JP7187908B2 - Chemical solution administration device and chemical injection controller used for the chemical solution administration device - Google Patents

Description

TECHNICAL FIELD The present invention relates to a liquid medicine administration device capable of automatic continuous injection of liquid medicine and rapid injection of liquid medicine by self-operation, and a liquid medicine injection controller for performing rapid injection of liquid medicine by self-operation in the liquid medicine injection apparatus. is.

Conventionally, there has been known a drug-solution administration device comprising a main line for continuously administering a drug-solution from a main reservoir using a diaphragm pump or the like, and a sub-line for performing rapid drug-solution administration from a sub-reservoir by self-operation. It is used, for example, for the internal administration of analgesics and anesthetics.

Such a liquid medicine administration device requires a priming operation for filling each line with a liquid medicine when it is used.

Conventionally, however, it has been necessary to circulate and prime the continuous chemical solution administration line (main line) and the rapid chemical solution administration line (subline) separately. Specifically, as shown, for example, in FIG. 13 of Japanese Patent No. 5517029 (Patent Document 1), the continuous drug delivery line primes with drug solution from the main reservoir, while the rapid drug delivery line , it was necessary to supply the drug solution from a syringe through a connection port such as a three-way stopcock provided on the line for priming. For this reason, not only is the priming work troublesome, but the chemical must be supplied from the outside using a syringe. Especially for chemicals that require careful handling, the management of the amount of the chemical becomes a burden, and unintended contact with the chemical becomes difficult. There was also a problem that the risk of

Japanese Patent No. 5517029

The present invention has been made against the background of the above circumstances, and an object thereof is to provide a novel structure that facilitates priming of a sub-line provided for rapid drug solution administration. An object of the present invention is to provide a drug solution administration device.

Another object of the present invention is to provide a liquid injection controller having a novel structure for use in a liquid medicine administration device.

Hereinafter, aspects of the present invention that have been made to solve such problems will be described. It should be noted that the constituent elements employed in each aspect described below can be employed in any possible combination.

That is, a first aspect of the present invention comprises a main line extending from a main reservoir to a drug solution administration port on the patient side through a flow control unit, and a sub-reservoir branching from the main line upstream of the flow control unit. and a sub-line that merges with the main line on the downstream side of the flow rate control unit, wherein the following (i) and (ii) are provided as a priming mechanism for priming the sub-line: A medicinal liquid administration device characterized by:
(i) A priming air release section provided downstream of at least one of the sub-reservoir and the flow control section.
(ii) A priming shut-off valve that is provided downstream of the priming air release portion and that is shut off during priming of the sub-line and communicated after priming.

According to the medical solution administration device constructed according to this aspect, the medical solution flows from the main reservoir to the line while the priming cutoff valve is closed, so that the priming air release portion is removed from the main reservoir via the sub-reservoir. A sub-line up to the installation position can be primed quickly.

Also, while outside the scope of this embodiment, during or after priming of the sublines, the mainlines may also be appropriately primed, if desired. Although the priming of the main line is not limited, for example, if the sub-line is cut off, the main line from the main reservoir to the drug solution administration port via the flow control section can also be primed. Therefore, for example, if there is a priming cutoff valve on the main line, if the priming cutoff valve is closed from the beginning, the priming of the subline will start as the chemical solution is injected and filled into the main reservoir at a predetermined pressure. This can be done automatically, followed by priming of the main line by opening the priming isolation valve. Further, for example, if there is a priming cutoff valve on the subline, by closing the priming cutoff valve, the subline is primed earlier than the main line with high flow resistance by the flow control unit, and the subline is primed. The main line is also primed when the sub-line is substantially cut off due to the completion of priming.

According to a second aspect of the present invention, in the drug-solution administration device according to the first aspect, the priming air vent is located near the confluence of the main line and the sub-line or from the sub-reservoir. It is provided between the main line and the confluence point of the sub-line.

According to the medical solution administration device constructed according to this aspect, for example, by arranging the priming air vent portion close to the confluence, the length of the line that is not filled with the medical solution during priming of the sub-line is sufficiently shortened, Even when the chemical liquid flows into the main line during priming of the sub-line, it is possible to reduce the amount of the chemical liquid flowing into the main line and suppress the amount of the chemical liquid that is discarded during priming of the main line. In this aspect, the priming air vent may be arranged at a position near the confluence of the main line and the sub-line, and may be arranged on either the main line or the sub-line. That is, depending on the arrangement position of the priming air release portion, the amount of chemical solution discarded during priming of the subline and the main line thereafter and the amount of air remaining after priming is completed differ. "" means a position where the amount of waste liquid and residual air can be substantially suppressed to a negligible level (for example, 3 ml or less, preferably 1 ml or less).

On the other hand, by providing the air vent for priming between the sub-reservoir and the confluence of the main line and the sub-line, it is possible to avoid filling the main line with the chemical after the confluence of the sub-lines when priming the sub-line. Even when, for example, priming of the main line is performed after completion of priming of the sub-line, it is possible to substantially eliminate the amount of chemical liquid (waste liquid amount) that unnecessarily flows out from the chemical liquid administration port. That is, when the air vent for priming is on the main line, the chemical solution is filled by priming the sub line from the confluence point of the main line and the sub line to the position of the air vent for priming, followed by priming of the main line. At this time, the chemical liquid filled up to the main line unnecessarily flows out from the chemical liquid port.

It is also possible to shut off the sub-line during priming of the sub-line and shut-off of the sub-line during priming of the main line by a common shut-off valve for priming. can also be simplified.

A third aspect of the present invention is the drug-solution administration device according to the first or second aspect, wherein the sub-line has a drug solution flow from a branch point with the main line to a confluence point with the main line. An on-off valve capable of closing the sub-line is provided on the road.

According to the drug-solution administration device structured according to this aspect, for example, when priming the main line after completing priming of the sub-line, the on-off valve is closed after priming of the sub-line is completed, and then priming of the main line is performed. , it is possible to prevent the priming liquid in the sub-line from flowing downstream from the junction with the main line.

A fourth aspect of the present invention is the drug-solution administration device according to the third aspect, wherein the shutoff valve for priming of (ii) is switched from the shutoff state to the open state, and the open/close valve is An on-off valve interlocking mechanism for switching from an open state to a closed state is provided.

According to the drug-solution administration device constructed according to this aspect, by switching the open state and closed state of the on-off valve for rapid drug-solution administration in conjunction with the shut-off state and communication state of the shut-off valve for priming, Following the sub-line priming described above, the main-line priming is also readily feasible.

Even if the priming shut-off valve is opened after priming of the sub-line is completed, the shut-off valve for priming is closed and the sub-line is shut off. It is possible to open the priming shut-off valve after priming of the sub-line is completed even if the priming is completed.

A fifth aspect of the present invention is the drug-solution administration device according to any one of the first to fourth aspects, comprising a drug-solution injection controller for performing rapid drug-solution administration from the sub-reservoir by self-operation. The liquid medicine injection controller has a housing for accommodating the sub-reservoir, and the priming air vent part (i) is incorporated in the housing.

According to the liquid medicine administration device constructed according to this aspect, the priming air vent does not become an obstacle during use, compared to the case where the priming air vent is provided on the line extending out of the housing. Also, the structure can be made compact. Further, when the priming air vent portion is accommodated in the housing, it is possible to prevent troubles caused by unintended external force acting on the priming air vent portion, thereby achieving excellent reliability. Note that the priming air release portion is incorporated in, for example, the housing so as to be accommodated or covered.

According to a sixth aspect of the present invention, the drug-solution administration device according to any one of the first to fifth aspects further includes the following (iii) as the priming mechanism.
(iii) In the main line, a flow controller side cutoff valve provided on a chemical liquid flow path from a branch point of the sub-line to a junction of the sub-lines via the flow controller.

According to the liquid medicine administration device constructed according to this aspect, the flow control unit side cutoff valve is provided, thereby reliably preventing the flow of the liquid medicine through the flow control unit and guiding the liquid medicine to the sub-line more efficiently. , the priming of the sub-lines can be done more quickly. In addition, for example, if the structure is such that the flow control unit side cutoff valve must be opened when priming the main line after completing the priming of the sub line, it is possible to prevent the user from forgetting to perform the switching operation.

A seventh aspect of the present invention is the medical-solution administration device according to the sixth aspect, wherein the priming cutoff valve of the priming mechanism in the above (ii) and the flow rate control of the priming mechanism in the above (iii) It has a shutoff valve interlocking mechanism that shuts off/communicates with the part side shutoff valve.

