JP7422374B2 - Cosmetics that suppress the ejection of stingers from cnidarians - Google Patents

Description

Article 30, Paragraph 2 of the Patent Act applies Exhibition date: December 8, 2018 (December 8, 2018 - December 9, 2018) Exhibition name and venue: 16th High School Student Science and Technology Challenge JSEC2018 (Miraikan, 2-3-6 Aomi, Koto-ku, Tokyo) [Publications] Broadcast date December 18, 2018, Broadcast program Ai TV Co., Ltd. N Star Ehime, Publisher Ai TV Co., Ltd. [Publications] etc.] Exhibition date February 13, 2019 (February 13, 2019 - February 15, 2019) Exhibition name, venue Interstyle Exhibition (1-1 Minato Mirai, Nishi-ku, Yokohama, Kanagawa Prefecture) 1 Pacifico Yokohama) [Publications, etc.] Broadcast date: March 10, 2019, Broadcast program: Nippon Television Broadcasting Network Co., Ltd. Tokoro-san no Me Ten, Publisher: Nippon Television Broadcasting Network, Inc. [Publications, etc.] Sales date: Heisei April 25, 2019, sales location: Alcohol Co., Ltd. (3-8-2 Nishiochiai, Shinjuku-ku, Tokyo) [Publications, etc.] Sales date: May 8, 2019, sales location: Arata Co., Ltd. (Koto, Tokyo) East 21 Tower, 6-3-2 Toyo, Ward) [Publications, etc.] Sales date: May 14, 2019, sales location: Wing Beat Co., Ltd. (Wing Beat Building 3F, 3-70-19 Ikebukuro, Toshima-ku, Tokyo) [Publications, etc.] Sales date: June 15, 2019, Sales location: East Collection Co., Ltd. (Shin-Matsudo Minami 2-21-3F, Matsudo City, Chiba Prefecture) [Publications, etc.] Sales date: September 9, 2019 , Sales location: Katase Co., Ltd. (2F Higashisen Building, 2-4-23 Minamisenba, Chuo-ku, Osaka-shi, Osaka)

The present invention relates to a cosmetic composition that suppresses the ejection of venomous stingers of cnidarians, and particularly to a cosmetic composition that has an improved effect of suppressing the ejection of venomous stingers of cnidarians such as jellyfish.

Minerals are contained in natural moisturizing factors (NMF) as sodium, potassium, magnesium, and calcium, and have traditionally been used in cosmetics to provide skin moisturizing effects. For example, Patent Document 1 discloses that (a) an oil content of 5.0 to 50.0% by weight, and (b) one or more specific amino acid surfactants, for the purpose of imparting a moisturizing effect. (c) 0.01 to 10.0% by weight of inorganic salts, and (d) 0.05 to 10.0% by weight of surfactant. something is disclosed.

Furthermore, in water-in-oil type emulsified cosmetics, so-called W/O type emulsions, a method has been used in which an inorganic salt is added to the aqueous phase to stabilize the emulsion by electric charge. As such technology, for example, Patent Document 2 discloses that the cosmetic contains (A) a divalent metal salt and (B) Gunjo surface-treated with silicones, and the divalent metal salt is present in the total amount of 0.05~ A water-in-oil emulsion cosmetic characterized by a water-in-oil emulsion cosmetic having a content of 2% by weight is disclosed, and Patent Document 3 also discloses that (I) one or more specific polyether-modified silicones, and (II) oil, (III) water and ethyl alcohol, and (IV) a water-soluble polymer having a molecular weight of 2,000 to 300,000 and having a content of 0.1% to 2.0% by weight based on the total amount of the emulsified composition; Alternatively, it contains 0.1% to 8% by weight of an inorganic salt or an amino acid salt, and is characterized by using polyether-modified silicone as an emulsifier without using a surfactant or an organically modified clay mineral as an emulsifier. Water-in-oil emulsifying compositions are disclosed.

Further, as an oil-in-water type emulsified cosmetic, Patent Document 4 discloses that one or more inorganic salts selected from magnesium chloride, sodium sulfate, potassium chloride, potassium bromide, and calcium chloride; - An oil-in-water emulsion composition containing pentanediol is disclosed.

