JP7206090B2 - automatic analyzer - Google Patents

Description

Embodiments of the present invention relate to automated analyzers.

Automated analyzers detect changes in color tone and turbidity caused by reactions between samples such as test samples collected from subjects and reagents for each test item. , Optically measured by a measuring unit such as a spectrophotometer or a nephelometer. This optical measurement generates test data indicating the test results represented by the concentration of each test item component in the material, the activity of enzymes, and the like.

This automatic analyzer measures by allowing the sample and reagent to react in the cell. Necessary items for pre- and post-processing are inserted. Ideally, when these probes and the like are moved to the position of the cell, the tip is positioned at the center of the cell.

However, there is a possibility that the tip will be bent by accident due to accidental contact during probe cleaning or reagent replenishment, or that the position will differ before and after probe replacement due to individual differences in probes. In such a case, the tip may deviate from the center of the cell and affect the test data, but there is no means for detecting this.

JP 2016-017775 A

Accordingly, embodiments of the present invention provide an automated analyzer that can detect whether a probe or the like is present at a desired location in a cell.

According to one embodiment, an automatic analyzer includes a reaction container for reacting a dispensed solution, a nozzle inserted into the reaction container, a moving mechanism for moving the reaction container, and a nozzle that moves to the reaction container. a plurality of detection sensors for detecting an insertion position; and when the reaction container is moved to the insertion position of the nozzle by the moving mechanism, the detection sensor controls to detect the insertion position of the nozzle; and a control unit.

1 is a block diagram showing an example of the configuration of an automatic analyzer according to one embodiment; FIG. FIG. 2 is a perspective view showing an example of a specific configuration of an analysis section in the automatic analyzer shown in FIG. 1; FIG. 2 is a plan view conceptually showing an example of a sensor in the automatic analyzer shown in FIG. 1; The figure which shows an example of the side view of the sensor shown in FIG. The figure which shows an example of the side view of the sensor shown in FIG. The figure which shows an example of the side view of the sensor shown in FIG. The figure which shows an example of the side view of the sensor shown in FIG. FIG. 2 is a plan view conceptually showing an example of a sensor in the automatic analyzer shown in FIG. 1; FIG. 2 is a plan view conceptually showing an example of a sensor in the automatic analyzer shown in FIG. 1; FIG. 2 is a plan view conceptually showing an example of a sensor in the automatic analyzer shown in FIG. 1;

An automatic analyzer according to this embodiment will be described below with reference to the drawings. In the following description, elements having substantially the same functions and configurations are denoted by the same reference numerals, and redundant description will not be given unless otherwise specified.

(First embodiment)
FIG. 1 is a block diagram schematically showing the configuration of an automatic analyzer 100 according to the first embodiment. The automatic analyzer 100 includes an analysis section 24 , a drive section 26 , an analysis control section 27 and a determination section 28 .

The analysis unit 24 generates blank data by blank measurement, generates standard data by standard measurement for measuring a mixture of a standard sample for each test item and a reagent used for analysis of each test item, and performs a test sample and a reagent. Generate test data by test measurement for measuring the mixed liquid of The drive unit 26 drives various constituent units of the analysis unit 24 . The analysis control section 27 controls the driving section 26 . Based on the blank data generated by the analysis section 24, the determination section 28 determines whether or not the predetermined unit is usable.

The automatic analyzer 100 further includes a data processing section 30 , an output section 40 , an operation section 50 and a system control section 60 . The data processing unit 30 processes the standard data, test data, or blank data generated by the analysis unit 24 to generate calibration data, analysis data, and the like. The calculation unit 31 performs calculations necessary for these processes, and the data storage unit 32 appropriately stores data required for these processes and generated data. The output unit 40 prints the calibration data, analysis data, etc. generated by the data processing unit 30 using the printing unit 41 and displays them using the display unit 42 .

The operation unit 50 is an input unit through which a user inputs instructions and information. Specifically, the user operates the operation unit 50 to input data for setting the sample dispensing amount, the reagent dispensing amount, the wavelength of the light source, etc. as analysis parameters for each inspection item. I do. Further, the user operates the operation unit 50 to perform input or the like for setting each inspection item necessary for inspection for each sample to be inspected. The system control unit 60 controls the analysis control unit 27, the determination unit 28, the data processing unit 30, and the output unit 40, and controls the automatic analysis apparatus 100 as a whole.

FIG. 2 is a perspective view showing an example of a specific configuration of the analysis section 24 in the automatic analyzer 100 shown in FIG. 1. As shown in FIG. The analysis unit 24 includes a sample disk 5, a reagent storage 1, a reagent storage 2, a reaction disk 4, a first reagent dispensing mechanism 14, a second reagent dispensing mechanism 15, a sample dispensing mechanism 16, A first stirring mechanism 18 and a second stirring mechanism 19 are provided.

The sample disk 5 holds a plurality of sample containers 17, and the sample containers 17 contain standard samples, test samples such as serum, and the like. The reagent storage 1 includes a reagent rack 1a that rotatably holds a plurality of reagent containers 6. The reagent rack 1a holds the first reagent contained in the reagent container 6 while keeping it cool. That is, the reagent container 6 accommodates, for example, one-reagent and two-reagent first reagents that react with components of test items contained in each sample such as a standard sample and a test sample.

The reagent storage 2 includes a reagent rack 2a that rotatably holds a plurality of reagent containers 7. The reagent rack 2a holds the second reagent contained in the reagent container 7 while keeping it cool. That is, the reagent container 7 accommodates the second reagent paired with the first reagent.

