JP7286135B2 - Blood circulation information calculation device, blood circulation information calculation method, and program - Google Patents

Description

The present invention relates to a blood circulation information calculation device, a blood circulation information calculation method, and a program.

Blood circulation information is one of the important indexes for grasping the health condition of the human body. For example, Patent Literature 1 describes measuring blood pressure, cardiac function, and peripheral vascular resistance, and outputting contributions of cardiac function and peripheral vascular resistance to blood pressure elevation. Further, Patent Document 2 describes that a piezoelectric element is used to measure a blood flow velocity and a blood vessel diameter, and furthermore, a blood vessel resistance and a blood pressure are calculated from the blood flow velocity and the blood vessel diameter.

JP-A-2000-37358 JP 2008-183414 A

The present inventors have studied how to easily obtain information on blood flow and blood pressure in small blood vessels in peripheral parts of the human body. One of the problems to be solved by the present invention is to easily obtain information on blood flow and blood pressure in small blood vessels at fingertips of a human body.

The invention according to claim 1 provides fingertip pulse wave information indicating the measurement result of the fine blood vessel pulse wave at the fingertip of the subject, and fingertip blood flow indicating the measurement result of the blood flow rate of the fine blood vessel at the fingertip of the subject. information, and an acquisition unit that acquires the fingertip pulse wave information to calculate information about the blood pressure of the small blood vessels in the fingertip of the subject, and the fingertip of the subject using the fingertip blood flow information and a calculation unit that calculates information about the blood flow volume of small blood vessels in the blood circulation information calculation device.

In the invention according to claim 8, the computer stores fingertip pulse wave information indicating the measurement result of the fine blood vessel pulse wave of the subject, fingertip blood flow information indicating the measurement result of the blood flow rate of the subject's small blood vessel, and calculating information on the blood pressure of the subject's small blood vessels using the fingertip pulse wave information, and calculating information on the blood flow rate of the subject's small blood vessels using the fingertip blood flow information, It is a blood circulation information calculation method.

The invention according to claim 9 is a program for causing a computer to perform the blood circulation information calculation method according to claim 8.

BRIEF DESCRIPTION OF THE DRAWINGS It is a figure which shows the blood circulation information calculation apparatus which concerns on embodiment with the usage environment. 3(a) to 3(d) are diagrams each showing an example of the configuration of a fingertip pulse wave measuring device. FIG. It is a figure which shows an example of the hardware constitutions of a blood circulation information calculation apparatus. 4 is a flow chart for explaining an example of the operation of the fingertip pulse wave measuring device; FIG. 5 is a flowchart for explaining the details of step S30 in FIG. 4; FIG. FIG. 6 is a flowchart showing a continuation of FIG. 5; FIG. It is a figure which shows the 1st example of the screen which a display process part displays on a display apparatus. FIG. 10 is a diagram showing a second example of a screen displayed on the display device by the display processing unit;

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described below with reference to the drawings. In addition, in all the drawings, the same constituent elements are denoted by the same reference numerals, and the description thereof will be omitted as appropriate.

FIG. 1 is a diagram showing a blood circulation information calculation device 30 according to an embodiment together with its usage environment. The blood circulation information calculation device 30 is a device for calculating information on the blood circulation of small blood vessels in the peripheral part of the subject (hereinafter referred to as blood circulation information). used with Note that the finger tips here include not only the fingers but also the toes, and are the terminal joints (peripheral side) of the fingers, not the base of the fingers or toes. In addition, the term "small blood vessel" as used herein refers to a blood vessel with a diameter of less than several hundred μm, generally less than 300 μm, that is, a blood vessel on the peripheral side from an arteriole (arteriole, capillary), and a blood vessel that is thicker than the arteriole. (with a diameter of approximately 1 mm or more) is not included. The blood circulation information of the fingertip microvessels includes blood pressure information of the fingertip microvessels (for example, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP)), and fingertip microvessel blood pressure information. blood flow information (eg, mean blood flow (Q)), as well as peripheral vascular resistance index and arterial stenosis index (FBI), and pulse rate updates.

