JP7425914B1 - Liquid delivery system - Google Patents

Abstract

An object of the present invention is to provide a liquid feeding system that can reduce residual liquid while using a single-use bag, increase the degree of freedom in arranging containers, etc., and automate liquid feeding. [Solution] A single-use bag 10 for storing liquid, a preparation tank, and a diluent supply device 3 are provided, and the liquid is sent from the single-use bag 10 to the preparation tank by creating negative pressure inside the preparation tank. , the diluent is supplied from the diluent supply device 3 to the single-use bag 10, and the liquid remaining in the single-use bag 10 is sent to the preparation tank together with the diluent. [Selection diagram] Figure 3

Description

The present invention relates to a liquid feeding system in which at least one of the liquid feeding source and the liquid feeding destination is a flexible single-use bag, and the remaining liquid at the liquid feeding source can be recovered.

2. Description of the Related Art Conventionally, disposable containers for storing liquids such as medical drugs, so-called single-use bags, have been known. When sending liquid from a single-use bag to another container, a peristaltic pump is often used (for example, see Patent Document 1). Specifically, a tube connecting the single-use bag and the container to which the liquid is to be sent is attached to a peristaltic pump to send the liquid.

However, when liquid is sent using a peristaltic pump, liquid remains inside the single-use bag. In addition, in order to collect the remaining liquid, it is possible to place the single-use bag and tube higher than the container to which the liquid is being sent, and use the head to collect the liquid. It requires manpower. Furthermore, there is a restriction that the source of the liquid must be placed higher than the destination, resulting in a lower degree of freedom in the arrangement of the containers and the like.

JP2013-244340A

In view of the above circumstances, it is an object of the present invention to provide a liquid feeding system that can reduce residual liquid while using a single-use bag, increase the degree of freedom in arranging containers, etc., and automate liquid feeding. With the goal.

An aspect of the present invention that solves the above problems includes a first container that stores a liquid, a second container that is arranged downstream of the first container and to which the liquid is fed from the first container, and a second container that stores the liquid. a diluent supply device for supplying a diluent to a diluent, the first container is a flexible single-use bag, the first container is pressurized from the outside, Alternatively, the liquid is fed from the first container to the second container by making the inside of the second container negative pressure, the diluent is supplied from the diluent supply device to the first container, and the diluent is supplied to the first container , The liquid feeding system is characterized in that the liquid remaining in the first container is fed to the second container together with the diluent by creating a negative pressure inside the liquid feeding system.

According to the present invention, there is provided a liquid feeding system that can reduce residual liquid while using a single-use bag, increase the degree of freedom in arranging containers, etc., and automate liquid feeding.

1 is a schematic diagram of a liquid feeding system according to Embodiment 1. FIG. 1 is a schematic diagram showing a state of the liquid feeding system according to Embodiment 1 before a liquid feeding process; FIG. FIG. 3 is a schematic diagram of the liquid feeding process of the liquid feeding system according to Embodiment 1. FIG. 2 is a schematic diagram showing the state of the liquid feeding system according to the first embodiment after a liquid feeding process. FIG. 3 is a schematic diagram of a residual liquid treatment process of the liquid feeding system according to the first embodiment. FIG. 2 is a schematic diagram showing the state of the liquid feeding system according to Embodiment 1 after a residual liquid treatment process. FIG. 2 is a schematic diagram of a liquid feeding system according to Embodiment 2. 3 is a schematic diagram of a liquid feeding system according to Embodiment 3. FIG. FIG. 7 is a schematic diagram showing a state of the liquid feeding system according to Embodiment 3 before a liquid feeding process. FIG. 7 is a schematic diagram of a liquid feeding process in a liquid feeding system according to Embodiment 3; FIG. 7 is a schematic diagram showing a state of the liquid feeding system according to Embodiment 4 before a liquid feeding process. FIG. 7 is a schematic diagram of a liquid feeding process in a liquid feeding system according to Embodiment 4. 1 is a schematic diagram of a pressurized or vacuum container containing a single-use bag; FIG.

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of a liquid feeding system according to the present invention will be described in detail with reference to the drawings.