The reaction disk 4 detachably holds a plurality of holders 3a on its circumference. This holder 3a holds a plurality of reaction vessels 3 in an arc shape with a predetermined interval. In this embodiment, the reaction container 3 is held by the holder 3a so as to be vertically detachable. That is, the reaction disk 4 movably holds a plurality of reaction vessels 3 .

The first reagent dispensing mechanism 14 includes a first reagent dispensing probe 14a, a first reagent dispensing arm 8, and a washing tank 14b. The first reagent dispensing probe 14a aspirates the first reagent in the reagent container 6 held in the reagent rack 1a and dispenses it into the reaction container 3 into which the sample has been discharged. The first reagent dispensing arm 8 holds the first reagent dispensing probe 14a rotatably and vertically movable. The cleaning tank 14b cleans the first reagent dispensing probe 14a each time dispensing of one reagent from the first reagent dispensing probe 14a is completed.

The second reagent dispensing mechanism 15 includes a second reagent dispensing probe 15a, a second reagent dispensing arm 9, and a washing tank 15b. The second reagent dispensing probe 15a aspirates the second reagent in the reagent container 7 held in the reagent rack 2a and dispenses it into the reaction container 3 into which the first reagent has been discharged. The second reagent dispensing arm 9 holds the second reagent dispensing probe 15a rotatably and vertically movable. The cleaning tank 15b cleans the second reagent dispensing probe 15a each time dispensing of one reagent from the second reagent dispensing probe 15a is completed.

The sample pipetting mechanism 16 includes a sample pipetting probe 16a, a sample pipetting arm 10, and a washing tank 16b. The sample dispensing probe 16 a aspirates the sample contained in the sample container 17 held on the sample disk 5 and discharges it into the reaction container 3 for dispensing. The sample pipetting arm 10 holds the sample pipetting probe 16a rotatably and vertically movable. The cleaning tank 16b cleans the sample pipetting probe 16a each time one sample has been pipetted from the sample pipetting probe 16a.

The first stirring mechanism 18 includes a first stirring element 18a, a first stirring arm 20, and a washing tank 18b. The first stirrer 18 a stirs the mixed liquid of the sample and the first reagent dispensed into the reaction vessel 3 . The first stirring arm 20 holds the first stirring element 18a rotatably and vertically movable. The cleaning tank 18b cleans the first stirrer 18a each time the mixed liquid is stirred.

The second stirring mechanism 19 includes a second stirring element 19a, a second stirring arm 21, and a washing tank 19b. The second stirrer 19a stirs the mixture of the sample, the first reagent, and the second reagent dispensed into the reaction container 3 . The second stirring arm 21 holds the second stirring element 19a rotatably and vertically movable. The cleaning tank 19b cleans the second stirrer 19a each time the mixed liquid is stirred.

Moreover, the automatic analyzer 100 further includes a cleaning mechanism 12 and a measurement unit 13 . The cleaning mechanism 12 cleans the reaction container 3 for which the subject measurement has been completed. Specifically, the cleaning mechanism 12 cleans the reaction container 3, dispenses blank water for blank measurement for the next measurement to be tested, and then dries.

The measurement unit 13 measures the light transmitted through the reaction container 3 among the light irradiated to the reaction container 3 containing a solution such as water or a mixed liquid. The cleaning mechanism 12 cleans and dries the inside of the reaction vessel 3 after the measurement of the mixed liquid by the measurement unit 13 is completed. Further, the cleaning mechanism 12 discharges a blank liquid such as pure water to the cleaned reaction vessel 3 for blank measurement.

In addition, the measurement unit 13 generates blank data by blank measurement in which light transmitted through the reaction container 3 into which the blank liquid is dispensed is detected. In addition, the measurement unit 13 generates standard data by standard measurement of detecting light transmitted through the mixed liquid in the reaction container 3 into which the standard sample and the reagent are dispensed. Further, test data is generated by test measurement in which light transmitted through the mixed liquid in the reaction container 3 into which the test sample and the reagent are dispensed is detected.

The configuration of the automatic analyzer 100 will be described in more detail with reference to FIGS. 1 and 2. First, the drive section 26 drives various constituent units in the analysis section 24 as described above. More specifically, the sample disk 5, the reagent rack 1a, and the reagent rack 2a are individually rotationally driven to move the sample container 17, the reagent container 6, and the reagent container 7, respectively. Further, the drive unit 26 rotates the reaction disk 4 to move the reaction container 3 . Furthermore, the drive unit 26 moves the sample dispensing arm 10, the first reagent dispensing arm 8, the second reagent dispensing arm 9, the first stirring arm 20, and the second stirring arm 21 up and down individually. and rotate to move the sample pipetting probe 16a, the first reagent pipetting probe 14a, the second reagent pipetting probe 15a, the first stirrer 18a, and the second stirrer 19a, respectively. .

The analysis control section 27 controls the drive section 26 to operate various constituent units of the analysis section 24 as described above. More specifically, the analysis control unit 27 sequentially assigns inspection items input from the operation unit 50 for each test sample to the reaction containers 3 that have been cleaned by the cleaning mechanism 12 in order to carry out the inspection. Then, into the reaction container 3 to which the inspection item is assigned, the cleaning mechanism 12 is caused to discharge the total amount of the blank liquid, which is the sum of the dispensing amount of the sample and the dispensing amount of the reagent set as the analysis parameter of the inspection item. . Subsequently, the measurement unit 13 is caused to perform a blank measurement of the reaction container 3 into which the blank liquid has been discharged, thereby generating blank data.