The fingertip measuring device 10 includes a fingertip pulse wave measuring section 14 and a fingertip blood flow measuring section 16 . The fingertip pulse wave measurement unit 14 measures the pulse wave of the small blood vessels of the subject's fingertip. The fingertip blood flow measurement unit 16 measures the blood flow in the small blood vessels of the subject's fingertip. The fingertip measurement device 10 outputs information indicating the measurement results to the blood circulation information calculation device 30 as the fingertip blood circulation information described above. This output may be performed by wire or wirelessly.

In the example shown in FIG. 1 , the fingertip measuring device 10 has a pressure unit 12 . The pressure unit 12 applies pressure to the fingertip during measurement. The pressurizing unit 12 may be structurally integrated with the fingertip pulse wave measuring unit 14 or may be provided separately from the fingertip pulse wave measuring unit 14 .

The upper arm measuring device 20 measures the pulse wave of the subject's upper arm. The upper arm measurement device 20 also measures systolic and diastolic blood pressure in the subject's upper arm. The upper arm measurement device 20 outputs the measurement result to the blood circulation information calculation device 30 as upper arm blood circulation information. This output may be performed by wire or wirelessly, or may be performed by manual input using an input device (not shown). Also, the upper arm measurement device 20 may be a general upper arm sphygmomanometer. The input device receives a user's operation. For example, the input device may be a keyboard placed over the display screen of the display device 40 , a remote controller, or a touch panel integrated with the display screen of the display device 40 . Alternatively, the input device may be any device (for example, keyboard, mouse, touch pad, voice operation, etc.) that receives user operations.

The blood circulation information calculation device 30 has an acquisition unit 32, a calculation unit 34, and an output unit 36, and measures results of the fingertip pulse wave measurement unit 14, the fingertip blood flow measurement unit 16, and the upper arm measurement device 20. to calculate the blood circulation information. The acquisition unit 32 acquires fingertip pulse wave information indicating the measurement result of the small blood vessel pulse wave of the subject and fingertip blood flow information indicating the measurement result of the small blood vessel blood flow of the subject. The calculator 34 uses the fingertip pulse wave information to calculate information about the blood pressure of the subject's small blood vessels, and uses the fingertip blood flow information to calculate information about the blood flow rate of the subject's small blood vessels. The output unit 36 generates display data using the results calculated by the calculation unit 34 and outputs this display data to the display device 40 . This display data includes data for displaying at least one of the graphs shown in FIGS. 7 and 8, for example. The display device 40 performs display based on display data. Details of the processing performed by the blood circulation information calculation device 30 and specific examples of the blood circulation information will be described later.

The blood circulation information calculation device 30 also has a control unit 38 . The controller 38 controls the fingertip measuring device 10 . More specifically, the control unit 38 controls the pressure applied to the fingertip by controlling the pressure applied to the pressure unit 12, and controls data acquisition in the fingertip pulse wave measurement unit 14 and the fingertip blood flow measurement unit 16. conduct. Also, the control unit 38 may control the upper arm measuring device 20 . Further, the fingertip measurement device 10 or the blood circulation information calculation device 30 has a heating control mechanism for heating the living body, and the trunk (head, neck, chest, abdomen, back, etc.) and peripheral parts (forearms). , upper arms, fingers, fingertips, lower limbs, toes, etc.) may be warmed. Further, the fingertip measurement device 10 or the blood circulation information calculation device 30 has a temperature/humidity measurement unit and a skin temperature measurement unit for acquiring the measurement environment. may be measured.

FIG. 2(a) is a diagram showing a first example of the configuration of the fingertip measuring device 10. FIG. A fingertip measurement device 10 shown in this figure includes an insertion section 18 and a fingertip blood flow measurement section 16 . The insertion portion 18 is a member into which the subject's fingertip is inserted, such as a cuff. In the case of a cuff, the insertion portion 18 can apply pressure to the fingertip by deforming the inner surface, that is, by inflating the air bag (bladder) of the cuff. That is, the insertion section 18 also serves as the pressure section 12 . The deformation of the insertion section 18 is controlled by the control section 38 of the blood circulation information calculation device 30, for example.