According to the drug-solution administration device constructed according to this aspect, there is no need to operate the priming cutoff valve and the flow control unit side cutoff valve separately, which simplifies the operation and allows the user to switch between these valves. Work can be done more reliably. In particular, when the priming shutoff valve is located on the main line, the priming of the subline and the priming of the main line can be easily performed by simultaneously shutting off/communicating the priming shutoff valve and the flow controller side shutoff valve. can be switched to

An eighth aspect of the present invention includes a main line extending from a main reservoir through a flow control section to a drug solution administration port on the patient side, and a main line branching from the upstream side of the flow control section and passing through a sub-reservoir. and a sub-line that merges with the main line on the downstream side of a flow rate control unit, and is used in a liquid medicine injection device for performing rapid liquid medicine injection from the sub-reservoir by self-operation, A housing that accommodates the sub-reservoir incorporates a priming air release portion provided downstream of the sub-reservoir, and the sub-line from a branch point from the main line to the sub-reservoir. An orifice passage extending in parallel connecting positions separated in the flow direction is incorporated in the housing, and a shut-off valve is incorporated in the housing on the sub-line extending in parallel with the orifice passage. , the closing valve is switched from the open state to the closed state as the priming cutoff valve incorporated in the housing and provided on the downstream side of the priming air vent portion is switched from the shutoff state to the open state. It is characterized by having a shut-off valve interlocking mechanism .

According to the liquid medicine injection controller constructed according to this aspect, with the priming cutoff valve closed, the liquid medicine is circulated from the main reservoir to the line, so that the priming air bleed portion passes from the main reservoir through the sub-reservoir. A sub-line up to the installation position can be primed quickly.

In addition, since the priming air release portion is incorporated in the housing, the priming air release portion does not interfere with use compared to the case where the priming air release portion is provided on a line extending out of the housing. and the structure can be made compact.

Furthermore, according to the chemical injection controller constructed according to this aspect, the flow rate of the sub-line is restricted by the orifice passage when the stop valve is closed, so the supply speed of the chemical solution from the main reservoir to the sub-reservoir is adjusted. be done. Therefore, it is necessary to take a sufficiently long time to fill the sub-reservoir with the liquid medicine, and by preventing continuous rapid liquid medicine injection by the liquid medicine injection controller, it is possible to prevent excessive injection of the liquid medicine. can be done.

In addition, the switching of the shut-off valve from the open state to the closed state is interlocked with the switching of the shut-off valve for priming from the shut-off state to the open state by the shut-off valve interlocking mechanism. The shut-off valve is closed together with the opening of the shut-off valve for the sub-line, so that the sub-line can be easily switched to the use state after the completion of priming.

A ninth aspect of the present invention includes a main line extending from a main reservoir to a drug solution administration port on the patient side through a flow control section, and a main line branching from the upstream side of the flow control section and passing through a sub-reservoir. and a sub-line that merges with the main line on the downstream side of a flow rate control unit, and is used in a liquid medicine injection device for performing rapid liquid medicine injection from the sub-reservoir by self-operation, A housing that accommodates the sub-reservoir incorporates a priming air release portion provided downstream of the sub-reservoir, and the sub-line from the sub-reservoir to a confluence with the main line. An on-off valve capable of closing the sub-line is incorporated in the housing, and a shutoff valve for priming, which is incorporated in the housing and provided downstream of the priming air vent portion, switches from the closed state to the open state. It is characterized by having an on-off valve interlocking mechanism in which the on-off valve is switched from an open state to a closed state as it is switched.

According to the chemical injection controller constructed according to this aspect, in addition to the effects described in [0028] and [0029] above, the outflow of the chemical from the subline to the main line is prevented by closing the on-off valve. be.

Further, after completion of priming of the sub-line, the priming cut-off valve is opened and the on-off valve is closed, so that the priming liquid can flow only from the main reservoir to the main line.

According to the present invention, it is possible to simply and quickly prime the sub-line with the chemical liquid flowing into the sub-line from the main reservoir without requiring an operation of directly injecting the chemical liquid into the sub-line with a syringe.

BRIEF DESCRIPTION OF THE DRAWINGS The front view which shows the medical-solution administration apparatus as the 1st Embodiment of this invention. The figure which shows roughly the structure of the medical-solution administration apparatus shown in FIG. FIG. 2 is a perspective view of a liquid injection controller that constitutes the liquid injection device shown in FIG. 1; FIG. 4 is a front view of the chemical injection controller shown in FIG. 3; FIG. 5 is a right side view of the liquid injection controller shown in FIG. 4; 4 is a perspective view of the liquid injection controller shown in FIG. 3 with the upper half of the housing removed; FIG. FIG. 7 is a front view of the chemical injection controller shown in FIG. 6; VIII-VIII cross-sectional view of FIG. IX-IX cross-sectional view of FIG. XX sectional view of FIG. XI-XI sectional view of FIG. FIG. 8 is a view corresponding to the XII-XII section of FIG. 7 and showing the state after the switch member has been pushed in; FIG. 8 is a view corresponding to the XIII-XIII section of FIG. 7, in which (a) shows the state before the switch member is pushed in, and (b) shows the state after the switch member is pushed in; FIG. 8 is a view corresponding to the XIV-XIV section of FIG. 7, in which (a) shows the state before the switch member is pushed in, and (b) shows the state after the switch member is pushed in; FIG. 7 is a cross-sectional view of the chemical injection controller shown in FIG. 6, showing a state in which the push button is depressed; FIG. 7 is a cross-sectional view of the chemical injection controller shown in FIG. 6, showing a state in which the push button is depressed; The figure which shows roughly the structure of the medical-solution administration apparatus as the 2nd Embodiment of this invention.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, embodiments of the present invention will be described with reference to the drawings.

1 and 2 show a drug-solution administration device 10 as a first embodiment of the present invention. The drug-solution administration device 10 has a structure in which a drug-solution container 12 and a drug-solution administration port 14 are connected by a drug-solution administration line 16 .

The drug solution container 12 has a structure in which a main reservoir 20 is accommodated within a hard housing 18 . The main reservoir 20 is a balloon made of an elastic material such as rubber or resin elastomer. It can be stored under pressure. The liquid medicine stored in the main reservoir 20 is pushed out from the main reservoir 20 based on the elasticity of the main reservoir 20 .

However, the specific structure of the chemical container is not particularly limited, and for example, a hard container body, a piston that can move linearly within the container body, and a coil spring that biases the piston in the movement direction. A main reservoir for storing the liquid medicine is formed between the container body and the piston, and the piston is moved by the biasing force of the biasing means to increase the volume of the main reservoir may gradually decrease to force the drug solution out of the main reservoir.

A drug solution administration line 16 is connected to the main reservoir 20 of the drug solution container 12 so that the drug solution stored in the main reservoir 20 of the drug solution container 12 is delivered to the drug solution administration line 16. The drug solution administration line 16 is composed of a plurality of tubes, and includes a main line 24 that connects the drug solution container 12 and the drug solution administration port 14, and a sub-line 26 that branches off from the main line 24 at a branch portion 34, which will be described later. .

The main line 24 includes an upstream tube 28 , a main branch tube 30 and a downstream tube 32 . The upstream tube 28 has one end connected to the main reservoir 20 of the drug solution container 12 and the other end connected to the branch portion 34 . A filter 36 for filtering out foreign substances in the chemical solution is provided in the intermediate portion of the upstream tube 28 . Note that the filter 36 may include both a filter for removing foreign matter and a ventilation filter for discharging air to the outside of the chemical liquid flow path.

Furthermore, one end of the main branch tube 30 is connected to a branch portion 34 provided at the other end of the upstream tube 28 . The other end of the main branch tube 30 is connected to one end of the downstream tube 32 by a confluence section 60 of the chemical injection controller 44, which will be described later. A flow control section 38 is provided in the intermediate portion of the main branch tube 30 . The flow control unit 38 has a small-diameter flow path inside, and the flow rate of the main line 24 per unit time is set by the flow control unit 38 . In addition, the flow control unit 38 may be capable of continuously or stepwisely changing the flow rate setting by a valve or the like. can be selectively set.

