JP7379390B2 - 癌の治療に使用するためのlif阻害剤と白金系抗悪性腫瘍剤の組み合わせ - Google Patents

癌の治療に使用するためのlif阻害剤と白金系抗悪性腫瘍剤の組み合わせ Download PDF

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JP7379390B2
JP7379390B2 JP2020570163A JP2020570163A JP7379390B2 JP 7379390 B2 JP7379390 B2 JP 7379390B2 JP 2020570163 A JP2020570163 A JP 2020570163A JP 2020570163 A JP2020570163 A JP 2020570163A JP 7379390 B2 JP7379390 B2 JP 7379390B2
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amino acid
acid sequence
lif
seq
certain embodiments
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JP2021533084A (ja
JPWO2019243900A5 (enExample
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ジョアン・セオアネ・スアレス
ジュディット・アニド・フォルゲイラ
ロビン・マシュー・ハレット
パトリシア・アン・ギブリン
ジェンヌ・マグラム
ナイミシュ・パーンディヤ
ロバート・ワッサーマン
アンガス・シンクレア
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Fundacio Privada Institut dInvestigacio Oncologica Vall dHebron
MedImmune Ltd
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Fundacio Privada Institut dInvestigacio Oncologica Vall dHebron
MedImmune Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/282Platinum compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020570163A 2018-06-18 2019-06-17 癌の治療に使用するためのlif阻害剤と白金系抗悪性腫瘍剤の組み合わせ Active JP7379390B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023187689A JP7603772B2 (ja) 2018-06-18 2023-11-01 癌の治療に使用するためのlif阻害剤と白金系抗悪性腫瘍剤の組み合わせ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18382432 2018-06-18
EP18382432.5 2018-06-18
PCT/IB2019/000812 WO2019243900A2 (en) 2018-06-18 2019-06-17 Combination of lif inhibitors and platinum-based antineoplastic agents for use in treating cancer

Related Child Applications (1)

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JP2023187689A Division JP7603772B2 (ja) 2018-06-18 2023-11-01 癌の治療に使用するためのlif阻害剤と白金系抗悪性腫瘍剤の組み合わせ

Publications (3)

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JP2021533084A JP2021533084A (ja) 2021-12-02
JPWO2019243900A5 JPWO2019243900A5 (enExample) 2022-06-24
JP7379390B2 true JP7379390B2 (ja) 2023-11-14

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JP2020570163A Active JP7379390B2 (ja) 2018-06-18 2019-06-17 癌の治療に使用するためのlif阻害剤と白金系抗悪性腫瘍剤の組み合わせ
JP2023187689A Active JP7603772B2 (ja) 2018-06-18 2023-11-01 癌の治療に使用するためのlif阻害剤と白金系抗悪性腫瘍剤の組み合わせ

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JP2023187689A Active JP7603772B2 (ja) 2018-06-18 2023-11-01 癌の治療に使用するためのlif阻害剤と白金系抗悪性腫瘍剤の組み合わせ

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Country Link
US (1) US20210187106A1 (enExample)
EP (1) EP3806899A2 (enExample)
JP (2) JP7379390B2 (enExample)
KR (1) KR20210022065A (enExample)
CN (1) CN112955178B (enExample)
AU (2) AU2019291307B2 (enExample)
CA (1) CA3103369A1 (enExample)
EA (1) EA202092964A1 (enExample)
IL (1) IL279444A (enExample)
MA (1) MA52300A (enExample)
SG (1) SG11202012576QA (enExample)
WO (1) WO2019243900A2 (enExample)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013523796A (ja) 2010-04-05 2013-06-17 フンダシオ プリバーダ インスティトゥト ディンベスティガシオ オンコロジカ バル デブロン(ウベアチェイーオー) ヒト白血病阻害因子(lif)を認識する抗体および望ましくない細胞増殖に関連する疾患の治療における抗lif抗体の使用
WO2016168440A1 (en) 2015-04-17 2016-10-20 Morphotek, Inc. Methods for treating lung cancer
JP2017527582A (ja) 2014-09-10 2017-09-21 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア K−Rasによって媒介されるシグナリング経路および悪性疾患の抗hLIF抗体によるターゲティング方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
AU4231393A (en) * 1992-05-08 1993-12-13 Genentech Inc. Antibodies to leukemia inhibitory factor
EP0714409A1 (en) 1993-06-16 1996-06-05 Celltech Therapeutics Limited Antibodies
KR101155191B1 (ko) 1999-01-15 2012-06-13 제넨테크, 인크. 효과기 기능이 변화된 폴리펩티드 변이체
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
ES2363358B1 (es) * 2009-04-03 2012-06-21 FUNDACIÓ INSTITUT DE RECERCA HOSPITAL UNIVERSITARI VALL D'HEBRON (Titular al Agentes terapéuticos para el tratamiento de enfermedades asociadas con una proliferación celular indeseable.
WO2018115960A1 (en) * 2016-12-19 2018-06-28 Mosaic Biomedicals, S.L. Antibodies against lif and uses thereof
KR20210008514A (ko) * 2018-05-14 2021-01-22 메디뮨 리미티드 Lif에 대한 항체 및 이의 투여 형태

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013523796A (ja) 2010-04-05 2013-06-17 フンダシオ プリバーダ インスティトゥト ディンベスティガシオ オンコロジカ バル デブロン(ウベアチェイーオー) ヒト白血病阻害因子(lif)を認識する抗体および望ましくない細胞増殖に関連する疾患の治療における抗lif抗体の使用
JP2017527582A (ja) 2014-09-10 2017-09-21 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア K−Rasによって媒介されるシグナリング経路および悪性疾患の抗hLIF抗体によるターゲティング方法
WO2016168440A1 (en) 2015-04-17 2016-10-20 Morphotek, Inc. Methods for treating lung cancer

Also Published As

Publication number Publication date
AU2024204564A1 (en) 2024-07-18
KR20210022065A (ko) 2021-03-02
AU2019291307A1 (en) 2021-02-04
WO2019243900A2 (en) 2019-12-26
EP3806899A2 (en) 2021-04-21
AU2019291307B2 (en) 2024-04-04
JP2024023212A (ja) 2024-02-21
JP2021533084A (ja) 2021-12-02
JP7603772B2 (ja) 2024-12-20
CA3103369A1 (en) 2019-12-26
IL279444A (en) 2021-01-31
MA52300A (fr) 2021-04-21
WO2019243900A3 (en) 2020-03-05
CN112955178A (zh) 2021-06-11
EA202092964A1 (ru) 2021-03-30
US20210187106A1 (en) 2021-06-24
SG11202012576QA (en) 2021-01-28
CN112955178B (zh) 2025-03-11

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