On the other hand, the relationship between metal ions and sea anemones has been studied, and for example, it has been reported in Non-Patent Document 1 that magnesium ions are related to the ejection of nematocysts of sea anemones. Regarding jellyfish, which are cnidarians like sea anemones, Non-Patent Document 2 reports that magnesium ions are related to the ejection of cnidocytes, and Non-Patent Document 3 reports that calcium ions are related to the ejection of cnidocytes. It has been reported that

Kaho Shigematsu, Miho Yamamoto, “Secret of nematocyst emission from sea anemones”, Japan Student Science Award submitted paper, 2014 Kaho Shigematsu, Miho Yamamoto, “Exploring the mechanism of jellyfish behavior,” Japan Student Science Award Submitted Paper, 2015 Asahiharu Morioka, “Effect of Ca2+ on nematocyst ejection,” Japan Student Science Award Submitted Paper, 2017

Japanese Patent Application Publication No. 6-287128 Patent No. 5108337 Patent No. 3579584 Patent No. 3565320

However, the technique described in Patent Document 1 focuses only on the moisturizing effect, and does not take into account at all the effect of preventing the ejection of poisonous stingers from cnidarians such as jellyfish. Furthermore, the technologies described in Patent Document 2 and Patent Document 3 focus only on the stability of water-in-oil type emulsified cosmetics, and do not have any effect on preventing the ejection of poisonous stingers from cnidarians such as jellyfish. It wasn't taken into consideration.

Furthermore, the technology described in Patent Document 4 focuses only on the stability of oil-in-water type emulsified cosmetics, and does not take into account at all the effect of preventing the ejection of poisonous stingers from cnidarians such as jellyfish. . Furthermore, although stability can be improved by containing 1,2-pentanediol, the influence of the charge of the metal salt cannot be sufficiently suppressed, and sufficient stability cannot be obtained.

Furthermore, although Non-Patent Document 1 describes the ejection of nematocysts from sea anemones, it was unclear about the effect of preventing the ejection of poisonous stingers from cnidarians such as jellyfish. Furthermore, Non-Patent Document 2 reports that magnesium ions are related to the ejection of nematocysts, and Non-Patent Document 3 reports that calcium ions are related to the ejection of nematocysts. However, the synergistic effect of magnesium ions and calcium ions had not been studied at all. Furthermore, since clownfish are not affected by the poisonous sting of the sea anemone, it is being considered to include this ingredient, but in the case of moon jellyfish, L-aspartic acid takes several minutes to eject nematocysts. In contrast, nematocyst ejection occurs instantaneously in the Japanese sea anemone, and in addition, nematocyst ejection in the moon jellyfish occurs at 800 μM (micromol) or more for L-glutamic acid and 400 μM (micromole) or more for L-aspartic acid. On the other hand, the nematocysts ejected by the sea anemone are over 50 μM (micromolar) for L-glutamic acid and over 0.5 μM (micromolar) for L-aspartic acid, and there is a considerable difference in concentration between the two. There are major differences in the sensitivity of receptors and the mechanism of nematocyst ejection, and the mechanism of nematocyst ejection is fundamentally different not only between moon jellyfish and sea anemones, but also between jellyfish and sea anemones. Therefore, although the components of clownfish have been studied, the specific synergistic effects of magnesium ions and calcium ions have not been considered.

SUMMARY OF THE INVENTION Therefore, an object of the present invention is to solve the problems of the prior art described above and to provide a cosmetic composition that is more effective in suppressing the ejection of poisonous stingers from cnidarians such as jellyfish.

As a result of intensive studies to solve the above problems, the present inventors have discovered that by combining specific magnesium ions and calcium ions, the above objects can be achieved and remarkable effects can be obtained. I was able to complete it.

That is, the cosmetic composition for suppressing the ejection of stingers of cnidarians of the present invention is characterized by containing a magnesium compound and a calcium compound.

In addition, the cosmetic composition for suppressing ejection of stings of cnidarians of the present invention is characterized in that the magnesium compound is magnesium chloride, magnesium carbonate, magnesium sulfate, magnesium phosphate, magnesium hydroxide, magnesium lactate, magnesium citrate, or ascorbyl phosphate. One or more selected from the group consisting of magnesium, magnesium gluconate, and silicic acid (Al/Mg), and the calcium compound is calcium chloride, calcium sulfate, calcium phosphate, calcium citrate, calcium pantothenate, calcium lactate. , calcium gluconate, and borosilicate (Ca/Na).

