JP7209016B2 - イオン性金属アルキリデン化合物及びオレフィンメタセシス反応におけるその使用 - Google Patents
イオン性金属アルキリデン化合物及びオレフィンメタセシス反応におけるその使用 Download PDFInfo
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- JP7209016B2 JP7209016B2 JP2020566205A JP2020566205A JP7209016B2 JP 7209016 B2 JP7209016 B2 JP 7209016B2 JP 2020566205 A JP2020566205 A JP 2020566205A JP 2020566205 A JP2020566205 A JP 2020566205A JP 7209016 B2 JP7209016 B2 JP 7209016B2
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- 229910052751 metal Inorganic materials 0.000 title description 14
- 239000002184 metal Substances 0.000 title description 13
- 125000001118 alkylidene group Chemical group 0.000 title description 7
- 238000005865 alkene metathesis reaction Methods 0.000 title description 6
- 150000001875 compounds Chemical class 0.000 claims description 105
- 239000002904 solvent Substances 0.000 claims description 61
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 44
- 125000000217 alkyl group Chemical group 0.000 claims description 43
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 39
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 34
- 125000003118 aryl group Chemical group 0.000 claims description 34
- 239000000203 mixture Substances 0.000 claims description 32
- -1 cyano , pyrazol-1-yl Chemical group 0.000 claims description 31
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 30
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 28
- 238000006243 chemical reaction Methods 0.000 claims description 27
- 239000002608 ionic liquid Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 239000003446 ligand Substances 0.000 claims description 22
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 20
- 229910052736 halogen Inorganic materials 0.000 claims description 18
- 150000002367 halogens Chemical class 0.000 claims description 18
- 125000003545 alkoxy group Chemical group 0.000 claims description 15
- 238000005649 metathesis reaction Methods 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- 150000001336 alkenes Chemical class 0.000 claims description 11
- 150000001450 anions Chemical class 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 claims description 10
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims description 10
- 238000006798 ring closing metathesis reaction Methods 0.000 claims description 10
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 claims description 10
- 229910052721 tungsten Inorganic materials 0.000 claims description 10
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 9
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 9
- 229910052801 chlorine Inorganic materials 0.000 claims description 8
- 229910052731 fluorine Inorganic materials 0.000 claims description 8
- 229910052750 molybdenum Inorganic materials 0.000 claims description 8
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 8
