JP7327960B2 - Film containing volatile chemicals - Google Patents

Description

The present invention relates to films containing volatile agents.

BACKGROUND ART Volatile chemical-containing films are known in which chemicals that volatilize at room temperature, such as antibacterial agents, insect repellents, and fragrances, are contained in the film, and the chemicals are gradually released to exert the effects of the chemicals.

As a technique for controlling the sustained release of a volatile drug, Patent Document 1 below discloses a means of impregnating the adhesive layer with a volatile drug after forming an adhesive layer on a base material. .

JP-A-6-212136

However, with the configuration disclosed in Patent Document 1, sustained release properties cannot be controlled to the extent that the efficacy of the drug can be maintained over a longer period of time.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a volatile drug-containing film that can maintain the efficacy of the drug over a longer period of time.

A volatile chemical-containing film according to the present invention for achieving the above object comprises a volatile chemical layer formed using a composition containing a volatile chemical and an adhesive, and outermost layers sandwiching the volatile chemical layer. and an adhesive layer disposed between said volatile drug layer and said volatile drug impermeable layer, said adhesive layer comprising: It has a channel through which the volatile chemical can flow out from the side surface of the adhesive layer. The flow path has a concave shape along the stacking direction.

According to the volatile chemical-containing film described above, since the volatile chemical has a flow path through which the volatile chemical can flow out, the effect of the chemical can be maintained over a longer period of time.

1 is a cross-sectional view showing a volatile drug-containing film according to an embodiment of the invention; FIG. It is a bottom view which shows one form of an adhesive bond layer. It is a bottom view which shows the modification of an adhesive bond layer. It is a bottom view which shows the modification of an adhesive bond layer.

Hereinafter, embodiments of the present invention will be described with reference to the attached drawings. In the description of the drawings, the same elements are denoted by the same reference numerals, and overlapping descriptions are omitted. Also, the dimensional ratios in the drawings are exaggerated for convenience of explanation, and may differ from the actual ratios.

In this specification, "X to Y" indicating a range means "X or more and Y or less". In addition, unless otherwise specified, operations, measurement of physical properties, etc. are performed under the conditions of room temperature (20 to 25° C.)/relative humidity of 45 to 55%. Volatile chemicals are also simply referred to as chemicals.

Hereinafter, a volatile chemical-containing film 1 according to this embodiment will be described with reference to FIGS. 1 and 2. FIG. FIG. 1 is a cross-sectional view showing a volatile chemical-containing film 1 according to an embodiment of the invention. FIG. 2 is a bottom view showing one form of the adhesive layer 40. FIG.

As shown in FIG. 1, the volatile chemical-containing film 1 according to this embodiment includes, in order from the bottom, a first volatile chemical-impermeable layer 10, a volatile chemical layer 20, and a chemical-permeable layer 30. , an adhesive layer 40 and a second volatile agent impermeable layer 50 .

<First volatile agent impermeable layer 10>
As the first volatile agent impermeable layer 10, a resin film such as polyester such as polyethylene terephthalate and polyethylene naphthalate, polyacrylonitrile, ethylene-vinyl alcohol copolymer, polyamide, polycarbonate, polyvinylidene chloride; (e.g., aluminum), metal oxides (e.g., aluminum oxide, silicon oxide, magnesium oxide, etc.), metal foils, and the like. From the viewpoint of workability and light weight, the first volatile chemical impermeable layer is preferably a resin film. Among them, from the viewpoint of dimensional stability, the first volatile chemical impermeable layer is polyethylene terephthalate. Preferably. The first volatile chemical impermeable layer may be a stretched film, a non-stretched film, or may be formed by a casting method or the like using process materials.

The thickness of the first volatile chemical impermeable layer 10 is preferably 5 to 200 μm in consideration of the impermeability of the chemical.

Here, it is preferable that the permeation amount of the drug through the first volatile drug impermeable layer 10 per day is 0.1% or less of the total permeation amount at 30°C. As used herein, the term “drug permeation amount per day” refers to the value obtained by dividing the permeation amount at the time when the drug is almost released by the number of days from the start until the drug is almost released, A value divided by the surface area of the drug-impermeable layer 10 is shown.

<Volatile chemical layer 20>
Volatile agent layer 20 is made using a composition that includes a volatile agent and an adhesive. A composition comprising a volatile agent and an adhesive is hereinafter also referred to as an adhesive composition.

