control unit 115) will be described later. do.

(Storage unit 20)
The storage unit 20 stores various information. In this embodiment, a GUI template 21, a display control program 22, a data processing program 23, and a three-dimensional data set D are stored in the storage unit 20.

The GUI template 21 includes templates for screens, dialogs, icons, etc. that are displayed on the display device 2 as a GUI.

The display control program 22 includes a program executed by the control unit 10 to control the GUI displayed based on the GUI template 21. In particular, the display control program 22 includes a program for the display control unit 11 to execute control for displaying GUIs and images. The display control of this embodiment is realized by cooperation between the display control unit 11 as hardware (processor) and the display control program 22 as software. A specific example of display processing will be described later.

The data processing program 23 includes a program executed by the data processing section 40 (and the control section 10) to perform various data processing. The data processing of this embodiment is realized by cooperation between the data processing unit 40 (and control unit 10) as hardware (processor) and the data processing program 23 as software. A specific example of data processing will be described later.

Three-dimensional data set D will be explained. The three-dimensional data set D is image data representing the state (form, function, etc.) of a three-dimensional region of the eye to be examined. The three-dimensional data set D may include image data in which the positions of pixels (pixels, voxels, etc.) are defined by a three-dimensional coordinate system. Examples of such image data include stack data formed by embedding two or more B-mode image data into a three-dimensional coordinate system, and volume data formed by converting pixels of stack data into voxels. Another example of three-dimensional data set D may include a group of B-mode image data in which pixel positions are defined by a two-dimensional coordinate system. As yet another example, the three-dimensional data set D may be time-series image data or image data constructed from time-series image data. Examples include three-dimensional image data (three-dimensional angiogram) in which blood vessels are emphasized, and image data representing blood flow dynamics in a plurality of longitudinal sections (B-scan planes) or three-dimensional regions. The type of the three-dimensional data set D is arbitrary, and the three-dimensional data set D is formed using a known OCT technique according to the type.

The three-dimensional data set D formed by the ophthalmologic OCT device (or a computer that processes data acquired by the device) is transmitted to and stored in an image management server installed within a medical institution, on a network, or the like, for example. Additional information is associated with the three-dimensional data set D. The supplementary information includes patient identification information (patient ID, etc.), left eye/right eye identification information, imaging date and time, medical institution identification information, and the like. As a specific operational example, the three-dimensional data set D is managed in a DICOM (Digital Imaging and Communication in Medicine) format, and at least a part of the supplementary information is included in the DICOM tag information. Alternatively, it is also possible to manage the three-dimensional data set D in association with the electronic medical record of the subject. In response to receiving a request from the ophthalmological image display device 1, the image management server searches for the three-dimensional data set D of the subject and transmits it to the ophthalmological image display device 1. As another example of operation, when the 3D data set D is stored in a portable recording medium or a mobile computer, the 3D data set D is stored in the portable recording medium or the like by a reader/writer (described later) of the ophthalmological image display device 1. is read from. The three-dimensional data set D thus input is stored in the storage section 20 by the control section 10.

The parts of the eye to be examined represented by the three-dimensional data set D are arbitrary, and include, for example, the fundus (retina, choroid, sclera, etc.), vitreous body, crystalline lens, and anterior segment (cornea, anterior chamber, iris, crystalline lens, ciliary body). , Chin's frenulum, etc.), and the eyelids. Hereinafter, a three-dimensional data set D obtained by OCT scanning a three-dimensional region of a subject's eye including a part of the fundus and a part of the vitreous body will be described as a typical example.

(Data input/output section 30)
The data input/output unit 30 inputs data to the ophthalmologic image display device 1 and outputs data from the ophthalmologic image display device 1 . Note that the data input/output unit 30 may be configured to only input or output data. The data input/output unit 30 may include, for example, a communication device for transmitting and receiving data via a communication line such as a LAN, the Internet, or a dedicated line. Further, the data input/output unit 30 may include a reader/writer for reading data from a recording medium and writing data to the recording medium. Further, the data input/output unit 30 may include a scanner that reads information recorded on a print medium or the like, a printer that records information on a paper medium, and the like.

(Data processing unit 40)
The data processing unit 40 includes a processor that executes the data processing program 23, and performs various data processing. For example, the data processing unit 40 performs image processing on image data of the eye to be examined. As a typical example, the data processing unit 40 executes rendering such as three-dimensional computer graphics (3DCG).

As shown in FIG. 2, the data processing section 40 includes an image processing section 41. The image processing unit 41 forms various images based on the three-dimensional data set D. For example, the image processing unit 41 forms, based on the three-dimensional data set D, a B-mode image, a plurality of front images, and a composite front image in which (at least a portion of) these front images are combined. The image processing section 41 includes a segmentation processing section 411 , a front image forming section 412 , a color conversion section 413 , a composite front image forming section 414 , a B mode image forming section 415 , and a segment specifying section 416 .

The segmentation processing unit 411 specifies a plurality of partial data sets corresponding to a plurality of tissues of the eye to be examined by analyzing the three-dimensional data set D. Segmentation is image processing for identifying specific tissues or tissue boundaries, and is widely used in ophthalmology OCT. For example, the segmentation processing unit 411 determines the gradient of pixel values (luminance values) in each A-mode image included in the three-dimensional data set D, and identifies a position where the gradient is large as a tissue boundary. Note that the A-mode image is one-dimensional image data extending in the depth direction of the fundus. Note that the depth direction of the fundus is defined as, for example, the Z direction, the incident direction of OCT measurement light, the axial direction, the optical axis direction of the objective lens, etc.

