JP2020110443A - Blood circulation information calculation apparatus, blood circulation information calculation method, and program - Google Patents

Abstract

To measure blood circulation information in a peripheral part of a human body easily.SOLUTION: A blood circulation information calculation apparatus 30 includes an acquisition unit 32, a calculation unit 34, and an output unit 36. The acquisition unit 32 acquires finger-tip pulse wave information and finger-tip blood flow rate information from a finger-tip part measuring apparatus. The blood circulation information calculation apparatus 30 calculates blood circulation information by using the finger-tip pulse wave information and the finger-tip blood flow rate information. The acquisition unit 32 further acquires upper arm blood circulation information indicating a result of blood pressure measurement in the upper arm of a subject from an upper arm part measuring apparatus. The calculation unit 34 further calculates blood circulation information by using the upper arm blood circulation information. The blood circulation information includes a degree of the arterial stenosis, for example.SELECTED DRAWING: Figure 3

Description

The present invention relates to a blood circulation information calculation device, a blood circulation information calculation method, and a program.

Blood circulation information is one of the important indicators for understanding the health condition of the human body. For example, Patent Document 1 describes that by measuring blood pressure, cardiac function, and peripheral vascular resistance, the contribution of increased blood pressure to cardiac function and peripheral vascular resistance is output. Further, Patent Document 2 describes that the blood flow velocity and the blood vessel diameter are measured using a piezoelectric element, and further the blood vessel resistance and the blood pressure are calculated from the blood flow velocity and the blood vessel diameter.

JP, 2000-37358, A JP, 2008-183414, A

The present inventor has studied how to easily obtain information on blood flow and blood pressure in small blood vessels in the peripheral part of the human body. As an example of the problem to be solved by the present invention, it is possible to easily obtain information on blood flow and blood pressure in small blood vessels in the fingertips of a human body.

The invention according to claim 1 is the fingertip pulse wave information indicating the measurement result of the pulse wave of the small blood vessels at the fingertip of the subject, and the fingertip blood flow amount indicating the measurement result of the blood flow rate of the small blood vessels at the fingertip of the subject. Information, and an acquisition unit for acquiring, and calculating information about blood pressure of small blood vessels in the fingertip of the subject using the fingertip pulse wave information, and the fingertip of the subject using the fingertip blood flow information And a calculation unit that calculates information about the blood flow volume of the small blood vessels.

The invention according to claim 8 is characterized in that the computer has fingertip pulse wave information indicating the measurement result of the pulse wave of the small blood vessels of the subject, and fingertip blood flow amount information indicating the measurement result of the blood flow volume of the small blood vessels of the subject, To obtain information about blood pressure of the small blood vessels of the subject using the fingertip pulse wave information, and calculate information about the blood flow of the small blood vessels of the subject using the fingertip blood flow information, This is a blood circulation information calculation method.

The invention described in claim 9 is a program for causing a computer to perform the blood circulation information calculation method according to claim 8.

It is a figure which shows the blood circulation information calculation apparatus which concerns on embodiment with its use environment. (A)-(d) is a figure which shows an example of a structure of a finger plethysmography device. It is a figure which shows an example of the hardware constitutions of a blood circulation information calculation apparatus. It is a flow chart for explaining an example of operation of a fingertip pulse wave measuring device. 6 is a flowchart for explaining details of step S30 of FIG. 4. It is a flowchart which shows the continuation of FIG. It is a figure which shows the 1st example of the screen which a display processing part makes a display display. It is a figure which shows the 2nd example of the screen which a display processing part makes a display display.

Hereinafter, embodiments of the present invention will be described with reference to the drawings. In all the drawings, the same constituents will be referred to with the same numerals, and the description thereof will not be repeated.