- 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 6
- 229910052794 bromium Inorganic materials 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 230000000269 nucleophilic effect Effects 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 5
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 5
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims description 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 4
- 239000011737 fluorine Substances 0.000 claims description 4
- 125000000593 indol-1-yl group Chemical group [H]C1=C([H])C([H])=C2N([*])C([H])=C([H])C2=C1[H] 0.000 claims description 4
- 238000005710 macrocyclization reaction Methods 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 4
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 3
- VUEDNLCYHKSELL-UHFFFAOYSA-N arsonium Chemical compound [AsH4+] VUEDNLCYHKSELL-UHFFFAOYSA-N 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- UNQNIRQQBJCMQR-UHFFFAOYSA-N phosphorine Chemical compound C1=CC=PC=C1 UNQNIRQQBJCMQR-UHFFFAOYSA-N 0.000 claims description 3
- 125000006239 protecting group Chemical group 0.000 claims description 3
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 claims description 3
- 125000001607 1,2,3-triazol-1-yl group Chemical group [*]N1N=NC([H])=C1[H] 0.000 claims description 2
- 125000001401 1,2,4-triazol-4-yl group Chemical group N=1N=C([H])N([*])C=1[H] 0.000 claims description 2
- 229910017008 AsF 6 Inorganic materials 0.000 claims description 2
- 229910020366 ClO 4 Inorganic materials 0.000 claims description 2
- 229910018286 SbF 6 Inorganic materials 0.000 claims description 2
- 239000007983 Tris buffer Substances 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims description 2
- 125000004536 indazol-1-yl group Chemical group N1(N=CC2=CC=CC=C12)* 0.000 claims description 2
- 150000002825 nitriles Chemical class 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 2
- JFZKOODUSFUFIZ-UHFFFAOYSA-N trifluoro phosphate Chemical compound FOP(=O)(OF)OF JFZKOODUSFUFIZ-UHFFFAOYSA-N 0.000 claims description 2
- PEUPUKDBCPLDIH-UHFFFAOYSA-N 1,2,4-triazole Chemical group C1=NC=N[N]1 PEUPUKDBCPLDIH-UHFFFAOYSA-N 0.000 claims 1
- JORCYNCKBLNWBB-UHFFFAOYSA-N [O-]C(C(F)(F)F)C(F)(F)F.[O-]C(C(F)(F)F)C(F)(F)F.[O-]C(C(F)(F)F)C(F)(F)F.OC(C(F)(F)F)C(F)(F)F.[Al+3] Chemical compound [O-]C(C(F)(F)F)C(F)(F)F.[O-]C(C(F)(F)F)C(F)(F)F.[O-]C(C(F)(F)F)C(F)(F)F.OC(C(F)(F)F)C(F)(F)F.[Al+3] JORCYNCKBLNWBB-UHFFFAOYSA-N 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 claims 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 42
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 39
- 239000003054 catalyst Substances 0.000 description 37
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 32
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 27
- 239000000243 solution Substances 0.000 description 22