FIG. 1 is a diagram showing a schematic configuration of a liquid feeding system. The liquid feeding system 1 is part of a plant that manufactures liquid pharmaceuticals (hereinafter referred to as liquid medicine) as an example of liquid. The liquid feeding system 1 includes a single-use bag 10 , a preparation tank 2 , a diluent supply device 3 , a liquid feeding path 4 , a drainage path 5 , a suction pump 6 , and a programmable logic controller that controls the liquid feeding process of the liquid feeding system 1 . It is equipped with a control device (not shown) such as a PLC (PLC).

The single-use bag 10 is a flexible container in which a medical solution is stored in advance. Specifically, a flexible bag body 11, a tube 12 communicating with the inside of the bag body 11, a connector 13 provided at the tip of the tube 12, and an on-off valve 14 provided in the middle of the tube 12. It is equipped with Since such a single-use bag 10 is a well-known product, a detailed explanation of its structure, materials, etc. will be omitted.

The preparation tank 2 is a tank that stores the medicinal solution pressure-fed from the single-use bag 10 via the liquid feeding path 4 and prepares the medicinal solution by mixing it with other raw materials. The preparation tank 2 is provided with an input port for receiving the chemical solution from the single-use bag 10 at the top and an outlet for discharging the chemical solution at the bottom. A liquid feed path 4 is connected to the input port, and a liquid drain path 5 is connected to the discharge port. The adjusted chemical solution is sent to the downstream device via the drainage path 5. Although not particularly shown, the preparation tank 2 is equipped with a pressure gauge (not shown) that measures the pressure of the gas inside. Furthermore, a liquid level gauge (not shown) is attached to the preparation tank 2 to measure the liquid level of the liquid stored inside.

The preparation tank 2 is equipped with a device group capable of reducing the pressure of the internal gas to negative pressure. Such a device group includes a suction pump 6 that discharges the gas inside the preparation tank 2 to the outside. The control device controls the suction pump 6 so that the pressure of the gas inside the preparation tank 2 reaches a predetermined pressure while referring to the pressure value measured by the pressure gauge. Note that a filter may be placed between the preparation tank 2 and the suction pump 6 to keep the inside sterile without exposing the preparation tank 2 to the outside.

The diluent supply device 3 is a device that supplies a diluent (for example, purified water) for diluting a chemical solution. Specifically, the diluent supply device 3 includes a container for storing the diluent, a mechanism for sending out the diluent from the container, various piping, valves, and the like. The mechanism for sending out the diluent includes, for example, a pump that pressurizes gas and supplies it to the container, a regulator that adjusts the pressure of the gas, and the like. Of course, the mechanism is not limited to such a mechanism, and a pump or the like that directly feeds the diluted liquid may be used. The diluent supply device 3 supplies the diluent to the single-use bag 10 via the liquid feed path 4 . The diluent supply device 3 can supply, stop, and adjust the supply amount of the diluent under control by a control device.

The liquid feeding path 4 is a flow path that interconnects the diluent supply device 3, the single-use bag 10, and the preparation tank 2. Specifically, the liquid feeding path 4 is provided at a main pipe 4a connecting the diluent supply device 3 and the preparation tank 2, a branch pipe 4b branched from the middle of the main pipe 4a, and a tip of the branch pipe 4b. and a mounting portion 4c. The connector 13 of the single-use bag 10 is attached to the attachment portion 4c. By attaching the connector 13 to the attachment part 4c, the tube 12 and the branch pipe 4b are communicated with each other, so that the chemical solution can flow inside. In addition, it is preferable that at least the attachment part 4c of the liquid feeding system 1 is arranged in a clean room, and the work of attaching the connector 13 to the attachment part 4c is performed in the clean room.

Further, in the liquid sending path 4, a first valve V1 is provided between the diluent supply device 3 and the branch pipe 4b, and a second valve V2 is provided between the branch pipe 4b and the preparation tank 2. . These first valve V1 and second valve V2 open and close the main pipe 4a, and are controlled to open and close by the control device.

Note that the single-use bag 10 is preferably arranged above the preparation tank 2 in the vertical direction. This is because the chemical solution is less likely to remain in the single-use bag 10 or the liquid feeding path 4. Of course, the single-use bag 10 does not need to be placed vertically above the preparation tank 2.