FIG. 1 is a diagram showing a blood circulation information calculation device 30 according to the embodiment together with its usage environment. The blood circulation information calculation device 30 is a device that calculates information (hereinafter, referred to as blood circulation information) regarding blood circulation of small blood vessels in the peripheral portion of the subject, and includes the fingertip measurement device 10, the upper arm measurement device 20, and the display device 40. Used with. Note that the fingertips here include not only the fingers but also the toes, and are the end nodes (peripheral side) of the fingers, not the bases of the fingers or the toes. Further, the small blood vessels here are blood vessels having a diameter of less than several hundreds μm, generally less than 300 μm, that is, blood vessels (arterioles, capillaries) distal to the arterioles, and blood vessels thicker than the arterioles. (Diameter is about 1 mm or more) is not included. The blood flow information of the small blood vessels of the fingertip includes blood pressure information of the small blood vessels of the fingertip (for example, systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP)), and small blood vessels of the fingertip. Blood flow information (for example, average blood flow (Q)), peripheral vascular resistance index, arterial stenosis (FBI), and latest pulse value.

The fingertip measuring device 10 includes a fingertip pulse wave measuring unit 14 and a fingertip blood flow measuring unit 16. The fingertip pulse wave measurement unit 14 measures the pulse wave of the small blood vessels of the fingertip of the subject. The fingertip blood flow measuring unit 16 measures the blood flow in the small blood vessels of the fingertip of the subject. The fingertip measuring device 10 outputs the information indicating the measurement result to the blood circulation information calculating device 30 as the fingertip blood circulation information. This output may be performed by wire or wirelessly.

In the example shown in FIG. 1, the fingertip measuring device 10 includes a pressing unit 12. The pressurizing unit 12 applies pressure to the fingertip when performing the measurement. The pressurizing unit 12 may be integrated with the fingertip pulse wave measuring unit 14 in terms of structure, or may be provided separately from the fingertip pulse wave measuring unit 14.

The upper arm measuring device 20 measures the pulse wave of the upper arm of the subject. The upper arm measurement device 20 further measures the systolic blood pressure and the diastolic blood pressure in the upper arm of the subject. The upper arm measurement device 20 outputs the measurement result to the blood circulation information calculation device 30 as upper arm blood circulation information. This output may be performed by wire or wirelessly, or may be performed manually by using an input device (not shown). The upper arm measurement device 20 may be a general upper arm sphygmomanometer. The input device receives a user operation. For example, the input device may be a keyboard installed over the display screen of the display device 40, a remote controller, or a touch panel integrated with the display screen of the display device 40. Alternatively, the input device may be any device that receives a user operation (for example, a keyboard, a mouse, a touch pad, a voice operation, or the like).

The blood circulation information calculation device 30 includes an acquisition unit 32, a calculation unit 34, and an output unit 36, and the measurement results of the fingertip pulse wave measurement unit 14, the fingertip blood flow measurement unit 16, and the upper arm measurement device 20. Is used to calculate blood circulation information. The acquisition unit 32 acquires fingertip pulse wave information indicating the measurement result of the pulse wave of the small blood vessels of the subject and fingertip blood flow amount information indicating the measurement result of the blood flow amount of the small blood vessels of the subject. The calculator 34 uses the fingertip pulse wave information to calculate information about the blood pressure in the small blood vessels of the subject, and uses the fingertip blood flow information to calculate information about the blood flow in the small blood vessels of the subject. The output unit 36 generates display data using the result calculated by the calculation unit 34, and outputs this display data to the display device 40. This display data includes, for example, data for displaying at least one of the graphs shown in FIGS. 7 and 8. The display device 40 displays based on the display data. Details of the processing performed by the blood circulation information calculation device 30 and a specific example of blood circulation information will be described later.

The blood circulation information calculation device 30 also has a control unit 38. The control unit 38 controls the fingertip measuring device 10. More specifically, the control unit 38 controls the pressure of the pressurizing unit 12 to control the pressure applied to the fingertip, and controls the data acquisition in the fingertip pulse wave measuring unit 14 and the fingertip blood flow measuring unit 16. To do. Further, the control unit 38 may control the upper arm measurement device 20. Further, the fingertip measuring device 10 or the blood circulation information calculating device 30 has a heating control mechanism for heating the living body, and the trunk (head, neck, chest, abdomen, back, etc.) and peripheral part (forearm). , Upper arm, fingers, fingertips, lower limbs, toes, etc.) may be heated. Further, the fingertip measuring device 10 or the blood circulation information calculating device 30 has a temperature/humidity measuring unit and a skin temperature measuring unit for acquiring the measurement environment, and includes, for example, room temperature and humidity at the measurement location, and the skin temperature of the subject. May be measured.

