JP7141957B2 - implant placement device - Google Patents

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an implant placement device that punctures the skin to place an implant in the body.

Various treatment methods have been proposed to treat tissue with reduced function, in which an implant that promotes tissue regeneration is placed at the site. For example, a method has been proposed in which porous collagen fibers having numerous pores formed therein are implanted into the injured site (Patent Document 1). When such collagen fibers are implanted, cells gather around them, which has the effect of promoting regeneration of damaged tissue.

Japanese translation of PCT publication No. 2012-500203

In general, the implant is implanted by incising the skin tissue to expose the damaged tissue and fixing the collagen fibers to be implanted to the damaged tissue with a ligating clip or a tissue adhesive. However, such a technique is highly invasive and imposes a heavy burden on the patient.

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide an implantable body placement device that can easily place an implantable body into a damaged site with minimal invasiveness.

One aspect of the present invention is a tubular member having a puncture section formed at its tip end that can puncture subcutaneous tissue and having an internal space extending in the axial direction, and a tip end having a diameter substantially the same as the inner diameter of the internal space. an implant body having a locking portion and a body portion extending from the locking portion in a thread-like shape toward the proximal end, and made of a material having the ability to promote tissue regeneration by adhering cells; a moving mechanism that is connected to the proximal end of the tubular member and circulates a liquid in the internal space to move the implant in the internal space of the tubular member ; a shaft hole portion provided between the tube member and the moving mechanism and accommodating the stopper of the implant body and the proximal end portion of the main body; The implant placement device further comprises an intermediate member having a cutting member for cutting the main body portion in the shaft hole to separate the stopper from the implant.

According to the implantable body placement device of the above aspect, the implantable body can be easily placed in the damaged site with minimal invasiveness.

1 is a cross-sectional view of an implantable body retention device according to a first embodiment; FIG. FIG. 2A is an explanatory view of a state in which the implantable body retention device of FIG. 1 is punctured into the skin of a living body, and FIG. 2B is an operation of feeding the implantable body of the implantable body retention device of FIG. It is an explanatory diagram showing. 3A is an explanatory view showing the operation of pulling out the implantable indwelling device of FIG. 1, and FIG. 3B is an explanatory view showing a method of treating the implant after the implantable indwelling device is pulled out from the living body. . 4A is a cross-sectional view of an implant used in manufacturing the implant retention device of FIG. 1, and FIG. 4B is a cross-sectional view showing a method of inserting the implant of FIG. 4A into the internal space of a tubular member. be. 5A is a cross-sectional view showing a method of cutting and removing the rigid member of the implant of FIG. 4B, and FIG. 5B is an explanatory view showing the operation of pushing the implant of FIG. 5A back into the inner space of the tubular member. 6A is a cross-sectional view showing another method of inserting the implant into the internal space of the tubular member, and FIG. 6B is an explanatory view showing a method of cutting and removing the rigid member of the implant shown in FIG. 6A. 7A is a cross-sectional view showing still another method of inserting the implant into the internal space of the tubular portion, and FIG. 7B is an explanatory view showing a method of cutting and removing the stopper of the implant shown in FIG. 7A. . FIG. 4 is a cross-sectional view of an implantable body retention device according to a second embodiment; 9A is an explanatory view showing the operation of puncturing the skin with the implantable body retention device of FIG. 8, and FIG. 9B is an explanatory view showing the operation of feeding the implantable body from the implantable body retention device of FIG. FIG. 10A is an explanatory view showing the operation of withdrawing the implantable body retention tool while leaving the implantable body in FIG. 8 at the target site, and FIG. is an explanatory diagram showing a method of processing a protruding portion of . FIG. 11 is a cross-sectional view of an implantable body retention device according to a third embodiment; FIG. 12 is an explanatory view showing a method of implanting an implant using the implant retainer of FIG. 11; FIG. 13A is a schematic diagram showing deformation of the subcutaneous tissue when the tubular member is withdrawn leaving the implant, and FIG. It is a schematic diagram which shows a mode that meandering arises in a body. 14A is a cross-sectional view of an implantable body retention device according to a fourth embodiment, and FIG. 14B is a cross-sectional view of the XIVB portion of FIG. 14A. FIG. 15A is a perspective view showing a state in which an implant is fed out by the implant retention device of FIG. 14A, and FIG. 15B is a perspective view showing an operation of pulling out the implant retention device of FIG. 14A. FIG. 11 is a cross-sectional view of an implantable body retention device according to a fifth embodiment; FIG. 17 is a perspective view showing the operation of the tube member of the implantable body retention device of FIG. 16; 18A is an explanatory view showing the operation of pulling out the second member of the tube member of FIG. 16, and FIG. 18B is an explanatory view showing how the subcutaneous tissue is deformed when the first member is pulled out from the state of FIG. 18A. . 19A is a cross-sectional view of an implantable body retention device according to a sixth embodiment, and FIG. 19B is an enlarged perspective view of the vicinity of the distal end of the outer tube member of FIG. 19A. FIG. 20 is a plan view of an implantable body retention device according to a seventh embodiment; FIG. 21 is a cross-sectional view of a tubular member of an implantable body retention device according to an eighth embodiment; FIG. 21 is a cross-sectional view of a tubular member of an implantable body retention device according to a ninth embodiment; FIG. 20 is a cross-sectional view of an implantable body retention device according to a tenth embodiment; 24A to 24E are cross-sectional views showing various forms of an implant according to the eleventh embodiment.

Preferred embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

(First embodiment)
As shown in FIG. 1, the implant placement device 10 of this embodiment incorporates an implant 20 that has the ability to promote tissue regeneration. is used to deliver to compromised tissues. Specifically, the implantable body retention device 10 includes a tubular member 12 having a puncture portion 14 capable of puncturing subcutaneous tissue 92 at its distal end, a hub body portion 16 provided on the proximal end side of the tubular member 12, and a moving mechanism 18 connected to the hub main body 16 .

The tubular member 12 is a tubular member elongated in the axial direction of the implantable body retention device 10, and has a through hole 12a (internal space) formed therein extending in the axial direction. The through-hole 12a is formed as a circular hole having a constant diameter from the distal end to the proximal end. The distal end side of the through-hole 12a is opened at the puncture portion 14. As shown in FIG. Further, the base end side of the through hole 12 a opens into the hollow portion 16 a of the hub main body portion 16 .

A puncture section 14 capable of puncturing the skin 90 of a living body is formed at the distal end of the tube member 12 . The puncture portion 14 is formed of a surface inclined with respect to the axis of the tubular member 12 as shown in the drawing, and a sharp needlepoint 14a is formed at the tip thereof.

The pipe member 12 can be made of, for example, a metal material such as stainless steel. The outer diameter of the tube member 12 can be, for example, approximately 0.7 mm to 3.0 mm, and the diameter of the through hole 12a can be approximately 0.5 mm to 1.2 mm. Further, the length from the tip 14a of the tube member 12 to the connecting portion with the hub main body 16 can be about 100 mm to 250 mm.