Volatile agents include, for example, lavender oil, peppermint oil, lemon oil, rose oil, camphor oil, sandalwood oil, cypress oil, citronella oil, cinnamon oil, tea tree oil, hiba oil, cinnamon oil, eucalyptus oil, and eucalyptus citrio. Natural fragrances such as vegetable fragrances composed of plant essential oils such as gora, coriander oil, and thyme oil; synthetic fragrances composed of terpene compounds, ester compounds, aromatic compounds, etc.; , ethyl isothiocyanate, allyl isothiocyanate, isobutyl isothiocyanate, n-butyl isothiocyanate, phenyl isothiocyanate, and benzyl isothiocyanate.

By "volatile" is meant exhibiting a pharmacologically effective degree of volatility at 25°C.

The amount of volatile chemicals in the film is preferably 0.01 g/m ² or more, more preferably 0.1 to 20.0 g/m ² from the viewpoint of exhibiting efficacy. By setting it as such a density|concentration, the effect of a chemical|medical agent is exhibited appropriately.

As a resin that can be used as an adhesive, a resin that can form a mixture with a volatile chemical is preferably selected appropriately in relation to the desired volatile chemical so that it is compatible with the volatile chemical. good. That is, the preferred form of the present invention is a form in which the adhesive is compatible with the volatile chemical. Here, the term "compatibility" refers to a uniform state when both are mixed. Adhesives that contain water or organic solvents, such as resins obtained by solution polymerization, are not suitable because they require a step of drying the solvent after mixing the resin and the chemical, resulting in volatilization of the volatile chemical. Therefore, in this embodiment, it is preferable to use a non-solvent type adhesive. The resin is preferably compatible with a volatile chemical, but may be a resin compatible with a mixture of a volatile chemical dissolved in an oil or the like.

As adhesives, styrene-isoprene-styrene block copolymer (SIS), styrene-butadiene-styrene block copolymer (SBS), styrene/ethylene-butylene copolymer/styrene (SEBS), styrene/ethylene-propylene Copolymer/styrene (SEPS), styrene/butadiene (SB), styrene/isoprene (SI), styrene/ethylene-butylene copolymer (SEB), styrene/ethylene-propylene copolymer (SEP), styrene/butadiene Thermoplastic elastomeric adhesives such as rubber (SBR), ethylene-vinyl acetate copolymer (EVA), ethylene-ethyl acrylate copolymer (EEA), and mixtures thereof (such as mixtures of polypropylene and EPDM) Synthetic rubbers such as isoprene rubber, polybutene rubber, butyl rubber, acrylic rubber, rubber adhesives such as natural rubber; Urethane resins such as one-component moisture-curing urethane resin adhesives and two-component reactive urethane resin adhesives Examples include adhesives and the like.

Moreover, as the resin that can be used as an adhesive, resins other than those exemplified here can be used as long as they are compatible with the volatile chemical.

Adhesives also include pressure-sensitive adhesives. The pressure-sensitive adhesive is not particularly limited, and includes acrylic pressure-sensitive adhesives, rubber-based pressure-sensitive adhesives, silicone-based pressure-sensitive adhesives, urethane-based pressure-sensitive adhesives, polyester-based pressure-sensitive adhesives, and vinyl alkyl ethers. A pressure-sensitive adhesive, a polyamide-based pressure-sensitive adhesive, a fluorine-based pressure-sensitive adhesive, or the like can be used. The above pressure-sensitive adhesives may be used singly or in combination of two or more.

As the pressure-sensitive adhesive, an acrylic pressure-sensitive adhesive can be preferably used from the viewpoint of adhesion reliability. The acrylic polymer that constitutes the acrylic pressure-sensitive adhesive has (meth)acrylic acid alkyl ester as the main monomer component, and if necessary, a monomer that can be copolymerized with (meth)acrylic acid alkyl ester (copolymer polymerizable monomer). Here, the main component refers to 50% by mass or more (upper limit of 100% by mass) in the monomer, preferably 65% by mass or more, more preferably 85% by mass or more.

When a copolymerizable monomer is used, it is preferably 0.1 to 35% by mass, more preferably 1 to 15% by mass, of the monomer components constituting the acrylic polymer.

Although the weight average molecular weight of the acrylic polymer is not particularly limited, it is preferably 100,000 to 1,000,000. In addition, a weight average molecular weight is the value of polystyrene conversion measured by the gel permeation chromatography (GPC) method.

The pressure-sensitive adhesive may contain a cross-linking agent in addition to the acrylic polymer. Examples of cross-linking agents include isocyanate-based cross-linking agents, epoxy-based cross-linking agents, and metal chelate-based cross-linking agents. The amount of the cross-linking agent added is preferably 0.001 to 10 parts by mass, more preferably 0.005 to 0.5 parts by mass, based on 100 parts by mass of the acrylic polymer.