FIG. 2A is a diagram showing a first example of the configuration of the fingertip measuring device 10. The fingertip measuring device 10 shown in the figure includes an insertion portion 18 and a fingertip blood flow measuring portion 16. The insertion portion 18 is a member into which a subject's fingertip is inserted, and is, for example, a cuff. In the case of a cuff, the insertion portion 18 can apply pressure to the fingertip by deforming the inner surface, that is, by expanding the air bag (bladder) of the cuff. That is, the insertion portion 18 also serves as the pressing portion 12. The deformation of the insertion section 18 is controlled by the control section 38 of the blood circulation information calculation device 30, for example.

Furthermore, the fingertip pulse wave measuring unit 14 is integrally provided in the insertion unit 18. The fingertip pulse wave measurement unit 14 has, for example, a cuff, and information indicating the pulse wave of the fingertip (hereinafter, referred to as fingertip pulse wave) at the same time when the fingertip is pressed (hereinafter, fingertip pulse wave information). Is described) and is output to the blood circulation information calculation device 30. The fingertip blood flow measuring unit 16 is attached to the insertion unit 18. In this form, the pressure of the fingertip by the cuff and the vibration of the blood vessel wall synchronized with the pulsation of the heart at the same time are used as pressure fluctuations in the cuff by a pressure transducer (such as an air pressure sensor) to generate a pulse wave (for example, a pressure pulse wave or a volume pulse). Wave) is detected. The fingertip blood flow measuring unit 16 preferably measures the flow of blood circulating through the tissue, that is, the flow rate of blood, and is, for example, a laser Doppler blood flow meter calculated by blood flow=blood volume×blood velocity. The fingertip blood flow amount information described above is generated and output to the blood circulation information calculation device 30. Since the laser Doppler method cannot obtain blood flow information in a deep portion of a living body, a laser doppler blood flow meter can be used to measure small blood vessels at the fingertip.

FIG. 2B is a diagram showing a second example of the configuration of the fingertip measuring device 10. The fingertip measuring device 10 shown in this figure is similar to the example shown in FIG. 2A, except that the fingertip pulse wave measuring unit 14 is separate from the insertion unit 18. In this mode, the fingertip pulse wave measuring unit 14 causes the pressure transducer (pressure sensor, load sensor) to vibrate the blood vessel wall in synchronization with the pulsation of the heart due to the compression of the fingertip portion by the pressurizing unit 12. May be performed as a pulse wave (pressure pulse wave), or as a pulse wave (volume pulse wave) by a photoelectric pulse wave sensor that detects the vibration of the blood vessel wall synchronized with the heartbeat as a volume change. It may be performed by what is detected. Further, in this embodiment, the pressurizing unit 12 may use a mechanical mechanism such as a motor in addition to the cuff.

FIG. 2C is a diagram showing a third example of the configuration of the fingertip measuring device 10. The fingertip measuring device 10 shown in this figure is different from that shown in FIG. 2B except that the fingertip pulse wave measuring unit 14 and the fingertip blood flow measuring unit 16 are stacked (or integrated). It is similar to the example shown in. It should be noted that the fingertip blood flow measurement unit 16 may be provided on the fingertip pulse wave measurement unit 14, or the fingertip blood flow measurement unit 14 may be provided on the fingertip blood flow measurement unit 16. Good. The fingertip pulse wave measuring unit 14 and the fingertip blood flow measuring unit 16 may be integrated and integrated on the same substrate.

FIG. 2D is a diagram showing a fourth example of the configuration of the fingertip measuring device 10. The fingertip measuring apparatus 10 shown in this figure is the same as the example shown in FIG. 2B except that a plurality of fingertip pulse wave measuring sections 14 are attached to the insertion section 18.