Here, in the liquid feeding system 1 having the above-described configuration, the operation (pressure feeding operation) of feeding the chemical solution from the single-use bag 10 to the preparation tank 2 will be described. It is assumed that the liquid feeding path 4 and the preparation tank 2 are cleaned in place (CIP) and sterilized in place (SIP) before the pressure feeding operation. The pressure feeding operation consists of a liquid feeding process and a residual liquid processing process.

[Liquid feeding process]
First, as shown in FIG. 2, the connector 13 of the single-use bag 10 is connected to the attachment part 4c of the liquid feeding path 4. At this time, the on-off valve 14 is kept closed.

Next, as shown in FIG. 3, the control device closes the first valve V1 and opens the second valve V2. Also, open the on-off valve 14 of the single-use bag 10. Thereby, the liquid can be sent from the single-use bag 10 to the preparation tank 2 via the liquid sending path 4. In this state, the control device operates the suction pump 6 to make the inside of the preparation tank 2 a negative pressure. The pressure value set inside the preparation tank 2 is not particularly limited, but it is set to a pressure value that allows the medical solution to be sucked from the single-use bag 10. By creating a negative pressure inside the preparation tank 2, the chemical solution is sent from the single-use bag 10 to the preparation tank 2.

The control device maintains the inside of the preparation tank 2 at negative pressure until most of the drug solution is transferred from the single-use bag 10 to the preparation tank 2. Most of the chemical liquid here refers to 90% or more of the chemical liquid stored in the single-use bag 10. Ideally, 100% of the chemical solution may remain in the single-use bag 10 or the liquid feeding path 4.

Specifically, the time (hereinafter referred to as target time) and pressure value (negative pressure) required for most of the chemical liquid to be discharged from the single-use bag 10 are measured in advance. Then, the target time and pressure value are stored in the control device. The on-off valve 14 is opened, and the control device closes the first valve V1 and opens the second valve V2 to start liquid feeding, as shown in FIG. 3, until the target time elapses. The suction pump 6 is controlled so that the pressure is maintained at that pressure value.

In addition, the control device operates the suction pump 6 so that the inside of the preparation tank 2 is maintained at the pressure value until the liquid level value measured by the liquid level gauge provided in the preparation tank 2 reaches the target liquid level value. May be controlled. The target liquid level value for this liquid level value is the liquid level value when 90% of the chemical liquid stored in the single-use bag 10 is stored in the preparation tank 2.

As shown in FIG. 4, by creating a negative pressure inside the preparation tank 2, most of the chemical solution is sent from the single-use bag 10 to the preparation tank 2, and a small amount of the drug solution is transferred to the single-use bag 10 and the liquid delivery path. It remains in a residual state.

[Residual liquid treatment process]
As shown in FIG. 5, the control device opens the first valve V1 and closes the second valve V2. Then, the diluent supply device 3 is caused to supply the diluent. Thereby, the diluent is fed to the liquid feeding path 4 and the single-use bag 10. Although the amount of the diluent is not particularly limited, it is preferable that the diluent be in an amount sufficient to touch the entire inner surface of the single-use bag 10.

In this way, by supplying the diluting liquid to the liquid feeding path 4 and the single-use bag 10, the chemical liquid remaining therein mixes with the diluting liquid. The determination as to whether the diluent has been supplied to the liquid feeding path 4 or the single-use bag 10 is performed as follows. For example, the time required from when the diluent supply device 3 starts supplying the diluent until enough diluent is supplied to the liquid feed path 4 and the single-use bag 10 (hereinafter referred to as target supply time) is measured and controlled in advance. Store the target supply time in the device. Then, the control device supplies the diluent until the target supply time elapses after the diluent supply device 3 supplies the diluent.

In addition, the amount of diluent required from when the diluent supply device 3 starts supplying the diluent until enough diluent is supplied to the liquid feed path 4 and the single-use bag 10 (hereinafter referred to as target supply amount) can be calculated. The target supply amount is measured in advance and stored in the control device. Then, the control device causes the diluent supply device 3 to supply the diluent until the target supply amount is reached. The target supply amount of diluent shall be an amount that does not exceed the amount of diluent contained in the final product manufactured in this plant.