Based on the blank data generated by the measurement unit 13, the determination unit 28 determines whether or not the reaction container 3 can be used for the inspection item. In this case, blank data are collected multiple times, so whether or not the reaction container 3 is ready for inspection is determined based on the collected multiple blank data.

When the determination unit 28 determines that the reaction container 3 is usable, the analysis control unit 27 dispenses the sample and the reagent for the inspection item assigned to the reaction container 3 . On the other hand, when the determination unit 28 determines that the reaction container 3 is unusable, the analysis control unit 27 stops the dispensing of the test item sample and reagent assigned to the reaction container 3 . In this case, the canceled inspection item is further assigned to the reaction container 3 to be washed next to the reaction container 3 determined to be unusable by the determination unit 28 .

The data processing unit 30 includes the calculation unit 31 and the data storage unit 32 as described above. More specifically, the calculation unit 31 processes the standard data and test data generated by the measurement unit 13 of the analysis unit 24 to generate calibration data, analysis data, and the like for each test item. The data storage unit 32 stores and holds collected standard data, test data, and the like, and also stores calibration data, analysis data, and the like generated by the calculation unit 31 .

Based on the standard data generated by the measurement unit 13 and the standard values preset for the standard sample of the standard data, the calculation unit 31 calculates calibration data representing the relationship between the standard values and the standard data for each inspection item. Generate. Then, the generated calibration data is output to the output unit 40 and stored in the data storage unit 32 .

Further, the calculation unit 31 reads from the data storage unit 32 the calibration data of the inspection item corresponding to the test data generated by the measurement unit 13, and expresses the concentration value and the activity value from the calibration data and the test data. generate analytical data that Then, the generated analysis data is output to the output unit 40 and stored in the data storage unit 32 .

The data storage unit 32 includes a memory device such as a hard disk, and holds the calibration data generated by the calculation unit 31 for each inspection item. Also, the analysis data of each test item generated by the calculation unit 31 is stored for each test sample.

The output unit 40 includes the printing unit 41 and the display unit 42 as described above. The printing unit 41 prints out calibration data, analysis data, and the like generated by the calculation unit 31 of the data processing unit 30 . That is, the printing unit 41 includes, for example, a printer, etc., and prints calibration data, analysis data, etc. on printer paper or the like according to a preset format.

The display unit 42 includes a monitor such as a CRT (Cathode Ray Tube), a liquid crystal panel, or the like, and displays and outputs calibration data, analysis data, and the like. The display unit 42 also displays an analysis parameter setting screen, an inspection item setting screen, etc., and allows the user to input various information. For example, the analysis parameter setting screen prompts the user to input the sample dispensing amount, the first reagent dispensing amount, or the first and second reagent dispensing amounts, which are the analysis parameters for each inspection item. Also, on the inspection item setting screen, the user is allowed to set the inspection items set on the analysis parameter setting screen for each test sample.

As described above, the operation unit 50 is a device for the user to input instructions, information, etc., and includes input devices such as a keyboard, mouse, buttons, and touch panel, for example. Then, input for setting the sample dispensing amount, the first reagent dispensing amount, the first and second reagent dispensing amounts, etc., as analysis parameters for each inspection item is enabled. In addition, input for setting information of each sample to be inspected and inspection items to be inspected for each information is performed.

The system control unit 60 performs overall control of the automatic analyzer 100 as described above. More specifically, the system control unit 60 includes a CPU (Central Processing Unit), a storage circuit, and the like, and stores input information such as analysis parameters and inspection items of each inspection item input by operation from the operation unit 50 in the storage circuit. Save to Then, based on the saved input information, the analysis control unit 27, the determination unit 28, the data processing unit 30, and the output unit 40 are integrated to control the automatic analysis apparatus 100 as a whole.

Hereinafter, various probes used for dispensing and discharging reagents, various stirrers used for stirring mixed solutions, units used for washing, and the like, which are inserted into reaction vessels, are referred to as nozzles. Various nozzles are inserted into the reaction container 3, for example, in the region where the holder 3a of the reaction disk 4 exists.

FIG. 3 is a plan view showing an example of the arrangement of reaction vessels 3. As shown in FIG. Here, the plan view indicates, for example, that the automatic analyzer 100 is drawn from above in the vertical direction. That is, it is a diagram showing the relationship on a horizontal plane that intersects, for example, is substantially perpendicular to the direction in which the nozzle is inserted (insertion direction) without considering the height of the reaction vessel 3 and the like. Horizontal does not mean strictly horizontal, and may be a surface that is substantially horizontal. Further, in the following description, the term “planar view” means viewing from a viewpoint that does not consider the height of the reaction vessel 3 when viewed from the direction in which the nozzle is inserted. For example, when the vertical direction of the nozzle is the y-axis, the x-axis and z-axis orthogonal to the y-axis are shown regardless of the value of y. That is, in this embodiment, the desired region where the nozzle is inserted is represented by coordinates including (x, z), and it is detected whether or not the position (x, z) where the nozzle is inserted is within the desired region. Similar to the above, the planes do not have to be strictly orthogonal.

It should be noted that the drawings used for the following description, including FIG. 3, are conceptually shown, and the relationship of the position, size, shape, angle, etc. of each element is not limited to this. For example, the distance between the reaction vessels 3 may be narrower or wider, and the relationship between the size of the reaction vessels 3 and the size of the circle in which the reaction vessels 3 are arranged may be different from that shown in this figure. does not match. Furthermore, the ratio of each side of the reaction vessel 3 is not limited to that shown in the figure. Also, in order to make the main points of the explanation easier to understand, the illustration of other parts such as the holder 3a is omitted.

