JP7203385B2 - 抗菌性ポリ（アルキル化イミダゾリウム）塩 - Google Patents

抗菌性ポリ（アルキル化イミダゾリウム）塩 Download PDF

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Publication number
JP7203385B2
JP7203385B2 JP2019556308A JP2019556308A JP7203385B2 JP 7203385 B2 JP7203385 B2 JP 7203385B2 JP 2019556308 A JP2019556308 A JP 2019556308A JP 2019556308 A JP2019556308 A JP 2019556308A JP 7203385 B2 JP7203385 B2 JP 7203385B2
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polymer
pim
number selected
formula
alkyl
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JP2020518685A5 (enExample
JP2020518685A (ja
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ビー・イン・メアリー・チャン
ポーラ・ティ・ハモンド
リウ・ボォ
ジョン・ウェンビン
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Nanyang Technological University
Massachusetts Institute of Technology
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Nanyang Technological University
Massachusetts Institute of Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G12/00—Condensation polymers of aldehydes or ketones with only compounds containing hydrogen attached to nitrogen
    • C08G12/02—Condensation polymers of aldehydes or ketones with only compounds containing hydrogen attached to nitrogen of aldehydes
    • C08G12/04—Condensation polymers of aldehydes or ketones with only compounds containing hydrogen attached to nitrogen of aldehydes with acyclic or carbocyclic compounds
    • C08G12/06—Amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/0605—Polycondensates containing five-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms
    • C08G73/0616—Polycondensates containing five-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms with only two nitrogen atoms in the ring
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3723—Polyamines or polyalkyleneimines
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D9/00—Compositions of detergents based essentially on soap
    • C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
    • C11D9/22—Organic compounds, e.g. vitamins
    • C11D9/30—Organic compounds, e.g. vitamins containing nitrogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Polymers & Plastics (AREA)
  • Communicable Diseases (AREA)
  • Birds (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Cosmetics (AREA)
JP2019556308A 2017-04-18 2018-04-18 抗菌性ポリ（アルキル化イミダゾリウム）塩 Active JP7203385B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762486613P 2017-04-18 2017-04-18
US62/486,613 2017-04-18
PCT/SG2018/050195 WO2018194521A1 (en) 2017-04-18 2018-04-18 Antimicrobial poly(alkylated imidazolium) salts

Publications (3)

Publication Number Publication Date
JP2020518685A JP2020518685A (ja) 2020-06-25
JP2020518685A5 JP2020518685A5 (enExample) 2021-05-20
JP7203385B2 true JP7203385B2 (ja) 2023-01-13

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JP2019556308A Active JP7203385B2 (ja) 2017-04-18 2018-04-18 抗菌性ポリ（アルキル化イミダゾリウム）塩

Country Status (5)

Country Link
US (1) US11439660B2 (enExample)
JP (1) JP7203385B2 (enExample)
CN (1) CN110914321B (enExample)
NZ (1) NZ759235A (enExample)
WO (1) WO2018194521A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115836103B (zh) * 2020-05-26 2026-02-27 南洋理工大学 可生物降解的聚咪唑鎓和低聚咪唑鎓
CN111921383B (zh) * 2020-07-16 2022-04-01 浙江工业大学 基于三嗪类多孔有机纳米粒子组装膜的制备方法
IL305859A (en) * 2021-03-19 2023-11-01 Ionomr Innovations Inc Antiviral and antimicrobial coatings and their methods
CN118804756A (zh) * 2022-01-06 2024-10-18 麻省理工学院 聚咪唑鎓基阳离子抗微生物聚合物用于新型乳腺炎预防解决方案
CN116554470B (zh) * 2023-04-17 2025-08-19 中山大学 一种基于咪唑的聚阳离子抗菌高分子及其制备与应用
CN121969378A (zh) * 2023-07-20 2026-05-01 南洋理工大学 可激活抗菌治疗用阳离子抗菌剂的可生物降解聚离子复合纳米颗粒
WO2025144104A1 (en) * 2023-12-29 2025-07-03 Nanyang Technological University Polyimidazolium-based cationic antimicrobial polymers retain efficacy in the presence of anionic surfactants
CN118639393B (zh) * 2024-05-30 2026-01-16 中山大学 一种双层多功能静电纺丝纤维膜伤口敷料及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201040211A (en) 2009-05-14 2010-11-16 Univ Chia Nan Pharm & Sciency Imidazolium-based poly(ionic liquid)s and method to prepare the same
JP2014514284A (ja) 2011-03-23 2014-06-19 ビーエーエスエフ ソシエタス・ヨーロピア イミダゾリウム基を含むポリマーのイオン性化合物を含有する組成物
WO2017025433A1 (en) 2015-08-11 2017-02-16 Basf Se Antimicrobial polymer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0425016B1 (en) 1989-10-27 1995-12-20 The Procter & Gamble Company Antimicrobial method and formulation employing type II endoglycosidase and antimicrobial agent
GB2271718B (en) * 1992-10-20 1995-11-01 Rhone Poulenc Chemicals Antimicrobial agents comprising polyquaternary ammonium compounds
US6689372B1 (en) 1998-08-04 2004-02-10 Ciba Specialty Chemicals Corporation Microbicidal active substances
US6903064B1 (en) 1999-05-26 2005-06-07 Procter & Gamble Company Detergent composition comprising polymeric suds volume and suds duration enhancers
FR2826269B1 (fr) * 2001-06-22 2003-09-26 Oreal Utilisation de polyammonium quaternaire dans le traitement de l'acne et des desordres cutanes lies a l'hyperseborrhee
WO2010072571A1 (de) * 2008-12-22 2010-07-01 Basf Se Verfahren zur herstellung von polymeren, ionischen imidazoliumverbindungen
CA2934448A1 (en) 2012-12-20 2014-06-26 Rajiv Bhushan Antimicrobial compositions
WO2016020216A1 (en) * 2014-08-06 2016-02-11 Basf Se Improved process for preparing polymeric, ionic imidazolium compounds
MX372696B (es) 2014-09-29 2020-05-27 Unilever Ip Holdings B V Composicion de limpieza antimicrobiana.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201040211A (en) 2009-05-14 2010-11-16 Univ Chia Nan Pharm & Sciency Imidazolium-based poly(ionic liquid)s and method to prepare the same
JP2014514284A (ja) 2011-03-23 2014-06-19 ビーエーエスエフ ソシエタス・ヨーロピア イミダゾリウム基を含むポリマーのイオン性化合物を含有する組成物
WO2017025433A1 (en) 2015-08-11 2017-02-16 Basf Se Antimicrobial polymer

Also Published As

Publication number Publication date
CN110914321B (zh) 2023-03-31
JP2020518685A (ja) 2020-06-25
NZ759235A (en) 2026-03-27
US20200046760A1 (en) 2020-02-13
WO2018194521A1 (en) 2018-10-25
US11439660B2 (en) 2022-09-13
CN110914321A (zh) 2020-03-24

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