Thereafter, as shown in FIG. 6, a mixed solution of the remaining chemical solution and diluent is sent to the preparation tank 2. The liquid mixture is fed by creating a negative pressure inside the preparation tank 2 using the suction pump 6. The mixed liquid may be fed in the same way as the chemical liquid is fed at a specified time, or it may be carried out until the liquid level gauge in the preparation tank 2 reaches a predetermined liquid level value. Good too.

In the liquid feeding system 1 described above, most of the medicinal solution is fed from the single-use bag 10 to the preparation tank 2 in the liquid feeding process. Then, the chemical solution remaining in the residual solution treatment step is sent to the preparation tank 2 together with the diluent. According to such a liquid delivery system 1, it is possible to send the liquid medicine stored in the single-use bag 10 to the preparation tank 2 without leaving it in the intermediate liquid feeding path or inside the single-use bag 10.

Further, the liquid feeding system 1 is configured to collect the drug solution to the preparation tank 2 under negative pressure, and is not configured to arrange the single-use bag 10 above the preparation tank 2 and transfer the liquid by a head. Conventionally, in order to transfer liquid using a head difference, a restriction arises in that the single-use bags 10 and the preparation tanks 2 must be arranged in such a way that they are stacked in the height direction. However, the liquid feeding system 1 of the present invention does not need to be arranged in consideration of the head difference, and the single-use bag 10 can be arranged at any position relative to the preparation tank 2. Increased freedom.

In addition, although the single-use bag 10 and the preparation tank 2 are relatively heavy objects, the liquid delivery system 1 of the present invention does not transfer liquid using a head, so there is no need to stack heavy objects in the height direction. It has the effect of not requiring any equipment or manpower to place it in a certain location. Furthermore, since the liquid feeding process and the residual liquid treatment process are automated by the control device, there is no need to allocate personnel for monitoring.

As described above, according to the liquid feeding system 1 of the present invention, it is possible to reduce residual liquid even though the single-use bag 10 is used, and the degree of freedom in the arrangement of the single-use bag 10, the preparation tank 2, etc. is increased. liquid delivery can be automated.

Note that the single-use bag 10 corresponds to a "first container," the preparation tank 2 corresponds to a "second container," and the suction pump 6 corresponds to a "suction device."

<Embodiment 2>
A liquid feeding system 1 according to Embodiment 2 of the present invention will be described using FIG. 7. Note that the same components as those in Embodiment 1 are given the same reference numerals, and redundant explanations will be omitted.

The liquid feeding system 1 is configured to be able to feed liquid from a plurality of single-use bags 10 to the preparation tank 2. Specifically, a plurality of (here, two) branch pipes 4b branch from the main pipe 4a of the liquid feeding path 4. Moreover, the liquid feeding path 4 has branch pipes 4d further branched from each branch pipe 4b. Further, the branch pipe 4b is provided with a third valve V3, and the branch pipe 4d is provided with a fourth valve V4. The fourth valve V4 is opened when the cleaning liquid and steam used in CIP and SIP are distributed, and is kept closed during the liquid feeding process and the residual liquid treatment process.

In this manner, the liquid feeding path 4 is provided with a plurality of attachment portions 4c corresponding to the plurality of single-use bags 10. By attaching the single-use bags 10 to these attachment parts 4c, it is possible to send liquid from the plurality of single-use bags 10 to the preparation tank 2.

As for the liquid feeding method, it is preferable to feed the liquid to the single-use bags 10 one by one. For example, in the liquid feeding step, for one single-use bag 10, the on-off valve 14 is opened, the first valve V1 is closed, the second valve V2 is opened, the third valve V3 corresponding to the single-use bag 10 is opened, and the third valve V3 corresponding to the single-use bag 10 is opened. 4 Close valve V4. The on-off valve 14 is closed for the other single-use bags 10, and the third valve V3 and fourth valve V4 corresponding to the single-use bag 10 are also closed. In this state, the internal pressure of the preparation tank 2 is set to negative pressure, and the drug solution is fed from one single-use bag 10.