In a typical example, the segmentation processing unit 411 analyzes a three-dimensional data set D representing the fundus of the eye (retina, choroid, etc.) and the vitreous body, thereby generating a plurality of partial data sets corresponding to multiple layer tissues of the fundus of the eye. Identify. Each partial data set is defined by the boundaries of the layer organization. Examples of layer organizations identified as partial datasets include the inner limiting membrane, nerve fiber layer, ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer, outer nuclear layer, and outer limiting membrane that make up the retina. , photoreceptor layer, and retinal pigment epithelial layer. As another example, partial data sets corresponding to Bruch's membrane, choroid, sclera, vitreous body, etc. can be identified. It is also possible to specify a partial dataset corresponding to a lesion. Examples of lesions include avulsions, edema, hemorrhages, tumors, and drusen.

The front image forming unit 412 forms a plurality of front images based on at least a portion of the plurality of partial data sets specified by the segmentation processing unit 411. Each frontal image is an image representing a predetermined slice range of the three-dimensional data set D. For example, the slice range has a thickness in the depth direction of the fundus. The slice range is set by the user or the ophthalmological image display device 1, for example.

The slice range may be a region corresponding to one or more of the plurality of partial data sets specified by the segmentation processing unit 411. For example, a slice range (superficial layer) that includes a partial dataset group corresponding to the range from the internal limiting membrane (ILM) to the inner plexiform layer (IPL), or a range from the outer nuclear layer (ONL) to the retinal pigment epithelial layer (RPE). Apply a slice range that includes a partial data set group corresponding to (outer retina), a slice range that includes a partial data set that corresponds to the choroid (Bruch's membrane (BM) to choroid-scleral boundary (CSI)), etc. is possible. In this way, the thickness of the slice range (distance between boundaries in the Z direction) does not have to be constant, but it is also possible to set a slice range with a constant thickness.

The front image forming unit 412 forms a front image by projecting data included in the set slice range in the depth direction (Z direction). Such a projected frontal image is called a shadowgram. Note that the projected front image covering the entire range of the three-dimensional data set D in the Z direction is called a projection image, and is used for registration between the fundus photograph and the three-dimensional data set D. The front image forming unit 412 can also set a C-mode image representing a cross section (XY cross section, horizontal cross section) of the three-dimensional data set D as the front image. Further, the front image may be any MPR image (for example, it may be an image of a cross section having a small angle with respect to the XY plane).

The frontal image formed by the frontal image forming unit 412 may be any type of OCT image, for example, an image representing the morphology of the eye to be examined (normal OCT image), a blood vessel emphasis image (angiogram), It may also be a blood flow dynamic image (phase image). The front image forming unit 412 can also form a front image (flattened image) by flattening the slice range corresponding to the layer (or layer boundary) specified by the segmentation processing unit 411 on the XY plane. It is.

The color conversion unit 413 converts at least one of the plurality of front images formed by the front image forming unit 412 from a grayscale image to a color image. The color conversion unit 413 replaces the values (luminance values) of at least some pixels of the front image with color values. The color value may be a constant value or may be a value over a predetermined range. Further, the color conversion unit 413 can perform a process of selecting pixels to be subjected to color conversion. This processing may include, for example, arbitrary image processing such as threshold processing regarding brightness values, shape analysis (pattern analysis, pattern matching, etc.), binarization, and filter processing.

A specific example will be explained. It is assumed that the frontal image is a blood vessel-enhanced image (angiogram). Although not intended to be limiting, in a typical blood vessel-enhanced image, pixels corresponding to blood vessels are expressed with relatively high brightness values. In other words, pixels corresponding to blood vessels are expressed as white (bright) on a black background. The color conversion unit 413 extracts pixels with relatively high brightness values (high-brightness pixels) from among the pixels included in the front image, using image processing such as threshold processing, binarization, or a high-pass filter. Further, the color conversion unit 413 replaces the extracted luminance value of each pixel with a predetermined color value. The color represented by this color value is a color assigned in advance to the front image. Although details will be described later, the color assigned to the front image may be, for example, the same (or similar) to the display color of the frame of the display area in the GUI screen where the front image is displayed. Furthermore, the same color value may be assigned to all high-luminance pixels, or different color values may be assigned depending on the magnitude of the luminance value, for example. In the former case, a predetermined color value (default value) is assigned. An example of the latter is color conversion using a color palette (lookup table) for pseudocolor display.

The composite frontal image forming unit 414 combines a plurality of frontal images including at least a portion of the one or more frontal images converted into color images by the color converting unit 413. The image obtained thereby is called a composite frontal image. Since the plurality of frontal images to be synthesized are formed from the same three-dimensional data set D, registration of the plurality of frontal images is not necessary. Alternatively, natural registration based on the positions of the plurality of frontal images (positions of the plurality of slice ranges) in the three-dimensional data set D can be applied to the plurality of composite images.