Furthermore, in the cosmetic composition for suppressing ejection of stingers of cnidarians of the present invention, the amount of the magnesium compound is 0.1 to 5% by mass, and the amount of the calcium compound is 0.1 to 5% by mass. %, and the blending ratio of the magnesium compound and the calcium compound is preferably 4:1 to 2:3 in terms of mass ratio.

Furthermore, the cosmetic composition for suppressing the ejection of stingers of cnidarians of the present invention preferably contains an ultraviolet absorber and/or an ultraviolet scattering agent, preferably contains a polyether-modified silicone, and preferably contains a film-forming agent. It is preferable to contain.

According to the present invention, it is possible to provide a cosmetic that has an improved effect of suppressing the ejection of poisonous stingers from cnidarians such as jellyfish.

This is a diagram showing that no nematocysts were ejected (0 points). 1-10% of nematocysts were ejected (0.5 points). 11-30% of nematocysts were ejected (1 point). This figure shows that 31-70% of the nematocysts were ejected (2 points). This figure shows that 71 to 100% of nematocysts were ejected (3 points).

Hereinafter, the cosmetic composition for inhibiting cnidarian sting ejaculation of the present invention will be specifically described.
The cosmetic composition of the present invention that inhibits ejaculation of stingers of cnidarians is characterized by containing a magnesium compound and a calcium compound. By combining a magnesium compound and a calcium compound, it is possible to provide a cosmetic that is more effective in suppressing the ejection of poisonous stingers from cnidarians such as jellyfish.

Further, in the present invention, the magnesium compound is not particularly limited as long as it can be used in ordinary cosmetics, and examples thereof include magnesium chloride, magnesium carbonate, magnesium sulfate, magnesium phosphate, magnesium hydroxide, One or more selected from the group consisting of magnesium lactate, magnesium citrate, magnesium ascorbyl phosphate, magnesium gluconate, and silicic acid (Al/Mg) can be used. In consideration, by using magnesium chloride, magnesium carbonate, magnesium sulfate, and magnesium phosphate, the effect of suppressing the ejection of poisonous stingers of cnidarians such as jellyfish can be further improved. In particular, magnesium chloride is preferable because it further improves the stability of cosmetics over time and further reduces irritation to the skin.

Furthermore, in the present invention, the calcium compound is not particularly limited as long as it can be used in ordinary cosmetics, and examples include calcium chloride, calcium sulfate, calcium phosphate, calcium citrate, calcium pantothenate, lactic acid. One or more selected from the group consisting of calcium, calcium gluconate, and borosilicate (Ca/Na) can be used, and among them, considering ease of dissolution in water, calcium chloride, calcium sulfate, By using calcium phosphate, the effect of suppressing the ejection of poisonous stingers of cnidarians such as jellyfish can be further improved. In particular, calcium chloride is preferred because it further improves the stability of cosmetics over time and further reduces irritation to the skin.

Furthermore, in the present invention, the amount of the magnesium compound blended is not limited as long as the effects of the present invention can be obtained and the stability of the cosmetic is good, but it is preferably 0.1 to 5% by mass, and 0.1% to 5% by mass. More preferably, it is .3 to 1.5% by mass. If the amount of the magnesium compound blended is too small, the effect of the present invention may be weakened, and if it is too large, the stability of the cosmetic may be impaired. The amount of the calcium compound to be blended is not limited as long as the effects of the present invention can be obtained and the stability of the cosmetic is good, but it is preferably 0.1 to 5% by mass, and 0.3 to 1% by mass. More preferably, it is 5% by mass. If the amount of the calcium compound is too small, the effect of the present invention may be weakened, and if it is too large, the stability of the cosmetic may be impaired.

Further, in the present invention, the blending ratio of the magnesium compound and the calcium compound is not limited as long as the effects of the present invention are obtained and the stability of the cosmetic is good, but the mass ratio is 4:1 to 2:3. The ratio is preferably 3:2 to 2:3, and even more preferably 3:2. This can further improve the effect of suppressing the ejection of poisonous stingers from cnidarians such as jellyfish.