In the residual liquid treatment step, the first valve V1 is opened, the second valve V2 is closed, and the diluted liquid supply device 3 is caused to supply the diluted liquid. Thereby, the diluent is supplied for one single-use bag 10 that has been sent. Thereafter, the first valve V1 is closed, the second valve V2 is opened, the inside of the preparation tank 2 is made negative pressure, and the mixed liquid of the diluent and the chemical solution is sucked into the preparation tank 2.

By performing such a liquid feeding step and a residual liquid treatment step in the same manner for the other single-use bags 10, the liquid is sequentially fed to the preparation tank 2 for each single-use bag 10. Note that the single-use bag 10 that is empty after liquid feeding can be removed by closing the third valve V3 even if another single-use bag 10 is feeding liquid. Before closing the third valve V3 and attaching the new single-use bag 10 containing the medicinal solution to the attachment part 4c, the attachment part 4c and the branch pipe 4d may be subjected to CIP and SIP. Specifically, with the third valve V3 closed and the empty single-use bag 10 attached to the attachment part 4c, the fourth valve V4 is opened and the cleaning liquid and steam are transferred from the fourth valve V4 to the branch pipe 4d. After a certain period of time, the cleaning liquid and steam are sucked out from the branch pipe 4d, and the empty single-use bag 10 is removed to complete CIP and SIP. In such CIP and SIP, the empty single-use bag 10 serves as a stopper for the attachment part 4c, but of course, the single-use bag 10 can be removed from the attachment part 4c and a separately prepared stopper can be inserted into the attachment part 4c. CIP and SIP may be performed on the branch pipe 4d by blocking it with a.

According to the liquid delivery system 1 of this embodiment, a plurality of single-use bags 10 are sequentially fed to the preparation tank 2 one by one, and when they are empty, they are removed, and a new single-use bag 10 in which the drug solution is stored is inserted. The attachment operation can be repeated, and liquid can be continuously transferred from a plurality of single-use bags 10 to the preparation tank 2.

<Embodiment 3>
A liquid feeding system 1 according to Embodiment 3 of the present invention will be described using FIGS. 8 to 10. Note that the same components as those in Embodiment 1 are given the same reference numerals, and redundant explanations will be omitted.

As shown in FIG. 8, the liquid feeding system 1 includes a pressurized container 20 that can accommodate the bag body 11. The pressurized container 20 has a box shape with an open top, and has a lid 21 that opens and closes the opening. Although not particularly illustrated, a support member for supporting the single-use bag 10 is arranged inside the pressurized container 20. Although not shown, the lid 21 is provided with an opening for sending pressurizing gas into the inside of the pressurized container 20. Furthermore, an insertion hole 22 through which the tube 12 of the single-use bag 10 is inserted is provided at the bottom of the pressurized container 20. The insertion hole 22 is provided with an annular elastic member 23 on its inner surface.

Further, the preparation tank 2 is provided with an air vent pipe 8, and the air vent pipe 8 is provided with a filter 7. The gas present in the preparation tank 2 is discharged from the air bleed pipe 8 when the chemical solution is sent to the preparation tank 2. Furthermore, the filter 7 ensures that the preparation tank 2 is kept in a sterile state.

As shown in FIG. 9, the single-use bag 10 is housed inside a pressurized container 20. Specifically, the bag body 11 is housed inside the pressurized container 20 , the elastic member 23 is pushed open, the connector 13 is inserted, and the elastic member 23 is positioned around the tube 12 . The reaction force of the elastic member 23 prevents air from leaking from the gap between the insertion hole 22 and the tube 12. The tube 11 and connector 13 are pulled out from the pressurized container 20, and the connector 13 is connected to the attachment part 4c.

The lid 21 of the pressurized container 20 is closed to seal the inside of the pressurized container 20. A pressurizing device 30 is connected to an opening provided in the lid 21. The pressurizing device 30 is a group of devices that adjust the pressure inside the pressurizing container 20 by supplying gas to the inside of the pressurizing container 20 or discharging the gas inside the pressurizing container 20 to the outside. . Specifically, it is provided in a regulator that takes in gas (for example, air or nitrogen gas) and adjusts it to a desired pressure, a group of piping for sending gas from the regulator to the pressurized container 20, piping that communicates with the pressurized container 20, etc. It consists of vent valves, etc. These regulators and vent valves can be controlled by a control device.

