JP7388281B2 - Liquid chromatograph and liquid chromatograph control method - Google Patents

Description

The present invention relates to a liquid chromatograph and a method for controlling a liquid chromatograph.

A liquid chromatograph is known as an analysis device that separates substances contained in a sample into different components. In a liquid chromatograph, a method file is created that describes sample analysis conditions and the like. Various components of the liquid chromatograph, such as pumps, are controlled based on the created method file.

Patent Document 1 describes a chromatograph device control device that creates a method file that can control a liquid chromatograph or a supercritical fluid chromatograph. In this chromatography apparatus control device, a user makes settings for a mobile phase and a column on a predetermined screen displayed on a display unit. Further, the user specifies a base method file in which standard analysis conditions are described in advance. A method file is created based on the configured mobile phase and column and the specified base method file.

International Publication No. 2018/131068

In liquid chromatographs, the mobile phase used is frequently changed depending on the sample to be analyzed. Therefore, it is necessary to create a method file corresponding to the mobile phase each time the mobile phase is replaced. However, in the chromatography apparatus control device of Patent Document 1, a user may make a mistake when creating a method file. In this case, a proper analysis of the sample cannot be performed.

An object of the present invention is to provide a liquid chromatograph and a method for controlling a liquid chromatograph that can easily perform appropriate analysis of a sample.

One aspect of the present invention includes a mobile phase monitor that monitors the remaining amount of the mobile phase and registers information about the mobile phase as mobile phase information, a pump that supplies the mobile phase, and a description of sample analysis conditions. a method file acquisition unit that acquires the method file obtained by the mobile phase monitor; a mobile phase information acquisition unit that acquires the mobile phase information from the mobile phase monitor; and a method file acquired by the method file acquisition unit and the mobile phase information acquisition unit that acquires the method file. a control information generation unit that generates control information for controlling the pump based on the mobile phase information obtained by the pump, and a plurality of mobile phase monitors are provided so as to respectively correspond to a plurality of types of mobile phases, A plurality of the pumps are provided, and the mobile phase information registered in each mobile phase monitor further includes a correspondence relationship between the mobile phase for the mobile phase monitor and the pump that supplies the mobile phase, and The present invention relates to a liquid chromatograph that generates control information further based on the correspondence acquired by the mobile phase information acquisition section .

Other aspects of the present invention include a step of acquiring a method file in which sample analysis conditions are described, and a mobile phase monitor that monitors the remaining amount of the mobile phase and registers information about the mobile phase as mobile phase information. and generating control information for controlling a pump that supplies a mobile phase based on the obtained method file and the obtained mobile phase information , A plurality of phase monitors are provided so as to correspond to a plurality of types of mobile phases, and a plurality of pumps are provided, and the mobile phase information registered in each mobile phase monitor includes the mobile phase for the mobile phase monitor, and the mobile phase information for the mobile phase monitor. The present invention relates to a method for controlling a liquid chromatograph, further including a correspondence relationship with a pump that supplies a mobile phase, and the step of generating the control information further including generating control information based on the obtained correspondence relationship.
Still other aspects of the present invention include a mobile phase monitor that monitors the remaining amount of the mobile phase and registers information about the mobile phase as mobile phase information, a pump that supplies the mobile phase, and sample analysis conditions. a method file acquisition unit that acquires a method file in which is written; a mobile phase information acquisition unit that acquires mobile phase information from the mobile phase monitor; and a method file and mobile phase information acquisition unit that acquires the method file acquired by the method file acquisition unit. and a control information generation unit that generates control information for controlling the pump based on the mobile phase information acquired by the mobile phase information, and the mobile phase monitor is provided with a plurality of mobile phase monitors each corresponding to a plurality of types of mobile phases. The present invention relates to a liquid chromatograph in which mobile phase information regarding a corresponding mobile phase is registered in each mobile phase monitor.
Still other aspects of the present invention include a step of acquiring a method file in which sample analysis conditions are described, and a mobile phase in which the remaining amount of the mobile phase is monitored and information about the mobile phase is registered as mobile phase information. acquiring mobile phase information from a monitor; and generating control information for controlling a pump that supplies a mobile phase based on the acquired method file and the acquired mobile phase information; The present invention relates to a liquid chromatograph control method in which a plurality of phase monitors are provided so as to correspond to a plurality of types of mobile phases, respectively, and mobile phase information regarding a corresponding mobile phase is registered in each mobile phase monitor.