Further, the insertion section 18 is integrally provided with a fingertip pulse wave measurement section 14 . The fingertip pulse wave measurement unit 14 has, for example, a cuff, and information (hereinafter referred to as fingertip pulse wave information) indicating the pulse wave of the fingertip (hereinafter referred to as fingertip pulse wave) simultaneously with pressurization to the fingertip ) is generated and output to the blood circulation information calculation device 30 . A fingertip blood flow measurement unit 16 is attached to the insertion unit 18 . In this form, pulse waves (e.g., pressure pulse wave, volume pulse wave) are detected by a pressure transducer (pneumatic sensor, etc.) using the vibration of the blood vessel wall synchronized with the heartbeat as the cuff internal pressure variation at the same time as the cuff compresses the fingertip. wave). The fingertip blood flow measurement unit 16 preferably measures the flow of blood circulating in the tissue, that is, the blood flow rate. The fingertip blood flow information described above is generated and output to the blood circulation information calculation device 30 . Since the laser Doppler method cannot obtain blood flow information in deep parts of the living body, small blood vessels at fingertips can be measured by using a laser Doppler blood flow meter.

FIG. 2(b) is a diagram showing a second example of the configuration of the fingertip measuring device 10. As shown in FIG. The fingertip measurement device 10 shown in this figure is similar to the example shown in FIG. In this embodiment, the fingertip pulse wave measurement unit 14 detects the vibration of the blood vessel wall synchronized with the heartbeat by pressing the fingertip with the pressurizing unit 12 to a pressure transducer (pressure sensor, load sensor). It may be performed by what is detected as a pulse wave (pressure pulse wave) by a pulse wave (volume pulse wave) by a photoelectric pulse wave sensor that detects the vibration of the blood vessel wall synchronized with the heartbeat as a volume change. It may be done by something that detects. In addition, in this embodiment, the pressurizing part 12 may be a cuff or a mechanical mechanism such as a motor.

FIG. 2(c) is a diagram showing a third example of the configuration of the fingertip measuring device 10. As shown in FIG. The fingertip measuring device 10 shown in this figure is similar to that shown in FIG. is similar to the example shown in The fingertip blood flow measurement unit 16 may be provided above the fingertip pulse wave measurement unit 14, or the fingertip pulse wave measurement unit 14 may be provided above the fingertip blood flow measurement unit 16. good too. Further, the fingertip pulse wave measurement unit 14 and the fingertip blood flow measurement unit 16 may be integrated and integrated on the same substrate.

FIG. 2D is a diagram showing a fourth example of the configuration of the fingertip measuring device 10. As shown in FIG. The fingertip measuring device 10 shown in this figure is the same as the example shown in FIG.

FIG. 3 is a diagram showing an example of the hardware configuration of the blood circulation information calculation device 30. As shown in FIG. A main configuration of the blood circulation information calculation device 30 is realized using an integrated circuit. The integrated circuit has a bus 402 , processor 404 , memory 406 , storage device 408 , input/output interface 410 and network interface 412 . The bus 402 is a data transmission path through which the processor 404, memory 406, storage device 408, input/output interface 410, and network interface 412 exchange data with each other. However, the method of connecting the processors 404 and the like to each other is not limited to bus connection. The processor 404 is an arithmetic processing device implemented using a microprocessor or the like. The memory 406 is a memory implemented using a RAM (Random Access Memory) or the like. The storage device 408 is a storage device implemented using a ROM (Read Only Memory), flash memory, or the like.

The input/output interface 410 is an interface for connecting the blood circulation information calculation device 30 with peripheral devices.

The network interface 412 is an interface for connecting the blood circulation information calculation device 30 to a communication network. A method for connecting the network interface 412 to the communication network may be a wireless connection or a wired connection.

The storage device 408 stores program modules for realizing each functional element of the blood circulation information calculation device 30 . The processor 404 implements each function of the blood circulation information calculation device 30 by reading this program module into the memory 406 and executing it. Storage device 408 also functions as information storage.

Note that the hardware configuration of the integrated circuit described above is not limited to the configuration shown in this figure. For example, program modules may be stored in memory 406 . In this case, the integrated circuit may not include storage device 408 .

