JP7403733B2 - インフルエンザｈａスプリットワクチンの製造方法 - Google Patents

インフルエンザｈａスプリットワクチンの製造方法 Download PDF

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Publication number
JP7403733B2
JP7403733B2 JP2018137952A JP2018137952A JP7403733B2 JP 7403733 B2 JP7403733 B2 JP 7403733B2 JP 2018137952 A JP2018137952 A JP 2018137952A JP 2018137952 A JP2018137952 A JP 2018137952A JP 7403733 B2 JP7403733 B2 JP 7403733B2
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Prior art keywords
influenza
split vaccine
vaccine
split
lah
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Japanese (ja)
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JP2019043937A5 (https=
JP2019043937A (ja
Inventor
宜聖 高橋
悠 安達
学 阿戸
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DIRECTOR-GENERAL NATIONAL INSTITUTE OF INFECTIOUS DISEASES
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DIRECTOR-GENERAL NATIONAL INSTITUTE OF INFECTIOUS DISEASES
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Priority to PCT/JP2018/032537 priority Critical patent/WO2019045090A1/ja
Priority to CA3074581A priority patent/CA3074581A1/en
Priority to EP18852584.4A priority patent/EP3679948A4/en
Priority to AU2018325899A priority patent/AU2018325899B2/en
Priority to CN201880070955.0A priority patent/CN111372605B/zh
Priority to EA202090587A priority patent/EA202090587A1/ru
Priority to SG11202001937TA priority patent/SG11202001937TA/en
Priority to MYPI2020001089A priority patent/MY204177A/en
Priority to KR1020207009033A priority patent/KR102733152B1/ko
Priority to US16/292,065 priority patent/US11732031B2/en
Publication of JP2019043937A publication Critical patent/JP2019043937A/ja
Priority to PH12020500414A priority patent/PH12020500414A1/en
Publication of JP2019043937A5 publication Critical patent/JP2019043937A5/ja
Priority to US18/341,960 priority patent/US20230406910A1/en
Application granted granted Critical
Publication of JP7403733B2 publication Critical patent/JP7403733B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/11—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2018137952A 2017-09-04 2018-07-23 インフルエンザｈａスプリットワクチンの製造方法 Active JP7403733B2 (ja)

Priority Applications (12)

Application Number Priority Date Filing Date Title
KR1020207009033A KR102733152B1 (ko) 2017-09-04 2018-09-03 인플루엔자 ha 스플릿 백신의 제조 방법
EP18852584.4A EP3679948A4 (en) 2017-09-04 2018-09-03 METHOD OF MANUFACTURING INFLUENZA-HA-SPLIT VACCINE
AU2018325899A AU2018325899B2 (en) 2017-09-04 2018-09-03 Method for producing influenza HA split vaccine
CN201880070955.0A CN111372605B (zh) 2017-09-04 2018-09-03 用于产生流感ha裂解疫苗的方法
EA202090587A EA202090587A1 (ru) 2017-09-04 2018-09-03 Способ получения сплит-вакцины с на гриппа
SG11202001937TA SG11202001937TA (en) 2017-09-04 2018-09-03 Method for producing influenza ha split vaccine
PCT/JP2018/032537 WO2019045090A1 (ja) 2017-09-04 2018-09-03 インフルエンザｈａスプリットワクチンの製造方法
CA3074581A CA3074581A1 (en) 2017-09-04 2018-09-03 Method for producing influenza ha split vaccine
MYPI2020001089A MY204177A (en) 2017-09-04 2018-09-03 Method for producing influenza ha split vaccine
US16/292,065 US11732031B2 (en) 2017-09-04 2019-03-04 Method for producing influenza HA split vaccine
PH12020500414A PH12020500414A1 (en) 2017-09-04 2020-03-02 Method for producing influenza ha split vaccine
US18/341,960 US20230406910A1 (en) 2017-09-04 2023-06-27 Method for producing influenza ha split vaccine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017169230 2017-09-04
JP2017169230 2017-09-04

Publications (3)

Publication Number Publication Date
JP2019043937A JP2019043937A (ja) 2019-03-22
JP2019043937A5 JP2019043937A5 (https=) 2021-09-02
JP7403733B2 true JP7403733B2 (ja) 2023-12-25

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JP2018137952A Active JP7403733B2 (ja) 2017-09-04 2018-07-23 インフルエンザｈａスプリットワクチンの製造方法