According to the present invention, it is possible to easily perform appropriate analysis of a sample.

1 is a diagram showing the configuration of a liquid chromatograph according to an embodiment of the present invention. It is a figure which shows an example of a method file. 2 is a diagram showing the configuration of the control device in FIG. 1. FIG. FIG. 3 is a diagram showing an example of mobile phase information. FIG. 7 is a diagram showing another example of mobile phase information. 4 is a flowchart illustrating an example of an algorithm of control processing executed by the control device of FIG. 3. FIG.

(1) Structure of Liquid Chromatograph Hereinafter, a liquid chromatograph and a method of controlling the liquid chromatograph according to an embodiment of the present invention will be described in detail with reference to the drawings. FIG. 1 is a diagram showing the configuration of a liquid chromatograph according to an embodiment of the present invention. As shown in FIG. 1, the liquid chromatograph 100 includes a mobile phase supply section 10, a sample supply section 20, a column oven 30, a detector 40, and a control device 50.

Mobile phase supply 10 includes one or more bottles 11 , one or more pumps 12 , one or more mobile phase monitors 13 and mixer 14 . When mobile phase supply section 10 includes only one pump 12, mobile phase supply section 10 does not need to include mixer 14. In this example, mobile phase supply unit 10 includes four bottles 11, four pumps 12, four mobile phase monitors 13, and mixer 14.

Hereinafter, when distinguishing between the four bottles 11, the four bottles 11 will be referred to as bottles 11A to 11D, respectively. When distinguishing between the four pumps 12, the four pumps 12 are referred to as pumps 12A to 12D, respectively. When distinguishing the four mobile phase monitors 13, the four mobile phase monitors 13 are called mobile phase monitors 13A to 13D, respectively.

Bottles 11A to 11D each store different types of aqueous solutions or organic solvents as mobile phases. In this example, pumps 12A-12D are connected to bottles 11A-11D, respectively. Note that the correspondence between the pump 12 and the bottle 11 is not limited to this example. One pump 12 may be connected to two or more bottles 11, or two or more pumps 12 may be connected to one bottle 11. Each pump 12 supplies the mobile phase stored in the corresponding bottle 11 downstream.

Mobile phase monitors 13A-13D correspond to bottles 11A-11D, respectively. Each mobile phase monitor 13 measures the remaining amount of mobile phase stored in the corresponding bottle 11. When the remaining amount of the mobile phase decreases to a predetermined value or less, the control device 50 issues a warning to the user or stops the operation of the liquid chromatograph 100. Furthermore, information about the mobile phase stored in the corresponding bottle 11 (hereinafter referred to as mobile phase information) is registered in each mobile phase monitor 13. Details of the mobile phase information will be described later. Mixer 14 mixes the mobile phases from pumps 12A to 12D and supplies the mixture to the downstream.

The sample supply unit 20 includes, for example, an autoinjector, and mixes the sample to be analyzed with the mobile phase from the mobile phase supply unit 10. The column oven 30 accommodates one or more separation columns 31 and adjusts the separation columns 31 to a predetermined temperature. The mobile phase mixed with the sample by the sample supply unit 20 is introduced into one of the separation columns 31 . The separation column 31 retains the components of the sample for different times depending on the affinity of each component of the sample in the introduced mobile phase with the separation column 31 and the mobile phase.

The detector 40 includes, for example, an absorbance detector or an RI (Refractive Index) detector, and sequentially detects the components of the sample eluted from the separation column 31 after the retention time by the separation column 31 has elapsed. Control device 50 includes a CPU (Central Processing Unit) and a storage section, and controls the operations of mobile phase supply section 10, sample supply section 20, column oven 30, and detector 40. Further, the control device 50 is connected to a database storage device 200 external to the liquid chromatograph 100. Details of the control device 50 will be described later.

The database storage device 200 stores in advance a plurality of method files in which sample analysis conditions are described. FIG. 2 is a diagram showing an example of a method file. In the example of FIG. 2, the total flow rate by the pump, the temperature of the column oven 30, and the amount of sample injected by the sample supply unit 20 are described in the method file as sample analysis conditions. If a gradient analysis of the sample is performed, the flow rate ratios of multiple pumps are further described in the method file. Identification information of the separation column 31, output format of analysis results, etc. may be further described in the method file.