FIG. 3 is a diagram illustrating an example of a hardware configuration of the blood circulation information calculation device 30. The main configuration of the blood circulation information calculation device 30 is realized by using an integrated circuit. This integrated circuit has a bus 402, a processor 404, a memory 406, a storage device 408, an input/output interface 410, and a network interface 412. The bus 402 is a data transmission path for the processor 404, the memory 406, the storage device 408, the input/output interface 410, and the network interface 412 to exchange data with each other. However, the method of connecting the processors 404 and the like to each other is not limited to bus connection. The processor 404 is an arithmetic processing unit realized by using a microprocessor or the like. The memory 406 is a memory realized by using a RAM (Random Access Memory) or the like. The storage device 408 is a storage device realized by using a ROM (Read Only Memory), a flash memory, or the like.

The input/output interface 410 is an interface for connecting the blood circulation information calculation device 30 to peripheral devices.

The network interface 412 is an interface for connecting the blood circulation information calculation device 30 to a communication network. The method of connecting the network interface 412 to the communication network may be wireless connection or wired connection.

The storage device 408 stores a program module for realizing each functional element of the blood circulation information calculation device 30. The processor 404 realizes each function of the blood circulation information calculation device 30 by reading this program module into the memory 406 and executing it. The storage device 408 also functions as information storage.

The hardware configuration of the integrated circuit described above is not limited to the configuration shown in this figure. For example, program modules may be stored in memory 406. In this case, the integrated circuit may not include the storage device 408.

FIG. 4 is a flowchart for explaining an example of the operation of the fingertip measuring device 10. The description using this figure also includes a part of the processing performed by the blood circulation information calculation device 30. First, the operator of the fingertip measuring device 10 and the blood circulation information calculating device 30 sets the subject information and the measurement conditions in the setting field 42 to the blood circulation information calculating device 30 using, for example, the input from the input device or the measurement result measured separately. Is set (step S10). The measurement conditions include those under pressure and those under constant pressure. More specifically, one of the measurement conditions at the time of pressurization is an upper limit value of pressure (for example, 150 mmHg), and the pressurization upper limit value necessary for each measurement may be set according to the upper arm blood pressure value of the subject. .. Further, one of the measurement conditions at a constant pressure is the pressure when the pressure becomes constant. Further, the set measurement conditions include the time to be kept at a constant pressure and the length of time to hold the Lissajous waveform on the Lissajous waveform display screen.

Next, the subject inserts his/her finger into the insertion portion 18 of the fingertip measuring device 10 (step S20). Next, the fingertip measurement device 10 and the blood circulation information calculation device 30 execute a blood circulation information generation process (step S30).

5 and 6 are flowcharts for explaining the details of step S30 in FIG. First, as shown in FIG. 5, the control unit 38 of the blood circulation information calculation device 30 deforms the inner surface of the insertion unit 18, that is, inflates the air bag (bladder) of the cuff, and more specifically, the test subject's Increase the pressure applied to the fingertip to the upper limit. The speed of increase in pressure at this time can be appropriately adjusted, and is, for example, 2 mmHg/sec or more and 3 mmHg/sec or less. While the pressure is increasing, the fingertip pulse wave measuring unit 14 continues to measure the vibration waveform (oscillation) due to the pulse wave of the fingertip of the subject (step S102). The measurement result is repeatedly output to the blood circulation information calculation device 30. Then, the calculation unit 34 of the blood circulation information calculation device 30 specifies the systolic blood pressure (fingertip systolic blood pressure) and the diastolic blood pressure (fingertip diastolic blood pressure) in the small blood vessels of the fingertip using this measurement result ( Step S104). For this identification, for example, the oscillometric method is used. For example, in repeated measurement (n=6) in one subject, when the brachial blood pressure is systolic 99±2 mmHg and diastolic 63±2 mmHg, the blood pressure measurement result of the fingertip is systolic 82±5 mmHg, diastolic 39±7 mmHg. Since the pressure at the fingertip is attenuated by the resistance of the small blood vessels, the pressure becomes lower than the brachial blood pressure value. It is known that the arteries at the base of the finger, which are thicker than the small blood vessels, are to be measured, so that the blood pressure is not significantly attenuated and the value is close to the brachial blood pressure value. Incidentally, in measuring the blood pressure of the fingertip, it is possible to carry out from the pulse wave measurement in the decompression process after the pressurization as is done in a general brachial sphygmomanometer. Since it is considered that the measurement in the depressurization process has a large physical effect due to the collapse of small blood vessels, the measurement in the pressurization process is preferable for higher accuracy, and the pressurization measurement example is shown in the examples.