One type of adhesive may be used alone, or two or more types may be used in combination.

The adhesive composition may further comprise a tackifier. Tackifiers include rosin, polymerized rosin, disproportionated rosin, hydrogenated rosin, maleated rosin, fumarated rosin, and their glycerin esters, pentaerythritol esters, methyl esters, triethylene glycol esters, phenol-modified products, and rosins such as phenol-modified esters; terpene-based resins such as terpene polymers, terpene phenols, β-pinene polymers, aromatic modified terpene polymers, α-pinene polymers and terpene-based hydrogenated resins; Petroleum-based resins obtained by polymerizing petroleum fractions having 5 carbon atoms or petroleum fractions having 9 carbon atoms, hydrogenated resins thereof, and the like.

When a tackifier is included, the content in the adhesive composition is appropriately set in consideration of adhesiveness, but it is preferably 1 to 500 parts by mass, and 10 to 300 parts by mass with respect to 100 parts by mass of the adhesive. Parts by mass are more preferred.

In addition, the volatile agent layer may contain fillers such as titanium oxide, zinc oxide, calcium carbonate, calcium phosphate, and the like.

Although the thickness of the volatile agent layer is not particularly limited, it is, for example, 0.05 to 50 μm.

The mixing ratio of the volatile agent is preferably 5 to 90% by mass, more preferably 20 to 85% by mass, in the volatile agent layer, taking into consideration the release property and adhesiveness of the agent. Since the chemical is volatile, the content of the chemical decreases over time.

As a method for forming the volatile chemical layer, for example, the method described in JP-A-2000-343640 or the method described in JP-A-6-212136 can be used.

<Drug Permeable Layer 30>
As the drug-permeable layer, various materials may be appropriately selected and used as long as they are permeable to the volatile drug, and may be a single layer or multiple layers. Examples of the drug-permeable layer include polyolefin resins such as polyethylene and polypropylene, biodegradable resins such as polylactic acid, resin films such as vinyl chloride, paper, nonwoven fabric, cloth, synthetic paper, and composites thereof. mentioned. Among them, the drug-permeable layer is preferably a resin film, a composite of a resin film and paper or a non-woven fabric, because the amount of the drug can be easily controlled and the mechanical strength is ensured, and a polyolefin resin film is preferred. It is more preferable to have

In the case of laminating a nonwoven fabric or paper on a resin film, an adhesive is usually used on the surface (outer surface side) of the resin film in order to laminate the fibrous film. As the adhesive, adhesives used in ordinary dry lamination methods and wet lamination methods can be used. For example, acrylic, polyurethane, vinyl acetate, vinyl chloride, rubber, and other solvent-based adhesives can be used. Alternatively, a water-soluble adhesive or the like can be suitably used.

The drug permeable layer can also serve as a substrate for the volatile drug layer.

In this case, the thickness of the volatile drug layer formed from the adhesive used for forming the composite is preferably 0.1 to 30 μm in consideration of the permeability and adhesiveness of the drug. .

Although the thickness of the nonwoven fabric or paper is not particularly limited, it is usually about 5 to 50 μm considering the thickness of the entire film.

Here, it is preferable that the permeation amount of the drug through the drug-permeable layer per day at 25° C. is 5% or more (upper limit of 100%) of the total permeation amount. By having such permeability, the effect of the drug is easily exhibited and the duration of time is appropriate.

The thickness of the drug-permeable layer is appropriately set in consideration of sustained release properties, mechanical strength, etc., and is preferably 5 to 200 μm, more preferably 10 to 100 μm.

<Adhesive Layer 40>
As shown in FIGS. 1 and 2, the adhesive layer 40 has a concave shape at the bottom, and the concave portion corresponds to a channel 41 through which the volatile chemical can flow out.

In this embodiment, the channel 41 is formed on the lower surface of the adhesive layer 40, as shown in FIG. In addition, the position where the flow path is formed is not limited to this, and may be formed inside or on the upper surface of the adhesive layer.

In this embodiment, the flow paths 41 are formed in a grid pattern, as shown in FIG. Note that the channel is not particularly limited as long as it communicates with the outside (atmosphere) and has a configuration that allows the volatile chemical to flow out to the outside. As modifications of the channel 41 of the adhesive layer 40 according to the present embodiment, the channels 141 and 241 of the adhesive layers 140 and 240 are, for example, striped as shown in FIG. It may be a shape that is continuously formed. In the channels 41, 141, and 241 configured in this manner, the drug releasability can be controlled by appropriately changing the cross-sectional area of the channels and the pitch between adjacent channels.