- 238000005160 1H NMR spectroscopy Methods 0.000 description 19
- 239000000460 chlorine Substances 0.000 description 19
- 125000004104 aryloxy group Chemical group 0.000 description 18
- 239000007787 solid Substances 0.000 description 18
- 230000015572 biosynthetic process Effects 0.000 description 14
- 239000006260 foam Substances 0.000 description 14
- 238000005481 NMR spectroscopy Methods 0.000 description 13
- 125000005647 linker group Chemical group 0.000 description 13
- 239000000758 substrate Substances 0.000 description 13
- 239000000725 suspension Substances 0.000 description 13
- 238000003786 synthesis reaction Methods 0.000 description 13
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
- 239000012071 phase Substances 0.000 description 9
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 8
- 239000013256 coordination polymer Substances 0.000 description 8
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 8
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 7
- 125000002091 cationic group Chemical group 0.000 description 7
- KWKAKUADMBZCLK-UHFFFAOYSA-N 1-octene Chemical compound CCCCCCC=C KWKAKUADMBZCLK-UHFFFAOYSA-N 0.000 description 6
- ADLVDYMTBOSDFE-UHFFFAOYSA-N 5-chloro-6-nitroisoindole-1,3-dione Chemical class C1=C(Cl)C([N+](=O)[O-])=CC2=C1C(=O)NC2=O ADLVDYMTBOSDFE-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- SBIGSHCJXYGFMX-UHFFFAOYSA-N methyl dec-9-enoate Chemical compound COC(=O)CCCCCCCC=C SBIGSHCJXYGFMX-UHFFFAOYSA-N 0.000 description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Substances C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
- 230000002051 biphasic effect Effects 0.000 description 5
- 238000005686 cross metathesis reaction Methods 0.000 description 5
- 238000000921 elemental analysis Methods 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- UJGFGHBOZLCAQI-UHFFFAOYSA-N tris(phosphanyl) borate Chemical compound POB(OP)OP UJGFGHBOZLCAQI-UHFFFAOYSA-N 0.000 description 5
- 239000010937 tungsten Substances 0.000 description 5
- 239000003039 volatile agent Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- XWJBRBSPAODJER-UHFFFAOYSA-N 1,7-octadiene Chemical compound C=CCCCCC=C XWJBRBSPAODJER-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- UHOVQNZJYSORNB-MZWXYZOWSA-N benzene-d6 Chemical compound [2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H] UHOVQNZJYSORNB-MZWXYZOWSA-N 0.000 description 4
- 229960003237 betaine Drugs 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 4
- 229930195733 hydrocarbon Natural products 0.000 description 4
- 150000002430 hydrocarbons Chemical group 0.000 description 4
- 238000002354 inductively-coupled plasma atomic emission spectroscopy Methods 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- 238000007152 ring opening metathesis polymerisation reaction Methods 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 4