Furthermore, it is preferable that the cosmetic composition for inhibiting cnidarian sting ejection of the present invention contains an ultraviolet absorber and/or an ultraviolet scattering agent. Since the present invention is aimed at suppressing the ejection of poisonous stingers of cnidarians such as jellyfish, it is often used in the sea, and by containing an ultraviolet absorber and/or an ultraviolet scattering agent. It can protect against ultraviolet rays.

The ultraviolet absorber is not particularly limited as long as it can be used in ordinary cosmetics, and examples include para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, and N,N-dipropoxy para-aminobenzoic acid ethyl ester. , N,N-diethoxypara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid butyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester, etc. UV absorbers, anthranilic acid UV absorbers such as homomenthyl-N-acetylanthranilate, salicylic acid and its sodium salts, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl Salicylic acid UV absorbers such as salicylate, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate , propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl para-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate mate (cinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl- Cinnamic acid UV absorbers such as diparamethoxycinnamate, ferulic acid and its derivatives, 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4' -dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy- 4-Methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3- Benzophenone UV absorbers such as carboxybenzophenone, 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2 '-Hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzaladine; dianisoyl Methane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane, octyl triazone; urocanic acid and ethyl urocanate urocanic acid derivatives such as 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidene dione, etc. Hydantoin derivatives such as oxoimidazolidine propionate 2-ethylhexyl, phenylbenzimidazole sulfonic acid, terephthalylidene dicanfursulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives, etc. can be mentioned.

The ultraviolet scattering agent is not particularly limited as long as it can be used in ordinary cosmetics, and examples thereof include titanium oxide and zinc oxide. It may be processed. Such surface treatment is not limited as long as it is a surface treatment commonly used for cosmetic powder, but examples include dimethicone treatment, methicone/hydrogen dimethicone treatment, dimethicone/hydrogen dimethicone treatment, triethoxycaprylylsilane treatment, and dimethiconol treatment.・Aminopropyltriethoxysilane treatment, 2Na N-stearoyl-L-glutamate, Al hydroxide treatment, palmitoylproline, Na palmitoylsarcosine, Mg palmitoylglutamate, palmitic acid treatment, isostearyl sebacate, 2Na stearoylglutamate, Al hydroxide treatment , dimyristic acid Al treatment, hydrogenated lecithin/trimyristic acid/hydroxide Al treatment, alginate Na treatment, and the like. In particular, it is preferable to subject the powder to hydrophobization treatment.

Furthermore, it is preferable that the cosmetic composition for inhibiting cnidarian sting ejection of the present invention contains polyether-modified silicone. Such polyether-modified silicones are not particularly limited as long as they can be used in ordinary cosmetics, and may be linear or branched. Further, the polyether-modified silicone may be a cross-linked type in which the main silicone chain is cross-linked with a polyether chain. Furthermore, the polyether-modified silicone may be a polyether-alkyl co-modified type having an alkyl chain. There may be.

Examples of the polyether-modified silicone include PEG-10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, cetyl PEG/PPG-10/1 dimethicone, (dimethicone/(PEG-10/15)) crosspolymer, ( Dimethicone/(PEG-10/15)) Crosspolymer, (PEG-15/Lauryl Dimethicone) Crosspolymer, (PEG-15/Lauryl Dimethicone) Crosspolymer, (PEG-15/Lauryl Dimethicone) Crosspolymer, (PEG-10 / lauryl dimethicone) crosspolymer, (lauryl dimethicone/polyglycerin-3) crosspolymer, PEG/PPG-19/19 dimethicone, lauryl PEG/PPG-18/18 methicone, lauryl PEG-10 tris(trimethylsiloxy)silylethyl dimethicone , (cetyl diglyceryl tris(trimethylsiloxy)silylethyl dimethicone), PEG-12 dimethicone/PPG-20 crosspolymer, PPG-12 dimethicone, PEG/PPG-20/15 dimethicone, PEG/PPG-20/15 dimethicone, etc. It can also be used.

Further, in the present invention, the amount of the polyether-modified silicone blended is not limited as long as the effects of the present invention are obtained and the stability of the cosmetic is good, but it is preferably 0.1 to 5.0% by mass. The content is preferably 1.5 to 3.0% by mass, and more preferably 1.5 to 3.0% by mass. If the amount of the polyether-modified silicone blended is too small, the stability of the cosmetic may be impaired when a UV absorber and/or UV scattering agent is blended in addition to the magnesium compound and calcium compound. Furthermore, if the amount of the polyether-modified silicone is too large, the waterproof property may be impaired.