The cross-sectional shape of the flow path 41 is triangular as shown in FIG. Note that the cross-sectional shape of the flow path is not limited to this, and may be rectangular, U-shaped, or the like.

In the triangular shape of the channel 41, the width at the bottom can be, for example, 0.01 mm to 2 mm. In addition, the triangular shape of the channel 41 can have a height of, for example, 1 μm to 50 μm. By setting the shape of the channel 41 to the above value, a desired amount of drug can be released.

As the adhesive, the same adhesive as described for the volatile chemical layer 20 can be used.

Here, the permeation amount of the drug per day in the flow path 41 of the adhesive layer 40 is greater than the permeation amount of the drug per day in the first volatile drug impermeable layer 10, and the drug permeable layer 30 less than the permeation amount per day of

The channel 41 can be formed by a method for manufacturing the volatile chemical-containing film 1, which will be described later.

<Second volatile agent impermeable layer 50>
As the second volatile chemical impermeable layer 50, the same material and thickness as those of the first volatile chemical impermeable layer 10 can be used.

<Method for producing volatile chemical-containing film 1>
Next, a method for manufacturing the volatile chemical-containing film 1 according to this embodiment will be described.

First, a pressure-sensitive adhesive is applied to a release liner (not shown). Here, the release liner is embossed to form projections corresponding to the flow paths 41 . Then, the adhesive layer 40 is formed on the release liner by drying and curing the pressure sensitive adhesive.

Then, the second volatile chemical impermeable layer 50 is attached to the adhesive layer 40 .

On the other hand, the volatile chemical layer 20 is laminated on the first volatile chemical impermeable layer 10 to form it. Next, the chemical permeable layer 30 is laminated on the surface of the volatile chemical layer 20 opposite to the first volatile chemical impermeable layer 10 .

Next, the release liner is peeled from the adhesive layer 40 and the adhesive layer 40 is adhered to the drug-permeable layer 30 to form the volatile drug-containing film 1 shown in FIG. At this time, flow paths 41 are formed in the adhesive layer 40 corresponding to the projections of the release liner.

As described above, the volatile chemical-containing film 1 according to the present embodiment sandwiches the volatile chemical layer 20 and the volatile chemical layer 20 formed using a composition containing a volatile chemical and an adhesive. a pair of volatile agent impermeable layers 10, 50 arranged as the outermost layers, and an adhesive layer 40 arranged between the volatile agent layer 20 and the volatile agent impermeable layers 10, 50; , and the adhesive layer 40 has a channel 41 through which the volatile chemical can flow out. The volatile chemical-containing film 1 configured as described above has the channel 41 through which the volatile chemical can flow out to the outside. Therefore, compared with a configuration in which the volatile chemical is released from the entire surface, the release path is narrow and long, so the amount of release can be reduced. Therefore, the efficacy of the drug can be maintained over a longer period of time.

It further has a drug-permeable layer 30 between the volatile drug layer 20 and the adhesive layer 40 . With this configuration, the amount of drug released is further reduced, and the effect of the drug is exhibited over a longer period of time. Furthermore, the mechanical strength of the volatile drug-containing film 1 is ensured.

Although the volatile chemical-containing film 1 according to the present invention has been described above through the embodiments, the present invention is not limited to the configurations described in the embodiments, and can be appropriately modified based on the description of the claims. Is possible.

For example, in the above-described embodiment, the volatile drug-containing film 1 has the drug-permeable layer 30, but it may be configured without the drug-permeable layer 30. FIG.

1 volatile agent-containing film,
10 first volatile agent-impermeable layer (volatile agent-impermeable layer),
20 volatile agent layer,
30 drug permeable layer,
40, 140, 240 adhesive layer,
41, 141, 241 channel,
50 Second volatile agent impermeable layer (volatile agent impermeable layer).

Claims (3)

a volatile agent layer formed using a composition containing a volatile agent and an adhesive;
a pair of volatile agent impermeable layers arranged as the outermost layers so as to sandwich the volatile agent layer;
an adhesive layer disposed between said volatile agent layer and said volatile agent impermeable layer;
The adhesive layer has a channel through which the volatile chemical can flow out from the side surface of the adhesive layer,
The volatile chemical-containing film , wherein the flow path has a concave shape along the stacking direction . A volatile drug-containing film according to claim 1, further comprising a drug-permeable layer between said volatile drug layer and said adhesive layer. A method for producing a volatile chemical-containing film according to claim 1 or 2,
A method for producing a volatile chemical-containing film, wherein the flow path is formed in the adhesive layer by transferring the convex shape of the release liner to the adhesive layer .