- ZDZHCHYQNPQSGG-UHFFFAOYSA-N binaphthyl group Chemical group C1(=CC=CC2=CC=CC=C12)C1=CC=CC2=CC=CC=C12 ZDZHCHYQNPQSGG-UHFFFAOYSA-N 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 239000012043 crude product Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- AUHZEENZYGFFBQ-UHFFFAOYSA-N mesitylene Substances CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 description 3
- 125000001827 mesitylenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] 0.000 description 3
- TVMXDCGIABBOFY-UHFFFAOYSA-N n-Octanol Natural products CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 125000006850 spacer group Chemical group 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- RIOQSEWOXXDEQQ-UHFFFAOYSA-O triphenylphosphanium Chemical compound C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-O 0.000 description 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 3
- AFFLGGQVNFXPEV-UHFFFAOYSA-N 1-decene Chemical compound CCCCCCCCC=C AFFLGGQVNFXPEV-UHFFFAOYSA-N 0.000 description 2
- LIKMAJRDDDTEIG-UHFFFAOYSA-N 1-hexene Chemical compound CCCCC=C LIKMAJRDDDTEIG-UHFFFAOYSA-N 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- ZWUUHZQYJJNNAQ-UHFFFAOYSA-N C1=CC=C(C=C1)C2=CC(=[N+](C(=C2)C3=CC=CC=C3)C4=CC(=C(C(=C4)C5=CC=CC=C5)O)C6=CC=CC=C6)C7=CC=CC=C7.C(F)(F)(F)S(=O)(=O)[O-] Chemical compound C1=CC=C(C=C1)C2=CC(=[N+](C(=C2)C3=CC=CC=C3)C4=CC(=C(C(=C4)C5=CC=CC=C5)O)C6=CC=CC=C6)C7=CC=CC=C7.C(F)(F)(F)S(=O)(=O)[O-] ZWUUHZQYJJNNAQ-UHFFFAOYSA-N 0.000 description 2
- UBJVUCKUDDKUJF-UHFFFAOYSA-N Diallyl sulfide Chemical compound C=CCSCC=C UBJVUCKUDDKUJF-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 238000010535 acyclic diene metathesis reaction Methods 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- YMWUJEATGCHHMB-DICFDUPASA-N dichloromethane-d2 Chemical compound [2H]C([2H])(Cl)Cl YMWUJEATGCHHMB-DICFDUPASA-N 0.000 description 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 2
- 235000019439 ethyl acetate Nutrition 0.000 description 2
- 235000019387 fatty acid methyl ester Nutrition 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 150000002678 macrocyclic compounds Chemical class 0.000 description 2
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 2
- 229940073769 methyl oleate Drugs 0.000 description 2
- 239000002808 molecular sieve Substances 0.000 description 2
- 239000011733 molybdenum Substances 0.000 description 2
- 125000001624 naphthyl group Chemical group 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 125000005496 phosphonium group Chemical group 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 238000007363 ring formation reaction Methods 0.000 description 2
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 125000002827 triflate group Chemical group FC(S(=O)(=O)O*)(F)F 0.000 description 2