FIG. 4 is a flow chart for explaining an example of the operation of the fingertip measuring device 10. As shown in FIG. A part of the processing performed by the blood circulation information calculation device 30 is also included in the explanation using this figure. First, the operator of the fingertip measurement device 10 and the blood circulation information calculation device 30 sets the subject information and the measurement conditions in the setting field 42 using, for example, the input from the input device or the measurement result separately measured, to the blood circulation information calculation device 30. (step S10). The measurement conditions include the measurement conditions at pressure rise and the measurement conditions at constant pressure. More specifically, one of the measurement conditions during pressurization is the upper limit of pressure (for example, 150 mmHg), and the upper limit of pressurization required for each measurement may be set according to the brachial blood pressure value of the subject. . One of the measurement conditions for constant pressure is the pressure when it becomes constant. The measurement conditions to be set include the length of time to hold the constant pressure and the length of time to hold the Lissajous waveform on the display screen of the Lissajous waveform.

Next, the subject inserts the finger into the insertion portion 18 of the fingertip measuring device 10 (step S20). Next, the fingertip measurement device 10 and the blood circulation information calculation device 30 execute blood circulation information generation processing (step S30).

5 and 6 are flow charts for explaining the details of step S30 in FIG. First, as shown in FIG. 5, the control unit 38 of the blood circulation information calculation device 30 deforms the inner surface of the insertion unit 18, that is, inflates the air bag (bladder) of the cuff, and more specifically, the subject's Increase the pressure applied to the fingertips to the upper limit. The pressure increase speed at this time can be appropriately adjusted, and is, for example, 2 mmHg/sec or more and 3 mmHg/sec or less. While the pressure is rising, the fingertip pulse wave measurement unit 14 continues to measure the pulse wave oscillation waveform (oscillation) of the subject's fingertip (step S102). This measurement result is repeatedly output to the blood circulation information calculation device 30 . Then, the calculation unit 34 of the blood circulation information calculation device 30 uses this measurement result to specify the systolic blood pressure (fingertip systolic blood pressure) and the diastolic blood pressure (fingertip diastolic blood pressure) in the small blood vessels of the fingertip ( step S104). For this identification, for example, an oscillometric method is used. For example, in repeated measurements in one subject (n = 6), when the brachial blood pressure was systolic 99 ± 2 mmHg and diastolic 63 ± 2 mmHg, the fingertip blood pressure measurement was systolic 82 ± 5 mmHg and diastolic 39 ± 7 mmHg. , and the pressure at the fingertips is attenuated by the resistance of the small blood vessels, resulting in a lower value relative to the brachial blood pressure. It is known that since arterioles, which are thicker than small blood vessels, are to be measured at the base of the finger, the blood pressure does not attenuate much and is close to the brachial blood pressure value. It should be noted that fingertip blood pressure measurement can be performed from pulse wave measurement during the decompression process after pressurization, as is done with a general upper arm sphygmomanometer. Measurement in the depressurization process is considered to have a large physical effect due to the crushing of small blood vessels, so measurement in the pressurization process is preferable for higher accuracy, and an example of pressurization measurement is shown in the examples.

Then, the control unit 38 temporarily lowers the pressure inside the insertion portion 18 and then pressurizes the inside of the insertion portion 18 again, and the pressure applied by the insertion portion 18 to the fingertip is applied to the finger specified by the blood circulation information calculation device 30. Maintain a constant pressure (eg, 10 mmHg) below apical diastolic pressure. While this is maintained, the fingertip pulse wave measuring unit 14 repeatedly measures the waveform of the subject's fingertip pulse wave (step S106). This measurement result also continues to be output to the blood circulation information calculation device 30 . The calculation unit 34 uses the area time average of the pulse wave and the fingertip systolic blood pressure and fingertip diastolic blood pressure calculated in step S104 to identify the average blood pressure of the small blood vessels of the fingertip (mean fingertip blood pressure). (Step S108), the pulse is also specified. The average fingertip blood pressure is calculated by integrating the area-time average of pulse waves for one beat or several beats, for example, by integrating the waveform on the time axis and dividing by the time. Mean fingertip blood pressure may be measured by other methods. For example, mean fingertip pressure is approximated by (fingertip diastolic pressure)+(fingertip systolic pressure-fingertip diastolic pressure)/3.