Furthermore, it is preferable that the cosmetic composition for inhibiting cnidarian sting ejection of the present invention contains a film-forming agent. Such film forming agents are not particularly limited as long as they can be used in ordinary cosmetics, and examples include (acrylates/polytrimethylsiloxy methacrylate) copolymer, (alkyl acrylate/dimethicone) copolymer, phenylpropyl One or more selected from the group consisting of dimethylsiloxysilicic acid, trimethylsiloxysilicic acid, polypropylsilsesquioxane, and trifluoroalkyldimethylsiloxytrimethylsiloxysilicic acid can be used, among which (acrylates/methacrylic acid polysilicate) By using trimethylsiloxy) copolymer, the stability of cosmetics can be further improved when a magnesium compound and a calcium compound are blended. In particular, by blending the polyether-modified silicone and the film-forming agent, the synergistic effect of the polyether-modified silicone and the film-forming agent allows the combination of highly polar ultraviolet absorbers, etc. in addition to magnesium compounds and calcium compounds. Even in the case of sunburn, the injection of stingers from cnidarians can be suppressed, the stability of cosmetics, and the waterproof effect can all be further improved. cosmetics).

Furthermore, in the present invention, the blending amount of the film forming agent is not limited as long as the effects of the present invention are obtained and the stability of the cosmetic is good, but it is preferably 0.1 to 3.0% by mass. It is preferably 0.5 to 2.0% by mass, and more preferably 0.5 to 2.0% by mass. If the amount of the film-forming agent blended is too small, the waterproof property may be impaired. Furthermore, if the amount of the film-forming agent is too large, cleaning with the detergent may be insufficient and cosmetics may remain on the skin.

In addition, in the present invention, the cosmetics in the cosmetics for suppressing the injection of stingers from cnidarians are those that can be used on the human body, etc., and are mainly cosmetics, but also include quasi-drugs and pharmaceuticals. This does not exclude other uses. Furthermore, the above-mentioned cosmetics include basic cosmetics, make-up cosmetics, hair cosmetics, etc., but since they are cosmetics that suppress the ejection of poisonous stingers of cnidarians, they are cosmetics used when swimming in the sea, etc. and sunscreen cosmetics are preferred.

Furthermore, in the present invention, other components may be added as appropriate to the extent that the effects of the present invention are not impaired. Any ingredient other than the above can be added qualitatively and quantitatively, including ingredients normally added to cosmetics, such as surfactants, oily ingredients, humectants, antioxidants, fragrances, and various vitamins. , chelating agents, coloring agents, medicinal ingredients, inorganic salts, etc. can be blended.

Examples of components that can be blended include nonionic surfactants such as monofatty acid polyglyceryl, polyfatty acid polyglyceryl, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, and polyoxyethylene propylene. Glycol fatty acid ester, polyoxyethylene castor oil derivative, polyoxyethylene hydrogenated castor oil derivative, polyoxyethylene sterol, polyoxyethylene hydrogenated sterol, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether , sucrose fatty acid ester, and the like.

Examples of amphoteric surfactant components include 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imitazolinium hydroxide-1-carboxyethyloxy 2-sodium Imidazoline amphoteric surfactants such as salts, betaine surfactants such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkylbetaine, amidobetaine, sulfobetaine, etc. etc.

Examples of higher alcohol components include lauryl alcohol, mystyl alcohol, cetyl alcohol, stearyl alcohol, cetostearyl alcohol, oleyl alcohol, behenyl alcohol, isostearyl alcohol, hexyldecanol, octyldodecanol, decyltetradecanol, oleyl alcohol, aracyl alcohol, Examples include behenyl alcohol, etc.

Examples of polyhydric alcohols include glycerin, 1,3-butylene glycol, propylene glycol, propanediol, 1,2-hexanediol, pentylene glycol, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, and polyethylene. Examples include one or more selected from the group consisting of glycol, dipropylene glycol, polypropylene glycol, ethylene glycol/propylene glycol copolymers, and polymers thereof.