Objects (blood vessels, lesions, layered tissues, etc.) in a plurality of slice ranges are expressed in the composite frontal image. At this time, the representation mode of the object can be changed depending on the positional relationship of the plurality of slice ranges. For example, objects in a slice range closer to the fundus surface (internal limiting membrane) can be preferentially presented. Furthermore, at least a portion of the object represented in the composite frontal image (such as a blood vessel in a predetermined slice range to which a color value is assigned) is displayed in color.

Note that, as described above, when the composite front image display control unit 113 uses a layer display function or the like to display multiple front images in an overlapping manner, the composite front image forming unit 414 is unnecessary or Operation is stopped. Further, the processing regarding the opacity (α value) of the layer is an alternative to the preferential presentation according to the slice range (described above).

The B-mode image forming unit 415 forms a B-mode image representing a preset longitudinal section (a section perpendicular to the cross section) based on the three-dimensional data set D. Known image processing such as MPR processing is applied to this processing.

The segment specifying unit 416 selects the B mode corresponding to the slice range (segment) of the three-dimensional data set D represented by the frontal image formed by the frontal image forming unit 412 (particularly the frontal image used to form the composite frontal image). A partial area of the B-mode image formed by the image forming unit 415 is specified. Identifying this partial region corresponds to a process of finding a common region between the target slice range and the longitudinal section of the B-mode image.

The functions of the data processing section 40 are not limited to the above. For example, the data processing unit 40 may be capable of executing the functions described below as appropriate or any known functions.

(Operation unit 50)
The operation unit 50 is used by the user to input instructions to the ophthalmologic image display device 1 . The operation unit 50 may include a known operation device used in computers. For example, the operation unit 50 may include a pointing device such as a mouse, touch pad, or trackball. Further, the operation unit 50 may include a keyboard, a pen tablet, a dedicated operation panel, and the like. When the ophthalmologic image display device 1 is connected to an ophthalmologic device (for example, an OCT device), instructions can be input to the ophthalmologic image display device 1 using an operating device (joystick, button, switch, etc.) provided on the ophthalmologic device. It is possible to configure In that case, the operation unit 50 includes an operation device for the ophthalmological apparatus.

[Display screen and usage pattern]
A typical usage pattern of the ophthalmologic image display device 1 will be explained along with an example of a display screen. In the following example, the control unit 10 displays a GUI screen etc. based on the GUI template 21 and the display control program 22, and displays an image etc. based on the display control program 22. Further, the data processing unit 40 executes various processes based on the data processing program 23.

First, a user (such as a doctor) of the ophthalmologic image display device 1 inputs an instruction to start using the GUI. Upon receiving this instruction, the display control unit 11 (GUI display control unit 111) starts the display control program 22 and displays a GUI screen on the display device 2 based on the GUI template 21. The user inputs the patient ID using the operation unit 50 on this GUI screen. Alternatively, the ophthalmological image display device 1 receives the patient ID by reading a patient card or the like with a card reader included in the data input/output unit 30. The method of inputting the patient ID is not limited to these methods. Note that there are cases where it is not necessary to input the patient ID, such as when a three-dimensional data set D stored in a recording medium is input to the ophthalmologic image display device 1.

The control unit 10 sends the input patient ID to the image management server via the network by controlling a communication device included in the data input/output unit 30. The image management server accepts this patient ID, searches for image data associated with it, and sends the searched image data to the ophthalmological image display device 1. In this step, for example, all or some image data acquired in the past for the subject's eye (and the patient's other eye) are retrieved and transmitted. The image data transmitted from the image management server includes a three-dimensional data set D.

The communication device included in the data input/output unit 30 receives image data transmitted from the image management server. The control unit 10 stores the accepted image data in the storage unit 20 together with the patient ID. Thereby, image data including at least the three-dimensional data set D is stored in the storage unit 20. In this example, it is assumed that the three-dimensional data set D is image data representing a three-dimensional region of the fundus, and is included in the image data of the fundus image (fundus photograph).

The GUI display control unit 111 displays a list of image data of the eye to be examined (or the patient) on the GUI screen. The user uses the operation unit 50 to select desired image data. Here, it is assumed that three-dimensional data set D has been selected. The control unit 10 reads the selected three-dimensional data set D from the storage unit 20 and sends it to the data processing unit 40.

At this time, a GUI screen 1000 shown in FIG. 3 is displayed on the display device 2. The GUI screen 1000 is provided with various software keys and a plurality of image display areas. Specifically, the plurality of image display areas include four image display areas provided in the upper tier and three image display areas provided in the lower tier.

A front image formed based on the three-dimensional data set D is displayed in four image display areas (front image display areas) 1101 to 1104 arranged in the upper row. Each frame of the front image display areas 1101 to 1104 is displayed in a predetermined color. The colors of the four frames are all different. For example, the frames of the front image display areas 1101 to 1104 are displayed in orange, yellow-green, sky blue, and blue, respectively.