- 150000008648 triflates Chemical class 0.000 description 2
- CYPYTURSJDMMMP-WVCUSYJESA-N (1e,4e)-1,5-diphenylpenta-1,4-dien-3-one;palladium Chemical compound [Pd].[Pd].C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 CYPYTURSJDMMMP-WVCUSYJESA-N 0.000 description 1
- 125000003626 1,2,4-triazol-1-yl group Chemical group [*]N1N=C([H])N=C1[H] 0.000 description 1
- PAAZPARNPHGIKF-UHFFFAOYSA-N 1,2-dibromoethane Chemical compound BrCCBr PAAZPARNPHGIKF-UHFFFAOYSA-N 0.000 description 1
- QTYUSOHYEPOHLV-FNORWQNLSA-N 1,3-Octadiene Chemical compound CCCC\C=C\C=C QTYUSOHYEPOHLV-FNORWQNLSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- MCTWTZJPVLRJOU-UHFFFAOYSA-N 1-methyl-1H-imidazole Chemical compound CN1C=CN=C1 MCTWTZJPVLRJOU-UHFFFAOYSA-N 0.000 description 1
- UWOVWIIOKHRNKU-UHFFFAOYSA-O 2,6-diphenyl-4-(2,4,6-triphenylpyridin-1-ium-1-yl)phenol Chemical compound OC1=C(C=2C=CC=CC=2)C=C([N+]=2C(=CC(=CC=2C=2C=CC=CC=2)C=2C=CC=CC=2)C=2C=CC=CC=2)C=C1C1=CC=CC=C1 UWOVWIIOKHRNKU-UHFFFAOYSA-O 0.000 description 1
- VADKRMSMGWJZCF-UHFFFAOYSA-N 2-bromophenol Chemical compound OC1=CC=CC=C1Br VADKRMSMGWJZCF-UHFFFAOYSA-N 0.000 description 1
- WDBQJSCPCGTAFG-QHCPKHFHSA-N 4,4-difluoro-N-[(1S)-3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-pyridin-3-ylpropyl]cyclohexane-1-carboxamide Chemical compound FC1(CCC(CC1)C(=O)N[C@@H](CCN1CCC(CC1)N1C(=NN=C1C)C(C)C)C=1C=NC=CC=1)F WDBQJSCPCGTAFG-QHCPKHFHSA-N 0.000 description 1
- BWGRDBSNKQABCB-UHFFFAOYSA-N 4,4-difluoro-N-[3-[3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-thiophen-2-ylpropyl]cyclohexane-1-carboxamide Chemical compound CC(C)C1=NN=C(C)N1C1CC2CCC(C1)N2CCC(NC(=O)C1CCC(F)(F)CC1)C1=CC=CS1 BWGRDBSNKQABCB-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 1
- XJUZRXYOEPSWMB-UHFFFAOYSA-N Chloromethyl methyl ether Chemical compound COCCl XJUZRXYOEPSWMB-UHFFFAOYSA-N 0.000 description 1
- 101000801643 Homo sapiens Retinal-specific phospholipid-transporting ATPase ABCA4 Proteins 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- LFZAGIJXANFPFN-UHFFFAOYSA-N N-[3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-thiophen-2-ylpropyl]acetamide Chemical compound C(C)(C)C1=NN=C(N1C1CCN(CC1)CCC(C=1SC=CC=1)NC(C)=O)C LFZAGIJXANFPFN-UHFFFAOYSA-N 0.000 description 1
- 229910019398 NaPF6 Inorganic materials 0.000 description 1
- 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 102100033617 Retinal-specific phospholipid-transporting ATPase ABCA4 Human genes 0.000 description 1
- 238000004639 Schlenk technique Methods 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- SHDVNSOOOAXWJF-UHFFFAOYSA-N [Cl-].C1(=CC=CC=C1)C=1C=C(C=C(C=1O)C1=CC=CC=C1)[N+]1=C(C=C(C=C1C1=CC=CC=C1)C1=CC=CC=C1)C1=CC=CC=C1 Chemical compound [Cl-].C1(=CC=CC=C1)C=1C=C(C=C(C=1O)C1=CC=CC=C1)[N+]1=C(C=C(C=C1C1=CC=CC=C1)C1=CC=CC=C1)C1=CC=CC=C1 SHDVNSOOOAXWJF-UHFFFAOYSA-N 0.000 description 1