Examples of polymeric components include xanthan gum, gellan gum, gum arabic, gum tragacanth, galactan, guar gum, carrageenan, pectin, agar, quince seed, dextran, pullulan, casein, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, gelatin methyl cellulose, and sodium alginate. , carboxyvinyl polymer and the like.

Extract liquid components include, for example, chamomile extract, parsley extract, honeysuckle extract, rice extract, rice bran extract, hop extract, burax extract, sagebrush extract, Japanese japonica extract, melilot extract, birch extract, licorice extract, peony extract, soapwort extract, loofah extract. , capsicum extract, lemon extract, gentian extract, perilla extract, aloe extract, rosemary extract, sage extract, thyme extract, eucalyptus extract, tea extract, seaweed extract, cucumber extract, clove extract, carrot extract, horse chestnut extract, hamamelis extract, mulberry extract , chimpi extract, pecan nut extract, grapefruit extract, shikkuwasa extract, passion fruit extract, loquat extract, grape extract, rose fruit extract, clara extract, peppermint extract and the like.

Examples of moisturizing ingredients include xylitol, sorbitol, maltitol, sodium chondroitin sulfate, elastin, glucosamine, hyaluronic acid, cyclodextrin, collagen, and bile salts.

Medicinal ingredients include, for example, vitamins such as vitamin A, vitamin B, vitamin C, vitamin D, and vitamin E, and their derivatives, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, various salts such as urea, creatinine, and CoQ10. , astaxanthin, polyphenol, and ceramide.

In addition, in the present invention, the cosmetic can be produced by a normal cosmetic production method, such as a method of producing by heating an oil phase component and an aqueous phase component, a D-phase emulsification method, etc. be able to.

The present invention also provides a method for suppressing the ejection of poisonous stingers from cnidarians such as jellyfish. Specifically, by applying the cosmetic composition for inhibiting the ejection of stingers of cnidarians of the present invention to the skin, it is possible to suppress the ejection of stingers of cnidarians such as jellyfish.

EXAMPLES Hereinafter, the present invention will be explained in more detail using Examples, but the present invention is not limited to these Examples. In addition, the numbers in the table regarding the following prescriptions indicate mass %.

(Example 1)
Using the formulation shown in Table 1 below, the cnidarian stinger ejaculation inhibiting cosmetic composition (SPF5, PA+++ sunscreen cosmetic composition) of Example 1 was prepared according to the following procedures (1) to (8).
(1) No. in Table 1 below. Mix ingredients 1-9 until homogeneous.
(2) No. in Table 1 below. 10 to 12 ingredients are mixed and uniformly dispersed.
(3) Add (2) above to (1) above and mix.
(4) No. in Table 1 below. Mix ingredients 13-15 until homogeneous.
(5) No. in Table 1 below. Mix components 16 to 17 uniformly at 20°C (6) No. 1 in Table 1 below. Mix components 18 to 19 uniformly at 20° C. (7) While stirring the mixture of (3) above, slowly add the mixtures of (4) to (6) above one after another.
(8) The mixture was further stirred for 10 minutes to produce the cosmetic composition for inhibiting cnidarian sting ejection of Example 1.

(Comparative example 1)
A cosmetic composition of Comparative Example 1 (sunscreen cosmetic composition with SPF5 and PA+++) was prepared using the formulation shown in Table 2 below and following the procedures (1) to (6) below.
(1) No. in Table 2 below. Mix ingredients 1-9 until homogeneous.
(2) No. in Table 2 below. 10 to 12 ingredients are mixed and uniformly dispersed.
(3) Add (2) above to (1) above and mix.
(4) No. in Table 2 below. Mix ingredients 13-16 until homogeneous.
(5) While stirring the mixture of (3) above, slowly add the mixture of (4) above to it.
(6) The mixture was further stirred for 10 minutes to produce the cosmetic of Comparative Example 1.

The cosmetic composition for suppressing the ejection of stingers of cnidarians of Example 1 was not stung by any of the moon jellyfish, the red jellyfish, and the jellyfish jellyfish, and was able to suppress the ejection of the stingers of jellyfish. Furthermore, despite the combination of a magnesium compound and a calcium compound, the cosmetic had good stability and had a moderate waterproof effect. On the other hand, the cosmetic of Comparative Example 1 was attacked by jellyfish stingers and could not suppress the ejection of jellyfish stingers.