Focus on the reaction container 300 shown in the center. In FIG. 3 , for example, the first reagent dispensing probe 14 a is inserted into the reaction container 300 and the first reagent is discharged into the reaction container 300 . As described above, the nozzles such as the first reagent dispensing probe 14a are desirably positioned in the center of the reaction vessel 300. FIG. This preferred insertion position does not indicate a single point, but is meant to be in a given area. For example, when the reaction vessel 3 is viewed from above, each side may be divided into thirds, and the center 1/3 area may be defined for both sides. The setting of this area is not limited to the area based on the trisecting point, and may be freely changed by the user and the administrator.

In order to confirm whether the first reagent dispensing probe 14a is inserted in the center of the reaction container 300, the automatic analyzer 100 has two pairs of detection sensors at the ideal position where the nozzle to be confirmed is inserted. , a first detection sensor 310 and a second detection sensor 312 . The first detection sensor 310 includes a first light projection sensor 310a and a first light reception sensor 310b. Each of these sensors is installed so as to be fixed within the automatic analyzer 100, for example, without depending on the movement of the reaction container 3. FIG. A dotted line between the light-projecting sensor and the light-receiving sensor indicates the path of light.

The first light emitting sensor 310a is a device that emits light, preferably directional light, toward the first light receiving sensor 310b through an ideal position where the nozzle is inserted. Diode) and LD (Laser Diode). The first light receiving sensor 310b is a device that receives light emitted by the first light emitting sensor 310a, and includes, for example, a photodiode. The light emitted by the first light sensor 310a has a width that is sufficiently small compared to the size of the reaction container 300 . At least in the ideal insertion area of the nozzle, the beam width is small compared to the size of the reaction vessel 300 .

The second light sensor 312a is a device that emits light, preferably directional light, toward the second light sensor 312b through an ideal position where the nozzle is inserted. Prepare. The second light receiving sensor 312b is a device that receives light emitted by the second light emitting sensor 312a, and includes, for example, a photodiode. The light emitted by the second light sensor 312a has a width that is sufficiently small compared to the size of the reaction container 300 . At least in the ideal insertion area of the nozzle, the beam width is small compared to the size of the reaction vessel 300 .

When the width of the light beam is sufficiently small, for example, the intensity of the light received by the first light receiving sensor 310b when the nozzle is inserted into the reaction vessel 300 in an ideal region is the same as when the nozzle is not inserted. Refers to the width of a ray that is significantly smaller in comparison, eg, 80% intensity. Note that 80% or the like is described as an example, and is not limited to this, and may be a larger value such as 90% or a smaller value such as 50%. For example, a threshold value is provided for the intensity of light from the light-projecting sensor received by the light-receiving sensor, and it is detected whether or not the nozzle is in the desired region. Therefore, background processing may be performed in a state in which light is not emitted from the light projection sensor before performing nozzle detection.

The first detection sensor 310 and the second detection sensor 312 are installed in a direction in which the optical path of the first detection sensor 310 and the optical path of the second detection sensor 312 intersect in plan view. That is, it is desirable that the nozzle be inserted in an area where the light emitted from the first light projection sensor 310a and the light emitted from the second light projection sensor 312a intersect. It is desirable that the mutual optical paths intersect at an angle close to 90°, but the present invention is not limited to this. It doesn't matter if it's not.

When the nozzle is in the ideal area, the light emitted from the first light emitting sensor 310a is blocked by the nozzle and part or all of it does not reach the first light receiving sensor 310b. Therefore, a predetermined threshold value is set so that it can be determined that the nozzle exists in an ideal area. In the direction orthogonal to the optical path of the sensor 310, it can be detected that the nozzle exists in the ideal area. The same is true for the second detection sensor 312, and in the direction perpendicular to the optical path of the second detection sensor 312, it can be detected whether or not the nozzle is inserted into an ideal area.

By using two pairs of detection sensors in this way, it is possible to detect whether or not the nozzle is inserted into an ideal area in the direction perpendicular to the optical path of each detection sensor. , it becomes possible to detect whether or not the nozzle is inserted into an ideal region in the plan view of the reaction container 300 .

For example, even if the first detection sensor 310 detects that the nozzle is in the desired position, the nozzle exists on the optical path of the first detection sensor 310 but is out of the desired area. Sometimes. In such a case, by referring to the detection result of the second detection sensor 312 having an optical path that intersects the optical path of the first detection sensor 310, it can be detected that the nozzle does not exist at the desired position. On the other hand, when the nozzle is inserted into the desired area, it can be detected that the nozzle is inserted in the desired area because any sensor detects that the nozzle is present in the desired area.

FIG. 4 is a cross-sectional view taken along line AA in FIG. That is, it is a side view of the reaction container 300 and the detection sensor in FIG. As shown in FIG. 4, the first light emitting sensor 310a, the first light receiving sensor 310b, the second light emitting sensor 312a, and the second light receiving sensor 312b may be provided on the same horizontal plane. In this case, identical does not necessarily have a strict meaning. Also, the plane may not be strictly horizontal, and may intersect with the vertical direction in a direction slightly deviated from the right angle.