A condition setting section 1200 for setting conditions regarding the front image is provided below each of the front image display areas 1101 to 1104. The condition setting section 1200 is provided with various soft keys. The condition setting unit 1200 in this example includes the following software keys: a pull-down menu for selecting the slice range to be imaged from predetermined options (Superficial, Deep, Outer retina, Choriocapillaris, etc.); Check box to select presence/absence; Pull-down menu to select the layer (boundary) of the fundus that is the upper end of the slice range; Up/down buttons and offset display to move this upper end position in the depth direction (Z direction) section; pull-down menu for selecting the layer (boundary) of the fundus that is the lower end of the slice range; up and down buttons and offset display section for moving this lower end position in the depth direction; Reset button. Typical examples of options for the upper and lower ends of the slice range are ILM (internal limiting membrane), NFL/GCL (nerve fiber layer - ganglion cell layer boundary), IPL/INL (inner plexiform layer - inner nuclear layer). IS/OS (inner segment outer segment junction), RPE (retinal pigment epithelium), BM (Bruch's membrane), and CSI (choroid-scleral interface). The user sets the desired boundaries (tissues and tissue boundaries are collectively referred to as boundaries) in the pull-down menu at the top and the pull-down menu at the bottom, and then operates the up and down buttons while referring to the B-mode image, etc. It is possible to set the offsets of the upper and lower ends. The area in the three-dimensional data set D that corresponds to the set boundary is specified based on the result of segmentation of the three-dimensional data set D.

In the lower row, a B-mode image display area 1400, a composite front image display area 1300, and a fundus image display area 1500 are arranged in order from the left side.

Note that at this stage, the image of the eye to be examined is not displayed on the GUI screen 1000. However, the fundus image may already be displayed in the fundus image display area 1500 at this stage.

The B-mode image forming section 415 of the data processing section 40 forms a B-mode image based on the three-dimensional data set D. Setting of the cross section of the B-mode image is executed by the user or the B-mode image forming unit 415. The B-mode image display control unit 114 displays the formed B-mode image H in the B-mode image display area 1400 (see FIG. 3). The user can perform operations to change the B-scan plane. For example, by moving a slider provided below the B-mode image display area 1400 in the left-right direction, the B-scan plane can be moved in parallel. The B-mode image forming unit 415 forms a new B-mode image representing a cross section according to the position of the slider. B-mode image display control unit 114 updates B-mode image H with this new B-mode image.

Furthermore, the segmentation processing unit 411 performs segmentation of the three-dimensional data set D. In this example, a plurality of partial data sets corresponding to a plurality of layer tissues constituting the retina, a partial data set corresponding to the choroid, and a partial data set corresponding to the vitreous body are specified by segmentation. The B-mode image display control unit 114 can change the display mode of an image area in the B-mode image H that corresponds to the layer structure or its boundary identified by segmentation.

The user can refer to the B-mode image H to set the desired slice range. When the slice range and the like are set using the condition setting unit 1200, the front image forming unit 412 forms a front image based on the set slice range. The front image display control unit 112 displays the formed front image in a front image display area corresponding to this condition setting unit 1200 (one of the front image display areas 1101 to 1104 located above this condition setting unit 1200). ). By repeating such operations and processing, front images G1 to G4 are displayed in front image display areas 1101 to 1104, respectively (see FIG. 3).

The color conversion unit 413 converts at least part of the front images (grayscale images) of the four front images G1 to G4 (partially) into a color image. The color given to the front image is the same as the color of the frame of the front image display area in which the front image is displayed. For example, the color conversion unit 413 executes some or all of the following four processes: The same orange color as the frame of the front image display area 1101 is applied to the pixels of the blood vessel region depicted in the front image G1. Assign the same yellow-green color as the frame of the front image display area 1102 to the pixels of the blood vessel region depicted in the front image G2; Assign the frame of the front image display region 1103 to the pixels of the blood vessel region depicted in the front image G3 The same blue color as the frame of the front image display area 1104 is assigned to the pixels of the blood vessel region depicted in the front image G4.

The composite front image forming unit 414 forms a composite front image by combining a plurality of front images including part or all of the front image converted into a (partial) color image by the color conversion unit 413. The process of forming a composite frontal image will be described with reference to FIGS. 4 and 5. Note that for the sake of understanding the explanation, figures are drawn in place of images of the eye to be examined in FIGS. 4 and 5.

As shown in FIG. 4, a frame 1101a of the front image display area 1101 is displayed in orange, and a front image G1 in which a circle G1a is drawn is displayed within the frame 1101a. A frame 1102a of the front image display area 1102 is displayed in yellow-green, and a front image G2 in which a triangle G2a is drawn is displayed within the frame 1102a. A frame portion 1103a of the front image display area 1103 is displayed in sky blue, and a front image G3 in which a diamond G3a is drawn is displayed within the frame portion 1103a. A frame 1104a of the front image display area 1104 is displayed in blue, and a front image G4 in which a pentagon G4a is drawn is displayed within the frame 1104a.

The composite frontal image forming unit 414 combines three frontal images G1 to G3 of the four frontal images G1 to G4. The color conversion unit 413 assigns an orange color to a pixel (high-brightness pixel) corresponding to the circle G1a of the front image G1. The color conversion unit 413 assigns yellow-green to the pixel (high-brightness pixel) corresponding to the triangle G2a of the front image G2. The color conversion unit 413 assigns sky blue to the pixel (high-brightness pixel) corresponding to the diamond G3a of the front image G3.