Furthermore, the downstream tube 32 , one end of which is connected to the main branch tube 30 by a junction 60 (described later), is connected to the drug solution administration port 14 at the other end. The drug solution administration port 14 has a connector structure that can be connected to an indwelling needle (not shown) that is percutaneously indwelled in a patient's blood vessel or the like. Furthermore, in this embodiment, a cap 39 having an air-permeable filter is attached to the liquid medicine administration port 14 to prevent the liquid medicine from flowing out of the liquid medicine injection port 14 .

On the other hand, one end of a sub-branch tube 40 forming the sub-line 26 is connected to the branch portion 34 provided at the other end of the upstream tube 28 . The other end of the sub-branch tube 40 is indirectly connected to a sub-reservoir 42 of a chemical injection controller 44 , and the chemical is supplied from the main reservoir 20 to the sub-reservoir 42 through the upstream portion of the sub-line 26 including the sub-branch tube 40 . It has become so. In addition, the branch portion 34 connects the upstream tube 28 on the upstream side and the main branch tube 30 and the sub-branch tube 40 on the downstream side.

Further, the sub-reservoir 42 is connected to the downstream tube 32 via a junction 60 which will be described later. In short, the sub-line 26 branched from the main line 24 at the branching portion 34 passes through the sub-reservoir 42 and joins the main line 24 at the joining portion 60 . Accordingly, in the present embodiment, the branching portion 34 serves as the branching point of the main line 24 and the subline 26 and the merging portion 60 serves as the merging point of the mainline 24 and the subline 26 .

By the way, the sub-reservoir 42 on the sub-line 26 is provided in a liquid injection controller 44 as shown in FIGS. 6 to 12, a sub-reservoir 42 and portions of the main line 24 and the sub-line 26 are housed within a housing 46, as shown in FIGS. It has a structure in which and are incorporated in an accommodated state. In the following description of the liquid injection controller 44, as a general rule, the vertical direction refers to the left-right direction in FIG. 5, the front-rear direction refers to the axial direction in FIG. The direction is called respectively.

More specifically, the housing 46 is made of a hard synthetic resin or the like, and has a generally bottomed cylindrical shape as a whole. Three insertion holes 48a, 48b, 48c through which the tube 40 is inserted are formed. The housing 46 of this embodiment is configured by combining an upper half portion 50 and a lower half portion 52 in the vertical direction. 6 to 16, the illustration of the upper half portion 50 is omitted in order to make the internal structure of the liquid injection controller 44 easier to see.

A tube connection member 54 that connects the main branch tube 30, the downstream tube 32, and the sub-branch tube 40 is attached to the housing 46 in an accommodated state. The tube connection member 54 is a soft member made of rubber, resin elastomer, or the like, and has three tube connection ports 56a, 56b, 56c to which the tubes 30, 32, 40 are connected.

Furthermore, the tube connection port 56a to which the main branch tube 30 is connected and the tube connection port 56b to which the downstream tube 32 is connected are both connected to the confluence portion 60 and communicate with each other. As shown in FIGS. 7 and 10, the confluence portion 60 is accommodated in the housing 46 and provided in the tube connecting member 54, and has a tubular shape extending in the vertical direction. A filter 62 that constitutes a priming air release portion is fitted to the upper opening portion of the confluence portion 60 . This filter 62 has the property of allowing gas to pass through but not liquid. The filter 62 is not particularly limited as long as it has the above properties. A sintered porous body, a hydrophobic non-woven fabric, a porous body, or the like can be preferably employed. In particular, when a filter containing a super absorbent polymer (SAP) is adopted as the filter 62, gas is allowed to pass in the initial state until the water touches the filter 62, and when the water touches the filter 62, the gas passes through. It reacts with water (absorbs water) and swells to block the passage of gas. Note that the filter provided on the cap 39 is made of substantially the same material as the filter 62 of the confluence portion 60 . Furthermore, when the filter 36 arranged on the upstream side (medical solution container 12 side) of the branch portion 34 is provided with a ventilation filter, the same material as the filter 62 of the confluence portion 60 can be adopted.

Furthermore, as shown in FIGS. 7 and 9, the tube connection port 56c to which the sub-branch tube 40 is connected is integrally formed with a tube-like chemical supply tube 64 in a serially connected manner. An orifice tube 66 forming an orifice passage is connected to the chemical supply tube 64 . The orifice tube 66 is provided in parallel with the intermediate portion of the chemical supply tube 64 within the housing 46 , and is located upstream of the sub-reservoir 42 at two points apart in the flow direction of the chemical supply tube 64 . It constitutes a connecting bypass channel. Furthermore, since the orifice tube 66 has a smaller inner diameter than the chemical supply tube 64, the chemical supply tube 64 is cut off at a portion extending in parallel with the orifice tube 66, so that the subline 26 The orifice tube 66 limits the flow rate per unit time.

6 and 7, the chemical liquid supply tube 64 is connected to the chemical liquid inlet portion 70 of the base member 68. As shown in FIGS. The base member 68 has a substantially disk shape, and is formed with a liquid medicine inflow portion 70 and a liquid medicine outflow portion 72 penetrating therethrough. Further, the base member 68 has a plurality of locking projections 74 protruding rearward (upward in FIG. 7), and the base member 68 is connected to the guide member 76 by these locking projections 74 . .

The guide member 76 has a substantially cylindrical shape and is provided with a flange-like engaging portion 78 protruding toward the outer circumference at one end in the axial direction. The base member 68 and the guide member 76 are connected in the axial direction by hooking the protrusions 74 . Furthermore, the locking portion 78 of the guide member 76 is provided with engaging hooks 80 at two locations in the circumferential direction. The engaging hook 80 integrally includes an extending portion 82 extending rearward from the engaging portion 78 and an engaging claw portion 84 projecting from the tip of the extending portion 82 toward the outer periphery. The rear end surface of the engaging hook 80 is tapered to be inclined forward toward the outer periphery.

A sub-reservoir 42 is arranged on the inner peripheral side of the guide member 76 . As shown in FIGS. 8 to 10, the sub-reservoir 42 is made of rubber, resin elastomer, or the like and has flexibility. A flange-like clamping portion 86 projecting to the outer periphery is integrally formed on the portion.

The sub-reservoir 42 is arranged on the inner circumference of the guide member 76, and is supported by the clamping portion 86 sandwiched between the base member 68 and the guide member 76 in the axial direction (front-rear direction). 68 and guide member 76 . In such an assembled state, the opening of the sub-reservoir 42 is closed by the base member 68, and the inner lumen of the chemical solution supply tube 64 attached to the base member 68 communicates with the inner circumferential space of the sub-reservoir 42. It is Since the base member 68 and the guide member 76 are supported by the housing 46, the sub-reservoir 42 is positioned with respect to the housing 46, and the bottom portion of the sub-reservoir 42 is moved forward and backward with respect to the housing 46. Such deformation of the sub-reservoir 42 is allowed. In addition, when the sub-reservoir 42 is assembled to the base member 68 and the guide member 76 , the bottom portion of the sub-reservoir 42 protrudes outward beyond the axial end of the guide member 76 .

A plunger 88 is superimposed on the bottom of the sub-reservoir 42 . The plunger 88 has a structure in which a substantially bottomed cylindrical plunger body 90 and a cylindrical guide tube portion 92 provided so as to surround the outer periphery of the plunger body 90 are integrally connected at the rear end. there is Further, the guide tube portion 92 is partially thinned at two locations on the circumference and widens toward the outer circumference, and the thinned portions constitute hook receiving portions 94 . The hook receiving portions 94, 94 are provided at positions corresponding to the engaging hooks 80, 80 of the guide member 76 in the circumferential direction.

Also, the plunger 88 is inserted in a push button 96 as an operating member. The push button 96 has a substantially cylindrical shape with a bottom. Further, a small-diameter cylindrical spring support portion 98 projecting forward is integrally formed on the inner peripheral portion of the bottom portion of the push button 96 .

Further, as shown in FIG. 11, the push button 96 is integrally formed with a main moving piece 100 . The driving piece 100 protrudes forward from the open end of the push button 96 and extends to the outer circumference of the guide member 76 . Furthermore, the protruding tip portion of the main moving piece 100 is formed into two sliding contact portions 102, 102 arranged in parallel. It is composed of an inclined surface 104 that inclines to . Note that the inclined surface 104 of the present embodiment is provided on the upper portion of the sliding contact portion 102 and has a shape that slopes downward toward the projecting tip, so the sliding contact portion 102 is tapered.