As described above, according to this embodiment, it is possible to detect whether or not the nozzle insertion position exists in an ideal region by adding a simple device of two pairs of light emitting sensor and light receiving sensor. It becomes possible. The light-projecting sensor is, for example, an LED, and the light-receiving sensor is, for example, a photodiode, which are smaller in size than a laser device, a camera, or the like. Furthermore, it is possible to install in a state in which the influence on other devices is small. Further, unlike the case of using a camera, detection is possible from the intensity of the light received by the light receiving sensor. Therefore, the nozzle can be detected without photographing with a camera and image processing of the photographed image. It is possible.

(Second embodiment)
FIG. 5 is a diagram showing an example of installation positions of the reaction vessel 300 and each sensor of the automatic analyzer 100 according to the second embodiment. The plan view is similar to that shown in FIG. 3 as in the previous embodiment. The first light emitting sensor 310a, the first light receiving sensor 310b, the second light emitting sensor 312a, and the second light receiving sensor 312b do not all exist on the same horizontal plane, but exist on different horizontal planes. In this way, all the sensors do not necessarily need to be on the same plane, and may be installed so as to intersect in a desired area where the nozzles are present in a plan view.

In FIG. 5, the first light sensor 310b and the second light sensor 312a are at the same height, but the position of the first light sensor 310a and the first light sensor 310b is not limited to this. It may be reversed. In this case, the light emitting sensors and the light receiving sensors are at the same height. Other combinations, such as a combination in which the light-projecting sensor is installed lower than the light-receiving sensor, may also be used. Also, two of them are at the same height, but not limited to this. For example, all sensors may have different heights, three sensors may be at the same height, and the remaining sensors may be in These height settings can be arbitrarily changed depending on the relationship between other components in the automatic analyzer 100 and the installation position of each sensor.

(Third Embodiment)
In the first and second embodiments described above, the detection is performed in a state where the nozzle is fixed at the insertion position of the nozzle, but the present invention is not limited to this. For example, the nozzle may be moved up and down while the detection operation is being performed.

FIG. 6 is a diagram showing an example in which the first reagent dispensing probe 14a is moved up and down at the sensor position shown in FIG. For example, as shown in FIG. 6, consider the case where the first reagent dispensing probe 14a is bent (curved or bent) in the middle. In such a case, it is not possible to detect that the tip is bent in a stationary state, as in the previous embodiment.

Therefore, in the present embodiment, the sensor detects the nozzles in a state in which the nozzles are moved up and down, not in a state in which the nozzles are stationary. It is assumed that the first reagent dispensing probe 14a is not detected by at least one sensor at the position indicated by the solid line, and is detected by both sensors at the position indicated by the dotted line.

When it is in the position of the solid line, in the relationship between the length of the nozzle and the position of the arm, if it is in the desired position, it should be detected by both sensors, but it is not detected by at least one sensor, When it is in the position of the dotted line, it is detected by both sensors. In such a case, it is possible to detect that the tip of the nozzle is bent, as shown in FIG.

In particular, according to this embodiment, if one sensor detects the position indicated by the solid line and both sensors detect the position indicated by the dotted line, this does not mean that the nozzle insertion position is not in the desired region, and that the nozzle Even if the insertion position of the nozzle itself is in a desired position, it is possible to detect problems in the nozzle itself, such as a bent tip of the nozzle.

In the above description, the case where the desired vertical position of the nozzle has been obtained in advance has been described, but the present invention is not limited to this. For example, by setting the movement distance of the nozzle in the direction of insertion and detecting the degree of light reception when the nozzle is moved along the movement direction, bending (bending, bending) of the nozzle can be detected. can be

(Fourth embodiment)
7 is a diagram showing still another arrangement of the sensors in FIG. 3. FIG. As shown in FIG. 7, the first detection sensor 310 and the second detection sensor 312 may be positioned at different heights. That is, the area connecting the light projecting portions and light receiving portions of the first light projecting sensor 310a and the first light receiving sensor 310b and the region connecting the light transmitting portions and light receiving portions of the second light projecting sensor 312a and the second light receiving sensor 312b are , do not necessarily intersect in the height direction. However, even in this case, in plan view, as shown in FIG.

As described above, the position of each sensor is such that the light beams of the respective paired sensors intersect when viewed from above, that is, when the reaction vessel 300 is viewed from the vertical direction, but do not necessarily intersect in the height direction. You don't have to be. By using this relationship, it becomes possible to set the position of each sensor more freely.

5, the positions of the first light emitting sensor 310a and the first light receiving sensor 310b, and the positions of the second light emitting sensor 312a and the second light receiving sensor 312b are exchangeable.

(Fifth embodiment)
In each of the above-described embodiments, a case in which a single nozzle is configured has been described, but in this embodiment, a case in which a plurality of nozzles are arranged will be described. FIG. 8 is a diagram showing the positions of the detection sensors according to the present embodiment in plan view.

The nozzle of the automatic analyzer 100 may exist singly as in each of the above-described embodiments, but a plurality of nozzles, for example, two nozzles are arranged for the adjacent reaction vessels 3. in some cases. In FIG. 8, nozzles are respectively inserted into reaction vessels 300 and 302 that are placed next to each other. In such a case, by using two pairs of detection sensors for the reaction container 300 and two pairs of detection sensors for the reaction container 302, the position of the nozzle can be detected in the same manner as in the above-described embodiment. It is possible.

However, installing two pairs of detection sensors for each reaction vessel may result in insufficient installation space. Moreover, depending on the positional relationship of the reaction container, the installation positions of the detection sensors may overlap, and the installation may not be easy.

In such a case, as shown in FIG. 8, by using three pairs of detection sensors 310, 312, 314, it is possible to detect the insertion of the nozzles of the two reaction vessels 300, 302. FIG.