The hub body portion 16 is a member provided on the proximal end side of the tubular member 12 . The hub body portion 16 is a member formed to have a diameter larger than that of the tube member 12, is formed in a cylindrical shape, and is formed to extend a predetermined length in the axial direction. The hub main body portion 16 is a portion to which an operation force is input to pierce the skin 90 of the tube member 12 and push it forward into the subcutaneous tissue 92 . It is formed to have a length (length in the axial direction).

Inside the hub body 16, a hollow portion 16a for mounting the moving mechanism 18 is formed. The hollow portion 16a has a circular cross section and extends in the axial direction. The tip of the hollow portion 16 a communicates with the through hole 12 a of the pipe member 12 . Further, the hollow portion 16a is opened toward the proximal end side in the axial direction, and is configured to be able to accommodate the moving mechanism 18 from the opening portion. The inner diameter of the hollow portion 16 a is formed to be large enough to accommodate the outer diameter portion of the syringe that constitutes the moving mechanism 18 . The hollow portion 16a may be tapered such that the diameter gradually increases from the distal end to the proximal end in order to connect the moving mechanism 18 in an air-tight and liquid-tight manner.

The hub main body 16 can be made of, for example, a resin material such as polycarbonate, polypropylene, or polyethylene resin. In this case, the hub main body 16 and the pipe member 12 are joined with an adhesive or the like, and are configured to move integrally with each other. When the hub main body 16 is made of a resin material, it is preferable to use a transparent resin material so that the base end 28b of the embedded body 20 can be visually recognized so that the position of the embedded body 20 can be confirmed. be. It should be noted that the hub main body portion 16 may be formed integrally with the pipe member 12 from the same material as the pipe member 12 .

The moving mechanism 18 is configured by, for example, a syringe. The moving mechanism 18 includes a cylindrical portion 18b extending in the axial direction, a gasket 24 provided inside the cylindrical portion 18b, and a pusher 22 provided on the base end side of the gasket 24. ing. The moving mechanism 18 has a cylindrical portion 18b whose distal end is inserted into the hub main body 16 and joined in a liquid-tight and air-tight manner. An empty chamber 18a is formed inside the tubular portion 18b and is partitioned by a gasket 24, and the inside of the empty chamber 18a is filled with a liquid 30. As shown in FIG. A nozzle 18c is provided on the tip side of the cylindrical portion 18b. The hollow portion 16a of the hub main body portion 16 and the empty chamber 18a of the tubular portion 18b communicate with each other through a nozzle 18c.

The liquid 30 is, for example, liquid such as physiological saline or Ringer's solution. When the moving mechanism 18 pushes the pusher 22 toward the tip in the axial direction, the gasket 24 is displaced toward the tip in the axial direction, and the liquid 30 in the empty chamber 18a flows out from the nozzle 18c. The liquid 30 flowing out from the moving mechanism 18 flows into the through hole 12a of the pipe member 12 via the hollow portion 16a, and flows through the through hole 12a of the pipe member 12 toward the distal end side in the axial direction. Further, when the pusher 22 of the moving mechanism 18 is pulled toward the proximal end side in the axial direction, the liquid 30 in the hollow portion 16a is sucked into the empty chamber 18a through the nozzle 18c, and the through hole 12a of the tube member 12 moves toward the distal end side. It is configured such that the liquid 30 flows from the end toward the base end side.

The embedded body 20 is accommodated in the through hole 12a of the tubular member 12 with the engaging portion 26 facing the distal end. The implant 20 includes a body portion 28 formed like a thread, and a locking portion 26 provided at a distal end portion 28 a (tip) of the body portion 28 . The main body portion 28 and the locking portion 26 are made of, for example, porous collagen fibers having a large number of micropores formed therein. Such porous collagen fibers are known to have the effect of facilitating regeneration of tissues with reduced function by gathering various cells from the surroundings when left in vivo (see Patent Document 1). For example, the collagen fibers of the main body 28 have an average diameter of about 0.4 mm in a dry state, about 0.6 mm in a wet state, and lengths of about 50 mm to 300 mm.

The locking portion 26 is provided on the tip portion 28a side of the body portion 28 . The locking portion 26 is formed to have a larger diameter than the body portion 28 in order to lock the implant 20 to the living tissue and prevent it from moving from the target site when the implant 20 is left in the living body. The locking portion 26 is configured, for example, as a knot that ties the body portion 28 . Alternatively, the engaging portion 26 may be formed by attaching another member to the distal end portion 28a of the body portion 28 and increasing the diameter thereof.

The diameter of the engaging portion 26 is approximately the same as the inner diameter of the through hole 12 a of the tube member 12 . That is, the engaging portion 26 is in close contact with the through hole 12a, and can move along with the liquid 30 in the axial direction of the through hole 12a in the distal direction or the proximal direction as the liquid 30 flows through the through hole 12a. is configured to

The physical properties of the embedded body 20, such as its thickness and lengthwise dimension, differ between the dry state and the wet state. Therefore, if the indwelling is started in a dry state and gradually becomes wet with the liquid 30 or the blood in the living body during indwelling, it is not preferable from the viewpoint of the stability of the indwelling operation. Therefore, as shown in the figure, the cavity 16a of the hub body 16 and the through hole 12a of the tubular member 12 may be filled with the liquid 30 in advance so that the entire area from the proximal end to the distal end of the implant 20 is wet. preferable. Alternatively, instead of filling the hollow portion 16a and the through hole 12a with the liquid 30 in advance, the plunger 22 of the moving mechanism 18 may be pushed in to bring the implant 20 into contact with the liquid 30 immediately before starting placement. good.

The implant placement device 10 described above can be used, for example, in a technique of placing the implant 20 in the vicinity of a lymph node having a dysfunctional lymph vessel. Lymphatic dysfunction is caused by lymph node dissection, radiation therapy, and the like during tumor treatment. When the lymphatic vessels become dysfunctional, lymph cannot flow normally and edema may occur. In order to improve such dysfunction, the implant 20 made of collagen fibers can be placed to induce cell proliferation and organization, thereby promoting regeneration of lymphatic vessels. The operation of the implantable body indwelling device 10 and its usage method will be described below.

As shown in FIG. 2A, the puncturing portion 14 of the tubular member 12 of the implant placement device 10 is punctured into the skin 90 near the target site where the implant 20 is to be placed. Since the tube member 12 has a sharp needle tip 14a at its tip and is formed to have a thickness not much different from that of a needle tube of an injection needle, it can easily penetrate the skin 90 and subcutaneous tissue 92. Damage to 90 and subcutaneous tissue 92 can be minimized. In addition, since the cut of the skin 90 is small, infection from the wound can be minimized.

