JP7406192B2 - 線維症治療薬 - Google Patents

線維症治療薬 Download PDF

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Publication number
JP7406192B2
JP7406192B2 JP2020568610A JP2020568610A JP7406192B2 JP 7406192 B2 JP7406192 B2 JP 7406192B2 JP 2020568610 A JP2020568610 A JP 2020568610A JP 2020568610 A JP2020568610 A JP 2020568610A JP 7406192 B2 JP7406192 B2 JP 7406192B2
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JP
Japan
Prior art keywords
collagen
fibrosis
hph
acid
skin
Prior art date
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Application number
JP2020568610A
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English (en)
Japanese (ja)
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JPWO2020158890A1 (https=
JPWO2020158890A5 (https=
Inventor
琳 倉原
浩信 尹
雅巳 大塚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SCIENCE FARM LTD.
Link Genomics Inc
Original Assignee
SCIENCE FARM LTD.
Link Genomics Inc
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Publication of JPWO2020158890A1 publication Critical patent/JPWO2020158890A1/ja
Publication of JPWO2020158890A5 publication Critical patent/JPWO2020158890A5/ja
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020568610A 2019-01-31 2020-01-30 線維症治療薬 Active JP7406192B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019015226 2019-01-31
JP2019015226 2019-01-31
PCT/JP2020/003522 WO2020158890A1 (ja) 2019-01-31 2020-01-30 線維症治療薬

Publications (3)

Publication Number Publication Date
JPWO2020158890A1 JPWO2020158890A1 (https=) 2020-08-06
JPWO2020158890A5 JPWO2020158890A5 (https=) 2023-06-14
JP7406192B2 true JP7406192B2 (ja) 2023-12-27

Family

ID=71841860

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020568610A Active JP7406192B2 (ja) 2019-01-31 2020-01-30 線維症治療薬

Country Status (3)

Country Link
US (1) US12138251B2 (https=)
JP (1) JP7406192B2 (https=)
WO (1) WO2020158890A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023176879A1 (ja) * 2022-03-16 2023-09-21 国立大学法人 熊本大学 生活習慣病の予防又は治療に使用するための医薬組成物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HOSONO, Tetsuji et al.,Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure acti,Bioorganic & Medicinal Chemistry Letters,2008年,Vol.18,pp.371-374
LUONG, Vu Huy et al.,Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosi,Arthritis Research & Therapy,2018年,Vol.20:46,pp.1-13,doi.org/10.1186/s13075-018-1534-y
RIEDER, Florian and FIOCCHI, Claudio,Intestinal fibrosis in inflammatory bowel disease Current knowledge and future perspectives,Journal of Crohn's and Colitis,2008年,Vol.2,pp.279-290

Also Published As

Publication number Publication date
WO2020158890A1 (ja) 2020-08-06
JPWO2020158890A1 (https=) 2020-08-06
US20220096448A1 (en) 2022-03-31
US12138251B2 (en) 2024-11-12

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