In addition, the subject uses the upper arm measuring device 20 to measure the diastolic blood pressure and systolic blood pressure of the upper arm. The acquisition unit 32 also acquires this measurement result. The calculation unit 34 then calculates the ratio of the fingertip systolic blood pressure to the upper arm systolic blood pressure (step S110). This ratio indicates the degree of arterial stenosis, which is the arteriosclerosis index distal to the upper arm, and may be expressed as a percentage. The brachial blood pressure is measured, for example, during step S102 described above, that is, while the pressure of the insertion portion 18 is increasing, the fingertip pulse wave measurement unit 14 measures the vibration waveform (oscillation) of the fingertip pulse wave of the subject. should be measured at the same time as the timing for continuing to measure . However, the measurement of the brachial blood pressure may be performed before step S102, or the first brachial blood pressure measurement may be performed before step S102, and the second brachial blood pressure may be measured after all the measurements are completed. Measurements may be taken and the two averages used to calculate the ratio of the brachial systolic pressure to the fingertip systolic pressure.

Next, as shown in FIG. 6, the control unit 38 of the blood circulation information calculation device 30 once lowers the pressure inside the insertion portion 18, and then pressurizes the inside of the insertion portion 18 again so that the insertion portion 18 touches the fingertip. The applied pressure is maintained at a constant pressure (eg 10 mmHg). In this state, the fingertip blood flow measurement unit 16 generates data indicating the fingertip blood flow, such as a fingertip blood flow waveform, and outputs the data to the blood circulation information calculation device 30 . The calculation unit 34 of the blood circulation information calculation device 30 uses this data to calculate the time average value (average blood flow) of the blood flow at the fingertip (step S112). After that, the pressure inside the insertion portion 18 is lowered.

Next, the calculation unit 34 of the blood circulation information calculation device 30 divides the average fingertip blood pressure specified in step S108 by the time average value of blood flow in the fingertip calculated in step S112, thereby obtaining a peripheral vascular resistance index (peripheral Blood vessel resistance index) is calculated (step S114).

After that, the control unit 38 of the blood circulation information calculation device 30 once lowers the pressure inside the insertion unit 18, pressurizes the inside of the insertion unit 18 again, and the pressure applied by the insertion unit 18 to the fingertip is used for blood circulation information calculation. Maintain a constant pressure (eg, 10 mmHg) lower than the fingertip diastolic pressure specified by device 30 . The calculation unit 34 of the blood circulation information calculation device 30 obtains data for drawing a graph (Lissajous curve) in which the horizontal axis is the AC component of the fingertip blood flow waveform and the vertical axis is the AC component of the fingertip pulse waveform. arterial elasticity is generated by processing this data (step S116). A rule for calculating the arterial elasticity from the Lissajous curve is determined by, for example, extracting the feature quantity of the shape of the Lissajous curve and processing the data statistically. This arterial elasticity also indicates the degree of arteriosclerosis on the distal side of the upper arm.

Measurement of fingertip systolic blood pressure and diastolic blood pressure by increasing pressure, measurement of fingertip average blood pressure by holding constant pressure, measurement of fingertip average blood flow by holding constant pressure, and Lissajous curve drawing by holding constant pressure. , can be changed to a more appropriate order. For example, at the beginning of a series of sequences, an average fingertip blood flow measurement may be performed by holding a constant pressure. Alternatively, when the constant pressure holding conditions are the same for the sequence of measuring the average fingertip blood pressure by holding a constant pressure and drawing the Lissajous curve by holding a constant pressure, the measurements may be performed at the same time.

Thereafter, the calculator 34 generates display data (step S118), and causes the display device 40 to display a display screen using this data (step S120).

FIG. 7 shows a first example of a screen that the output section 36 causes the display device 40 to display. This example is a screen for medical personnel (for example, doctors, nurses, clinical laboratory technologists) who actually operate the measurement start button 41 for starting the operation of the fingertip measurement device 10 and the blood circulation information calculation device 30. , a setting column 42 for inputting subject information and measurement conditions of the fingertip measuring device 10 and the blood circulation information calculating device 30, a display column 43 for the time displacement (raw waveform) of the fingertip blood flow, and a raw waveform of the fingertip pulse wave. , a display field 45 for the Lissajous waveform, a display field 46 for the measured waveform, and a display field 47 for the value specified by the calculator 34 . Although an input device for the setting field 42 is not shown, the input may be performed automatically or manually, and a general input device such as a keyboard, touch panel, or voice input may be used. The measured waveform displayed in the display field 46 is at least one of the time displacement of the cuff pressure at the time of pressure rise or constant pressure measurement, the time displacement of the fingertip blood flow, and the time displacement of the fingertip pulse wave. Further, in the display field 47, blood pressure information of the small blood vessels of the fingertip (for example, systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP)) and blood flow information of the small blood vessels of the fingertip ( For example, mean blood flow (Q)), peripheral vascular resistance index and arterial stenosis index (FBI), and pulse rate updates are displayed simultaneously. Further, the display device 40 may display the environmental conditions such as the temperature and humidity of the measurement location and the measurement results of the subject's skin temperature.