- WEVYAHXRMPXWCK-FIBGUPNXSA-N acetonitrile-d3 Chemical compound [2H]C([2H])([2H])C#N WEVYAHXRMPXWCK-FIBGUPNXSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000004450 alkenylene group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 150000003842 bromide salts Chemical class 0.000 description 1
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229940061627 chloromethyl methyl ether Drugs 0.000 description 1
- 229940126214 compound 3 Drugs 0.000 description 1
- 229940125898 compound 5 Drugs 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 150000001923 cyclic compounds Chemical class 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000003919 heteronuclear multiple bond coherence Methods 0.000 description 1
- 238000005570 heteronuclear single quantum coherence Methods 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000011244 liquid electrolyte Substances 0.000 description 1
- 238000000120 microwave digestion Methods 0.000 description 1
- DNMUKQULDTZTPX-UHFFFAOYSA-N naphthalen-1-yl(phenyl)phosphane Chemical group C=1C=CC2=CC=CC=C2C=1PC1=CC=CC=C1 DNMUKQULDTZTPX-UHFFFAOYSA-N 0.000 description 1
- SFBTTWXNCQVIEC-UHFFFAOYSA-N o-Vinylanisole Chemical compound COC1=CC=CC=C1C=C SFBTTWXNCQVIEC-UHFFFAOYSA-N 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 229940031826 phenolate Drugs 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- QGNRLAFFKKBSIM-UHFFFAOYSA-N prop-2-enylsulfanylbenzene Chemical compound C=CCSC1=CC=CC=C1 QGNRLAFFKKBSIM-UHFFFAOYSA-N 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 125000004353 pyrazol-1-yl group Chemical group [H]C1=NN(*)C([H])=C1[H] 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- QRUBYZBWAOOHSV-UHFFFAOYSA-M silver trifluoromethanesulfonate Chemical compound [Ag+].[O-]S(=O)(=O)C(F)(F)F QRUBYZBWAOOHSV-UHFFFAOYSA-M 0.000 description 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- CMSYDJVRTHCWFP-UHFFFAOYSA-N triphenylphosphane;hydrobromide Chemical compound Br.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 CMSYDJVRTHCWFP-UHFFFAOYSA-N 0.000 description 1
- KHKSXAYMYFVLBL-UHFFFAOYSA-N tris(phosphanyl) phosphate Chemical compound POP(=O)(OP)OP KHKSXAYMYFVLBL-UHFFFAOYSA-N 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
Classifications
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- C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic Table
-
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- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
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- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
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- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
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- C07C67/293—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Description
Mは、Mo又はWから選択され;
Xは、O又はNR5から選択され;