Then, the control unit 38 once lowers the pressure inside the insertion unit 18, then pressurizes the inside of the insertion unit 18 again, and the pressure applied by the insertion unit 18 to the fingertip is determined by the blood circulation information calculation device 30. Maintain a constant pressure (eg, 10 mmHg) lower than the apex diastolic pressure. The fingertip pulse wave measuring unit 14 repeatedly measures the waveform of the pulse wave of the fingertip of the subject even during this maintenance (step S106). This measurement result also continues to be output to the blood circulation information calculation device 30. The calculating unit 34 uses the area-time average of the pulse wave and the fingertip systolic blood pressure and the fingertip diastolic blood pressure calculated in step S104 to specify the average blood pressure of the small blood vessels of the fingertip (fingertip average blood pressure). (Step S108), the pulse is also specified. The fingertip average blood pressure is calculated by integrating the area-time average of pulse waves for one or several beats, for example, integrating the waveform on the time axis and dividing by time. Average fingertip blood pressure may be measured by other methods. For example, the average fingertip blood pressure is estimated by (fingertip diastolic blood pressure)+(fingertip systolic blood pressure-fingertip diastolic blood pressure)/3.

Further, the test subject measures the diastolic blood pressure and systolic blood pressure of the upper arm using the upper arm measurement device 20. The acquisition unit 32 also acquires this measurement result. Then, the calculation unit 34 calculates the ratio of the fingertip systolic blood pressure to the systolic blood pressure of the upper arm (step S110). This ratio indicates the degree of arterial stenosis, which is an arteriosclerosis index distal to the upper arm, and may be expressed as a percentage. The brachial blood pressure is measured, for example, during step S102 described above, that is, while the pressure of the insertion portion 18 is rising, the fingertip pulse wave measurement unit 14 causes the vibration waveform (oscillation) of the pulse wave of the fingertip of the subject. It is desirable that the measurement be performed at the same time as the measurement is continued. However, the measurement of the brachial blood pressure may be performed at the timing before step S102, or the first brachial blood pressure measurement is performed at the timing before step S102, and the second brachial blood pressure is measured after all the measurements are completed. The measurement may be performed and the ratio between the systolic blood pressure of the upper arm and the systolic blood pressure of the fingertip may be calculated using the two average values.

Next, as shown in FIG. 6, the control unit 38 of the blood circulation information calculation device 30 once lowers the pressure inside the insertion unit 18 and then pressurizes the inside of the insertion unit 18 again, so that the insertion unit 18 is moved to the fingertip. The applied pressure is maintained at a constant pressure (for example, 10 mmHg). In this state, the fingertip blood flow rate measurement unit 16 generates data indicating the blood flow rate of the fingertip, for example, a blood flow waveform of the fingertip and outputs the data to the blood circulation information calculation device 30. Using this data, the calculation unit 34 of the blood circulation information calculation device 30 calculates the time average value (average blood flow amount) of the blood flow amount at the fingertip (step S112). Then, the pressure inside the insertion portion 18 is reduced.

Then, the calculation unit 34 of the blood circulation information calculation device 30 divides the fingertip average blood pressure specified in step S108 by the time average value of the blood flow volume of the fingertip calculated in step S112 to obtain a peripheral vascular resistance index (peripheral resistance index). A blood vessel resistance index) is calculated (step S114).