After that, the first nozzle is inserted into the first reaction container 300, the detection of the first nozzle is performed by the first detection sensor 310 and the second detection sensor 312, the second nozzle is inserted into the second reaction container 302, and the A case in which two nozzles are detected by the first detection sensor 310 and the third detection sensor 314 will be described.

The first detection sensor 310 is installed, for example, so that light used for detection passes through desired insertion regions of the first nozzle and the second nozzle in the first reaction container 300 and the second reaction container 302, respectively. The second detection sensor 312 is installed such that the optical path used for detection intersects with the optical path of the first detection sensor 310 in the desired insertion region of the first nozzle in the first reaction vessel 300 . The third detection sensor 314 is installed such that the optical path used for detection intersects the optical path of the first detection sensor 310 in the desired insertion region of the second nozzle in the second reaction vessel 302 .

When the first detection sensor 310, the second detection sensor 312, and the third detection sensor 314 are installed in this way and the first nozzle of the first reaction container 300 is detected, the first detection sensor 310 and the second detection sensor When the sensor 312 is used to detect the second nozzle of the second reaction container 302, the first detection sensor 310 and the third detection sensor 314 are used. By detecting the nozzles inserted into the respective reaction containers at different timings, it is possible to detect the nozzles of the two reaction containers using three pairs of detection sensors.

As described above, according to the automatic analyzer according to the present embodiment, normally two pairs of detection sensors are required to detect one nozzle, but the nozzles are inserted into adjacent reaction vessels. In some cases, three pairs of detection sensors allow detection for two reaction vessels. By installing the detection sensors as shown in FIG. 8, it is possible to reduce the required number of each sensor and secure an area for installing each sensor. It should be noted that the position of each sensor in the height direction can be set to various positions as in each of the above-described embodiments.

(Sixth embodiment)
In each of the above-described embodiments, the detection sensor is configured with a pair of a light projecting sensor and a light receiving sensor, but is not limited to this. In this embodiment, the light emitted from the light projection sensor is reflected by the nozzle, and the reflected light is used to detect the nozzle.

FIG. 9 is a diagram showing the positions of the detection sensors according to the present embodiment in plan view. The first detection sensor 310 includes a first light projecting/receiving sensor 310c. The first light projecting/receiving sensor 310c is a sensor that includes a light projecting sensor and a light receiving sensor. The light-projecting sensor and the light-receiving sensor may be the same device or may be separate devices.

If they are the same device, they are installed so that the projected light beam is reflected by the nozzle and returns to the same device. For example, the device is installed so that the light beam is emitted on a plane that is perpendicular to the desired installation position and direction of the nozzle.

If they are separate devices, they are installed at positions where the light emitted from the light emitting sensor and reflected by the nozzle returns to the light receiving sensor. For example, the positions and angles of the light emitting sensor and the light receiving sensor are set so as to have an angle opposite to the plane perpendicular to the desired installation position and direction of the nozzle.

As described above, according to the present embodiment, it is possible to detect whether or not the nozzle is inserted into the desired region where the nozzle exists, and to reduce the installation locations of each sensor, as in the above-described embodiment. It becomes possible. In FIG. 9, the sensor is positioned inside where the reaction vessels are arranged, but the present invention is not limited to this, and the sensor may be positioned outside the circumference where the reaction vessels are arranged. By reducing the number of sensors, it is possible to increase the degree of freedom in installing each sensor.

(Seventh embodiment)
In each of the above-described embodiments, for example, a sensor that emits light having a certain degree of directivity and high intensity, such as an LED, is used as a light projection sensor. A sensor may be used.

FIG. 10 is a diagram showing the positions of the detection sensors according to the present embodiment in plan view. The first light projection sensor 310a does not have to be a device that does not spread the beam diameter as much as the LED, but is a device that spreads the beam diameter to some extent. In such a case, for example, by placing masks 310M on both sides of the sensor, the beam system is narrowed so that the light reaches the first light receiving sensor 310b. Similarly, the beam diameter of the second projection sensor 312a is narrowed by the mask 312M.

In this way, the light projection sensor may be formed using a mask. By using a mask, it is also possible to use a light source that originally has a wide beam diameter as a light projection sensor. The mask for the light projection sensor can also be used when LEDs are used as light sources.

As described above, according to this embodiment, even if a device such as an LED cannot be prepared or cannot be connected for some reason, by using a simpler light projection sensor and a mask, the above-described It becomes possible to obtain the same effect as each embodiment of.

(Eighth embodiment)
Although the nozzles are detected in each of the above-described embodiments, it is also possible to correct the positions of the nozzles using the detection results.

For example, in FIG. 3, if the first detection sensor 310 does not detect the nozzle, the nozzle position is finely adjusted to a position where the first detection sensor 310 detects the nozzle. After that, the second detection sensor 312 detects the nozzles. When the nozzle is detected by the first detection sensor 310 and the nozzle is not detected by the second detection sensor 312 , the nozzle is moved so as to move along the optical path of the first detection sensor 310 . This movement moves to a position where the second detection sensor 312 detects the nozzle. When moved in this manner, the nozzle is detected by both the first detection sensor 310 and the second detection sensor 312, and it can be estimated that the nozzle has moved to the desired position.

As described above, according to this embodiment, it is possible to adjust and correct the position of the nozzle by using the detection sensor in each embodiment described above. This position correction may be performed manually by the user, or may be performed automatically using a sensor and a moving mechanism.