8 and 9, a coil spring 106 is arranged between the plunger 88 and the push button 96 in the axial direction. One end of the coil spring 106 is inserted into the inner periphery of the plunger body 90, and the other end is externally inserted into the spring support portion 98 of the push button 96 so as to be positioned in the direction perpendicular to the axis. .

On the other hand, as shown in FIGS. 7 and 10 , a chemical discharge tube 108 is connected to the chemical outlet 72 of the base member 68 . The chemical discharge tube 108 is a flexible tube made of rubber, resin elastomer, or the like. Connected to the opening. In this embodiment, the sub-line 26 is configured by the sub-branch tube 40 and the chemical supply tube 64 that connect the branch portion 34 and the sub-reservoir 42, and the sub-reservoir 42 and the chemical discharge tube 108 that connects the sub-reservoir 42 and the confluence portion 60. It is

An on-off valve 110 is arranged above the intermediate portion of the chemical discharge tube 108 . The on-off valve 110 is inserted into a cylindrical on-off valve support portion 112 provided in the lower half portion 52 of the housing 46 and is assembled with the housing 46 in a state in which relative displacement in the vertical direction is permitted. More specifically, the on-off valve 110 has a substantially disk-shaped valve body 114 integrally formed with a tubular spring guide portion 116 projecting upward and downward. It has a structure in which a pair of driven pieces 118, 118 inserted into the on-off valve support portion 112 are integrally formed.

The valve main body 114 is provided with a flat plate-shaped clamping projection 120 protruding downward at the front-rear central portion, and the distal end portion of the clamping projection 120 is tapered. Further, the valve main body 114 is provided with a switch engaging projection 122 that protrudes to the outer periphery in a part of the circumferential direction.

A coil spring 124 as a biasing means is inserted into the spring guide portion 116 , and the coil spring 124 inserted into the spring guide portion 116 is vertically moved between the valve main body 114 and the upper half portion 50 of the housing 46 . Compressed. As a result, a downward biasing force is applied to the on-off valve 110 by the coil spring 124 .

As shown in FIG. 11, the follower piece 118 has a plate-like shape extending in the vertical direction, and the lower surface thereof is an inclined surface 126 that inclines upward toward the rear. A clamp projection 120 is provided between the base ends of the pair of driven pieces 118 , 118 . A portion of the drug solution discharge tube 108 extends back and forth between the pair of driven pieces 118 , 118 , and the valve body 114 having the clamp protrusion 120 is positioned above the drug solution discharge tube 108 .

6, the valve main body 114 of the on-off valve 110 resists the urging force of the coil spring 124 by engaging the switch engaging protrusion 122 with the switch member 128 in the vertical direction, thereby dispersing the chemical liquid. It is held above the discharge tube 108 . As also shown in FIG. 8, the switch member 128 has a plate-like body portion 130, and a guide slit 132 is formed through the body portion 130 in the horizontal direction and extending in the vertical direction. Furthermore, a rectangular box-shaped switch operating portion 134 is provided above the main body portion 130 .

Furthermore, as shown in FIGS. 8 and 13, an engagement receiving portion 136 is provided behind the main body portion 130 of the switch member 128 to engage with the switch engagement projection 122 of the on-off valve 110 in the vertical direction. As shown in FIGS. 9 and 13, a closing piece 138 serving as a closing valve for closing the chemical supply tube 64 is provided in the shape of a plate extending substantially orthogonally to the front-rear direction.

Furthermore, as shown in FIG. 6, a shut-off valve portion 140 serving as both a priming shut-off valve and a flow control portion-side shut-off valve is provided in front of the body portion 130 of the switch member 128 . As shown in FIGS. 11 and 14, the shut-off valve portion 140 has a plate-like shape extending substantially perpendicularly to the front-rear direction, and a tube insertion region 142 penetrating therethrough in the front-rear direction is formed. The upper portion of the tube insertion region 142 is a wide region that allows insertion without crushing the main branch tube 30 and the downstream tube 32, while the lower portion has constriction pieces 144, 144 protruding from both left and right sides. By doing so, the width in the left-right direction is narrower than that of the upper portion. In addition, the lower ends of the constriction pieces 144, 144 gradually decrease in laterally inward projection dimension and widen downward.

The switch member 128 is assembled to the housing 46, and as shown in FIGS. It is exposed outside the housing 46 . Further, as shown in FIG. 8, the tube connection member 54 and the housing 46 are inserted into the guide slit 132 of the switch member 128 so as to be vertically slidable. 46, while being positioned in the longitudinal direction, relative displacement in the vertical direction is allowed.

13A, when the switch member 128 is assembled to the housing 46, the closing piece 138 of the switch member 128 is positioned above the chemical supply tube 64, and the chemical supply tube 64 is positioned above the chemical supply tube 64. They are in a communicating state without being crushed by the closing piece 138 . In addition, when the switch member 128 is assembled to the housing 46 , the closing piece 138 is positioned between the two points to which the orifice tube 66 is connected in the flow direction of the chemical liquid supply tube 64 . It is possible to cut off the chemical solution supply tube 64 at the portion bypassed by .

Furthermore, as shown in FIG. 14(a), a shut-off valve portion 140 is arranged in each intermediate portion of the main branch tube 30 and the downstream tube 32, and the main branch tube 30 and the downstream tube 32 are switch members. 128 between the constriction strips 144,144 and is crushed between the constriction strips 144,144 and a tube support projection 148 of the housing 46 interposed between the constriction strips 144,144. As a result, the main branch tube 30 that constitutes the upstream side of the confluence portion 60 of the main line 24 is shut off by the flow control portion side shutoff valve composed of the shutoff valve portion 140 having the constriction pieces 144, 144. At the same time, the downstream tube 32 that constitutes the downstream side of the confluence portion 60 of the main line 24 is shut off by a priming shutoff valve composed of a shutoff valve portion 140 having constriction pieces 144 , 144 .

Furthermore, as shown in FIG. 13(a), the on-off valve 110 is configured such that the switch engaging protrusion 122 is engaged with the engagement receiving portion 136 of the switch member 128 in the vertical direction so that the valve main body of the on-off valve 110 is 114 is held above the drug solution discharge tube 108 against the biasing force of the coil spring 124, and the drug solution discharge tube 108 constituting the subline 26 is in a communicating state without being crushed by the clamp projection 120 of the on-off valve 110. It is said that

In short, in the initial state before use of the chemical injection controller 44, the entire sub-line 26 is in a communicating state, while the main line 24 is connected to the flow rate control section 38 and the confluence section 60 upstream of the confluence section 60. is shut off by a flow control unit side shutoff valve composed of a shutoff valve portion 140 between the is shut off by a priming shut-off valve.

Furthermore, the shutoff valve portion 140 that constitutes the shutoff valve for priming and the shutoff valve on the side of the flow control portion is positioned close to the junction portion 60 . In the present embodiment, the priming shutoff valve and the flow control unit side shutoff valve, which are configured by the shutoff valve section 140 , are provided at approximately the same distance from the confluence section 60 . Preferably, the confluence portion 60 and the priming air vent portion 62 are arranged so that the volume of the chemical flow path (the lumen of the chemical solution administration line 16) from the confluence portion 60 to the priming air vent portion 62 is 3 ml or less, preferably 1 ml or less. The distance of the air vent portion 62 is set.

In the drug solution administration device 10 having the drug solution injection controller 44 having such a structure, the main line 24 and the sub line 26 are primed before use. Priming is the operation of feeding the chemical solution into the main line 24 and the sub-line 26 filled with air before use, discharging the air from the main line 24 and the sub-line 26, and filling the main line 24 and the sub-line 26 with the chemical solution. In the medical-solution administration device 10 of this embodiment, such priming can be easily performed.

That is, when the drug solution is supplied to the balloon (not shown) of the drug solution container 12 in the initial state, the drug solution sent out by the elasticity of the balloon flows into the sub-line 26 at the branch portion 34 because the main line 24 is blocked by the shutoff valve portion 140. flow in. The liquid medicine that has flowed into the sub-line 26 flows into the confluence portion 60 via the sub-reservoir 42 while pushing air toward the liquid medicine administration port 14 side. Since the air-permeable filter 62 is attached to the merging portion 60, the air in the sub-line 26 is discharged to the outside through the filter 62 before the chemical liquid flows into the merging portion 60, and the sub-line to the merging portion 60 is discharged. The inside of 26 is filled with the chemical solution. Priming of the sub-line 26 is thus completed. Since there is no passage such as a hole through which air is released by the priming shut-off valve downstream from the merging portion 60, the chemical solution stops at the merging portion 60. FIG.