Thereafter, as shown in FIG. 2B, the tubular member 12 is pushed through the subcutaneous tissue 92 to move the puncture portion 14 at the distal end thereof to the target site. Next, pusher 22 is pushed toward the tip in the axial direction as shown. As a result, the liquid 30 is pushed out from the moving mechanism 18, and the liquid 30 flows through the through hole 12a of the pipe member 12 toward the distal end side in the axial direction.

The pressure and flow of the liquid 30 push out the embedded body 20 accommodated in the through-hole 12a toward the distal end side of the through-hole 12a in the axial direction. Then, the locking portion 26 of the implant 20 protrudes from the puncture portion 14 . Here, when correcting the position of the embedded body 20, the pusher 22 of the moving mechanism 18 is pulled toward the proximal end side in the axial direction to pull the locking portion 26 back into the through hole 12a. Thereafter, by moving the tubular member 12, the position of the implant 20 can be corrected.

After the positioning of the implant 20 is completed, the pusher 22 of the moving mechanism 18 is further pushed to project the locking portion 26 of the implant 20 into the subcutaneous tissue 92 as shown in FIG. 3A. As a result, the engaging portion 26 is engaged with the subcutaneous tissue 92, and the position of the distal end of the implant 20 is determined.

Next, the hub body 16 is pulled proximally to withdraw the tube member 12 from the skin 90 . This leaves the implant 20 in the deployed position. In this case, since a tensile force does not act on the embedding body 20 itself, it is possible to suppress damage to fine structures such as micropores of the embedding body 20 . As a result, the implant 20 can be placed at the target site without impairing the fixation of cells.

Thereafter, as shown in FIG. 3B, if necessary, the proximal end portion 28b of the implant 20 protruding from the skin 90 is cut off by the cutting means 34, and the implantation of the implant 20 is completed. In order to promote regeneration of a wide tissue such as lymphoid tissue, a plurality of implants 20 may be implanted in parallel. In this case, the desired number of implants 20 can be implanted by repeating the operations shown in FIGS. 2A to 3B.

Next, a method for manufacturing the implant placement device 10 of this embodiment will be described with reference to FIGS. 4A to 7B.

The method of manufacturing the implant placement device 10 consists of joining the tube member 12 to the hub body 16, then inserting the implant 20 into the through hole 12a of the tube member 12, and finally attaching the moving mechanism to the hub body 16. 18 is basically configured. In carrying out such a manufacturing method, a method for efficiently inserting the implant 20 into the thin through hole 12a of the tubular member 12 is required. Here, the method of inserting the embedded body 20 into the through hole 12a will be focused on and explained.

In the first method, as shown in FIG. 4A, a precursor member 120 is prepared in which a rigid member 32 with high rigidity extends from the distal end side of the engaging portion 26 of the implant 20 . The rigid member 32 is a member having a diameter approximately equal to that of the main body portion 28 and is formed to extend linearly. The rigid member 32 of the precursor member 120 is formed by forming the engaging portion 26 near the center of the elongated main body portion 28, and then reinforcing one main body portion 28 extending from one side of the engaging portion 26 with an adhesive or the like. It can be formed by dipping and solidifying the member. Also, the rigid member 32 may be formed by joining a wire or the like to the locking portion 26 of the implant 20 .

Next, as shown in FIG. 4B, the rigid member 32 of the precursor member 120 is inserted into the through-hole 12a of the tubular member 12 from the hollow portion 16a side of the hub body portion 16. As shown in FIG. Since the rigid member 32 is formed to be less likely to bend, positioning is easy, and the rigid member 32 can be easily inserted into the through hole 12a.

After that, as shown in FIG. 5A, the rigid member 32 in the through hole 12a is moved to the distal end side and completely pulled out from the through hole 12a. Then, the rigid member 32 beyond the engaging portion 26 is cut and removed by the cutting means 34 .

Next, as shown in FIG. 5B, the locking portion 26 of the implant 20 is pushed back into the through hole 12a to complete the insertion of the implant 20 into the through hole 12a of the tubular member 12. As shown in FIG. It should be noted that the locking portion 26 can be pushed back into the through hole 12a by, for example, blowing a fluid such as air into the through hole 12a.

In the second method, as shown in FIG. 6A, a precursor member 120A having a rigid member 32A extending from the proximal end 28b of the main body 28 of the implant 20 is prepared. The rigid member 32A is a member having approximately the same diameter as that of the body portion 28, and is formed to extend linearly. The rigid member 32A of the precursor member 120A can be formed by immersing a reinforcing member such as an adhesive in a part of the base end side of the elongated main body 28, stretching it linearly, and solidifying it. Also, the rigid member 32A may be formed by joining a wire or the like to the base end portion 28b of the main body portion 28. As shown in FIG.

Next, as illustrated, the rigid member 32A of the precursor member 120A is inserted into the through hole 12a of the tube member 12 from the puncture portion 14 side. Since the rigid member 32A is hard to deform, positioning is easy, and it can be easily inserted into the through hole 12a. After that, the rigid member 32A is pushed toward the proximal end.

Next, as shown in FIG. 6B, the rigid member 32A projecting toward the hollow portion 16a of the hub main body portion 16 is pulled out toward the proximal end side, and the engaging portion 26 of the precursor member 120A is inserted into the through hole 12a of the tubular member 12. move to Then, the rigid member 32A extending toward the base end of the body portion 28 is cut and removed by the cutting means 34, thereby obtaining the implant 20 with the locking portion 26 inserted into the through hole 12a.

A third method, as shown in FIG. 7A, involves a precursor member 120B provided with a stopper 36 on the base end side of the body portion 28 of the implant 20, and a locking portion 26 of the implant 20 that is separated by fluid flow. is inserted into the through hole 12a of the pipe member 12, and an insertion jig 38 is used. The stopper 36 of the precursor member 120B is formed to have a diameter larger than the inner diameter of the through hole 12a in order to prevent the engaging portion 26 and the body portion 28 from slipping out of the through hole 12a of the pipe member 12. As shown in FIG.

The insertion jig 38 is composed of, for example, a syringe, and contains therein the precursor member 120B together with a fluid 44 such as water or air. As shown, the insertion jig 38 is attached to the hollow portion 16a of the hub main body 16, and the pusher 42 of the insertion jig 38 is pressed to move the gasket 40 axially to the distal end side.

As a result, the fluid 44 inside the insertion jig 38 is pushed out and flows into the through hole 12 a of the pipe member 12 . Due to this flow of fluid 44, as shown in FIG. 7B, locking portion 26 of precursor member 120B is inserted into through-hole 12a.

The stopper 36 is pulled out from the cavity 16a of the hub main body 16 and cut off by the cutting means 34 to obtain the embedded body 20 with the engaging portion 26 inserted into the through hole 12a. Thus, according to this method, by utilizing the flow of the fluid 44, the implant 20 can be inserted into the through-hole 12a without performing positioning in the narrow through-hole 12a.

As yet another method, the body portion 28 of the implant 20 is reinforced with a material that is biodegradable and has lower stretchability than the collagen fibers that constitute the body portion 28. The implant 20 may be inserted into the hole 12a.

