JP7308261B2 - ジェノタイピングpcrアッセイのための機械学習システム - Google Patents
ジェノタイピングpcrアッセイのための機械学習システム Download PDFInfo
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- G—PHYSICS
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- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
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- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N20/00—Machine learning
- G06N20/10—Machine learning using kernel methods, e.g. support vector machines [SVM]
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
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Description
本明細書で使用される用語は、関連技術におけるそれらの通常の意味、または文脈におけるそれらの使用によって示される意味を与えられるべきであるが、明示的な定義が提供される場合、その意味が制御する。
Claims (7)
- 品質管理システムであって、
アッセイを含むqPCRシステムと、
前記アッセイに対する前記qPCRシステムの動作から生じる生画像データの第1の信号を受信するように前記qPCRシステムに結合された記憶システムと、
コンピューティングシステムであって、
前記第1の信号を受信し、
前記記憶システムから標識データセットである生画像データの第2の信号を受信し、
サポートベクターマシン(SVM)を動作させて、前記第2の信号に基づいて前記第1の信号の遺伝子型の分類を生成して、前記分類に基づいて前記qPCRシステムを調整する電子回路を含む、コンピューティングシステムと、を備え、
前記SVMは、放射基底関数カーネルを含み、
前記放射基底関数カーネルは、
- 前記記憶システムおよびSVMは、クラウドサーバシステムによって提供される、請求項1に記載の品質管理システム。
- 前記SVMは、前記アッセイのモデルを生成するように構成されている、請求項1に記載の品質管理システム。
- 前記モデルは、SVM線形、多項式、および放射型分類器カーネルのうちの1つを含む、請求項4に記載の品質管理システム。
- 前記記憶システムおよびSVMは、クラウドサーバシステムによって提供される、請求項6に記載の品質管理方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862725171P | 2018-08-30 | 2018-08-30 | |
US62/725,171 | 2018-08-30 | ||
PCT/US2019/048551 WO2020047081A1 (en) | 2018-08-30 | 2019-08-28 | Machine learning system for genotyping pcr assays |
Publications (2)
Publication Number | Publication Date |
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JP2021535514A JP2021535514A (ja) | 2021-12-16 |
JP7308261B2 true JP7308261B2 (ja) | 2023-07-13 |
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Application Number | Title | Priority Date | Filing Date |
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JP2021511645A Active JP7308261B2 (ja) | 2018-08-30 | 2019-08-28 | ジェノタイピングpcrアッセイのための機械学習システム |
Country Status (6)
Country | Link |
---|---|
US (2) | US20200075129A1 (ja) |
EP (1) | EP3844757A1 (ja) |
JP (1) | JP7308261B2 (ja) |
CN (1) | CN112602153A (ja) |
SG (1) | SG11202101782YA (ja) |
WO (1) | WO2020047081A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US11982620B2 (en) * | 2019-03-18 | 2024-05-14 | Life Technologies Corporation | Multi-capillary optical detection system |
US20220220547A1 (en) * | 2019-05-20 | 2022-07-14 | 3M Innovative Properties Company | System and method for detecting inhibition of a biological assay |
JP2021153516A (ja) * | 2020-03-27 | 2021-10-07 | シスメックス株式会社 | 核酸増幅の成否判定方法、核酸増幅の成否判定装置、及び核酸増幅の成否判定システム |
CN114622006B (zh) * | 2022-05-16 | 2022-08-26 | 浙江正合谷生物科技有限公司 | 一种基于12v电压驱动的核酸变温扩增系统 |
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WO2013138727A1 (en) | 2012-03-15 | 2013-09-19 | Sabiosciences Corp. | Method, kit and array for biomarker validation and clinical use |
WO2018119443A1 (en) | 2016-12-23 | 2018-06-28 | The Regents Of The University Of California | Method and device for digital high resolution melt |
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- 2019-08-28 WO PCT/US2019/048551 patent/WO2020047081A1/en unknown
- 2019-08-28 SG SG11202101782YA patent/SG11202101782YA/en unknown
- 2019-08-28 EP EP19766154.9A patent/EP3844757A1/en active Pending
- 2019-08-28 JP JP2021511645A patent/JP7308261B2/ja active Active
- 2019-08-28 CN CN201980056219.4A patent/CN112602153A/zh active Pending
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2023
- 2023-08-23 US US18/237,358 patent/US20230395195A1/en active Pending
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Also Published As
Publication number | Publication date |
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EP3844757A1 (en) | 2021-07-07 |
CN112602153A (zh) | 2021-04-02 |
SG11202101782YA (en) | 2021-03-30 |
US20200075129A1 (en) | 2020-03-05 |
WO2020047081A1 (en) | 2020-03-05 |
US20230395195A1 (en) | 2023-12-07 |
JP2021535514A (ja) | 2021-12-16 |
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