As can be seen from the above description, the drug-solution administration device 10 in the initial state is in the priming mode for the subline 26 . In this embodiment, the priming mechanism that realizes the priming mode for the subline 26 includes a priming air release portion that discharges the air in the subline 26 to the outside during priming of the subline 26, and a space between the filter 62 and the chemical solution administration port 14. It includes a priming shut-off valve for shutting off, and a flow control unit side shut-off valve for shutting off the main line 24 between the branch portion 34 and the merging portion 60 . The filter 62 constitutes the priming air release portion, the shutoff valve portion 140 constitutes the priming shutoff valve and the flow control portion side shutoff valve, and the housing 46 accommodates the priming mechanism.

In the present embodiment, the filter 62 incorporated in the housing 46 is arranged downstream of the sub-reservoir 42 on the drug solution administration line 16 through the sub-line 26, thereby forming an air release portion for priming. there is When the priming cutoff valve is closed, the air on the upstream side of the filter 62 is discharged to the outside through the filter 62, so that the upstream side of the filter 62 is filled with the chemical solution, while the downstream side of the filter 62 is filled with the chemical solution. The chemical solution does not flow into the Therefore, the amount of air remaining in the subline 26 is reduced by arranging the priming air vent portion near the junction of the subline 26 with the main line 24 . In particular, in the present embodiment, since the priming air release portion is provided in the confluence portion 60, residual air in the sub-line 26 after completion of priming can be minimized.

The air discharged into the housing 46 through the filter 62 is discharged from the housing 46 through the boundary between the upper half portion 50 and the lower half portion 52 of the housing 46, and formed above the filter 62. It is also discharged from the housing 46 to the outside through the ventilation hole 149 . In addition, in the present embodiment, when the chemical comes into contact with the filter 62, the superabsorbent polymer of the filter 62 swells and the air permeability of the filter 62 is lost. entry into the subline 26 through the filter 62 of .

As described above, according to the medical-solution administration device 10 according to the present embodiment, when priming the sub-line 26, there is no need to supply the medical solution to the sub-line 26 with a syringe or the like. The priming of the sub-line 26 can be performed by . Therefore, the priming operation of the sub-line 26 is simplified, and the risk of spilling the chemical solution when attaching or detaching the syringe is reduced.

Moreover, since the liquid injection controller 44 is in a state in which the subline 26 can be primed in the initial state, the liquid injection device 10 can open and close valves, clamp the liquid injection line 16 at a predetermined position, and so on. The priming of the sub-line 26 can be easily performed by simply filling the main reservoir 20 with the chemical solution without requiring the work of .

Furthermore, in the present embodiment, when priming the subline 26, the chemical liquid supply tube 64 having a larger flow rate than the orifice tube 66 is in communication, so that the priming of the subline 26 can be performed more quickly. Even if air remains in the orifice tube 66, the amount is extremely small, so it is unlikely to pose a problem. Alternatively, the liquid medicine can be guided to the orifice tube 66 .

Next, after completing the priming of the subline 26 , the switch operation portion 134 of the liquid injection controller 44 is pushed into the inner peripheral side of the housing 46 . The height of the switch operating portion 134 that has been pushed in protrudes from the housing 46 is made sufficiently small. I can't.

By pressing the switch operating portion 134, the switch member 128 is displaced downward relative to the housing 46, and shifts to the priming mode for the main line 24 shown in FIGS. 13(b) and 14(b). .

That is, as shown in FIG. 13B, the closing piece 138 of the switch member 128 is displaced downward, and the chemical solution supply tube 64 is crushed between the closing piece 138 and the supply tube support portion 150 of the housing 46. closed. As a result, in the sub-line 26 , the chemical solution is supplied from the main reservoir 20 to the sub-reservoir 42 through the orifice passage formed by the inner lumen of the orifice tube 66 .

Furthermore, as shown in FIG. 14(b), both the main branch tube 30 and the downstream tube 32 relatively move upward relative to the constriction pieces 144, 144 of the switch member 128. It is in a state of being inserted above the region 142 . As a result, the main branch tube 30 is released from the shutoff by the flow control unit side shutoff valve constituted by the shutoff valve portion 140 to be in a communicating state, and the downstream tube 32 is priming cutoff constituted by the shutoff valve portion 140. The shutoff by the valve is released and the communication state is established. As a result, the interruption of the main line 24 is released, and the entire main line 24 is brought into a communicating state.

Furthermore, as shown in FIG. 13B, the switch member 128 of the on-off valve 110 is disengaged from the switch member 128 and the coil spring 124 is disengaged. It is displaced downward relative to the housing 46 by the biasing force. The valve main body 114 of the on-off valve 110 is held in a closed state by being pressed against the drug solution discharge tube 108 by the biasing force of the coil spring 124 , so that the drug solution discharge tube 108 is connected to the valve main body 114 and the discharge tube of the housing 46 . The drug solution discharge tube 108 is blocked by being crushed between the support portion 152 and the support portion 152 . As a result, the subline 26 including the chemical discharge tube 108 is kept shut off by the on-off valve 110, and the supply of the chemical from the main reservoir 20 to the subline 26 in the priming completed state is stopped. In particular, in this embodiment, since the valve body 114 of the on-off valve 110 is provided with the clamp projection 120, the chemical discharge tube 108 can be locally crushed easily.

In this way, the main line 24 is opened while the sub-line 26 is blocked, so that the drug solution delivered from the main reservoir 20 to the drug solution administration line 16 is efficiently guided to the main line 24, and the main line 24 is closed. Priming can be completed quickly. In the present embodiment, the main line 24 is switched to the communicating state by the priming shutoff valve and the flow control unit side shutoff valve, which are composed of the shutoff valve section 140, and the subline 26 is switched to the shutoff state by the opening/closing valve 110. , from the priming mode for the sub-lines 26 to the priming mode for the main lines 24 . Therefore, the on-off valve 110 not only functions as an on-off valve for rapid drug solution administration, which will be described later, but also switches from the priming mode for the sub line 26 to the priming mode for the main line 24 in conjunction with the cutoff valve section 140 ( It also functions as a priming switching valve that switches to a state in which the priming liquid flows only from the main reservoir 20 to the main line 24). In this way, when the priming cutoff valve is opened, priming from the main line 24 to the drug solution administration port 14 is possible, while the priming solution is prevented from flowing from the main line 24 to the sub line 26. The priming liquid inside is never discharged.

In this embodiment, simply by pressing the switch member 128, the priming cutoff valve and the flow control section side cutoff valve are interlocked and switched from the communication state to the cutoff state, and the priming cutoff. Together with the switching of the valve from the open state to the shut off state, the shut-off valve composed of the shut-off piece 138 is switched from the open state to the closed state, and further together with the switching of the priming shut-off valve from the open state to the shut off state. , the on-off valve 110 is switched from an open state to a closed state. In this way, the priming cutoff valve formed by the cutoff valve section 140 is blocked/communicated, the flow rate control side cutoff valve formed by the cutoff valve section 140 is blocked/connected, and the closing piece 138 is formed. The open state/closed state of the valve and the open state/closed state of the on-off valve 110 are switched at once by a simple operation of pressing the switch member 128, and the priming mode for the sub line 26 is switched to the priming mode for the main line 24. Switching between modes can be realized very easily.

In short, in the present embodiment, a shutoff valve interlocking mechanism for interlocking shutoff/communication of the shutoff valve for priming and the shutoff valve on the side of the flow controller, and a shutoff mechanism composed of the shutoff/communication of the shutoff valve for priming and the closing piece 138. A shut-off valve interlocking mechanism that interlocks and switches between the open/closed state of the valve, and an on-off valve interlocking mechanism that interlocks and switches between the shut-off/communication of the shut-off valve for priming and the open/closed state of the on-off valve 110, It is composed of one switch member 128 .

In addition, since the priming air release portion composed of the filter 62 is provided on the subline 26, the chemical solution does not enter the main line 24 (downstream tube 32) during priming of the subline 26. Therefore, it is possible to prevent the chemical liquid in the main line 24 from being discharged and wasted during the priming of the main line 24, thereby saving the chemical liquid and simplifying the management of the amount of the chemical liquid.

Next, after the priming of the subline 26 and the main line 24 is completed, the cap 39 of the drug solution administration port 14 is removed, and the drug solution administration port 14 is percutaneously indwelled in the patient's blood vessel, such as an indwelling needle (not shown). By connecting to , it is possible to continuously administer a predetermined amount of the drug solution to the patient.