After that, the control unit 38 of the blood circulation information calculation device 30 once lowers the pressure inside the insertion unit 18, then pressurizes the inside of the insertion unit 18 again, and calculates the pressure applied by the insertion unit 18 to the fingertip to calculate the blood circulation information. The device 30 maintains a constant pressure (for example, 10 mmHg) lower than the fingertip diastolic blood pressure. The calculation unit 34 of the blood circulation information calculation device 30 stores data for drawing a graph (Lissajous curve) in which the horizontal axis represents the AC component of the blood flow waveform of the fingertip and the vertical axis represents the AC component of the pulse waveform of the fingertip. It is generated and the arterial elasticity is generated by processing this data (step S116). The rule for calculating the arterial elasticity from the Lissajous curve is determined, for example, by extracting the feature amount of the shape of the Lissajous curve and statistically processing the data. This arterial elasticity also indicates the degree of arteriosclerosis on the peripheral side of the upper arm.

The sequence of each sequence of measuring fingertip systolic blood pressure and diastolic blood pressure by pressurization, measuring fingertip average blood pressure by holding constant pressure, measuring fingertip average blood flow by holding constant pressure, and drawing Lissajous curve by holding constant pressure is , It is possible to change in a more appropriate order. For example, the fingertip average blood flow measurement by maintaining a constant pressure may be performed at the beginning of a series of sequences. Alternatively, if the fingertip average blood pressure measurement with constant pressure retention and the constant pressure retention condition of the Lissajous curve drawing sequence with constant pressure retention are the same, the measurements may be performed simultaneously.

After that, the calculation unit 34 generates data for display (step S118) and causes the display device 40 to display the display screen using this data (step S120).

FIG. 7 shows a first example of a screen displayed by the output unit 36 on the display device 40. This example is a screen for medical personnel who actually operate (for example, a doctor, a nurse, a clinical technologist), and a measurement start button 41 for starting the operation of the fingertip measurement device 10 and the blood circulation information calculation device 30. Setting field 42 for inputting subject information and measurement conditions of fingertip measuring device 10 and blood circulation information calculating device 30, display field 43 of time displacement (raw waveform) of fingertip blood flow, raw waveform of fingertip pulse wave Display column 44, a Lissajous waveform display column 45, a measurement waveform display column 46, and a value display column 47 specified by the calculation unit 34. Although an input device to the setting field 42 is not shown, it may be input automatically, may be input manually, and a general input device such as a keyboard, a touch panel, or voice input may be used. The measurement waveform displayed in the display field 46 is at least one of the time displacement of the cuff pressure during the pressurization or the constant pressure measurement, the time displacement of the blood flow of the fingertip, and the time displacement of the pulse wave of the fingertip. Further, in the display field 47, blood pressure information of the small blood vessels of the fingertip (for example, systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP)), and blood flow information of the small blood vessels of the fingertip ( For example, the average blood flow (Q), the peripheral vascular resistance index, the degree of arterial stenosis (FBI), and the latest value of the pulse are simultaneously displayed. The display device 40 may also display environmental conditions such as temperature and humidity at the measurement location, and the measurement result of the skin temperature of the subject.

The screen shown in FIG. 7 also includes a stop button 48 for stopping the operation of the fingertip measuring device 10 and the blood circulation information calculating device 30.

FIG. 8 shows a second example of a screen displayed by the output unit 36 on the display device 40. This example is a screen for a subject in addition to a medical worker, including a graph showing the value of the peripheral vascular resistance index on one axis and the arterial stenosis or arterial elasticity as the arteriosclerosis index on the other axis. There is. For display on the graph, when one axis is the degree of arterial stenosis, the reciprocal thereof is more preferable. The graph also includes information indicating a normal area. The data of the subject is shown as a circle in this graph, and the size of this circle is proportional to the average blood flow. The size of this circle may be represented by at least one of blood flow information or blood pressure information of small blood vessels, for example, the calculated fingertip blood pressure value, that is, systolic blood pressure, diastolic blood pressure, and average blood pressure of the fingertip. The graph may be displayed three-dimensionally. Therefore, the test subject can easily recognize whether or not his or her measurement result is normal. Further, when the measurement result of the subject is located outside the normal region, the measurement result of the subject is a specific disease type, for example, a condition in hypertension (for example, senile systolic hypertension or essential hypertension). May be displayed together with the information (for example, the text data shown in Display Example 1 and Display Example 2). The blood circulation information calculation device can be applied to analysis of detailed pathological conditions in hypertension and evaluation of peripheral vascular disorders such as diabetic microangiopathy based on the fingertip blood circulation information.