[Liquid feeding process]
As shown in FIG. 10, with the connector 13 of the single-use bag 10 connected to the attachment part 4c of the liquid supply path 4, the control device closes the first valve V1 and opens the second valve V2. Also, open the on-off valve 14 of the single-use bag 10. Thereby, the liquid can be sent from the single-use bag 10 to the preparation tank 2 via the liquid sending path 4. In this state, the control device operates the pressurizing device 30 to pressurize the inside of the pressurizing container 20. The pressure value set inside the pressurized container 20 is not particularly limited, but is set to a pressure value that can press the bag body 11 with gas and push out the medicinal solution. By pressurizing the inside of the pressurized container 20, the drug solution is sent from the single-use bag 10 to the preparation tank 2.

The control device maintains the pressurized state inside the pressurized container 20 until most of the drug solution is transferred from the single-use bag 10 to the preparation tank 2. Specifically, the time (hereinafter referred to as target time) and pressure value (negative pressure) required for most of the chemical liquid to be discharged from the single-use bag 10 are measured in advance. Then, the target time and pressure value are stored in the control device. The on-off valve 14 is opened, and the control device closes the first valve V1 and opens the second valve V2 to start liquid feeding, as shown in FIG. The pressurizing device 30 is controlled so that the internal pressure is maintained at that pressure value.

In addition, the control device includes a pressurizing device so that the inside of the pressurized container 20 is maintained at the pressure value until the liquid level value measured by the liquid level gauge provided in the preparation tank 2 reaches the target liquid level value. 30 may be controlled. The target liquid level value for this liquid level value is the liquid level value when 90% of the chemical liquid stored in the single-use bag 10 is stored in the preparation tank 2.

[Residual liquid treatment process]
Although not particularly shown in the figure, by pressurizing the inside of the pressurized container 20, most of the medicinal solution was sent from the single-use bag 10 to the preparation tank 2, and a small amount of the medicinal solution remained in the single-use bag 10 and the liquid delivery path. state. The remaining chemical solution is subjected to a residual solution treatment step in the same manner as in the first embodiment, and is recovered using a diluting solution.

According to the liquid feeding system 1 of this embodiment, the bag body 11 is housed in the pressurized container 20, and the stored medicinal liquid is fed to the preparation tank 2 by pressurizing the gas. The liquid feeding system 1 having such a configuration also has the same effects as the first embodiment. Although it is possible to push out and deliver the drug solution by pressing the single-use bag 10 with an instrument, etc., the bag body 11 is generally made of a fragile material, so the load from the instrument etc. is concentrated. There is a risk that the bag body 11 may be damaged. However, in the liquid feeding system 1 of this embodiment, the entire surface of the bag body 11 can be evenly pressurized with gas, so damage to the bag body 11 can be avoided. Note that a liquid may be used instead of gas for pressurizing the bag body 11 inside the pressurized container 20.

<Embodiment 4>
A liquid feeding system 1 according to Embodiment 4 of the present invention will be described using FIGS. 11 and 12. Note that the same components as those in Embodiment 1 are given the same reference numerals, and redundant explanations will be omitted.

As shown in FIG. 11, in the liquid feeding system 1, a single-use bag 40 is used downstream of the single-use bag 10 instead of the preparation tank 2. The single-use bag 40 has the same structure as the single-use bag 10, but is given a different reference numeral for distinction. That is, "41" indicates the bag body 11, "42" indicates the tube 12, "43" indicates the connector 13, and "44" indicates the on-off valve 14. However, the inside of the single-use bag 40 is left empty.

The liquid sending path 4 includes a mounting portion 4e on the tip side of the main pipe 4a. That is, in the liquid feeding path 4, the connector 13 of the single-use bag 10 is connected to the attachment part 4c, and the connector 43 of the single-use bag 40 is connected to the attachment part 4e.

The liquid feeding system 1 also includes a reduced pressure container 50 that can accommodate the bag body 41. The reduced pressure container 50 has a box shape with an open top, and has a lid 51 that opens and closes the opening. Although not particularly illustrated, a support member for supporting the single-use bag 10 is disposed inside the vacuum container 50. Although not shown, the lid 51 is provided with an opening through which a pipe for creating a negative pressure inside the reduced pressure container 50 is inserted. Further, the lid 51 is provided with an insertion hole 52 through which the tube 42 of the single-use bag 40 is inserted. The insertion hole 52 is provided with an annular elastic member 53 on its inner surface.