The implant placement device 10 and the implant 20 of this embodiment have the following effects.

The implantable body indwelling device 10 of the present embodiment includes a tubular member 12 having a sharp needle tip 14a at its distal end that can pierce subcutaneous tissue 92 and having a through hole 12a (internal space) extending in the axial direction, It has a locking portion 26 formed to have a diameter substantially the same as the inner diameter of the through hole 12a, and a main body portion 28 extending like a thread from the locking portion 26, and has the ability to promote tissue regeneration by attaching cells. and a moving mechanism connected to the base end side of the tube member 12 to circulate the liquid 30 through the through hole 12a to move the implant 20 through the through hole 12a of the tube member 12. 18 and.

According to the implant placement device 10 described above, since the implant 20 is protected inside the tubular member 12, a tensile force acts on the implant 20 when the implant 20 is transported to the target site. It is possible to prevent the fine structure of the implant 20 from being damaged. In addition, since the implant 20 can be moved by the action of the liquid 30, the implant 20 can be easily placed. In addition, since a mechanism for transferring the implant 20 to the tube member 12 is not required, the tube member 12 can be made thinner, less invasive, and less burdensome to the patient.

In the implant placement device 10, the locking portion 26 of the implant 20 is formed in a mass having a diameter larger than that of the main body 28, and is in liquid-tight contact with the through hole 12a (internal space). good. As a result, the pressure of the liquid 30 by the moving mechanism 18 can be efficiently transmitted to the implant 20 , and the implant 20 can be reliably moved within the tubular member 12 .

In the implantable body placement device 10, the liquid 30 may be physiological saline or Ringer's solution. This allows the implant 20 to protrude from the tubular member 12 without imposing a burden on the living body.

In the implantable body retention device 10, the moving mechanism 18 may be a syringe. In this case, by operating the pusher 22, the flow of the liquid 30 can be easily controlled.

The implant placement device 10 may be provided with a hub main body 16 made of a transparent resin material that allows the proximal end 28b of the implant 20 to be visually recognized on the proximal end side of the tubular member 12 . As a result, the protruding state of the locking portion 26 of the implant 20 can be confirmed from the position of the base end portion 28b, and the implant 20 can be implanted more reliably.

The implant 20 of the present embodiment has a locking portion 26 formed in a mass and a main body portion 28 extending like a thread from the locking portion 26. Cells are attached to promote tissue regeneration. It is made of materials that have the ability. In this case, porous collagen fibers in which countless micropores are formed can be used as the material of the implant 20 . With such a configuration, the locking portion 26 can be locked to the target site of the subcutaneous tissue 92, and the implant 20 can be implanted accurately.

(Second embodiment)
As shown in FIG. 8, the implantable body retention device 10A of this embodiment has a tubular member 12A with a through hole 12b opening at an opening 12c on the side (peripheral surface), as shown in FIG. It differs from the implant placement device 10 . The hub main body 16 and the moving mechanism 18 other than the pipe member 12A are the same as those of the implantable body retention device 10 of FIG. do.

A through hole 12b extending in the axial direction is formed inside the tubular member 12A. The through-hole 12b opens toward the hollow portion 16a of the hub main body portion 16 on the base end side. Most of the through-hole 12b extends along the axis of the tubular member 12A from the proximal side to the vicinity of the distal end. The vicinity of the tip of the through-hole 12b curves toward the side of the tube member 12A, and opens at an opening 12c in the outer peripheral surface of the side near the tip of the tube member 12A. That is, the implant placement device 10A of the present embodiment is configured such that the implant 20 accommodated in the through hole 12b is pushed out from the outer peripheral surface of the side portion of the tubular member 12A.

A piercing portion 14A is formed at the distal end of the tube member 12A and has a conical shape whose diameter gradually decreases toward the center of the shaft toward the distal end. A sharp needle tip 14b is formed at the distal end of the puncture section 14A. The needle tip 14b is provided on an extension line of the shaft of the tubular member 12A.

The operation of the implantable body retention device 10A of the present embodiment will be described below together with the method of use.

As shown in FIG. 9A, the skin 90 is punctured by the puncture portion 14A of the tubular member 12A of the implantable body retention device 10A. Further, the tubular member 12A is pushed through the subcutaneous tissue 92 to move the opening 12c provided on the side of the tubular member 12A to the target site. The tube member 12A of the present embodiment has the needle tip 14b located on the axis of the tube member 12A, so that it is excellent in straightness when pushed forward.

After that, as shown in FIG. 9B, the pusher 22 of the moving mechanism 18 of the implantable body retention device 10A is pushed to push out the liquid 30 inside. As a result, the liquid 30 flows through the through hole 12b of the tube member 12A toward the distal end side, and the locking portion 26 of the implant 20 is pushed out toward the distal end side. Then, as illustrated, the locking portion 26 protrudes from the opening 12c of the through hole 12b. As a result, the locking portion 26 is caught in the subcutaneous tissue 92, thereby locking the distal end of the implant 20 at the target site.

After that, as shown in FIG. 10A, the implant placement device 10A is pulled out. As the tubular member 12A is pulled out from the subcutaneous tissue 92, the implant 20 is pulled out from the through hole 12b of the tubular member 12A, and the body portion 28 of the implant 20 is embedded in the subcutaneous tissue 92.

After that, as shown in FIG. 10B , the portion of the body portion 28 of the implant 20 protruding from the skin 90 is cut off by the cutting means 34 . The body part 28 slightly protruding from the skin 90 can be buried in the skin 90 by moving the skin 90 . As described above, the implantation of the implant 20 is completed.

The implantable body retention device 10A of this embodiment has the following effects.

In the implantable body retention device 10A of the present embodiment, the distal end side of the through hole 12b is curved to open at the opening 12c on the outer peripheral surface of the tubular member 12A. With such a configuration, when the tube member 12A is pushed forward in the subcutaneous tissue 92, it is possible to prevent the subcutaneous tissue 92 from clogging the through hole 12b and making it difficult to push out the implant 20.

Further, in the implant placement device 10A, the needle tip 14b of the puncture portion 14A of the tubular member 12A may be arranged on the axis of the tubular member 12A. As a result, when the puncture portion 14A is pushed into the subcutaneous tissue 92, it is less likely to be subjected to a drag in a direction inclined from the axial direction, and the straightness of the tubular member 12A is improved. Thereby, the pipe member 12A can be easily and accurately moved to the target site.

(Third Embodiment)
As shown in FIG. 11, in the implant placement device 10B of the present embodiment, an intermediate member 46 is attached between the hub body 16 and the moving mechanism 18, and a stopper 37 is provided at the proximal end. It differs from the implant placement device 10 in FIG. 1 in that it uses the implant 20A. In the implant placement device 10B, the same components as those of the implant placement device 10 of FIG. 1 are denoted by the same reference numerals, and detailed description thereof will be omitted.