As described above, according to the present embodiment, since the fingertip measuring device 10 is used, blood circulation information in the peripheral part of the human body can be easily measured. In addition, the medical personnel and the subject can easily recognize the measurement result from the screens shown in FIGS. 7 and 8.

The embodiments and examples have been described above with reference to the drawings, but these are examples of the present invention, and various configurations other than the above can be adopted.

DESCRIPTION OF SYMBOLS 10 Finger tip measuring device 12 Pressing part 14 Finger pulse wave measuring part 16 Finger tip blood flow measuring part 18 Inserting part 20 Upper arm measuring device 30 Blood circulation information calculating device 32 Acquisition part 34 Calculation part 36 Output part 38 Control part 40 Display device 41 Measurement start button 42 Setting field 43 Display field 44 Display field 45 Display field 46 Display field 47 Display field

Claims (9)

Fingertip pulse wave information indicating the measurement result of the pulse wave of the small blood vessels in the fingertip of the subject, and fingertip blood flow information indicating the measurement result of the blood flow volume of the small blood vessels in the fingertip of the subject, and an acquisition unit that acquires the ,
The fingertip pulse wave information is used to calculate information about blood pressure of small blood vessels in the subject's fingertip, and the fingertip blood flow information is used to calculate information about blood flow of fine blood vessels in the subject's fingertip. A calculation unit that
A blood circulation information calculation device comprising: The blood circulation information calculation device according to claim 1,
The information about the blood pressure of the small blood vessels at the fingertip includes the systolic blood pressure, the diastolic blood pressure, and the average blood pressure of the small blood vessels, and the information about the blood flow volume of the small blood vessels at the fingertip includes the average blood flow volume of the small blood vessels. Blood circulation information calculation device. The blood circulation information calculation device according to claim 1 or 2,
The calculation unit,
Area time average of the pulse wave of the small blood vessels, and calculate the average blood pressure in the small blood vessels using the systolic blood pressure and diastolic blood pressure of the small blood vessels measured from the fluctuation of the pulse wave,
A blood circulation information calculation device that calculates a vascular resistance index of the small blood vessels by using the mean blood pressure and the fingertip blood flow information. In the blood circulation information calculation device according to any one of claims 1 to 3,
The calculation unit is a blood circulation information calculation device that calculates an arterial stenosis degree using upper arm blood circulation information and information on blood pressure of the small blood vessels. The blood circulation information calculation device according to any one of claims 1 to 4,
Further, a blood circulation information calculating device including a display processing unit that generates graph information for displaying a graph in which one axis indicates the value of the vascular resistance index of the small blood vessels and the other axis indicates the degree of arterial stenosis or the elasticity of arteries. .. The blood circulation information calculation device according to claim 5,
The blood flow information calculation device, wherein the display processing unit generates the graph information so that the graph further indicates blood flow information or blood pressure information of the small blood vessels. The blood circulation information calculation device according to claim 5 or 6,
The blood flow information calculation device, wherein the graph information includes information for displaying a normal region in the graph in a recognizable state. Computer
Fingertip pulse wave information showing the measurement result of the pulse wave of the small blood vessels of the subject, and fingertip blood flow information showing the measurement result of the blood flow volume of the small blood vessels of the subject, and acquiring,
Using the fingertip pulse wave information to calculate information on blood pressure in the small blood vessels of the subject, and calculating information on blood flow in the small blood vessels of the subject using the fingertip blood flow information, a blood flow information calculation method .. A program for causing a computer to perform the blood circulation information calculation method according to claim 8.

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