Further, a suction pump 6 is connected to the decompression container 50 to create a negative pressure inside the container. The interior of the reduced pressure container 50 is set to a desired negative pressure by the suction pump 6 discharging gas.

The single-use bag 40 is housed inside a vacuum container 50. Specifically, the bag main body 41 is housed inside the vacuum container 50, the elastic member 53 is pushed open, the connector 43 is inserted, and the elastic member 53 is positioned around the tube 42. The reaction force of the elastic member 53 prevents air from leaking from the gap between the insertion hole 52 and the tube 42. The lid 51 of the reduced pressure container 50 is closed to seal the inside of the reduced pressure container 50. A suction pump 6 is connected to an opening provided in the lid 51.

[Liquid feeding process]
First, the control device operates the suction pump 6 to make the inside of the decompression container 50 a negative pressure with the second valve V2 closed. As a result, since the bag body 41 of the single-use bag 40 is pulled outward, the inside becomes negative pressure.

Next, as shown in FIG. 12, while the inside of the single-use bag 40 is under negative pressure, the connector 13 of the single-use bag 10 is connected to the attachment part 4c of the liquid supply path 4, and the control device is connected to the first valve. Close V1 and open second valve V2. Also, open the on-off valve 14 of the single-use bag 10. Since the inside of the single-use bag 40 is under negative pressure, the medical solution is delivered from the single-use bag 10 to the single-use bag 40. Note that the timing of opening and closing the valve is not limited to this example. For example, by opening the on-off valve 14 and the on-off valve 44, closing the first valve V1, and opening the second valve V2, the liquid can be transferred from the single-use bag 10 to the single-use bag 40. Then, the suction pump 6 may be operated to make the inside of the reduced pressure container 50 a negative pressure.

The control device maintains the negative pressure inside the reduced pressure container 50 until most of the drug solution is transferred from the single-use bag 10 to the single-use bag 40. Specifically, the time (hereinafter referred to as target time) and pressure value (negative pressure) required for most of the chemical liquid to be discharged from the single-use bag 10 are measured in advance. Then, the target time and pressure value are stored in the control device. The on-off valve 14 and the on-off valve 44 are opened, and the control device closes the first valve V1 and opens the second valve V2 to start liquid feeding, as shown in FIG. The suction pump 6 is controlled so that the pressure inside the container 50 is maintained at that pressure value.

[Residual liquid treatment process]
Although not particularly shown in the drawings, by creating a negative pressure inside the reduced pressure container 50, most of the medicinal solution is sent from the single-use bag 10 to the single-use bag 40, and a small amount of the medicinal solution is delivered to the single-use bag 10 and the liquid feeding path 4. It remains in a residual state. The remaining chemical liquid is subjected to a residual liquid treatment step in the same manner as in Embodiment 1, and is recovered using a diluent.

According to the liquid feeding system 1 of the present embodiment, the single-use bag 40 is housed in the vacuum container 50 instead of a general tank made of stainless steel, etc., and the interior of the single-use bag 40 is made negative pressure. By setting negative pressure to the single-use bag 10, the medicinal solution in the single-use bag 10 is sent to the single-use bag 40. Even in the liquid feeding system 1 having such a configuration, the same effects as in the first embodiment are achieved. The medical solution stored in the single-use bag 40 can be moved to another location in a sterile state by closing the on-off valve 44 and removing the connector 43 from the attachment part 4e. In this embodiment, the configuration is for transferring the medical solution from the single-use bag 10 to the single-use bag 40, but the configuration is not limited to this. For example, a preparation tank or the like may be arranged upstream of the single-use bag 40 instead of the single-use bag 10. In other words, the single-use bag 40 can be used to collect the chemical solution prepared in the upstream device. Note that the preparation tank and the like arranged upstream of the single-use bag 10 and the single-use bag 40 correspond to a "first container," and the single-use bag 40 corresponds to a "second container."

<Other embodiments>
Although the embodiments of the present invention have been described above, the present invention is not limited to the above-described embodiments.