Further, when the patient or doctor presses the push button 96 of the liquid medicine injection controller 44 as necessary, more liquid medicine can be temporarily administered to the patient.

That is, when push button 96 is depressed, push button 96 and plunger 88 are brought closer together and the coil spring is contracted between push button 96 and plunger 88, as shown in FIGS.

Further, the push button 96 axially approaches the guide member 76 supported by the housing 46 so that the engaging hook 80 of the guide member 76 is axially engaged with the hook receiving portion 94 of the push button 96 . As a result, the push button 96 is held in the depressed state. In the engaged state of the engaging hook 80 and the hook receiving portion 94 , the engaging claw portion 84 of the engaging hook 80 is inserted into the hook engaging hole 154 opened in the peripheral wall of the push button 96 .

Furthermore, as shown in FIG. 15, the driving piece 100 of the push button 96 moves forward (downward in FIG. 15), and the front end of the driving piece 100 comes into contact with the lower end of the driven piece 118 of the on-off valve 110. . Since the inclined surface 104 of the driving piece 100 and the inclined surface 126 of the driven piece 118 are in sliding contact with each other, the operating force applied to the push button 96 (the force pushing the push button 96 ) varies depending on the inclination angle of the inclined surface 126 . It is transmitted to the on-off valve 110 as a component force. This sliding mechanism applies an upward force to the on-off valve 110, and the on-off valve 110 moves upward against the biasing force of the coil spring 124 as shown in FIG. can be switched to As a result, the sub-line 26 that has been shut off by the on-off valve 110 is switched to the open state. As described above, in this embodiment, the sliding mechanism in which the main moving piece 100 and the driven piece 118 are in sliding contact with each other on the inclined surfaces 104 and 126 interlocks the linear movement caused by pressing the push button 96 and the opening operation of the on-off valve 110 . Mechanism is constructed. The ratio between the forward acting component force and the upward acting component force exerted on the driven piece 118 can be appropriately set by adjusting the inclination angles of the inclined surfaces 104 and 126 . 15 is a diagram corresponding to the cross section of FIG. 11, and FIG. 16 is a diagram corresponding to the cross section of FIG.

The plunger 88 is then pressed against the sub-reservoir 42 by the biasing force of the compressed coil spring 106 . As a result, the chemical liquid stored in the sub-reservoir 42 is delivered to the chemical liquid discharge tube 108 . The medical solution delivered from the sub-reservoir 42 merges with the medical solution flowing through the main line 24 at the junction 60 and is administered from the medical solution administration port 14 into the patient's body. As a result, in addition to the continuous administration of the drug solution through the main line 24, the drug solution is also administered from the subline 26, so that a larger amount of the drug solution is temporarily administered into the patient's body. In this manner, the opening operation of the on-off valve 110 enables rapid administration of the liquid medicine stored in the sub-reservoir 42. Therefore, the on-off valve 110 of the present embodiment constitutes a priming switching valve, and at the same time, It is used as an on-off valve for rapid chemical administration.

When the temporary rapid administration of the liquid medicine through the subline 26 is completed, the liquid medicine in the sub-reservoir 42 is temporarily exhausted, so the rapid injection of the liquid medicine cannot be continuously executed, and the predetermined time elapses. Then, the liquid medicine is stored again in the sub-reservoir 42, so that rapid administration can be performed again. In the present embodiment, part of the flow path connecting the main reservoir 20 and the sub-reservoir 42 in the sub-line 26 is configured by the orifice tube 66, thereby limiting the flow rate of the liquid medicine from the main reservoir 20 to the sub-reservoir 42. The time required for the liquid medicine to be stored in the sub-reservoir 42 is adjusted. Therefore, by changing the inner diameter of the orifice tube 66 or the like, it is possible to adjust the time required until rapid administration can be reused.

Further, when the liquid medicine flows from the main reservoir 20 into the sub-reservoir 42 and the sub-reservoir 42 swells, the plunger 88 and the push button 96 are pushed backward by the sub-reservoir 42 and moved to their initial positions. Accordingly, by pressing the push button 96 again, rapid administration of the liquid medicine through the subline 26 can be re-executed. When the plunger 88 is moved forward by the biasing force of the coil spring 106, an engagement release portion (not shown) provided on the outer periphery of the plunger 88 presses against the tapered surface of the rear end of the engagement hook 80 in the axial direction. be done. As a result, an inward force is exerted on the rear portion of the engaging hook 80 , and the extending portion 82 is flexurally deformed, thereby engaging the engaging claw portion 84 of the engaging hook 80 and the hook receiving portion 94 of the push button 96 . is disengaged to allow push button 96 to move rearward.

Furthermore, in this embodiment, a slit 156 extending in the axial direction is provided in the peripheral wall of the push button 96, and a projecting mark 158 provided on the guide member 76 is inserted into the slit 156, The position of the push button 96 relative to the guide member 76 in the axial direction can be grasped from the outside. In short, the state in which the mark 158 has moved to the front end of the slit 156 is the state in which the sub-reservoir 42 is sufficiently filled with the chemical solution.

FIG. 17 shows a drug-solution administration device 160 as a second embodiment of the present invention. The drug solution administration device 160 includes a main line 24 that connects the main reservoir 20 and the drug solution administration port 14, and a sub-line that branches off from the main line 24 at a branch portion 34 and joins the main line 24 at a junction portion 60 via a sub-reservoir 42. 26. In the following description, members and portions that are substantially the same as those of the first embodiment are denoted by the same reference numerals in the drawings, and description thereof is omitted.

In the drug-solution administration device 160 of the present embodiment, the priming cutoff valve 162 is arranged between the sub-reservoir 42 and the confluence section 60 , and the priming cutoff valve 162 is provided on the subline 26 . Further, the filter 62 that constitutes the priming air release portion is arranged upstream of the priming cutoff valve 162 , and thus is arranged on the sub-line 26 upstream of the confluence portion 60 .

As shown in the above embodiment, the priming air vent portion 62 is desirably provided close to the confluence portion 60, so that after priming of the sub-line 26 is completed, the priming air vent portion 62 and the priming air vent portion 62 are The amount of air remaining between the junctions 60 can be sufficiently reduced. The distance between the priming air vent portion 62 and the merging portion 60 is set according to the allowable residual amount of air. is 3 ml or less, preferably 1 ml or less.

The priming shut-off valve 162 of the present embodiment also serves as an on-off valve that is opened during rapid administration of the chemical solution, and the number of valves is reduced compared to the chemical solution administration device 10 of the first embodiment. Furthermore, the priming cutoff valve 162 also functions as a priming switching valve that switches between the priming mode for the subline 26 and the priming mode for the main line 24 in conjunction with the on-off valve 110, so the number of valves is further increased. are being reduced. In the present embodiment, the priming shutoff valve 162 is closed during priming of the subline 26 and the main line 24, and the priming shutoff valve 162 is also closed during normal continuous injection, so that the subline 26 and the main line 24 is prevented, while the priming shut-off valve 162 is switched to an open state during rapid administration by self-operation of the push button 96, so that the medication is administered from the sub-reservoir 42.

In the drug-solution administration device 160 of the present embodiment, the priming cutoff valve 162 and the flow control unit side cutoff valve 140 are closed, and the subline 26 is primed with the shutoff valve 138 open. As a result, the chemical solution can be efficiently guided to the subline 26, and the priming of the subline 26 can be completed quickly.

Next, while the priming cutoff valve 162 remains closed, the flow control unit side cutoff valve 140 is opened, and the shutoff valve 138 is closed to perform priming of the main line 24 . In this embodiment, a valve interlocking mechanism between the priming shutoff valve 162 and the flow control unit side shutoff valve 140 and shutoff valve 138 is not configured. It is possible to provide a valve interlocking mechanism that interlocks the switching of the open state/closed state of 138 .

After the priming of the main line 24 is completed, the drug solution is continuously injected little by little from the main reservoir 20 into the patient's body by connecting the drug solution administration port 14 to an indwelling needle (not shown). Also, by appropriately opening the priming shut-off valve 162 by self-operation, the drug solution delivered from the sub-reservoir 42 is rapidly administered into the patient's body.

As shown in this embodiment, the priming cutoff valve 162 is provided on the chemical liquid flow path through the subline 26 from the main reservoir 20 to the chemical liquid administration port 14 via the sub-reservoir 42. It may be arranged on the sub-line 26 or may be arranged on the main line 24 as long as it is provided on the downstream side. In this case as well, by closing the priming cutoff valve 162, the air can escape only through the priming air vent, preventing the chemical from entering the main line 24 during priming of the subline 26. can.