Detection according to each embodiment can be performed at any timing. For example, it may be performed to confirm the position of each nozzle immediately before performing analysis using an analysis device. As another example, after an analysis is completed, it may be performed in preparation for the next analysis. As yet another example, it may be performed after replacing the nozzle. In addition, it may be performed at a timing such as during inspection or after maintenance of the apparatus.

In the description of each embodiment described above, the nozzle is the first reagent dispensing probe 14a, but it is not limited to this, and other probes, stirrers, and nozzles of the washing unit may be used. Also, the insertion destination is the reaction container 3, but is not limited to this, and may be a reagent container, a sample container, or a washing tank into which various nozzles are inserted. It is possible to detect the position of the nozzle with respect to the insertion destination by appropriately installing the detection sensor described above for the corresponding nozzle and the insertion destination of the nozzle.

Further, each sensor may be installed on the stage provided with a stage for the sensor in the automatic analyzer 100 . For example, it may be installed fixedly at the position where the first reagent dispensing probe 14a is inserted so as not to be moved by the reaction disk 4 . When the first reagent dispensing arm 8 and the reaction container 300 are aligned, each sensor rotates along with the first reagent dispensing arm 8. It may be installed on the note arm 8 .

The control of the arms to which the sensors and nozzles are connected may be performed by the system controller 60 . That is, it may be performed by a processing circuit, or each sensor may be controlled via the processing circuit by software processing. This processing circuit may be a CPU as described above, or may be implemented by an FPGA (Field Programmable Gate Array) or an ASIC (Application Specific Integrated Circuit).

Although several embodiments have been described above, these embodiments are presented by way of example only and are not intended to limit the scope of the invention. The novel apparatus and methods described herein can be embodied in various other forms. In addition, various omissions, substitutions, and alterations may be made to the forms of the apparatus and methods described herein without departing from the spirit of the invention. The appended claims and their equivalents are intended to cover such forms and modifications as fall within the scope and spirit of the invention.

For example, in each of the above-described embodiments, it is assumed that a sensor using visible light is used, but the present invention is not limited to this, and it is also possible to use various radio waves such as ultraviolet light, infrared light, and microwaves. . Moreover, it is not limited to this, and a directional ultrasonic wave may be used.

DESCRIPTION OF SYMBOLS 1... Reagent storage 1a... Reagent rack 2... Reagent storage 2a... Reagent rack 3... Reaction container 3a... Holder 4... Reaction disk 5... Sample disk 6... Reagent container 7... Reagent container 8 1st reagent dispensing arm 9 2nd reagent dispensing arm 10 sample dispensing arm 12 cleaning mechanism 13 measurement section 14 first reagent dispensing mechanism 14a first reagent dispensing Probe, 14b... Washing tank, 15... Second reagent dispensing mechanism, 15a... Second reagent dispensing probe, 15b... Washing tank, 16... Sample dispensing mechanism, 16a... Sample dispensing probe, 16b... Washing tank, 17 Sample container 18 First stirring mechanism 18a First stirring element 18b Washing tank 19 Second stirring mechanism 19a Second stirring element 19b Washing tank 20 First stirring arm 21 2nd stirring arm 24 analysis unit 26 drive unit 27 analysis control unit 28 determination unit 30 data processing unit 31 calculation unit 32 data storage unit 32a blank data storage unit , 32b... Measurement data storage unit, 32c... Determination parameter storage unit, 32d... Test data storage unit, 40... Output unit, 41... Printing unit, 42... Display unit, 50... Operation unit, 60... System control unit, DESCRIPTION OF SYMBOLS 100...Automatic analyzer, 300...Reaction container, 310...First detection sensor, 310a...First light emitting sensor, 310b...First light receiving sensor, 310c...First light emitting/receiving sensor, 310M...Mask, 312...Second detection Sensors 312a... Second light emitting sensor 312b... Second light receiving sensor 312c... Second light emitting/receiving sensor 312M... Mask 314... Third detection sensor 314a... Third light emitting sensor 314b... Third light receiving sensor

Claims (14)