The intermediate member 46 is a member formed in a substantially cylindrical shape, and is provided with a connecting portion 51 having an outer diameter substantially the same as that of the hollow portion 16 a of the hub main body portion 16 at its distal end side. The connecting portion 51 is inserted into the hollow portion 16a and joined in an airtight and liquid-tight manner. A shaft hole portion 46 a extending in the axial direction is formed inside the intermediate member 46 . A protruding portion 50 that protrudes in the inner peripheral direction is provided near the center in the axial direction of the shaft hole portion 46a. The projecting portion 50 is formed in an annular shape over the entire circumferential direction. A circular opening 50 a through which the liquid 30 can flow is formed on the inner peripheral side of the protrusion 50 . The protrusion 50 divides the shaft hole portion 46a into a distal side shaft hole portion 46a1 and a proximal side shaft hole portion 46a2.

The proximal side shaft hole portion 46a2 is open to the proximal side in the axial direction, and the moving mechanism 18 is inserted into the proximal end portion thereof. The moving mechanism 18 is in liquid-tight contact with the base end side shaft hole portion 46a2. A stopper 37 provided at the proximal end portion of the implant 20A is inserted into the proximal side shaft hole portion 46a2. The stopper 37 has a larger diameter than the center opening 50a of the protrusion 50 in order to prevent the implant 20A from protruding too much, and is configured not to move beyond the protrusion 50 toward the distal end. there is The outer diameter of the stopper 37 is formed smaller than the inner diameter of the proximal side shaft hole portion 46a2 so that the liquid 30 can flow between the stopper 37 and the proximal side shaft hole portion 46a2.

The body portion 28 extends from the stopper 37 of the implant 20A toward the distal end side of the distal end side shaft hole portion 46a1. A cutting blade 48 (cutting member) is provided in the distal end side shaft hole portion 46a1 so as to protrude from the side thereof toward the central axis. It is configured to cut the body portion 28 of the implant 20A when the cutting blade 48 is pushed toward the central axis.

The intermediate member 46 can be made of a transparent resin material so that the position of the stopper 37 can be visually recognized. Thus, the intermediate member 46 is configured so that the advance of the implant 20A can be visually confirmed through the position of the stopper 37. As shown in FIG.

The implant 20A of this embodiment includes a locking portion 26, a body portion 28 extending from the locking portion 26, and a stopper 37 provided at the proximal end portion of the body portion 28. As shown in FIG. The stopper 37 is formed in a size that can be locked to the protrusion 50 of the intermediate member 46 . The body portion 28 has a length that allows the locking portion 26 to protrude from the puncture portion 14 at the distal end of the tubular member 12 when the stopper 37 comes into contact with the projection portion 50 and stops.

Further, as shown in the figure, the shaft hole portion 46a of the intermediate member 46 and the hollow portion 16a of the hub main body portion 16 are preferably filled with the liquid 30 in advance.

The implantable body retention device 10B of the present embodiment is configured as described above, and the operation thereof will be described below.

As shown in FIG. 12, the implant placement device 10B is used by piercing the puncture portion 14 of the tubular member 12 through the skin 90 and pushing it through the subcutaneous tissue 92 to move the puncture portion 14 to the target site.

After that, as shown in the figure, the pusher 22 of the moving mechanism 18 is pushed in to allow the liquid 30 to flow through the through hole 12a of the tube member 12, thereby protruding the locking portion 26 of the implant 20A from the tube member 12. FIG. At this time, by confirming the advance of the stopper 37 of the implant 20A through the transparent intermediate member 46, it is possible to visually confirm that the implant 20A has advanced. As a result, the implant 20A can be implanted more reliably.

After that, the cutting blade 48 is pushed toward the center in the radial direction to cut the main body 28, thereby separating the stopper 37 from the implant 20A. After that, the tubular member 12 is pulled out from the skin 90, and the main body portion 28 projecting from the skin 90 is cut off to complete the implantation of the implant 20A.

The implantable body retention device 10B of this embodiment has the following effects.

The implant placement device 10B includes a stopper 37 to which the implant 20A is connected to the base end of the main body 28, is provided between the tube member 12 and the moving mechanism 18, and extends in the axial direction. A shaft hole portion 46a for accommodating the stopper 37 of the body 20A and the proximal end portion of the body portion 28, and a cutting blade 48 for cutting the body portion 28 in the shaft hole portion 46a to separate the stopper 37 from the implant body 20A. It further comprises an intermediate member 46 having a. In this case, the intermediate member 46 may be made of a transparent resin material. With this configuration, the advance of the implant 20A can be visually confirmed from the position of the stopper 37, and the implant 20A can be reliably implanted.

In the implant placement device 10B described above, a gap through which the liquid 30 flows may be provided between the base end side shaft hole portion 46a2 and the stopper 37. FIG. This allows the liquid 30 in the moving mechanism 18 to flow through the through hole 12 a of the tube member 12 via the intermediate member 46 .

(Fourth embodiment)
As shown in FIGS. 13A and 13B, when the implant placement device 10 is punctured into the subcutaneous tissue 92 and the tubular member 12 is pulled out leaving the implant 20, the implant 20 is in a meandering state. I can put it away. This is because, as shown in FIG. 13A, when the tubular member 12 is pulled out from the subcutaneous tissue 92, the boundary portion 94 becomes white due to frictional resistance between the tubular member 12 and the boundary portion 94 of the subcutaneous tissue 92. This is caused by pulling the pipe member 12 in the drawing direction as indicated by the drawing arrow. That is, when the tubular member 12 is completely withdrawn, the subcutaneous tissue 92 restores its original shape, as indicated by the white arrow in FIG. 13B. At that time, the boundary portion 94 shrinks and meanders. As a result, the embedded body 20 embedded along the boundary portion 94 also meanders. Such meandering of the implant 20 is likely to occur when the subcutaneous tissue 92 contains a large amount of soft fatty tissue.

Therefore, in this embodiment, an implant placement device 10C that can be implanted without meandering the implant 20 will be described. As shown in FIG. 14A, an implant placement device 10C of this embodiment includes a tubular member 12B that can be divided into two semicircular parts and a hub main body 16B.

The tube member 12B includes a first tube member 52 having a sharp needle tip 14a and a second tube member 54 arranged to face the first tube member 52 . Semicircular concave portions 52a and 54a extending in the axial direction are formed inside the first pipe member 52 and the second pipe member 54, respectively. The first pipe member 52 and the second pipe member 54 are in contact with each other at the contact portion 12d to form a cylindrical pipe member 12B. . The first pipe member 52 and the second pipe member 54 are temporarily fixed with an adhesive or the like so that the liquid 30 does not leak from the through hole 12a.