In the third embodiment, the pressurized container 20 is provided with the insertion hole 22 and the elastic member 23 to draw out the tube 12 of the single-use bag 10 to the outside, but the present invention is not limited to such a configuration. As shown in FIG. 13(a), the attachment part 4c is attached to the pressurized container 20 so that the connector 13 can be attached inside the pressurized container 20. For example, a through hole is provided in the bottom surface of the pressurized container 20, and the attachment portion 4c is attached so as to close the through hole. Of course, the mounting position of the mounting portion 4c is not limited to the bottom surface, but may be any surface of the pressurized container 20. As shown in FIG. 13(b), the entire single-use bag 10 is housed in a pressurized container 20. Connector 13 is attached to mounting portion 4c, on-off valve 14 is opened, and lid 21 is closed to seal. Then, as described in the third embodiment, by pressurizing the inside of the pressurized container 20, the medical solution in the single-use bag 10 is sent to the liquid sending pipe 4. Since the on-off valve 14 is opened when the product is housed in the pressurized container 20, an on-off valve may be provided in the middle of the branch pipe 4b. By providing an on-off valve in the branch pipe 4b, it is possible to avoid sending the liquid to the liquid sending path 4 at an unintended timing.

Furthermore, the pressurized container 20 is not limited to a configuration in which the lid 21 is closed and hermetically sealed while the on-off valve 14 is open. For example, the lid 21 may be closed and hermetically sealed while the on-off valve 14 is closed. Specifically, the pressurized container 20 is provided with a mechanism that can open and close the on-off valve 14 inside the pressurized container 20 by operating from outside the pressurized container 20. By operating the mechanism, the on-off valve 14 of the single-use bag 10 housed in the pressurized container 20 in a closed state can be opened and closed. The reduced pressure container 50 may also have the same configuration as the pressurized container 20 described in other embodiments.

Further, in the above-described embodiment, the present invention has been described using a liquid delivery system that transports a medicinal solution as an example, but the present invention is also applicable to an apparatus for delivering a liquid other than a medicinal solution, such as cosmetics, beverages, ink, etc. It can also be applied to

1... Liquid feeding system, 2... Preparation tank (second container), 3... Diluent supply device, 4... Liquid feeding path, 6... Suction pump (suction device), 10... Single-use bag (first container), 11 ... Bag main body, 12 ... Tube, 20 ... Pressure container, 30 ... Pressure device, 40 ... Single-use bag (second container), 41 ... Bag main body, 42 ... Tube, 50 ... Decompression container

Claims (4)

a first container that stores a liquid;
a second container disposed downstream of the first container and to which liquid is sent from the first container;
a diluent supply device that supplies a diluent to the first container;
A liquid delivery system comprising:
The first container is a flexible single-use bag,
Transferring the liquid from the first container to the second container by pressurizing the first container from the outside or making the inside of the second container negative pressure,
supplying the diluent from the diluent supply device to the first container;
A liquid feeding system characterized in that the liquid remaining in the first container is transferred to the second container together with the diluent by creating a negative pressure inside the second container. The liquid delivery system according to claim 1,
comprising a suction device that makes the inside of the second container negative pressure;
The first container is the single-use bag including a bag body that stores a flexible liquid and a tube for feeding the liquid from the bag body,
A liquid feeding system characterized in that the liquid is transferred from the first container to the second container by applying negative pressure to the second container using the suction device. The liquid delivery system according to claim 1,
The first container is the single-use bag including a bag body that stores a flexible liquid and a tube for feeding the liquid from the bag body,
a pressurized container that accommodates the bag body of the first container and that can pressurize the inside while the tube of the first container is pulled out;
A liquid feeding system characterized in that the liquid is transferred from the first container to the second container by pressurizing the inside of the pressurized container. The liquid delivery system according to claim 1,
The second container is the single-use bag including a bag body that stores a flexible liquid and a tube for feeding the liquid from the bag body,
a vacuum container that accommodates the bag body of the second container and is capable of reducing the pressure inside while the tube of the second container is pulled out;
A liquid feeding system characterized in that the liquid is transferred from the first container to the second container by reducing the pressure inside the vacuum container to create a negative pressure inside the bag body.

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