(2) Control device FIG. 3 is a diagram showing the configuration of the control device 50 in FIG. 1. As shown in FIG. 3, the control device 50 includes a method file acquisition section 51, a mobile phase information acquisition section 52, a control information generation section 53, an apparatus control section 54, an analysis result acquisition section 55, and a report creation section as functional sections. Contains 56. Functional units of the control device 50 are realized by the CPU of the control device 50 executing the control program stored in the storage unit. Part or all of the functional units of the control device 50 may be realized by hardware such as an electronic circuit.

The method file acquisition unit 51 acquires one of the method files from the database storage device 200. The user can specify a desired method file to be acquired by the method file acquisition unit 51. If a plurality of method files are stored in advance in the storage section of the control device 50, the method file acquisition section 51 may acquire the method files from the storage section.

The mobile phase information acquisition unit 52 acquires mobile phase information registered in each mobile phase monitor 13. The mobile phase information includes the name of the mobile phase stored in the bottle 11 corresponding to the mobile phase monitor 13, the compression ratio of the mobile phase, the remaining amount of the mobile phase, and the identification information of the pump 12 corresponding to the mobile phase. When the user changes the mobile phase by replacing the bottle 11, etc., the user displays the name of the changed mobile phase, the compression ratio of the mobile phase, and the mobile phase corresponding to the changed mobile phase on the mobile phase monitor 13 corresponding to the bottle 11. Enter the identification information of the pump 12 to be used. In this case, the mobile phase information registered in the mobile phase monitor 13 is updated.

The control information generation unit 53 generates control information based on the analysis conditions in the method file acquired by the method file acquisition unit 51 and the compression rate of the mobile phase in the mobile phase information acquired by the mobile phase information acquisition unit 52. do. The control information is information for controlling the operations of the pump 12, mixer 14, sample supply section 20, column oven 30, and detector 40 so as to analyze the sample under predetermined analysis conditions and the compressibility of the mobile phase.

The device control section 54 controls the operations of the pump 12, mixer 14, sample supply section 20, column oven 30, and detector 40 according to the control information generated by the control information generation section 53. The analysis result acquisition unit 55 acquires analysis results by processing the detection results by the detector 40. The analysis results include a liquid chromatogram showing the relationship between the retention time of each component of the sample by the separation column 31 and the detection intensity.

The report creation unit 56 creates a report in which the name of the mobile phase used, the analysis conditions, and the analysis results obtained by the analysis result acquisition unit 55 are described. The report may further include the compressibility of the mobile phase and the remaining amount of mobile phase.

FIG. 4 is a diagram showing an example of mobile phase information. In the example of FIG. 4, the mobile phase name, mobile phase compressibility, mobile phase remaining amount, and pump identification information corresponding to the first mobile phase monitor 13A are "mobile phase A" and "A [/ GPa], “A [mL]” and “Pump A”. The name of the mobile phase, the compressibility of the mobile phase, the remaining amount of the mobile phase, and the pump identification information corresponding to the second mobile phase monitor 13B are "mobile phase B", "B[/GPa]", and "B [mL]” and “Pump B”.

The mobile phase name, mobile phase compressibility, remaining amount of mobile phase, and pump identification information corresponding to the third mobile phase monitor 13C are "mobile phase C", "C[/GPa]", and "C [mL]” and “Pump C”. The mobile phase name, mobile phase compressibility, remaining amount of mobile phase, and pump identification information corresponding to the fourth mobile phase monitor 13D are "mobile phase D", "D[/GPa]", and "D [mL]” and “Pump D”. Note that "Pump A" to "Pump D" are identification information of the first to fourth pumps 12A to 12D (FIG. 1), respectively.

In the example of FIG. 1, the first to fourth pumps 12A to 12D are connected to the first to fourth bottles 11A to 11D, but the embodiment is not limited thereto. FIG. 5 is a diagram showing another example of mobile phase information. In the example of FIG. 5, first to third pumps 12A to 12C are connected to first to third bottles 11A to 11C, respectively. A fourth pump 12D and a fifth pump (identification information "Pump E"), not shown, are connected to the fourth bottle 11D. In this case, as shown in FIG. 5, the identification information of the pumps corresponding to the fourth mobile phase monitor 13D are "pump D" and "pump E."