The composite frontal image forming unit 414 composites the three frontal images G1 to G3 (see FIG. 5). As a result, a composite front image G is obtained in which an orange circle G1a, a yellow-green triangle G2a, and a sky blue diamond G3a are depicted. The composite front image display control unit 113 displays the formed composite front image G in the composite front image display area 1300. When the three frontal images G1 to G3 shown in FIG. 3 are synthesized, the frontal images G1 to G3 are blood vessel-enhanced images (angiograms) at different depth positions. The blood vessel region in the front image G1 is expressed in orange, the blood vessel region in the front image G2 is expressed in yellow-green, and the blood vessel region in the front image G3 is expressed in sky blue. That is, blood vessels existing at various depths are identifiably expressed using colors depending on the depth position.

The segment specifying unit 416 specifies a partial area of the B-mode image H corresponding to each slice range (segment) of the front images G1 to G4. The segment display control unit 115 causes segment information indicating the partial area of the B-mode image H specified by the segment specifying unit 416 to be displayed on the B-mode image H. Each segment information is displayed in the color assigned to the corresponding front image.

FIG. 3 shows an example of displaying segment information. In this example, the slice range of the front image G1 is set to "Superficial," the slice range of the front image G2 is set to "Deep," the slice range of the front image G3 is set to "Outer retina," and the slice range of the front image G4 is set to "Outer retina." The slice range of is set to "Choriocapillaris".

The slice range of the front image G1 corresponds to a partial area H1 having the boundary B1 as the upper end and the boundary B2 as the lower end, and the partial area H1 is presented in orange (the color of the frame 1101a) as segment information representing this. The slice range of the front image G2 corresponds to a partial region H2 having the boundary B2 as the upper end and the boundary B3 as the lower end, and the partial region H2 is presented in yellow-green (the color of the frame portion 1102a) as segment information representing this. The slice range of the front image G3 corresponds to a partial area H3 having the boundary B3 as the upper end and the boundary B4 as the lower end, and the partial area H3 is presented in sky blue (the color of the frame portion 1103a) as segment information representing this. The slice range of the front image G4 corresponds to a partial area H4 whose upper end is the boundary B4, and the partial area H4 is presented in blue (the color of the frame 1104a) as segment information representing this. Note that the symbol H5 indicates a partial region corresponding to the vitreous body.

Here, it is not necessary to present segment information for all of the front images G1 to G4. For example, segment information can be presented only for the front images G1 to G3 used to form the composite front image G.

The user can specify a desired front image among the front images G1 to G4. Designation of a desired front image is performed, for example, by clicking on one or more front images using a pointing device included in the operation unit 50. The segment display control unit 115 displays only segment information corresponding to the designated front image. For example, when the front image G1 is specified, segment information is attached only to the corresponding partial area H1 (that is, it is displayed in orange), and the other partial areas H2 to H5 are displayed in gray scale. Thereby, the segment corresponding to the front image of interest can be easily grasped. Note that the segment corresponding to the specified front image may be displayed in pseudo color so that the segment can be observed in detail.

A user can select a frontal image to be used for forming a composite frontal image. This selection is performed, for example, by clicking on two or more front images using a pointing device included in the operation unit 50. It is also possible to delete or replace any of the frontal images used to form the current composite frontal image, or to add a new frontal image. The composite front image forming unit 414 forms a new composite front image based on a new combination of front images (including a color-converted front image). The composite front image display control unit 113 displays a new composite front image instead of the current composite front image. Thereby, a composite front image based on the combination of front images specified by the user can be observed.

It is also possible to configure the front image to be automatically selected. For example, a front image can be selected based on a set slice range. As a specific example, if a part of the choroid or a part of the vitreous body is specified as a slice range, such a slice range can be excluded from the formation of a composite frontal image. Many small blood vessels are distributed within the choroid, and if colors are assigned to blood vessel regions, the entire frontal image will appear to be lightly colored, which may hinder understanding of the distribution of retinal blood vessels. The vitreous body is generally not necessary for observing fundus blood vessels. Note that when observing an abnormality of the vitreous body such as vitreous body traction, a composite frontal image can be formed including a slice range that includes a part of the vitreous body. Furthermore, when it is desired to observe the contact surface between the vitreous body and the retina or the vitreous body near the retina, it is possible to form a composite frontal image including a slice range that includes a part of the vitreous body. Further, depending on the type of the three-dimensional data set D (vessel-enhanced image, morphological image, blood flow dynamics image, etc.), the slice range that is the target of forming the composite frontal image can be switched.

The user can arbitrarily change the slice range of a desired front image among the current front images G1 to G4. The condition setting unit 1200 is used to change the slice range. The user sets a desired slice range by operating software keys in the condition setting section 1200 using a pointing device (such as a mouse) included in the operation section 50.

For example, when the slice range of the front image G1 is changed, the front image forming unit 412 forms a new front image based on the newly set slice range. The front image display control unit 112 displays a new front image instead of the current front image G1.

Further, the color conversion unit 413 assigns a color (orange) corresponding to the front image G1 to a part of the new front image (such as a blood vessel region). The composite front image forming unit 414 uses this new front image instead of the front image G1 to form a new composite front image. The composite front image display control unit 113 displays a new composite front image instead of the current composite front image G. In the new composite frontal image, blood vessel regions and the like in the new frontal image are expressed in the same color as the frontal image G before updating.