The proximal end portions of the first pipe member 52 and the second pipe member 54 are joined to the hub body portion 16B. As shown in FIG. 14B, the hub main body 16B of the present embodiment is provided with a pair of groove-shaped recesses 60. As shown in FIG. The pair of recesses 60 are provided facing each other across the shaft, and are formed at the same position in the circumferential direction as the contact portion 12d of the pipe member 12B. The recess 60 can be easily torn off to separate the hub body 16B into semicircular pieces. That is, when the hub main body portion 16B is torn at the recess 60, the hub main body portion 16B is separated into the first hub member 56 and the second hub member 58. As shown in FIG. The first tube member 52 is joined to the first hub member 56 , and the second tube member 54 is joined to the second hub member 58 . Therefore, the second hub member 58 and the second pipe member 54 can be separated from the first hub member 56 and the first pipe member 52 by tearing the hub body portion 16B.

In the implant body placement device 10C, the implant body 20 and the moving mechanism 18 are the same as those of the implant placement device 10 of FIG. 1, so description thereof will be omitted. In the above description, an example in which the pipe member 12B and the hub main body 16B are divided into two with a semicircular cross section has been described. It may be configured to be divided into a plurality of parts.

The implantable body retention device 10C of the present embodiment is configured as described above, and the operation thereof will be described below together with the method of use.

As shown in FIG. 15A, the implant placement device 10C punctures the tubular member 12B into the subcutaneous tissue 92 until the locking portion 26 of the implant 20 protrudes from the punctured portion 14 of the tubular member 12B. The operation is the same as that of the implant placement device 10 .

As shown in FIG. 15A, in the implantable body retention device 10C of the present embodiment, the operation of pulling out the tubular member 12B from the subcutaneous tissue 92 is performed as follows. First, the moving mechanism 18 is removed from the hub body 16B. Then, it is torn at the recessed portion 60 of the hub main body portion 16B. Thereafter, as shown in FIG. 15B, the second hub member 58 and second tubular member 54 (see FIG. 14A) are axially proximally removed while leaving the first hub member 56 and first tubular member 52 in place. pull to the side.

When pulling out the second tube member 54 , a frictional force acts between the second tube member 54 and the subcutaneous tissue 92 , and a pulling force acts on the subcutaneous tissue 92 . However, in the implantable body retention device 10C of the present embodiment, the other first tubular member 52 remains in the subcutaneous tissue 92, and this first tubular member 52 prevents the subcutaneous tissue 92 from extending. Then, as shown in the drawing, half of the body portion 28 of the implant 20 is exposed, and the body portion 28 and the subcutaneous tissue 92 are in close contact.

Next, the first hub member 56 and the first tube member 52 are pulled out. In this case, the subcutaneous tissue 92 is stretched by the frictional force between the first tubular member 52 and the subcutaneous tissue 92 , but the main body portion 28 of the implant 20 already in close contact with the subcutaneous tissue 92 is also stretched by the subcutaneous tissue 92 . extend together with Therefore, even if the subcutaneous tissue 92 restores its original shape after the first tubular member 52 is completely pulled out, the implant 20 does not meander and returns to its original linear shape. Thus, according to the implant placement device 10C of the present embodiment, the implant 20 can be implanted without meandering.

The implantable body retention device 10C of this embodiment has the following effects.

In the implant placement device 10C, the tubular member 12B is divided into a plurality of parts in the circumferential direction, and each part (the first tubular member 52 and the second tubular member 54) of the divided tubular member 12B can be removed separately. , at least one divided pipe member 12B is configured to be axially movable. As a result, when the implant 20 first adheres to the subcutaneous tissue 92 , the remaining portion of the first tube member 52 can prevent the subcutaneous tissue 92 from stretching. As a result, even if the subcutaneous tissue 92 is stretched when the first tubular member 52 is subsequently removed, the implant 20 extends following the subcutaneous tissue 92, and the implant 20 can be prevented from meandering.

(Fifth embodiment)
As shown in FIG. 16, the implant placement device 10D of this embodiment includes a tubular member 12C configured to be split in the circumferential direction, and a hub main body 16B. In the implant placement device 10D, the implant 20 and the moving mechanism 18 are the same as those of the implant placement device 10 shown in FIG. 1, so description thereof will be omitted.

12 C of pipe members of this embodiment are divided|segmented into the circumferential direction by the base end side rather than the puncture part 14 comprised by the inclined surface. That is, the tube member 12C includes a first member 62 having the puncture portion 14 and the needle tip 14a, and a second member 64 arranged to face the first member 62. As shown in FIG. The first member 62 has a tip tube member 12e on the puncture part 14 side, and is formed over the entire circumference of the tip tube member 12e. A portion of the first member 62 closer to the proximal end than the tip tube member 12e is formed as a notch portion 12f in which a half circumference portion is notched.

The second member 64 is formed in a semicircular shape and arranged to cover the notch 12f. As shown in FIG. 17, the distal end of the second member 64 is formed with an engaging portion 64b having a diameter smaller than that of the proximal end. By engaging with the inner peripheral side of the tip tube member 12e, the first member 62 and the second member 64 are integrally connected in the circumferential direction. As shown, when the second member 64 is pulled out proximally, the engaging portion 64b is disengaged from the distal tube member 12e, and the first member 62 and the second member 64 can be separated.

As shown in FIG. 16, a hub body portion 16B is provided on the base end side of the tubular member 12C. Hub body portion 16B is similar to hub body portion 16B described with reference to FIGS. 14A and 14B, and is torn along groove-shaped recesses 60 to separate first hub member 56 and second hub member 58. is configured to be divisible into In this embodiment, a first member 62 is joined to the first hub member 56 and a second member 64 is joined to the second hub member 58 . Therefore, by tearing the hub body portion 16B, it is divided in the circumferential direction into a portion where the first hub member 56 and the first member 62 are integrated and a portion where the second hub member 58 and the second member 64 are integrated. configured as possible.

The implantable body retention device 10D of this embodiment is configured as described above, and the operation thereof will be described below.

As shown in FIG. 18A, before pulling out the tube member 12C, the implant placement device 10D tears the hub main body 16B (see FIG. 16) to separate the first hub member 56 and the first member 62 and the second hub member 56 and the second member 62 from each other. The hub member 58 and the second member 64 are split. Thereafter, the second hub member 58 and the second member 64 are withdrawn axially to remove the second member 64 from the subcutaneous tissue 92 .

Since the first member 62 remains when the second member 64 is removed, the extension of the subcutaneous tissue 92 can be prevented. When the second member 64 is removed, the implant 20 is exposed and fixed in close contact with the boundary portion 94 of the subcutaneous tissue 92 as indicated by the solid line arrow. However, since the tip tube member 12e receives pressure from the subcutaneous tissue 92 as indicated by the white arrow, the subcutaneous tissue 92 is kept apart from the implant 20. FIG. That is, the implant 20 is in an unfixed state at the tip tube member 12e.