(3) Control Processing FIG. 6 is a flowchart showing an example of an algorithm for the control processing executed by the control device 50 of FIG. 3. First, the method file acquisition unit 51 determines whether a method file has been specified (step S1). The user specifies a desired method file from a plurality of method files stored in the database storage device 200 or the storage section of the control device 50. If no method file is specified, the method file acquisition unit 51 waits until a method file is specified.

If a method file is specified, the method file acquisition section 51 acquires the specified method file from the database storage device 200 or the storage section of the control device 50 (step S2). The mobile phase information acquisition unit 52 acquires registered mobile phase information from each mobile phase monitor 13 (step S3). In this example, step S3 is executed in response to step S2 being executed, but step S3 may be executed at any time before step S4.

The control information generation unit 53 generates control information based on the method file acquired in step S2 and the mobile phase information acquired in step S3 (step S4). Thereafter, the device control unit 54 determines whether or not an instruction to start analysis has been given (step S5). The user can instruct the device control unit 54 to start analysis. If the start of analysis is not instructed (for example, if another method file is specified), the device control unit 54 returns to step S1. Steps S1 to S5 are repeated until the start of analysis is commanded.

When the start of analysis is instructed, the device control unit 54 controls the operations of the pump 12, mixer 14, sample supply unit 20, column oven 30, and detector 40 based on the control information generated in step S4. , execute the analysis (step S6). The analysis result acquisition unit 55 acquires an analysis result by processing the detection result by the detector 40 (step S7).

The report creation unit 56 creates a report in which the analysis conditions of the method file acquired in step S2, the mobile phase information acquired in step S3, and the analysis results acquired in step S7 are described (step S8). . This ends the control process.

In the example of FIG. 6, the control process includes the process of step S5, but the embodiment is not limited thereto. The control process may not include the process of step S5. In this case, after control information is generated in step S4, analysis is started based on the control information. Alternatively, after the control information is generated in step S4, the control process may be ended without starting the analysis. In this case, the user can instruct the start of analysis based on the generated control information at a desired time.

(4) Effects In the liquid chromatograph 100 according to the present embodiment, information about the mobile phase is registered as mobile phase information in the mobile phase monitor 13 that monitors the remaining amount of the mobile phase. A method file in which sample analysis conditions are described is acquired by the method file acquisition unit 51. Mobile phase information is acquired from the mobile phase monitor 13 by the mobile phase information acquisition unit 52 . The control information generation unit generates control information for controlling the pump 12 that supplies the mobile phase based on the method file acquired by the method file acquisition unit 51 and the mobile phase information acquired by the mobile phase information acquisition unit 52. 53.

If the name of the mobile phase and the compressibility of the mobile phase are registered in the control device 50 as environmental information of the liquid chromatograph 100, control information for controlling the pump 12 using the environmental information registered in the control device 50. It is possible to generate However, in this case, each time the mobile phase is replaced with another mobile phase, it is necessary for a technician such as a field engineer to install the liquid chromatograph 100 and register the environmental information again. Therefore, the cost becomes high and the convenience of the liquid chromatograph 100 decreases.

In contrast, according to the present embodiment, the compression ratio of the mobile phase is acquired from the mobile phase monitor 13. Thereby, control information for controlling the pump 12 is automatically generated. Therefore, the user does not need to input the compression ratio of the mobile phase when generating control information. Therefore, control information including the compression ratio of the mobile phase can be generated while preventing information input errors or operation errors by the user from occurring. As a result, the sample can be easily analyzed appropriately. Further, it is possible to prevent an increase in costs and a decrease in the convenience of the liquid chromatograph 100.

The mobile phase information further includes the correspondence between the mobile phase and the pump 12 that supplies the mobile phase. Therefore, even if the liquid chromatograph 100 is provided with a plurality of pumps 12 and a plurality of types of mobile phases are used for analysis, control information can be easily generated.

In addition, the report describes the analysis results and also describes the mobile phase information registered in the mobile phase monitor 13. Therefore, the user does not need to input mobile phase information when creating a report. Therefore, a report can be created while preventing information input errors or operation errors by the user from occurring. This allows accurate recording of information about the mobile phase used in the analysis. As a result, the usability of the liquid chromatograph 100 can be further improved without impairing the reliability of analysis results.

(5) Other Embodiments Although the control device 50 includes a device control section 54, an analysis result acquisition section 55, and a report creation section 56, the embodiments are not limited thereto. If the control processing ends after the control information is generated, the control device 50 does not need to include the device control section 54, the analysis result acquisition section 55, and the report creation section 56. Furthermore, if the report does not include mobile phase information, the control device 50 does not need to include the report creation unit 56.