The screen shown in FIG. 7 also includes a stop button 48 for stopping the operations of the fingertip measuring device 10 and the blood circulation information calculating device 30. FIG.

FIG. 8 shows a second example of a screen displayed on the display device 40 by the output unit 36. As shown in FIG. This example is a screen for subjects as well as medical professionals, and includes a graph showing the degree of arterial stenosis or arterial elasticity as an arteriosclerosis index, with one axis being the value of the peripheral vascular resistance index and the other axis. there is When one axis is the degree of arterial stenosis, its reciprocal is more preferable for display on the graph. The graph also includes information indicating normal regions. In this graph, the subject's data is indicated by a circle, and the size of this circle is proportional to the average blood flow. The size of this circle may be represented by at least one of small blood vessel blood flow information or blood pressure information, for example, a calculated fingertip blood pressure value, that is, fingertip systolic blood pressure, diastolic blood pressure, or mean blood pressure. Also, the graph may be displayed three-dimensionally. Therefore, the subject can easily recognize whether his/her measurement result is normal. In addition, if the subject's measurement result is located outside the normal range, the subject's measurement result indicates a specific disease type, such as a pathology in hypertension (such as senile systolic hypertension or essential hypertension). (for example, text data shown in Display Example 1 and Display Example 2). It should be noted that this blood circulation information calculation device can be applied to the detailed analysis of the pathological condition of hypertension and the evaluation of peripheral vascular disorders such as diabetic microangiopathy, based on the blood circulation information of fingertips.

As described above, according to the present embodiment, since the fingertip measuring device 10 is used, the blood circulation information in the peripheral part of the human body can be easily measured. Further, the screens shown in FIGS. 7 and 8 allow medical personnel and subjects to easily recognize the measurement results.

Although the embodiments and examples have been described above with reference to the drawings, these are examples of the present invention, and various configurations other than those described above can be adopted.
Examples of reference forms are added below.
1. an acquisition unit that acquires fingertip pulse wave information indicating the measurement result of the pulse wave of the microvessels in the fingertip of the subject and fingertip blood flow information indicating the measurement result of the blood flow rate of the microvessels in the fingertip of the subject; ,
Using the fingertip pulse wave information to calculate information about the blood pressure of the small blood vessels in the fingertip of the subject, and using the fingertip blood flow information to calculate information about the blood flow of the small blood vessels in the fingertip of the subject. a calculation unit for
Blood circulation information calculation device.
2. 1. In the blood circulation information calculation device according to
The information about the blood pressure of the microvessels at the fingertip includes systolic blood pressure, diastolic blood pressure, and mean blood pressure of the microvessels, and the information about the blood flow rate of the microvessels at the fingertip includes the mean blood flow rate of the microvessels. Blood circulation information calculation device.
3. 1. or 2. In the blood circulation information calculation device according to
The calculation unit
calculating the average blood pressure in the microvessels using the area-time average of the microvessel pulse wave and the systolic blood pressure and diastolic blood pressure of the microvessels measured from the variations in the pulse wave;
A blood circulation information calculation device for calculating a blood vessel resistance index of the small blood vessels using the average blood pressure and the fingertip blood flow information.
4. 1. ~3. In the blood circulation information calculation device according to any one of
The calculation unit is a blood circulation information calculation device that calculates a degree of arterial stenosis using blood circulation information in the upper arm and information on the blood pressure of the small blood vessels.
5. 1. ~ 4. In the blood circulation information calculation device according to any one of
Further, the blood circulation information calculating apparatus includes a display processing unit for generating graph information for displaying a graph in which one axis is the value of the vascular resistance index of the small blood vessel and the other axis is the degree of arterial stenosis or arterial elasticity. .
6. 5. In the blood circulation information calculation device according to
The display processing unit is a blood circulation information calculation device that generates the graph information such that the graph further indicates blood flow information or blood pressure information of the small blood vessels.
7. 5. or 6. In the blood circulation information calculation device according to
The blood circulation information calculation device, wherein the graph information includes information for displaying a normal region in the graph in a recognizable state.
8. the computer
Acquiring fingertip pulse wave information indicating the measurement result of the pulse wave of the subject's small blood vessels and fingertip blood flow information indicating the measurement result of the blood flow rate of the subject's small blood vessels,
A method of calculating blood circulation information, comprising: calculating information about the blood pressure of the subject's small blood vessels using the fingertip pulse wave information; and calculating information about the blood flow of the subject's small blood vessels using the fingertip blood flow information. .
9. 8. to the computer; A program for performing the blood circulation information calculation method described in .