Next, as shown in FIG. 18B, an operation is performed to pull the first member 62 toward the base end side and pull out the first member 62 . In this case, the implant 20 is separated from the boundary portion 94 of the subcutaneous tissue 92 at the portion indicated by the white arrow, but remains fixed to the subcutaneous tissue 92 at the other portions. As the first member 62 is pulled out, the subcutaneous tissue 92 is stretched, and the implant 20 is extended following the extension of the subcutaneous tissue 92 . Also, at this time, by providing a part of the implant 20 separated from the subcutaneous tissue 92, the stress between the subcutaneous tissue 92 and the implant 20 can be alleviated, and the embedding can be performed more smoothly. Body 20 can be secured within subcutaneous tissue 92 .

The implantable body retention device 10D of this embodiment has the following effects.

In the implant placement device 10D, the tube member 12C includes a first member 62 having the needle tip 14a and a second member 64 separable from the first member 62. The second member 64 is the first member. The needle tip 14a of 62 is configured to be separable from the first member 62 on the proximal end side of the puncture portion 14 (inclined surface). As a result, the implant 20 and the subcutaneous tissue 92 can be partially separated when the first member 62 is pulled out, and the stress between the subcutaneous tissue 92 and the implant 20 can be relieved. The implant 20 can be snugly locked into the subcutaneous tissue 92 . As a result, it is possible to more effectively prevent deformation of the implant 20 after the tubular member 12C is pulled out.

(Sixth embodiment)
As shown in FIG. 19A, an implant placement device 10E of this embodiment differs from the implant placement device 10 of FIG. In addition, in the implant placement device 10E, the same components as those of the implant placement device 10 are denoted by the same reference numerals, and detailed description thereof will be omitted.

As shown in FIG. 19B, the outer tube member 70 is a cylindrical member elongated in the axial direction, and has an insertion hole 70a formed therein. As shown in FIG. 19A, the insertion hole 70a has an inner diameter through which the pipe member 12 can be inserted. In the illustrated example, a gap is formed between the insertion hole 70a and the pipe member 12, but it is not always necessary to provide the gap. good too.

The outer tubular member 70 extends along the tubular member 12 to the vicinity of the puncture portion 14 of the tubular member 12 and is configured to be punctured into the subcutaneous tissue 92 of the living body together with the tubular member 12 . The tip of the outer tube member 70 is provided with a tapered portion 74 whose diameter decreases toward the tip in order to reduce resistance during puncture.

A hub portion 72 for manipulating the outer tubular member 70 is provided on the proximal end side of the outer tubular member 70 . The hub portion 72 is formed to have an outer diameter that is easy to hold by hand. The distal end side of the outer tubular member 70 can be made of metal such as stainless steel, and the base end side hub portion 72 can be made of resin, for example.

The implantable body retention device 10E of the present embodiment punctures the subcutaneous tissue 92 of the living body together with the tubular member 12 while the outer tubular member 70 is attached. Then, the implant 20 housed inside the tube member 12 is pushed out by the action of the liquid 30 of the moving mechanism 18 . After that, the inner pipe member 12 is pulled out first.

In this embodiment, since most of the outer peripheral portion of the tubular member 12 is covered with the outer tubular member 70, even if the tubular member 12 is pulled out, the subcutaneous tissue 92 is not pulled. Therefore, the tube member 12 is pulled out and the implant 20 is left in a state in which the subcutaneous tissue 92 does not extend. When the tubular member 12 is pulled out, the implant 20 is exposed and fixed to the subcutaneous tissue 92 at the opening 70 b of the outer tubular member 70 .

After that, the outer tubular member 70 is removed. In this case, the implant 20 is pulled out while being separated from the subcutaneous tissue 92 at the frame portion 74a on the distal end side of the opening 70b of the outer tubular member 70 . As a result, the stress between the implant 20 and the subcutaneous tissue 92 is relieved when the implant 20 is pulled out from the subcutaneous tissue 92 , so that the implant 20 can be comfortably embedded in the subcutaneous tissue 92 .

The implantable body retention device 10E of this embodiment has the following effects.

The implant placement device 10E includes a tubular tubular member 12 that houses the implant 20, and an outer tubular member 70 that covers the outer periphery of the tubular member 12 and has an opening 70b on the side. In addition, the tubular member 12 is configured to be removable prior to the outer tubular member 70 . Thereby, meandering of the implant 20 in the subcutaneous tissue 92 can be prevented. Moreover, the stress between the implant 20 and the subcutaneous tissue 92 is relieved, and the implant 20 can be embedded in the subcutaneous tissue 92 with good familiarity.

(Seventh embodiment)
As shown in FIG. 20, in the implant placement device 10F of the present embodiment, the hub body portion 16D is made of a transparent resin material, and the body portion 28 of the implant body 20 arranged therein is based on the hub body portion 16D. The end portion 28b is configured to be visible. Further, the hub body portion 16D is provided with a scale portion 76 so that the displacement of the implant 20 can be visually confirmed.

According to the implant placement device 10F of the present embodiment, the proximal end of the tubular member 12 is provided with the hub main body 16D made of a transparent resin material through which the proximal end of the implant 20 can be visually recognized. This allows visual confirmation of advancement or retraction of the implant 20 through the proximal end of the implant 20 .

According to the implant placement device 10F of the present embodiment, the displacement of the implant 20 can be visually confirmed by the scale portion 76 of the hub body portion 16D, and the displacement of the implant 20 can be visually confirmed from the position of the base end portion 28b. The position of the engaging portion 26 of 20 can be confirmed more accurately. Thereby, the implanting operation of the implant 20 can be performed accurately.

(Eighth embodiment)
As shown in FIG. 21, the implantable body retention device 10G of this embodiment is provided with a marker member 78 near the distal end of the tubular member 12. As shown in FIG. The marker member 78 is annularly provided all around the axis of the pipe member 12 . The marker member 78 contains a confirming substance that produces a clear image in a means for imaging the inside of the living body by seeing through it.

For example, when the imaging means is an ultrasonic imaging device, the marker member 78 can be configured to contain air bubbles (air) or metal. Further, for example, when the imaging means is an X-ray imaging device, the marker member 78 can be configured including a metal or a material with a large atomic number such as barium sulfate. Moreover, when the imaging means is a near-infrared imaging device, the marker member 78 can be configured to contain metal. Alternatively, the marker member 78 may be made of a fluorescent substance so that fluorescence is generated by irradiating the skin with ultraviolet light so that the marker member 78 can be directly visually recognized.

The implantable body retention device 10G of this embodiment is provided with a marker member 78 that indicates the position at the distal end of the tubular member 12 . As a result, the position of the tubular member 12 can be confirmed through the marker member 78, so that the puncture of the tubular member 12 can be performed more accurately.

(Ninth embodiment)
As shown in FIG. 22, in the implantable body retention device 10H of this embodiment, the outer peripheral portion of the tubular member 12 is coated with an antibacterial substance 80. As shown in FIG. Other configurations are the same as those of the implantable body retention device 10 of FIG. In addition, in the implantable body indwelling device 10H of the present embodiment, the liquid 30 may contain the antibacterial substance 80 . Alternatively, the antibacterial substance 80 may be adhered to the porous portion of the porous collagen fibers forming the implant 20 .