(6) Aspects Those skilled in the art will understand that the multiple exemplary embodiments described above are specific examples of the following aspects.

(Section 1) The liquid chromatograph according to one embodiment includes:
a mobile phase monitor that monitors the remaining amount of the mobile phase and registers information about the mobile phase as mobile phase information;
a pump supplying a mobile phase;
a method file acquisition unit that acquires a method file that describes sample analysis conditions;
a mobile phase information acquisition unit that acquires mobile phase information from the mobile phase monitor;
The method may further include a control information generation section that generates control information for controlling the pump based on the method file acquired by the method file acquisition section and the mobile phase information acquired by the mobile phase information acquisition section. .

In this liquid chromatograph, information about the mobile phase is registered as mobile phase information in a mobile phase monitor that monitors the remaining amount of the mobile phase. A method file in which sample analysis conditions are described is acquired by the method file acquisition unit. Mobile phase information is acquired from the mobile phase monitor by a mobile phase information acquisition unit. Based on the method file acquired by the method file acquisition unit and the mobile phase information acquired by the mobile phase information acquisition unit, control information for controlling the pump that supplies the mobile phase is generated by the control information generation unit. Ru.

According to this configuration, control information for controlling the pump is automatically generated by acquiring mobile phase information from the mobile phase monitor. Therefore, the user does not need to input mobile phase information when generating control information. Therefore, control information including mobile phase information can be generated while preventing information input errors or operation errors by the user from occurring. As a result, the sample can be easily analyzed appropriately.

(Section 2) In the liquid chromatograph described in Section 1,
The mobile phase information registered in the mobile phase monitor includes a compression ratio of the mobile phase,
The control information generation unit may generate control information based on the method file acquired by the method file acquisition unit and the compression rate of the mobile phase acquired by the mobile phase information acquisition unit.

In this case, control information including the compression ratio of the mobile phase can be generated while preventing information input errors or operation errors by the user from occurring. Thereby, the sample can be easily analyzed appropriately.

(Section 3) In the liquid chromatograph according to Item 1 or 2,
A plurality of mobile phase monitors are provided so as to correspond to a plurality of types of mobile phases, respectively,
A plurality of the pumps are provided,
The mobile phase information registered in each mobile phase monitor further includes a correspondence relationship between the mobile phase for the mobile phase monitor and the pump that supplies the mobile phase,
The control information generation section may generate control information further based on the correspondence acquired by the mobile phase information acquisition section.

According to this configuration, control information can be easily generated even when a liquid chromatograph is provided with a plurality of pumps and a plurality of types of mobile phases are used for analysis.

(Section 4) The liquid chromatograph according to any one of Items 1 to 3,
an apparatus control unit that controls operation of the pump based on control information generated by the control information generation unit;
The apparatus may further include an analysis result acquisition section that acquires analysis results of the sample using the mobile phase supplied by the pump.

In this case, based on the generated control information, a sample can be analyzed using the mobile phase supplied by the pump, and analysis results can be obtained.

(Section 5) The liquid chromatograph described in Section 4 is
The apparatus may further include a report creation section that creates a report in which mobile phase information registered in the mobile phase monitor and analysis results acquired by the analysis result acquisition section are described.

In this case, the report describes the analysis results and also describes the mobile phase information registered in the mobile phase monitor. Therefore, the user does not need to input mobile phase information when creating a report. Therefore, a report can be created while preventing information input errors or operation errors by the user from occurring. This allows accurate recording of information about the mobile phase used in the analysis. As a result, the convenience of the liquid chromatograph can be improved without impairing the reliability of analysis results.

(Section 6) A method for controlling a liquid chromatograph according to another aspect includes:
a step of obtaining a method file that describes sample analysis conditions;
monitoring the remaining amount of the mobile phase and acquiring mobile phase information from a mobile phase monitor in which information about the mobile phase is registered as mobile phase information;
The method may include a step of generating control information for controlling a pump that supplies a mobile phase based on the acquired method file and the acquired mobile phase information.

According to this liquid chromatograph control method, control information for controlling the pump is automatically generated by acquiring mobile phase information from a mobile phase monitor. Therefore, the user does not need to input mobile phase information when generating control information. Therefore, control information including mobile phase information can be generated while preventing information input errors or operation errors by the user from occurring. As a result, the sample can be easily analyzed appropriately.