Furthermore, the segment specifying unit 416 newly obtains a partial region of the B-mode image H that corresponds to the slice range of the new front image. The segment display control unit 115 displays new segment information indicating the newly specified partial area instead of the segment information corresponding to the current front image G1.

According to such a configuration, it is possible to automatically update the front image, update the composite front image, and update the segment information in response to any change in the slice range of the front image.

[Action/Effect]
The functions and effects of the ophthalmologic image display device according to the embodiment will be described.

The ophthalmologic image display device (1) of the embodiment includes a storage section (20), an image processing section (41), and a display control section (11). The storage unit (20) stores a three-dimensional data set (D) obtained by scanning the subject's eye using OCT. The image processing unit (41) synthesizes the B-mode image (H), the plurality of frontal images (G1 to G4), and the plurality of frontal images (G1 to G4) based on the three-dimensional data set (D). A composite frontal image (G) is formed. The display control unit (11) causes the display means (display device 2) to display the B-mode image (H), the plurality of front images (G1 to G4), and the composite front image (G) in a predetermined layout. The GUI screen 1000 of the above embodiment provides an example of the display layout of these images.

The display control unit (11) displays identification color information (colors of frames 1101a to 1104a) for identifying the plurality of front images (G1 to G4) by color. The display control unit (11) also displays partial regions (H1 to H4) of the B-mode image (H) corresponding to the slice range of the three-dimensional data set (D) represented by each of the plurality of frontal images (G1 to G4). slice range information (presentation colors of partial areas H1 to H4) is displayed in a color corresponding to the identification color information. Further, the display control unit (11) displays a composite front image (G) based on at least a portion of the plurality of front images (G1 to G4), each of which is expressed in a color according to the identification color information.

According to such an embodiment, when observing a plurality of frontal images, the position (depth position) of the frontal images and the positional relationship between the frontal images can be grasped by the slice range information, and furthermore, The state and distribution of objects (vessels, lesions, layered tissues, etc.) can be understood using a composite frontal image. Therefore, it becomes possible to easily and comprehensively understand the conditions of the eye to be examined at various depth positions.

The embodiment may include a first operation section (operation section 50). When an operation for changing the slice range of the first front image, which is one of the plurality of front images (G1 to G4), is performed using the first operation section, the image processing section (41) A new front image is formed based on the slice range, and the first front image is replaced with the new front image to form a new composite front image. Further, the display control unit (11) displays new slice range information indicating a partial area of the B-mode image corresponding to the new slice range, displays a new front image in place of the first front image, and , executes control to display a new composite front image instead of the composite front image.

According to such a configuration, first, the user can display a front image of a desired slice range. Furthermore, in response to the change in the slice range, a front image corresponding to the new slice range is automatically displayed, new slice range information indicating this new slice range is automatically displayed, and this new front image is automatically displayed. A new composite frontal image using the images is automatically displayed. In other words, various images and information are automatically updated in response to changes in the slice range. Therefore, observation at a desired depth position can be easily performed.

In addition, in this example, the display control unit (11) can display new slice range information in a color according to the identification color information corresponding to the first front image. That is, although the slice range information is updated in response to changes in the slice range, the slice range information can be displayed in the same color before and after the update. Further, the first operation unit may include a pointing device (such as a mouse) for performing operations on the slice range information or the B-mode image.

The embodiment may include a second operation section (operation section 50). When an operation for specifying a second front image, which is any one of the plurality of front images (G1 to G4), is performed using the second operation section, the display control section (11) causes the display control section (11) to specify the second front image, which is any one of the plurality of front images (G1 to G4). Control can be performed so that only slice range information corresponding to the second front image is displayed among the plurality of slice range information corresponding to G4).

According to such a configuration, the user can easily and clearly understand the desired slice range of the front image.

In the embodiment, the image processing unit (41) assigns a color according to identification color information to each of the high-intensity pixels in each of the plurality of front images (G1 to G4), and then assigns a color to at least one of the plurality of front images (G1 to G4). It may be configured to combine some of the images to form a composite frontal image (G).

According to such a configuration, it is possible to display objects expressed with relatively high brightness in different colors depending on the position (depth position) of the slice range. This example is effective for observing blood vessels and lesions.

The embodiment may include an image selection unit for selecting two or more front images from among the plurality of front images. In the above embodiment, for example, a part of the control unit 10 functions as an image selection unit. The image selection unit includes a processor that operates according to a computer program therefor. The image selection unit may be configured to automatically select a frontal image by referring to predetermined attributes (for example, the type of slice range, the type of three-dimensional dataset, etc.), or may be configured to automatically select a front image by referring to a predetermined attribute (for example, the type of slice range, the type of three-dimensional dataset, etc.) The front image may be selected based on the received information. That is, the selection of the front image in this example may be automatic selection or manual selection. The image processing section (41) forms another composite frontal image based on the two or more frontal images selected by the image selection section. The display control unit (11) displays another newly formed composite front image in place of the currently displayed composite front image (G).

According to such a configuration, a new composite front image can be automatically formed from two or more front images automatically or manually selected, and the display of the composite front image can be automatically updated. Therefore, it is possible to facilitate observation work.