R1及びR2は、独立して、H、C1-6アルキル、及びアリールから選択され;C1-6アルキル及びアリールは、所望に応じて、C1-6アルキル、C1-6アルコキシ、及びO-C6H5のうちの1又は複数で置換されており;
R3は、窒素含有の、前記窒素を介してMと結合している芳香族ヘテロ環;ハロゲン;及びトリフラートから選択され;
R4は、アリールオキシ基であって、前記アリールオキシ基の前記酸素を介してMと結合している、アリールオキシ基であり;前記アリールオキシ基の前記アリール基Arは、Cat基と、Zが共有結合又はリンカーの何れかであるカチオン性リガンドCat+-Z-ArO-を形成するように結合しており;
R5は、所望に応じて置換されているアルキル又はアリールであり;並びに
YΘは、非求核性アニオンである。
(A)式IIの化合物、
[Cat+-Z-ArOH]YΘ
III
と反応させて、式Iの化合物を得ること、
を含み、式中、M、X、R1、R2、R3、Cat+-Z-ArO、及びYΘは、第一の態様で定められる通りの意味を有し、並びにR4=R3である。
R=CH3;Y=B[3,6-(CF3)2C6H3]4;
R=C6H5;Y=Al[O-C(CF3)3];
R=CH3;Y=Al[O-C(CF3)3];
R=C6H5;Y=B(C6F5)4;
R=C6H5;Y=CF3SO3
(B)第一の態様で定められる化合物の存在下、又は第三の態様で定められる組成物の存在下での、第一のオレフィンと第二のオレフィンとの反応であって、第一のオレフィンは、第二のオレフィンと同一又は異なる、反応すること、
を含む。
(a)第一の態様で定められる化合物の使用を含み;又は
(b)第三の態様で定められる組成物の使用を含み;又は
(c)第三の態様で定められる組成物、及びさらなる溶媒の使用であって、さらなる溶媒は、ピロール、アセトニトリル、ジメチルホルムアミド、ジメチルスルホキシド、ヘキサメチルホスホラミド、ジメチルアセタミド、及びスルホラン、又はイオン液体よりも低い極性を有し、それによって、前記ピロール、アセトニトリル、ジメチルホルムアミド、ジメチルスルホキシド、ヘキサメチルホスホラミド、ジメチルアセタミド、及びスルホラン、又はイオン液体とさらなる溶媒とが、2つの相を形成する、使用を含む。
[a]25℃、内標準としてドデカン、6時間、触媒:基質=1:1000。[b]ピロール:ヘプタン(2:3)、25℃、内標準としてドデカン、6時間、触媒:基質=1:1000。[c]IL1:ヘプタン(1:3)、25℃、内標準としてメシチレン、6時間、触媒:基質=1:1000。
[a]クロロベンゼン、25℃、内標準としてドデカン、8時間、触媒:基質=1:10000
[b]IL1/ヘプタン(1:3)、25℃、内標準としてメシチレン、8時間
Mは、Mo又はWから選択され;
Xは、O又はNR5から選択され;
R1及びR2は、独立して、H、C1-6アルキル、及びアリールから選択され;C1-6アルキル及びアリールは、所望に応じて、C1-6アルキル、C1-6アルコキシ、及びO-C6H5のうちの1又は複数で置換されており;
R3及びR4は、互いに独立して、アリールオキシ基であって、前記アリールオキシ基の前記酸素を介してMと結合している、アリールオキシ基であり;前記アリールオキシ基の前記アリール基は、Cat基と、Zが共有結合又はリンカーの何れかであるカチオン性リガンドCat+-Z-ArO-を形成するように結合しており;
R5は、所望に応じて置換されているアルキル又はアリールであり;並びに
Y1 Θ及びY2 Θは、それぞれ、トリフラートである。
(A)式Vの化合物であって、
式VIの化合物であって、
Cat+-Z-ArOΘ
VI
式中、Cat+-Z-ArOは、第五の態様で定められる通りの意味を有し、並びに式VIの化合物は、双性イオンである、式VIの化合物、
と反応させて、式IVの化合物を得ること、
を含む。
[a]クロロベンゼン、25℃、内標準としてドデカン、8時間、触媒:基質=1:1000。
[b]IL1:ヘプタン=1:3、25℃、内標準としてメシチレン、8時間、触媒:基質=1:1000。9-DAME=9-デセン酸メチルエステル。
Mは、Mo又はWから選択され;
Xは、O又はNR5から選択され;
R1及びR2は、独立して、H、C1-6アルキル、及びアリールから選択され;C1-6アルキル及びアリールは、所望に応じて、C1-6アルキル、C1-6アルコキシ、及びO-C6H5のうちの1又は複数で置換されており;
R4は、アリールオキシ基であって、前記アリールオキシ基の前記酸素を介してMと結合している、アリールオキシ基であり;前記アリールオキシ基の前記アリール基は、Cat基と、Zが共有結合又はリンカーの何れかであるカチオン性リガンドCat+-Z-ArO-を形成するように結合しており;
TfOは、CF3SO2の意味を有し、
カチオン性リガンドの正の電荷は、化合物中の負の電荷によって相殺されている。
t[分] 出力[W] T[℃]
20 0 室温
10 600 室温~160℃
60 600 160℃
30 0 160℃~室温
[00170]
1H-NMR(300MHz,C6D6):δ=0.87(s,9H,tBu),1.37(s br,3H,CH3 ネオフィリデン),1.67(s,3H,CH3 ネオフィリデン),1.80(s,6H,CH3 Mes オルソ),1.87(s,6H,CH3 Mes オルソ),2.02(s br,6H,CH3 ピロール),2.10(s,6H,CH3 Mes パラ),6.08(s,2H,CH ピロール),6.68(s,2H,CH Mes),6.71(s,2H,CH Mes),6.84(m,6H,Cmeta-H P-Ph),6.96(m,11H,Cortho-H P-Ph,Cpara-H P-Ph,Cmeta-H O-Ar),7.05(m,1H,Cpara-H ネオフィリデン Ph),7.13(m,2H,Cmeta-H ネオフィリデン Ph),7.26(m,2H,Cortho-H ネオフィリデン Ph),7.60(s br,4H,Cpara-H B(ArF)4),8.40(s br,8H,Cortho-H B(ArF)4),11.02(s,1H,Mo=CH)ppm;19F-NMR(282MHz,C6D6):δ=-62.2(B(ArF)4)ppm;31P-NMR(121MHz,C6D6):δ=22.8(PPh3)ppm;13C-NMR(HSQC及びHMBCから,75MHz,C6D6):δ=17.1(CH3 ピロール),19.5(CH3 Mes オルソ),20.2(CH3 Mes