JP7236398B2 - ドナー修復鋳型多重ゲノム編集 - Google Patents

ドナー修復鋳型多重ゲノム編集 Download PDF

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JP7236398B2
JP7236398B2 JP2019564394A JP2019564394A JP7236398B2 JP 7236398 B2 JP7236398 B2 JP 7236398B2 JP 2019564394 A JP2019564394 A JP 2019564394A JP 2019564394 A JP2019564394 A JP 2019564394A JP 7236398 B2 JP7236398 B2 JP 7236398B2
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dna
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cells
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JP2020507342A (ja
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ベクスン リ，
アレクサンダー アストラカーン，
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２セブンティ バイオ インコーポレイテッド
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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JP2019564394A 2017-02-15 2018-02-15 ドナー修復鋳型多重ゲノム編集 Active JP7236398B2 (ja)

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US201762459203P 2017-02-15 2017-02-15
US62/459,203 2017-02-15
PCT/US2018/018370 WO2018152325A1 (en) 2017-02-15 2018-02-15 Donor repair templates multiplex genome editing

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JP2020507342A JP2020507342A (ja) 2020-03-12
JP2020507342A5 JP2020507342A5 (enExample) 2021-03-25
JPWO2018152325A5 JPWO2018152325A5 (enExample) 2022-10-17
JP7236398B2 true JP7236398B2 (ja) 2023-03-09

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US (2) US11499149B2 (enExample)
EP (2) EP3583203B1 (enExample)
JP (1) JP7236398B2 (enExample)
CN (1) CN110446781A (enExample)
AU (1) AU2018221730B2 (enExample)
CA (1) CA3053499A1 (enExample)
DK (1) DK3583203T5 (enExample)
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US11667911B2 (en) 2015-09-24 2023-06-06 Editas Medicine, Inc. Use of exonucleases to improve CRISPR/CAS-mediated genome editing
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EP4047092B1 (en) 2016-04-13 2025-07-30 Editas Medicine, Inc. Cas9 fusion molecules, gene editing systems, and methods of use thereof
US11293021B1 (en) 2016-06-23 2022-04-05 Inscripta, Inc. Automated cell processing methods, modules, instruments, and systems
US10011849B1 (en) 2017-06-23 2018-07-03 Inscripta, Inc. Nucleic acid-guided nucleases
US9982279B1 (en) 2017-06-23 2018-05-29 Inscripta, Inc. Nucleic acid-guided nucleases
AU2018291041B2 (en) 2017-06-30 2021-08-05 Inscripta, Inc. Automated cell processing methods, modules, instruments, and systems
US11866726B2 (en) 2017-07-14 2024-01-09 Editas Medicine, Inc. Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
CA3097648A1 (en) 2018-04-18 2019-10-24 Altius Institute For Biomedical Sciences Animal pathogen-derived polypeptides and uses thereof for genetic engineering
US10557216B2 (en) 2018-04-24 2020-02-11 Inscripta, Inc. Automated instrumentation for production of T-cell receptor peptide libraries
US10858761B2 (en) 2018-04-24 2020-12-08 Inscripta, Inc. Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
US12264181B2 (en) 2018-06-27 2025-04-01 Altius Institute For Biomedical Sciences Nucleic acid binding domains and methods of use thereof
AU2019292919A1 (en) 2018-06-30 2021-03-11 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
US11142740B2 (en) 2018-08-14 2021-10-12 Inscripta, Inc. Detection of nuclease edited sequences in automated modules and instruments
PL3867372T3 (pl) 2018-10-16 2025-06-23 Blueallele Corporation Sposoby ukierunkowanego wprowadzania dna do genów
US11214781B2 (en) 2018-10-22 2022-01-04 Inscripta, Inc. Engineered enzyme
EP3938501A4 (en) * 2019-03-14 2023-03-08 The Regents Of The University Of California CLUSTERED KNOCK-IN SCREENING AND CO-EXPRESSED HETEROLOGOUS POLYPEPTIDES DRIVEN BY ENDOGENOUS LOCI
CN113631713A (zh) 2019-03-25 2021-11-09 因思科瑞普特公司 酵母中的同时多重基因组编辑
US11001831B2 (en) 2019-03-25 2021-05-11 Inscripta, Inc. Simultaneous multiplex genome editing in yeast
EP3953477A4 (en) 2019-06-06 2022-06-22 Inscripta, Inc. HARDENING FOR RECURSIVE NUCLEIC ACID-DRIVEN CELL EDITING
CN110358792A (zh) * 2019-07-19 2019-10-22 华中农业大学 外源基因定点整合至actb基因下游的打靶载体构建方法及其应用
US11203762B2 (en) 2019-11-19 2021-12-21 Inscripta, Inc. Methods for increasing observed editing in bacteria
WO2021126886A1 (en) 2019-12-18 2021-06-24 Inscripta, Inc. Cascade/dcas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells
CN115135370A (zh) 2020-01-27 2022-09-30 因思科瑞普特公司 电穿孔模块和仪器
US20210332388A1 (en) 2020-04-24 2021-10-28 Inscripta, Inc. Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
WO2022060749A1 (en) * 2020-09-15 2022-03-24 Inscripta, Inc. Crispr editing to embed nucleic acid landing pads into genomes of live cells
US11512297B2 (en) 2020-11-09 2022-11-29 Inscripta, Inc. Affinity tag for recombination protein recruitment
US11306298B1 (en) 2021-01-04 2022-04-19 Inscripta, Inc. Mad nucleases
WO2022150269A1 (en) 2021-01-07 2022-07-14 Inscripta, Inc. Mad nucleases
US11884924B2 (en) 2021-02-16 2024-01-30 Inscripta, Inc. Dual strand nucleic acid-guided nickase editing
CN118401548A (zh) * 2021-11-26 2024-07-26 伊蒙纽斯治疗有限公司 细胞表面上的结合结构域分子
US20250207153A1 (en) * 2022-03-14 2025-06-26 The Regents Of The University Of California Integration of large nucleic acids into genomes
CN116212022A (zh) * 2022-12-19 2023-06-06 中国医学科学院医学生物学研究所 一种芳香烃受体基因AhR作为治疗靶点在制备抗HSV-1病毒药物中的应用
CN118538425B (zh) * 2024-06-06 2024-10-29 北京大学第一医院(北京大学第一临床医学院) 一种vhl综合征肾癌的诊断模型及其应用

Citations (4)

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