In the embodiment, the image processing section (41) may include a segmentation processing section (411) and a front image forming section (412). The segmentation processing unit specifies a plurality of partial data sets corresponding to a plurality of tissues of the eye to be examined by analyzing the three-dimensional data set. The front image forming unit forms a plurality of front images based on at least a portion of the plurality of identified partial data sets.

Further, the image processing unit (41) generates a partial area ( H1 to H4) may be included.

According to such a configuration, processing for forming a front image of a laminated tissue such as the fundus of the eye can be suitably performed. For example, it is possible to provide a frontal image representing a single layered structure or a frontal image representing a combination of two or more layered structures. Furthermore, the positions of the layered structures and the positional relationships between the layered structures can be easily understood with reference to the B-mode image. Note that this configuration can also be applied to ocular tissues other than laminated tissues.

In the embodiment, the identification color information for identifying the plurality of front images (G1 to G4) by color is the frame part of the plurality of display areas (1101 to 1104) in which the plurality of front images (G1 to G4) are displayed. (1101a to 1104a) may be included.

Note that the identification color information is not limited to such an exemplary form, and may be in any form as long as it is information that allows the plurality of front images (G1 to G4) to be identified by color. As another example, the identification color information may include the display colors of the plurality of front images (G1 to G4) themselves.

For example, it is possible to display a front image in which some or all of the pixel values have been converted into color values by the color conversion unit 413 of the above embodiment. As a specific example, a frontal image G1 in which a blood vessel region is expressed in orange is displayed in the frontal image display area 1101, a frontal image G2 in which a blood vessel region is expressed in yellow-green is displayed in the frontal image display area 1102, A frontal image G3 in which blood vessel regions are expressed in sky blue can be displayed in the frontal image display area 1103, and a frontal image G4 in which blood vessel regions are expressed in blue can be displayed in the frontal image display area 1104. In this example, the color of the blood vessel region at each depth position in the composite frontal image matches the color of the blood vessel region in the frontal image at each depth position, so it is easy to understand the correspondence between the two. There are advantages.

Furthermore, as another example, an icon or image of a predetermined color may be displayed on or near the front image, or a character string representing a color (color name, etc.) may be displayed on or near the front image. It is possible.

The functions and effects of the embodiments are not limited to these, and the functions and effects provided by each item described as an embodiment and the functions and effects provided by a combination of multiple items should also be considered.

<Ophthalmology imaging device>
The ophthalmologic imaging device according to the embodiment may include, for example, a part or all of the ophthalmologic image display device of the embodiment described above. An example of the configuration of an ophthalmologic imaging device is shown in FIG. Note that the same components as those of the ophthalmological image display device 1 (FIG. 1) of the above embodiment are given the same reference numerals, and the description thereof will be omitted unless specifically mentioned. Further, the ophthalmologic imaging apparatus 100 shown in FIG. 6 may include part or all of the configuration shown in FIG. 2. Furthermore, the display screen and display image may be the same as or similar to the mode shown in FIG. 3, and the mode of identification color information may also be the same as that shown in FIG. Furthermore, with respect to data processing such as image processing, it is possible to apply some or all of the processing described with reference to FIGS. 4 and 5, and further modifications thereof.

The ophthalmologic imaging apparatus 100 has a function of collecting data of the eye to be examined using OCT, and a function of displaying a GUI for observing an image of the eye to be examined and various information regarding the eye to be examined on the display device 2. The display device 2 may be a part of the ophthalmologic imaging apparatus 100 or may be an external device connected to the ophthalmologic imaging apparatus 100.

The ophthalmologic imaging apparatus 100 includes a control section 10, a storage section 20, a data processing section 40, an operation section 50, and a data collection section 110. The control section 10 includes a display control section 11 . Similar to the embodiment described above, the storage unit 20 stores a GUI template 21, a display control program 22, a data processing program 23, and a three-dimensional data set D. The three-dimensional data set D is created by the data collection unit 10 and stored in the storage unit 20. The control unit 10, the storage unit 20, the data processing unit 40, and the operation unit 50 may include at least the same functions as those in the ophthalmologic image display device 1 of the above embodiment.

The data collection unit 110 collects a three-dimensional data set by performing OCT on the eye to be examined. The data collection unit 110 includes a configuration (optical system, drive system, control system, etc.) for performing measurement using, for example, spectral domain OCT or swept source OCT, and forms image data based on data acquired by OCT. and a configuration (processor) for doing so. Image data formation processing includes processing such as noise removal (noise reduction), filter processing, and FFT (Fast Fourier Transform), for example, similar to conventional OCT technology.

The data collection unit 110 scans a three-dimensional region of the eye to be examined. The scan mode at that time is, for example, raster scan (three-dimensional scan). This raster scan is performed, for example, so that each of the plurality of B cross sections is scanned a predetermined number of times, that is, the plurality of B cross sections are sequentially scanned a predetermined number of times. The data collection unit 110 forms a plurality of cross-sectional images (B-mode images) for each B-section based on data collected by raster scanning. Stack data is formed by embedding these cross-sectional images into a single three-dimensional coordinate system. In this stack data, a predetermined number of cross-sectional images are assigned to each B cross-section. Further, volume data (voxel data) is formed by performing interpolation processing or the like on this stack data. Regarding this volume data as well, a predetermined number of voxel groups are assigned to positions corresponding to each B cross section. Stack data and volume data are examples of three-dimensional data set D. The created three-dimensional data set D is stored in the storage unit 20 by the control unit 10.