Furthermore, according to the present embodiment, the priming shut-off valve 162 also serves as an open/close valve for rapid administration of the liquid medicine, so the number of valves can be reduced, and the structure can be simplified.

In this embodiment, the filter 62 constituting the priming air release portion is arranged on the sub-line 26 upstream of the junction 60 of the main line 24 and the sub-line 26. The extraction portion may be arranged downstream of the sub-reservoir 42 on the chemical liquid flow path through the sub-line 26 , or may be arranged downstream of the confluence portion 60 .

Although the embodiments of the present invention have been described in detail above, the present invention is not limited by the specific descriptions. For example, in the above-described embodiment, when priming the sub-line 26, an example was shown in which a flow rate control section side shutoff valve was provided to shut off the main line 24 between the flow rate control section 38 and the merging section 60. A shut-off valve is not essential and can be omitted. That is, in the medical-solution administration device 10 shown in the first embodiment, plumbing of the sub-line 26 is completed in a short time because the main line 24 has the flow control section 38 without the flow control section-side cutoff valve. In addition, in the medical-solution administration device 160 shown in the second embodiment, if the flow control section side shutoff valve is eliminated, the main line 24 will not be completely blocked during priming of the subline 26. Since the flow rate of is limited, the chemical liquid can be preferentially directed to the subline 26 to prime the subline 26 .

Also, unlike the first and second embodiments, the priming shut-off valve may be realized by a cap provided on the drug solution administration port 14 . By providing a cap that restricts the passage of both liquid and gas with a valve or a filter that restricts the passage of liquid, by removing a part of the cap at the drug solution administration port 14, the liquid can be released while allowing the passage of gas. You can also restrict the passage of For example, if the cap is a priming cutoff valve and the priming air release portion 62 is located between the sub-reservoir 42 and the merging portion 60 or between the flow control portion 38 and the merging portion 60, the merging portion 60 Priming on the upstream side is possible, and after that, by giving the drug solution administration port 14 a ventilation function by removing the whole or part of the cap, priming up to the drug solution administration port 14 can be performed. Further, when the cap is a shutoff valve for priming and the priming air release portion 62 is located downstream of the merging portion 60, priming on the upstream side of the priming air release portion 62 is possible, and then the chemical solution administration port is closed. By imparting a ventilation function to 14 , priming can be performed up to the drug solution administration port 14 . In this way, the priming cutoff valve is configured to temporarily make the priming air release portion 62 the only escape route for air. It is sufficient if it is downstream from the part.

Further, in the above embodiment, the shutoff/communication of the shutoff valve for priming, the shutoff/communication of the shutoff valve on the side of the flow controller, the open/closed state of the on/off valve, and the open/closed state of the shutoff valve are: By operating one switch member 128, the switches are interlocked, but they may be operated separately. Further, when the valve interlocking mechanism is provided, it is not necessarily limited to interlocking the above four valves, and two or three valves may be interlocked.

Also, the position of the filter 62 is not limited to the confluence point (confluence portion 60) of the main line 24 and the sub-line 26 as in the above embodiment, but the filter 62 is preferably located close to the confluence portion 60. placed. For example, when the filter 62 is arranged on the subline 26, the position of the filter 36 may be set so that the amount of air remaining in the subline 26 is less than a predetermined amount when the subline 26 is primed. Desirably, the filter 62 is arranged in a 50% area (preferably 20% area) near the junction 60 with respect to the line length from the sub-reservoir 42 to the junction 60 in the sub-line 26 . Similarly, when the filter 62 is arranged on the main line 24 , the position of the filter 62 is such that the chemical solution entering the downstream side of the confluence portion 60 of the main line 24 is positioned before the start of priming of the main line 24 . It is desirable to be set to be equal to or less than a predetermined amount. Preferably, the filter 36 is arranged in a region near the junction 60 in the main line 24 from the junction 60 to the sub-reservoir 42 . . As a result, when priming the main line 24 after priming the sub-line 26, the amount of discharged chemical solution can be reduced and the amount of air remaining in the sub-line 26 can be reduced, and the administration of the chemical solution can be started. In doing so, the amount of residual air entering the patient's body through the subline 26 can be reduced to an insignificant extent.

Furthermore, the position of the filter 62 is not particularly limited as long as it is downstream of the sub-reservoir 42 or downstream of the flow control section 38, and the filter 62 may be provided downstream of the junction section 60 in the main line 24. However, a filter 62 is preferably provided between the sub-reservoir 42 and the junction 60 in the sub-line 26 . This prevents the chemical solution from entering the main line 24 on the downstream side of the junction 60 during priming of the subline 26, and reduces the amount of the chemical solution discharged during priming of the main line 24. - 特許庁

In the above-described embodiment, the priming switching valve for allowing the priming fluid to flow only from the main reservoir 20 to the main line 24 includes the on-off valve 110 for rapid drug solution administration. , for example, may be provided independently of the other valves.

Further, in the above embodiment, the sliding mechanism (sliding lever) between the main moving pieces 100, 100 and the driven pieces 118, 118 is exemplified as the interlocking mechanism for transmitting the operating force exerted on the push button 96 to the on-off valve 110. , the interlocking mechanism is not limited to the mechanism shown in the above embodiment. Specifically, for example, the interlocking mechanism can be configured by a known mechanism such as a rack and pinion, a link mechanism, or a cam mechanism. In particular, if a force boosting mechanism or a force boosting mechanism is employed, the biasing force of the coil spring 124 acting on the on-off valve 110 is increased to ensure that the on-off valve 110 is kept closed. It is also possible to reduce the operating force required to shift to the open state.