10... Mobile phase supply section, 11, 11A to 11D... Bottle, 12, 12A to 12D... Pump, 13, 13A to 13D... Mobile phase monitor, 14... Mixer, 20... Sample supply section, 30... Column oven, 31... Separation column, 40...Detector, 50...Control device, 51...Method file acquisition section, 52...Mobile phase information acquisition section, 53...Control information generation section, 54...Device control section, 55...Processing section, 56...Report Creation unit, 100...Liquid chromatograph, 200...Database storage device

Claims (8)

a mobile phase monitor that monitors the remaining amount of the mobile phase and registers information about the mobile phase as mobile phase information;
a pump supplying a mobile phase;
a method file acquisition unit that acquires a method file that describes sample analysis conditions;
a mobile phase information acquisition unit that acquires mobile phase information from the mobile phase monitor;
a control information generation unit that generates control information for controlling the pump based on the method file acquired by the method file acquisition unit and the mobile phase information acquired by the mobile phase information acquisition unit ,
A plurality of mobile phase monitors are provided so as to correspond to a plurality of types of mobile phases, respectively,
A plurality of the pumps are provided,
The mobile phase information registered in each mobile phase monitor further includes a correspondence relationship between the mobile phase for the mobile phase monitor and the pump that supplies the mobile phase,
The control information generation section is a liquid chromatograph that generates control information further based on the correspondence acquired by the mobile phase information acquisition section. The mobile phase information registered in the mobile phase monitor includes a compression ratio of the mobile phase,
The liquid according to claim 1, wherein the control information generation unit generates control information based on the method file acquired by the method file acquisition unit and the compression ratio of the mobile phase acquired by the mobile phase information acquisition unit. Chromatograph. an apparatus control unit that controls operation of the pump based on control information generated by the control information generation unit;
The liquid chromatograph according to claim 1 or 2 , further comprising an analysis result acquisition section that acquires an analysis result of the sample using the mobile phase supplied by the pump. The liquid chromatograph according to claim 3 , further comprising a report creation unit that creates a report in which mobile phase information registered in the mobile phase monitor and analysis results acquired by the analysis result acquisition unit are described. . a step of obtaining a method file that describes sample analysis conditions;
monitoring the remaining amount of the mobile phase and acquiring mobile phase information from a mobile phase monitor in which information about the mobile phase is registered as mobile phase information;
generating control information for controlling a pump that supplies a mobile phase based on the acquired method file and the acquired mobile phase information ,
A plurality of mobile phase monitors are provided so as to correspond to a plurality of types of mobile phases, respectively,
A plurality of the pumps are provided,
The mobile phase information registered in each mobile phase monitor further includes a correspondence relationship between the mobile phase for the mobile phase monitor and the pump that supplies the mobile phase,
A method for controlling a liquid chromatograph, wherein the step of generating control information further includes generating control information based on the obtained correspondence . a mobile phase monitor that monitors the remaining amount of the mobile phase and registers information about the mobile phase as mobile phase information;
a pump supplying a mobile phase;
a method file acquisition unit that acquires a method file that describes sample analysis conditions;
a mobile phase information acquisition unit that acquires mobile phase information from the mobile phase monitor;
a control information generation unit that generates control information for controlling the pump based on the method file acquired by the method file acquisition unit and the mobile phase information acquired by the mobile phase information acquisition unit,
A plurality of mobile phase monitors are provided so as to correspond to a plurality of types of mobile phases, respectively,
A liquid chromatograph in which mobile phase information about a corresponding mobile phase is registered in each mobile phase monitor. 7. The liquid chromatograph according to claim 6, wherein the mobile phase information registered in the mobile phase monitor includes a name and/or a compression ratio of the mobile phase. a step of obtaining a method file that describes sample analysis conditions;
monitoring the remaining amount of the mobile phase and acquiring mobile phase information from a mobile phase monitor in which information about the mobile phase is registered as mobile phase information;
generating control information for controlling a pump that supplies a mobile phase based on the acquired method file and the acquired mobile phase information,
A plurality of mobile phase monitors are provided so as to correspond to a plurality of types of mobile phases, respectively,
A liquid chromatograph control method in which mobile phase information about a corresponding mobile phase is registered in each mobile phase monitor.

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