The ophthalmologic imaging device 100 provides the same GUI, control, and data processing as the ophthalmologic image display device 1 of the embodiment described above, based on the three-dimensional data set D obtained in this way. Based on the three-dimensional data set D, the data processing unit 40 forms a B-mode image, a plurality of front images, and a composite front image in which some or all of these front images are combined. This process may be similar to that of the image processing unit 41 of the above embodiment (see FIG. 2).

The display control unit 11 causes the display device 2 to display the B-mode image, the plurality of front images, and the composite front image formed by the data processing unit 40 in a predetermined layout. Furthermore, the display control unit 11 displays identification color information for identifying the plurality of front images by color. Further, the display control unit 11 displays slice range information indicating a partial region of the B-mode image corresponding to the slice range of the three-dimensional data set D represented by each of the plurality of front images in a color according to the identification color information. . In addition, the display control unit 11 displays a composite front image based on a plurality of front images, each of which is expressed in a color according to the identification color information.

In this way, the ophthalmologic imaging apparatus 100 can be said to have a configuration in which a data collection section (OCT function and OCT image forming function) is added to the ophthalmologic image display apparatus according to the embodiment. Further, the ophthalmologic imaging device 100 may include any items (configuration, control, action, effect, etc.) regarding the ophthalmologic image display device of the above embodiment.

According to such an ophthalmologic photographing apparatus 100, as with the ophthalmologic image display apparatus 1 of the embodiment described above, it is possible to easily and comprehensively understand the conditions of the subject's eye at various depth positions.

<Modified example>
The configuration described above is only one example for suitably implementing the present invention. Therefore, any modification (omission, substitution, addition, etc.) can be made as appropriate within the scope of the gist of the present invention.

For example, in the ophthalmologic image display device and the ophthalmologic imaging device according to the embodiments, the color display of the various information described above is not limited to monochromatic expression, but may be gradation expression. For example, part or all of the front image G1 is displayed with a gradation based on orange (e.g., a gradation from black to white mixed with orange), and a gradation based on yellow-green (e.g., from black to white mixed with yellow-green) is displayed. It is possible to display a part or all of the front image G2 with a gradation based on sky blue (for example, a gradation from black to white mixed with sky blue), and display a part or all of the front image G3 with a gradation based on sky blue (for example, a gradation from black to white mixed with sky blue). can. As the segment information displayed with the B-mode image H, the partial area H1 is displayed with an orange-based gradation, the partial area H2 is displayed with a yellow-green-based gradation, and the partial area H2 is displayed with a sky blue-based gradation. The area H3 can be displayed, and the partial area H4 can be displayed with a gradation based on blue.

Furthermore, it is possible to set a gradation depending on the depth position. For example, a lookup table in which depth positions (Z coordinates) and gradations (gradation values) are associated is stored in advance in the storage unit 212, and by referring to this lookup table, the depth position of the front image can be determined. A corresponding gradation can be specified, and part or all of the front image can be displayed using the specified gradation. Furthermore, the segment information displayed together with the B-mode image H can also be displayed with the same gradation as the corresponding front image. When this example is applied, the colors assigned to multiple frontal images may be the same. In this case, the depth position of the object depicted in the plurality of frontal images is recognized by gradation. In this way, the color-based identification in the present invention includes not only identification methods using different colors but also gradation-based identification methods, and generally also includes identification methods using any color-related characteristics.

1 Ophthalmic image display device 2 Display device 10 Control section 11 Display control section 20 Storage section D 3D data set 40 Data processing section 41 Image processing section 50 Operation section

Claims (1)

a storage unit that stores a three-dimensional data set obtained by scanning a three-dimensional region of the eye to be examined including a part of the fundus and a part of the vitreous body using optical coherence tomography;
a segmentation processing unit that performs segmentation of the three-dimensional data set to identify a plurality of partial data sets corresponding to a plurality of layer tissues of the fundus and a partial data set corresponding to the vitreous body;
a B mode that represents both the fundus and the vitreous body based on the three-dimensional data set, the plurality of partial data sets corresponding to the plurality of layer tissues of the fundus, and the partial data set corresponding to the vitreous body; an image processing unit that forms a plurality of frontal images of the fundus having different depth positions from the image, and synthesizes the plurality of frontal images to form a composite frontal image;
a display control unit that causes a display unit to display the B-mode image, the plurality of front images, and the composite front image in a predetermined layout;
Equipped with an operation section and
After the display control unit displays the B-mode image, the plurality of frontal images, and the composite frontal image on the display means, the three-dimensional data set is displayed by one frontal image among the plurality of frontal images. When an operation for changing the slice range of the first front image is performed using the operation unit, the image processing unit forms a new front image based on this new slice range, and replacing with the new frontal image to form a new composite frontal image;
The display control unit displays new slice range information indicating a partial area of the B-mode image corresponding to the new slice range, and displays the new front image in place of the first front image, and , displaying the new composite front image in place of the composite front image;
When a part of the vitreous body is designated as a slice range of the three-dimensional data set, the image processing unit forms a composite frontal image in which the designated part of the vitreous body is excluded. An ophthalmological image display device.

Images