Further, the interlocking mechanism of the above-described embodiment constituted by sliding between the driving pieces 100, 100 and the driven pieces 118, 118 has the driving piece 100 having the inclined surface 104 and the driven piece 118 having the inclined surface 126. and the inclined surfaces 104 and 126 are in sliding contact with each other. Alternatively, the desired interlocking mechanism can be configured by a structure in which the other slides in contact with the inclined surface.
In addition, the present invention originally includes each of the inventions described in (viii) to (xiii) below, and the configuration and effects thereof will be added.
The present invention
(viii) a main line extending from the main reservoir to the patient-side drug administration port via the flow control unit, and a branch of the main line from the upstream side of the flow control unit to the downstream of the flow control unit via a sub-reservoir. and a sub-line joining the main line on the side of the drug-solution administration device for performing rapid drug-solution administration from the sub-reservoir by self-operation, the liquid-administration controller accommodating the sub-reservoir. A liquid injection controller characterized in that the housing incorporates a priming air vent provided downstream of the sub-reservoir,
(ix) orifice passages are incorporated in the housing and extend in parallel on the sub-line from a branch point of the main line to the sub-reservoir, connecting positions separated in the flow direction and extending in parallel; A shut-off valve is incorporated in the housing on the sub-line extending parallel to the passage, and a priming cut-off valve that is incorporated in the housing and provided downstream of the priming air release portion communicates from the shut-off state. The liquid injection controller according to (viii), which has a shut-off valve interlocking mechanism that switches the shut-off valve from an open state to a closed state as the state is switched,
(x) An on-off valve capable of closing the sub-line on the sub-line from the sub-reservoir to the confluence with the main line is incorporated in the housing, and is incorporated in the housing to provide the priming air vent. It has an on-off valve interlocking mechanism that switches the on-off valve from the open state to the closed state as the priming shut-off valve provided downstream of the part is switched from the shut-off state to the open state (viii ) or the liquid injection controller according to (ix),
(xi) a main line extending from a main reservoir to a patient-side drug administration port via a flow controller, and a branch of the main line from the upstream side of the flow controller via a sub-reservoir to the downstream of the flow controller and a sub-line joining the main line on the side of the drug-solution administration device for performing rapid drug-solution administration from the sub-reservoir by self-operation, the liquid-administration controller accommodating the sub-reservoir. An on-off valve for rapid drug administration is provided on the sub-line from the sub-reservoir to the confluence with the main line in the housing, and the on-off valve is held closed by biasing means. In addition, the on-off valve is interlocked via an interlocking mechanism for changing the movement direction with respect to the operating member that is moved by an external operating force to exert a pressing force on the sub-reservoir, The on-off valve is switched from the closed state to the open state against the urging force of the urging means by applying an external operating force applied to the operating member to the on-off valve. A dosing controller characterized by:
(xii) The interlocking mechanism is configured such that a main moving piece provided on the operating member side and a driven piece provided on the on-off valve side are slidably abutted on an inclined surface, so that the operating member is externally operated. The liquid injection controller according to (xi), which is composed of a sliding mechanism that is interlocked with a component force corresponding to the inclination angle of the inclined surface being transmitted to the on-off valve along with the linear movement by the operating force of
(xiii) a main line from the main reservoir to the patient-side drug administration port via the flow control unit, and a branch of the main line from the upstream side of the flow control unit to the downstream of the flow control unit via a sub-reservoir and a sub-line that merges with the main line at the side of the sub-line, and for self-operating and rapidly administering a liquid medicine from the sub-reservoir, the controller comprising: the main line and the sub-line A priming mechanism that performs priming is provided on the chemical liquid flow path from the branch point of the sub-line to the confluence point of the sub-line through the flow control unit in the main line in the housing that accommodates the sub-reservoir. A chemical injection controller comprising a flow control unit side cutoff valve,
including inventions related to
In the invention described in (viii) above, the liquid chemical is circulated from the main reservoir to the line while the priming cutoff valve is closed, so that the main reservoir passes through the sub-reservoir to reach the installation position of the priming air vent. sublines up to can be primed quickly. In addition, since the priming air release portion is incorporated in the housing, the priming air release portion does not interfere with use compared to the case where the priming air release portion is provided on a line extending out of the housing. and the structure can be made compact.
In the invention described in (ix) above, when the stop valve is closed, the flow rate of the sub-line is restricted by the orifice passage, so the supply speed of the chemical solution from the main reservoir to the sub-reservoir is adjusted. Therefore, it is necessary to take a sufficiently long time to fill the sub-reservoir with the liquid medicine, and by preventing continuous rapid liquid medicine injection by the liquid medicine injection controller, it is possible to prevent excessive injection of the liquid medicine. can be done. In addition, the switching of the shut-off valve from the open state to the closed state is interlocked with the switching of the shut-off valve for priming from the shut-off state to the open state by the shut-off valve interlocking mechanism. The shut-off valve is closed together with the opening of the shut-off valve for the sub-line, so that the sub-line can be easily switched to the use state after the completion of priming.
In the invention described in (x) above, the outflow of the chemical solution from the sub-line to the main line is prevented by closing the on-off valve. Further, after completion of priming of the sub-line, the priming cut-off valve is opened and the on-off valve is closed, so that the priming liquid can flow only from the main reservoir to the main line.
In the invention described in (xi) above, the on-off valve is switched from the closed state to the open state by applying an external operating force to the operating member, for example, by pressing the operating member with a finger, and the chemical liquid is submerged. It can be pushed out from the reservoir to the subline. Therefore, by a simple self-operation such as pressing the operating member, rapid administration of the liquid medicine can be performed as required. In particular, by adopting a force boosting mechanism or a boosting mechanism in the interlocking mechanism, the biasing force exerted by the biasing means on the on-off valve is increased, so that the closed state of the on-off valve can be reliably maintained. It is possible to reduce the operating force required to open the on-off valve.
In the invention described in (xii) above, the sub-reservoir is pressed by the operating member by linearly moving the operating member by self-operation such as pushing the operating member, for example, and the liquid medicine is pushed out from the sub-reservoir to the sub-line. Furthermore, since a component force acting in a predetermined tilt direction with respect to the moving direction of the operating member is transmitted to the on-off valve, it is necessary to match the moving direction of the operating member by the operating force and the opening operation direction of the on-off valve. It is possible to set them in directions that are inclined or orthogonal to each other, and a large degree of freedom in design can be obtained in the moving direction of the operating member and in the lower position of the on-off valve.
In the invention described in (xiii) above, the flow controller-side shutoff valve reliably prevents the flow of the chemical solution through the flow controller, and the chemical solution is more efficiently guided to the sub-line, thereby reliably priming the sub-line. and executed quickly. In particular, even when the flow resistance of a chemical solution is low or the control flow rate of the flow control unit is large, the main line is shut off by the flow control unit side shut-off valve, making it easier for the chemical solution to flow to the sub-line and priming the sub-line quickly and quickly. can be done with certainty.

10, 160: drug solution administration device, 14: drug solution administration port, 20: main reservoir, 24: main line, 26: sub line, 34: branch part, 38: flow control part, 42: sub reservoir, 44: drug solution injection controller, 46: housing, 60: confluence (confluence), 62: filter (priming air vent), 66: orifice tube (orifice passage), 96: push button (operating member), 100: main moving piece, 104, 126 : Inclined surface 110: On-off valve (priming switching valve) 118: Follower piece 124: Coil spring (biasing means) 128: Switch member (shutoff valve interlocking mechanism, shut-off valve interlocking mechanism, on-off valve interlocking mechanism), 138: Closing piece (shutoff valve), 140: Shutoff valve portion (priming shutoff valve, flow control unit side shutoff valve), 162: Priming shutoff valve

Claims (9)

a main line extending from a main reservoir to a drug solution administration port on the patient side through a flow control section; A drug-solution administration device comprising a sub-line joining the main line,
A drug-solution administration device characterized by having the following (i) and (ii) as a priming mechanism for priming the sub-line.
(i) A priming air release section provided downstream of at least one of the sub-reservoir and the flow control section.
(ii) A priming shut-off valve that is provided downstream of the priming air release portion and that is shut off during priming of the sub-line and communicated after priming. 2. The priming air release portion according to claim 1, wherein the priming air release portion is provided in the vicinity of the confluence of the main line and the sub-line or between the sub-reservoir and the confluence of the main line and the sub-line. liquid medicine administration device. 3. The liquid medicine administration according to claim 1 or 2, wherein in the subline, an on-off valve capable of closing the subline is provided on a liquid medicine flow path from a branch point with the main line to a confluence point with the main line. Device. 4. The on-off valve interlocking mechanism according to claim 3, which switches the on-off valve from an open state to a closed state as the priming shut-off valve (ii) is switched from the shut-off state to the open state. Chemical liquid administration device. A liquid medicine injection controller for performing rapid liquid medicine administration from the sub-reservoir by self-operation is provided, and the liquid medicine injection controller has a housing for accommodating the sub-reservoir. 5. The drug-solution administration device according to any one of claims 1 to 4, wherein an air vent is incorporated in the housing. The drug-solution administration device according to any one of claims 1 to 5, further comprising the following (iii) as the priming mechanism.
(iii) In the main line, a flow controller side cutoff valve provided on a chemical liquid flow path from a branch point of the sub-line to a junction of the sub-lines via the flow controller. It has a shut-off valve interlocking mechanism that shuts off/connects the priming shut-off valve in the above (ii) of the priming mechanism and the flow controller side shut-off valve in the above (iii) of the priming mechanism together. The drug-solution administration device according to claim 6. a main line extending from a main reservoir to a drug solution administration port on the patient side through a flow control section; and a sub-line that merges with the main line, and for self-operating to rapidly administer a chemical solution from the sub-reservoir, comprising:
A priming air release portion provided downstream of the sub-reservoir is incorporated in a housing that accommodates the sub-reservoir, and
Orifice passages are incorporated in the housing and extend in parallel connecting positions separated in the flow direction on the sub-line from a branch point from the main line to the sub-reservoir,
a shutoff valve is incorporated in the housing on the subline extending parallel to the orifice passage;
As the shut-off valve for priming, which is incorporated in the housing and provided on the downstream side of the air vent for priming, is switched from the shut-off state to the open state, the shut-off valve is switched from the open state to the closed state. A liquid injection controller characterized by having a shut-off valve interlocking mechanism. a main line extending from a main reservoir to a drug solution administration port on the patient side through a flow control section; and a sub-line that merges with the main line, and for self-operating to rapidly administer a chemical solution from the sub-reservoir, comprising:
A priming air release portion provided downstream of the sub-reservoir is incorporated in a housing that accommodates the sub-reservoir, and
an on-off valve capable of closing the sub-line on the sub-line from the sub-reservoir to the confluence with the main line is incorporated in the housing;
As the shutoff valve for priming incorporated in the housing and provided downstream of the air vent for priming is switched from the closed state to the open state, the on-off valve is switched from the open state to the closed state. A chemical injection controller characterized by having an on-off valve interlocking mechanism.

Images