オルソ),20.6(CH3 Mes パラ),30.3(CH3 tBu),29.5(CH3 ネオフィリデン),32.8(CH3 ネオフィリデン),52.3(C ネオフィリデン),75.8(C tBu),109.3(CH ピロール),117.6(d,1JCP=100Hz,Cipso P-Ph),117.7(Cpara-H B(ArF)4),124.4(q,1JCF=265Hz,CF3),126.2(ネオフィリデン Ph Cpara),126.4(ネオフィリデン Ph Cortho),127.8(ネオフィリデン Ph Cmeta),128.6(CH Mes),129.4(CH Mes),129.6(Cmeta P-Ph),132.3(Cipso Mes),133.4(NC ピロール,Cpara P-Ph),134.8(Cortho-H B(ArF)4),134.9(Cortho P-Ph),135.1(Cortho Mes),135.5(Cortho Mes),137.9(Cpara Mes),148.2(ネオフィリデン Ph Cipso),162.2(Cipso B(ArF)4),164.5(COMo),291.2pmp(1JCH,SYN=119.7Hz,Mo=CH)。
15mg(8.12μmol)の
Claims (13)
- 式Iの化合物であって、
式中:
Mは、Mo又はWから選択され;
Xは、O又はNR5から選択され;
R1及びR2は、独立して、H、C(CH3)2C6H5、C1-6アルキル、及びアリールから選択され;C1-6アルキル及びアリールは、所望に応じて、C1-6アルキル、C1-6アルコキシ、及びO-C6H5のうちの1又は複数で置換されており;
R3は、窒素含有の、前記窒素を介してMと結合している芳香族ヘテロ環;ハロゲン;及びトリフラートから選択され;
Arはアリール基であり;
Zは共有結合又はリンカーの何れかであり;
R5は、所望に応じて置換されているアルキル又はアリールであり、
Y-は、非求核性アニオンであり、
ここで式Iの化合物は窒素含有ヘテロ環カルベン(NHC)-リガンドを含有せず、
式Iの化合物は、所望に応じて、エーテル、ニトリル、又はピリジンより選ばれる中性リガンドを含み、
前記Cat基が、Z-ArO-と一緒になって、アンモニウム、ピリジニウム、ホスホニウム、ホスホリニウム、アルソニウム、スルホニウム、及びオキソスルホニウム基から選択されるCat+-Z-ArO-基を形成し、
前記非求核性アニオンY-が、ClO4 -、AsF6 -、SbF6 -、PF6 -、CH3SO3 -、CF3SO3 -、p-CH3C6H4SO3 -、BF4 -、B[3,5-(CF3)2C6H3]4 -、B[C6F5]4 -、Al[O-t-C(CH3)(CF3)2]4 -、及びAl[O-t-C(CF3)3]4 -から選択される、
式Iの化合物。 - R1及びR2が、独立して、H、C(CH3)3、C(CH3)2C6H5、及びo位においてC1-6アルコキシで置換されているフェニルから選択される、請求項1に記載の化合物。
- R3が、所望に応じてC1-6アルキル、C1-6アルコキシ、フェニル、ハロゲン、又はシアノから独立して選択される1又は複数の置換基で置換されている、ピロール-1-イル、ピラゾール-1-イル、イミダゾール-1-イル、1H-1,2,3-トリアゾール-1-イル、2H-1,2,3-トリアゾール-2-イル、1H-1,2,4-トリアゾール-1-イル、4H-1,2,4-トリアゾ-4-イル、インドール-1-イル、インダゾール-1-イル、及びアザインドール-1-イルから選択され、好ましくは、ピロール-1-イル、2,5-ジメチルピロール-1-イル、及び2,5-ジフェニルピロール-1-イル、又はインドール-1-イル、若しくは置換されたインドール-1-イルから選択される、請求項1又は2に記載の化合物。
- R3が、ハロゲンから選択される、請求項1又は2に記載の化合物。
- 前記Cat+-Z-ArO-中の前記Arが、2,6位において、それぞれ、所望に応じて置換されているフェニルで、又はイソプロピル若しくはt-ブチルで置換されたフェニルであるか、又は
Cat+-Z-ArO-中の前記Arが、4位においてCat+-Z-で置換されたフェニルであるか、又は
Cat+-Z-ArO-中の前記Arが、2,6位において、それぞれ、所望に応じて置換されているフェニルで、又はイソプロピル若しくはt-ブチルで置換されたフェニルであり、及び
4位においてCat+-Z-で置換されている、
請求項1~4の何れか一項に記載の化合物。 - 前記Cat+-Z-ArO-は、ピリジニウムN-フェノキシ基又はホスホニウムP-フェノキシ基である、
請求項1~5の何れか一項に記載の化合物。 - メタセシス反応を行う方法であって、工程(B):
(B)請求項1~8の何れか一項に記載の化合物の存在下、又は請求項10に記載の組成物の存在下での、第一のオレフィンと第二のオレフィンとの反応であって、前記第一のオレフィンは、前記第二のオレフィンと同一又は異なる、反応すること、
を含む、方法。 - 前記メタセシス反応が、請求項10に記載の組成物、及びさらなる溶媒の存在下で行われ、前記さらなる溶媒は、ピロール、アセトニトリル、ジメチルホルムアミド、ジメチルスルホキシド、ヘキサメチルホスホラミド、ジメチルアセタミド、及びスルホラン、又は前記イオン液体よりも低い極性を有し、それによって、前記ピロール、アセトニトリル、ジメチルホルムアミド、ジメチルスルホキシド、ヘキサメチルホスホラミド、ジメチルアセタミド、及びスルホラン、又はイオン液体と前記さらなる溶媒とが、2つの相を形成する、請求項11に記載の方法。
- 閉環メタセシス反応を行う方法であって、
(a)請求項1~8の何れか一項に記載の化合物の使用を含み;又は
(b)請求項10に記載の組成物の使用を含み;又は
(c)請求項10に記載の組成物、及びさらなる溶媒の使用であって、前記さらなる溶媒は、ピロール、アセトニトリル、ジメチルホルムアミド、ジメチルスルホキシド、ヘキサメチルホスホラミド、ジメチルアセタミド、及びスルホラン、又は前記イオン液体よりも低い極性を有し、それによって、前記ピロール、アセトニトリル、ジメチルホルムアミド、ジメチルスルホキシド、ヘキサメチルホスホラミド、ジメチルアセタミド、及びスルホラン、又はイオン液体と前記さらなる溶媒とが、2つの相を形成する、使用を含み、
好ましくは、前記閉環メタセシス反応は、大環状化である、方法。
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