Country Status (10)

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US (1) US11732031B2 (https=)
EP (1) EP3679948A4 (https=)
JP (1) JP7403733B2 (https=)
KR (1) KR102733152B1 (https=)
CN (1) CN111372605B (https=)
AU (1) AU2018325899B2 (https=)
CA (1) CA3074581A1 (https=)
EA (1) EA202090587A1 (https=)
PH (1) PH12020500414A1 (https=)
SG (1) SG11202001937TA (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7403733B2 (ja) 2017-09-04 2023-12-25 国立感染症研究所長 インフルエンザｈａスプリットワクチンの製造方法
CA3107409A1 (en) 2018-07-23 2020-01-30 Japan As Represented By Director General Of National Institute Of Infectious Diseases Composition containing influenza vaccine
EA202192398A1 (ru) 2019-03-04 2021-11-23 Джэпэн Эз Репризентид Баи Директор Дженерал Оф Нэшнл Инститьют Оф Инфекшес Дизизис Способ приготовления сплит-вакцины против гриппа на основе гемагглютинина
KR20220098370A (ko) * 2019-11-07 2022-07-12 세퀴러스 유케이 리미티드 감소된 입자 크기를 가지는 바이러스 백신을 제조하기 위한 조성물 및 방법
CN121816361A (zh) 2023-04-26 2026-04-07 国立健康危机管理研究机构 抗流感抗体

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WO2013173256A2 (en) 2012-05-16 2013-11-21 Kj Biosciences, Llc New and improved influenza vaccines
JP2014513680A (ja) 2011-04-21 2014-06-05 バクスター・インターナショナル・インコーポレイテッド ワクチンから抗原を単離し定量する方法
WO2016028776A1 (en) 2014-08-18 2016-02-25 Sanofi Pasteur Biologics Llc Alkylated influenza vaccines

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US8278083B2 (en) 2004-03-22 2012-10-02 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Inactivated influenza virus compositions
JPWO2008114819A1 (ja) 2007-03-20 2010-07-08 大日本住友製薬株式会社 新規アデニン化合物
CA2731686C (en) 2008-07-25 2020-04-07 Institute For Research In Biomedicine Neutralizing anti-influenza a virus antibodies and uses thereof
WO2010047509A2 (ko) 2008-10-24 2010-04-29 아주대학교 산학협력단 친화도와 안정성이 향상된 항 ｄｒ5 항체, 및 이를 포함하는 암 예방 또는 치료용 조성물
CN101524538A (zh) * 2009-03-26 2009-09-09 成都康华生物制品有限公司 一种流感-大流行流感二价联合疫苗及其制备方法
EP3098236A1 (en) 2010-03-08 2016-11-30 Celltrion, Inc. Human monoclonal antibodies derived from human b cells and having neutralizing activity against influenza a viruses
CN102939103A (zh) 2010-03-30 2013-02-20 西奈山医学院 流感病毒疫苗及其应用
KR20140118682A (ko) 2013-03-29 2014-10-08 (주)셀트리온 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물
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CA3107409A1 (en) 2018-07-23 2020-01-30 Japan As Represented By Director General Of National Institute Of Infectious Diseases Composition containing influenza vaccine

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JP2014513680A (ja) 2011-04-21 2014-06-05 バクスター・インターナショナル・インコーポレイテッド ワクチンから抗原を単離し定量する方法
WO2013173256A2 (en) 2012-05-16 2013-11-21 Kj Biosciences, Llc New and improved influenza vaccines
WO2016028776A1 (en) 2014-08-18 2016-02-25 Sanofi Pasteur Biologics Llc Alkylated influenza vaccines

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Also Published As

Publication number Publication date
EA202090587A1 (ru) 2020-08-24
AU2018325899B2 (en) 2023-04-20
KR102733152B1 (ko) 2024-11-21
EP3679948A1 (en) 2020-07-15
CN111372605A (zh) 2020-07-03
EP3679948A4 (en) 2021-04-28
AU2018325899A1 (en) 2020-04-09
CA3074581A1 (en) 2019-03-07
CN111372605B (zh) 2024-12-17
JP2019043937A (ja) 2019-03-22
KR20200047629A (ko) 2020-05-07
US20190345231A1 (en) 2019-11-14
PH12020500414A1 (en) 2021-03-08
SG11202001937TA (en) 2020-04-29
US11732031B2 (en) 2023-08-22

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