(Experiment example 1)
Using moon jellyfish and red jellyfish, we experimented with the optimal ratio of magnesium and calcium compounds. Using _{MgCl2.6H2O saturated} aqueous solution _{and CaCl2.2H2O} saturated aqueous solution _{, MgCl2.6H2O} : _CaCl2.2H2O =1:4, ₂ :3, 3:2 and 4:1. A mixed solution was prepared and used in the following proportions. For moon jellyfish, the mixture was diluted 10 times, and 2mM (millimoles) of L-aspartic acid was added to induce nematocyst injection. For red jellyfish, the mixture was diluted 4 times and 2mM (mmol) of L-aspartic acid was added. The cells were observed for 4 minutes at 200x magnification using an inverted optical microscope to confirm the presence and frequency of nematocyst injection.

(Evaluation of frequency of nematocyst injection)
The tentacles of moon jellyfish and red jellyfish were excised and collected using dissecting scissors and stored in a petri dish filled with natural seawater. Natural seawater was used for diluting all solutions. One of the collected tentacles was transferred to a petri dish for observation, and the surrounding seawater was removed with a micropipette. 10 μl of each test solution was added to this and the tentacles were immersed. The cells were observed for 4 minutes at 200x magnification using an inverted optical microscope to confirm the presence and frequency of nematocyst injection. The frequency of nematocyst injection was evaluated in five stages as shown in FIGS. 1 to 5. 0 point if no nematocyst injection could be observed, 0.5 point if 1-10% of the entire tentacle was visually observed, 1 if 11-30% of the ejaculation could be observed. Points were given, 2 points were given when 31-70% injection was observed, 3 points were given when 71-100% injection was observed, and the average value was calculated.

In moon jellyfish, MgCl ₂ .6H ₂ O:CaCl ₂ .2H ₂ O = 1:4 has 1.20 points, 2:3 has 1.20 points, 3:2 has 0.80 points, and 4:1 has 1. 00 points, and it was confirmed that nematocyst injection was suppressed. In addition, for red jellyfish, _MgCl2.6H2O : _{CaCl2.2H2O =} 2.00 points at 1:4, 1.75 points at 2:3, 1.00 points at 3:2, and 1.00 points at 4 _: 1. The score was 2,00 points, confirming suppression of nematocyst injection. Based on the above, a blending ratio of 3:2 is preferable.

Claims (6)

Contains a magnesium compound and a calcium compound,
The amount of the magnesium compound is 0.1 to 5% by mass, the amount of the calcium compound is 0.1 to 5% by mass,
A cosmetic composition for suppressing the ejection of stingers of cnidarians , characterized in that the blending ratio of the magnesium compound and the calcium compound is 4:1 to 2:3 in terms of mass ratio . Contains a magnesium compound and a calcium compound,
The amount of the magnesium compound is 0.3 to 1.5% by mass, the amount of the calcium compound is 0.3 to 1.5% by mass,
A cosmetic composition for suppressing the ejection of stingers of cnidarians, characterized in that a blending ratio of the magnesium compound and the calcium compound is 3:2 to 2:3 by mass. The magnesium compound is selected from the group consisting of magnesium chloride, magnesium carbonate, magnesium sulfate, magnesium phosphate, magnesium hydroxide, magnesium lactate, magnesium citrate, magnesium ascorbyl phosphate, magnesium gluconate, and silicic acid (Al/Mg). One or more types of
A claim in which the calcium compound is one or more selected from the group consisting of calcium chloride, calcium sulfate, calcium phosphate, calcium citrate, calcium pantothenate, calcium lactate, calcium gluconate, and borosilicate (Ca/Na). The cosmetic composition for inhibiting the ejection of stingers of cnidarians according to 1 or 2 . The cosmetic composition for suppressing ejection of stings of cnidarians according to any one of claims 1 to 3, which contains an ultraviolet absorber and/or an ultraviolet scattering agent. The cosmetic composition for inhibiting the ejection of stingers of cnidarians according to any one of claims 1 to 4, which contains a polyether-modified silicone. The cosmetic composition for inhibiting the ejection of stingers of cnidarians according to any one of claims 1 to 5, which contains a film-forming agent.