a reaction container for reacting the dispensed solution;
a nozzle inserted into the reaction vessel;
A plurality of detection sensors for detecting a position where the nozzle is inserted into the reaction vessel, wherein a position where positions capable of detecting whether the nozzle is inserted intersects is set as a desirable region for inserting the nozzle. a plurality of detection sensors arranged in a
with
the plurality of detection sensors,
a first detection sensor including a first light projection sensor and a first light reception sensor that receives light projected by the first light projection sensor;
a second detection sensor comprising a second light projection sensor and a second light reception sensor that receives light projected by the second light projection sensor;
with
It is desirable that the light projected by the first light projection sensor and the light projected by the second light projection sensor be such that the nozzle is inserted into the reaction vessel in plan view from the direction in which the nozzle is inserted. intersect in the area,
Automatic analyzer. a reaction container for reacting the dispensed solution;
a nozzle inserted into the reaction vessel;
A plurality of detection sensors for detecting a position where the nozzle is inserted into the reaction vessel, wherein a position where positions capable of detecting whether the nozzle is inserted intersects is set as a desirable region for inserting the nozzle. a plurality of detection sensors arranged in a
with
The nozzle is
A first nozzle and a second nozzle respectively inserted into the first reaction vessel and the second reaction vessel, which are two adjacent reaction vessels,
the plurality of detection sensors,
a first detection sensor including a first light projection sensor and a first light reception sensor that receives light projected by the first light projection sensor;
a second detection sensor comprising a second light projection sensor and a second light reception sensor that receives light projected by the second light projection sensor;
a third detection sensor comprising a third light projection sensor and a third light reception sensor that receives light projected by the third light projection sensor;
with
The light projected by the first light projection sensor and the light projected by the second light projection sensor are projected in a desired region where the first nozzle is inserted into the first reaction vessel in a plan view from the insertion direction. fellowship,
the light projected by the first light projection sensor and the light projected by the third light projection sensor intersect in a desirable region where the second nozzle is inserted into the second reaction container in the plan view;
Automatic analyzer. a reaction container for reacting the dispensed solution;
a nozzle inserted into the reaction vessel;
A plurality of detection sensors for detecting a position where the nozzle is inserted into the reaction vessel, wherein a position where positions capable of detecting whether the nozzle is inserted intersects is set as a desirable region for inserting the nozzle. a plurality of detection sensors arranged in a
with
the plurality of detection sensors,
projecting light, reflecting the projected light at the nozzle, and receiving the reflected light to detect whether the nozzle is in a desired area;
Automatic analyzer. 2. The automatic analyzer according to claim 1 , wherein a path of light emitted by said first light projection sensor and a path of light emitted by said second light projection sensor physically intersect. 2. The automatic analyzer according to claim 1 , wherein a path of light emitted by said first light projection sensor and a path of light emitted by said second light projection sensor do not physically intersect. The path of light emitted by the first light projection sensor, the path of light emitted by the second light projection sensor, the path of light emitted by the first light projection sensor, and the third light projection sensor 3. The automatic analyzer according to claim 2 , wherein paths of emitted light physically intersect. The path of light emitted by the first light projection sensor, the path of light emitted by the second light projection sensor, the path of light emitted by the first light projection sensor, and the third light projection sensor 3. The automated analyzer of claim 2 , wherein at least one of the exiting light paths do not physically intersect. The nozzle is a cleaning unit that is inserted into the reaction vessel when performing cleaning processing of the reaction vessel, a dispensing probe that dispenses a solution into the reaction vessel, or a liquid that is dispensed into the reaction vessel. 8. The automatic analyzer according to any one of claims 1 to 7 , which is a stirrer for stirring. 9. The automatic analyzer according to any one of claims 1 to 8 , wherein the nozzle is moved in the insertion direction, and bending or bending of the nozzle is detected based on detection results during movement. a movement mechanism for moving the reaction vessel in a plane direction intersecting the insertion direction in which the nozzle is inserted;
a control unit that controls the detection sensor to detect the insertion position of the nozzle when the reaction container is moved to the insertion position of the nozzle by the moving mechanism;
The automatic analyzer according to any one of claims 1 to 9 , further comprising: 11. The automatic analyzer according to claim 10 , wherein said controller adjusts the position of said nozzle with respect to said reaction container based on the detection result of said nozzle. a container provided with a sample or reagent to be dispensed into a reaction vessel for reacting the dispensed solution;
a nozzle inserted into the container;
a moving mechanism for moving the container;
a plurality of detection sensors that detect a position where the nozzle is inserted into the container;
a control unit that controls the detection sensor to detect the insertion position of the nozzle when the container is moved to the insertion position of the nozzle by the moving mechanism;
with
the plurality of detection sensors,
a first detection sensor including a first light projection sensor and a first light reception sensor that receives light projected by the first light projection sensor;
a second detection sensor comprising a second light projection sensor and a second light reception sensor that receives light projected by the second light projection sensor;
with
It is desirable that the light projected by the first light projection sensor and the light projected by the second light projection sensor be such that the nozzle is inserted into the reaction vessel in plan view from the direction in which the nozzle is inserted. intersect in the area,
Automatic analyzer. a container provided with a sample or reagent to be dispensed into a reaction vessel for reacting the dispensed solution;
a nozzle inserted into the container;
a moving mechanism for moving the container;
a plurality of detection sensors that detect a position where the nozzle is inserted into the container;
a control unit that controls the detection sensor to detect the insertion position of the nozzle when the container is moved to the insertion position of the nozzle by the moving mechanism;
with
The nozzle is
A first nozzle and a second nozzle respectively inserted into the first reaction vessel and the second reaction vessel, which are two adjacent reaction vessels,
the plurality of detection sensors,
a first detection sensor including a first light projection sensor and a first light reception sensor that receives light projected by the first light projection sensor;
a second detection sensor comprising a second light projection sensor and a second light reception sensor that receives light projected by the second light projection sensor;
a third detection sensor comprising a third light projection sensor and a third light reception sensor that receives light projected by the third light projection sensor;
with
The light projected by the first light projection sensor and the light projected by the second light projection sensor are projected in a desired region where the first nozzle is inserted into the first reaction vessel in a plan view from the insertion direction. fellowship,
the light projected by the first light projection sensor and the light projected by the third light projection sensor intersect in a desirable region where the second nozzle is inserted into the second reaction container in the plan view;
Automatic analyzer. a container provided with a sample or reagent to be dispensed into a reaction vessel for reacting the dispensed solution;
a nozzle inserted into the container;
a moving mechanism for moving the container;
a plurality of detection sensors that detect a position where the nozzle is inserted into the container;
a control unit that controls the detection sensor to detect the insertion position of the nozzle when the container is moved to the insertion position of the nozzle by the moving mechanism;
with
the plurality of detection sensors,
projecting light, reflecting the projected light at the nozzle, and receiving the reflected light to detect whether the nozzle is in a desired area;
Automatic analyzer.

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