10 fingertip measurement device 12 pressure unit 14 fingertip pulse wave measurement unit 16 fingertip blood flow measurement unit 18 insertion unit 20 upper arm measurement device 30 blood circulation information calculation device 32 acquisition unit 34 calculation unit 36 output unit 38 control unit 40 Display device 41 Measurement start button 42 Setting field 43 Display field 44 Display field 45 Display field 46 Display field 47 Display field

Claims (4)

an acquisition unit that acquires fingertip pulse wave information indicating the measurement result of the pulse wave of the microvessels in the fingertip of the subject and fingertip blood flow information indicating the measurement result of the blood flow rate of the microvessels in the fingertip of the subject; ,
Using the fingertip pulse wave information to calculate information about the blood pressure of the small blood vessels in the fingertip of the subject, and using the fingertip blood flow information to calculate information about the blood flow of the small blood vessels in the fingertip of the subject. a calculation unit for
a display processing unit for generating graph information for displaying a graph in which one axis is the vascular resistance index value of the small blood vessel and the other axis is the degree of arterial stenosis or arterial elasticity ;
the information about the blood pressure of the small blood vessels includes mean blood pressure of small blood vessels;
The information on the blood flow rate of the small blood vessels includes an average blood flow rate of the small blood vessels,
The vascular resistance index of the small blood vessels is calculated using the average blood pressure and the average blood flow,
The degree of arterial stenosis is calculated using brachial blood circulation information and information on blood pressure of the small blood vessels,
The arterial elasticity is obtained from data for drawing a Lissajous curve generated using the fingertip blood flow waveform indicated by the fingertip blood flow information and the fingertip pulse waveform indicated by the fingertip pulse wave information. , calculated using the rule,
The rule is a rule determined by extracting and statistically processing the feature amount of the shape of the Lissajous curve drawn using the blood flow waveform of the fingertip and the pulse waveform of the fingertip.
Blood circulation information calculation device. In the blood circulation information calculation device according to claim 1 ,
The blood circulation information calculation device, wherein the graph information includes information for displaying a normal region in the graph in a recognizable state. the computer
Acquiring fingertip pulse wave information indicating the measurement result of the pulse wave of the subject's small blood vessels and fingertip blood flow information indicating the measurement result of the blood flow rate of the subject's small blood vessels,
Using the fingertip pulse wave information to calculate information about the blood pressure of the subject's small blood vessels, and using the fingertip blood flow information to calculate information about the blood flow of the subject's small blood vessels,
generating graph information for displaying a graph in which one axis is the vascular resistance index value of the small blood vessel and the other axis is the degree of arterial stenosis or arterial elasticity;
the information about the blood pressure of the small blood vessels includes mean blood pressure of small blood vessels;
The information on the blood flow rate of the small blood vessels includes an average blood flow rate of the small blood vessels,
The vascular resistance index of the small blood vessels is calculated using the average blood pressure and the average blood flow,
The degree of arterial stenosis is calculated using brachial blood circulation information and information on blood pressure of the small blood vessels,
The arterial elasticity is obtained from data for drawing a Lissajous curve generated using the fingertip blood flow waveform indicated by the fingertip blood flow information and the fingertip pulse waveform indicated by the fingertip pulse wave information. , calculated using the rule,
The rule is a rule determined by extracting and statistically processing the feature amount of the shape of the Lissajous curve drawn using the blood flow waveform of the fingertip and the pulse waveform of the fingertip.
Blood circulation information calculation method. A program for causing a computer to perform the blood circulation information calculation method according to claim 3 .

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