According to the implant placement device 10H of the present embodiment, it is possible to prevent bacterial infection during and after placement of the implant 20 .

(Tenth embodiment)
As shown in FIG. 23, the implant placement device 10I of the present embodiment has a structure in which a hub body portion 82 provided on the proximal end side of the tubular member 12 is integrated with a moving mechanism. That is, the hub main body portion 82 has the gasket 24A inserted into the internal hollow portion 82a. Among the hollow portions 82a, the hollow portion 82a formed on the distal end side of the gasket 24A is filled with the liquid 30 for moving the implant 20. As shown in FIG. A pusher 22A is provided on the base end side of the gasket 24A, and the liquid 30 can be circulated through the through hole 12a of the tube member 12 by pushing the pusher 22A toward the tip side.

According to the implantable body retention device 10I of the present embodiment, the hub main body 82 also serves as the moving mechanism, thereby simplifying the configuration of the device.

(Eleventh embodiment)
Various forms of the implant 20 will be described in this embodiment.

An implant 20B according to the first aspect of the eleventh embodiment shown in FIG. 24A has a main body 28A made of porous collagen fibers mixed with an anticancer agent. Such an implant 20B is assumed to be used, for example, for lymphatic regeneration in cancer patients. As part of cancer therapy, lymphatic vessels are removed to prevent metastasis. The implant 20B of the present embodiment can be suitably used for regeneration of such lymph vessels. The implant 20B of the present embodiment can prevent cancer cells from metastasizing to regenerated lymphatic vessels.

The anticancer drug to be mixed in the implant 20B may be encapsulated in microcapsules. In this case, the anticancer drug component may be gradually released after the regeneration of the lymphatic vessel. As a result, the effect of preventing metastasis of cancer cells to lymphatic vessels can be obtained over a long period of time.

Further, as shown in this embodiment, the locking portion 26 may not be provided on the implant 20B. Even if the main body portion 28A has a sufficient length and is in close contact with the subcutaneous tissue, the locking effect necessary for placement of the implant 20B may be obtained.

In an implant 20C according to the second aspect of the eleventh embodiment shown in FIG. 24B, a thread-like marking member 84 (position confirming portion) is joined to the side portion of the main body portion 28B. The marking member 84 contains a confirming substance that produces a clear image in a means for imaging the inside of the living body by seeing through it.

As the confirming substance, in the case of an ultrasonic imaging device, air bubbles, metal, or the like can be used. Also, for X-ray imaging devices, metals or materials with high atomic numbers such as barium sulfate can be used. Furthermore, when the skin surface is irradiated with ultraviolet light from an ultraviolet irradiation device and directly viewed from above the skin, a fluorescent substance can be used as the substance for confirmation. Moreover, when using a near-infrared imaging device that irradiates near-infrared rays and sees through the inside of a living body, for example, a metal can be used as the confirming substance.

According to the implant 20C of this embodiment, the position of the implant 20C can be directly confirmed by the marking member 84, so that the implant 20C can be placed at a desired position with high accuracy. In the implant 20C, instead of arranging the marking member 84 parallel to the body portion 28, the confirmation substance contained in the marking member 84 may be mixed into the body portion 28B.

An implant 20D according to the third aspect of the eleventh embodiment shown in FIG. The implant 20D of this embodiment also provides the same effect as the implant 20C of FIG. 24B.

In an implant 20E according to the fourth aspect of the eleventh embodiment shown in FIG. 24D, a plurality of marking members 86 are provided on the main body 28 at predetermined intervals. The implant 20E of this embodiment also provides the same effect as the implant 20C of FIG. 24B.

In an implant 20F according to the fifth aspect of the eleventh embodiment shown in FIG. 24E, a locking portion 88 contains a confirming substance and constitutes a marking member. The implant 20F of this embodiment also provides the same effect as the implant 20C of FIG. 24B.

Although the preferred embodiments of the present invention have been described above, the present invention is not limited to the above embodiments, and it goes without saying that various modifications can be made without departing from the scope of the present invention. stomach.

Reference Signs List 10, 10A, 10B, 10C, 10D, 10E, 10F, 10G, 10H, 10I... Implantable body indwelling device 12, 12A, 12B, 12C... Tube member 12a, 12b... Through hole 14... Puncture part 14a... Needle point 16 , 16B, 16D, 82... Hub body 18... Moving mechanism 20, 20A, 20B, 20C, 20D, 20E, 20F... Implant 30... Liquid

Claims (9)

a tubular member having an inner space extending in the axial direction and having a piercing portion formed at the distal end thereof so as to be able to pierce the subcutaneous tissue;
It has a locking portion formed at the distal end with a diameter approximately equal to the inner diameter of the internal space, and a main body portion extending like a thread from the locking portion toward the base end side, and tissue regeneration is performed by adhesion of cells. an implant made of a material capable of promoting
a moving mechanism connected to the proximal end of the tubular member for circulating a liquid in the internal space to move the implant in the internal space of the tubular member ;
The implant has a stopper connected to the proximal end of the main body,
a shaft hole provided between the tube member and the moving mechanism for accommodating the stopper of the implant body and the proximal end of the main body; and a cutting member for separating the stopper from the implant. 2. The implant placement device according to claim 1, wherein said anchoring portion of said implant is formed in a mass having a larger diameter than said main body, and is in liquid-tight contact with said internal space. There is an implanted body placement device. 3. The implantable body placement device according to claim 1 or 2, wherein the distal end side of the internal space is bent to open to the outer peripheral surface of the tubular member. The implant placement device according to any one of claims 1 to 3 , wherein the tubular member is divided into a plurality of parts in the circumferential direction, and each part of the divided tubular member can be removed separately. and wherein at least one of the plurality of divided tubular members is movable in the axial direction. The implant placement device according to any one of claims 1 to 4 , wherein the tubular member comprises a tubular member that houses the implant, a tubular member that covers the outer periphery of the tubular member, and a and an outer tubular member provided with an opening, wherein the tubular member is configured to be removable prior to the outer tubular member. The implant placement device according to any one of claims 1 to 5 , wherein the main body of the implant is reinforced with a material that is biodegradable and has lower stretchability than the main body. Implantable body placement device. The implant placement device according to any one of claims 1 to 6 , wherein the implant is detected by any one of an ultrasonic imaging device, an X-ray imaging device, an ultraviolet irradiation device, and a near-infrared imaging device. An implantable body retention device having a position confirming part capable of confirming a retention position. The implantable placement device according to any one of claims 1 to 7 , wherein the outer surface of said tubular member is coated with an antibacterial substance. The implantable placement device according to any one of claims 1 to 8 , wherein said liquid or said implant contains at least one of an antibacterial substance and an anticancer drug.

Images